基本信息
袁莉 女 博导 生命科学学院
电子邮件：yuanli@gucas.ac.cn
通信地址：北京玉泉路19号甲
邮政编码：
电子邮件：yuanli@gucas.ac.cn
通信地址：北京玉泉路19号甲
邮政编码：
招生信息
招生专业
071010-生物化学与分子生物学
071008-发育生物学
071008-发育生物学
招生方向
哺乳动物的遗传与发育
发育中的信号传导
发育中的信号传导
教育背景
1995-01--2000-04 瑞典卡罗林斯卡研究院 博士生
学历
-- 研究生
学位
-- 博士
工作经历
工作简历
2009-07--今 中国科学院研究生院生命科学学院 教授，博士生导师
2004-01--2009-06 瑞典卡罗林斯卡研究院细胞分子生物学系 Principal Investigator
2004-01--2009-06 瑞典卡罗林斯卡研究院细胞分子生物学系 Principal Investigator
教授课程
发育生物学、 文献阅读课、 发育生物学及模式动物前沿问题讨论班、 模式动物、 发育生物学前沿问题讨论班
出版信息
Selected Publications
Fang G, Zhang D, Yin H, Zheng L, Bi X, Yuan L.Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.J Cell Sci 2014 127:1631-1639
Guan J, Kinoshita M and Yuan L*. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. BMC Dev Biol. 2009 Mar 19;9(1):23. [Epub ahead of print]
Guan J, Ekwurtzel E, Kvist U and Yuan L*. Cohesin protein SMC1 is a centrosomal protein. Biochem Biophys Res Commun. 2008, 372:761-4.
Hoja MR, Liu JG, Mohammadieh M, Kvist U and Yuan L*.
E2F1 deficiency impairs murine spermatogenesis and augments testicular degeneration in SCP3-nullizygous mice.
Cell Death Differ. 2004; 11:354-356
Yuan L, Liu JG, Hoja MR, Wilbertz J, Nordqvist K, Hoog C. Female germ cell
aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science. 2002; 296:1115-8
Fang G, Zhang D, Yin H, Zheng L, Bi X, Yuan L.Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.J Cell Sci 2014 127:1631-1639
Guan J, Kinoshita M and Yuan L*. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. BMC Dev Biol. 2009 Mar 19;9(1):23. [Epub ahead of print]
Guan J, Ekwurtzel E, Kvist U and Yuan L*. Cohesin protein SMC1 is a centrosomal protein. Biochem Biophys Res Commun. 2008, 372:761-4.
Hoja MR, Liu JG, Mohammadieh M, Kvist U and Yuan L*.
E2F1 deficiency impairs murine spermatogenesis and augments testicular degeneration in SCP3-nullizygous mice.
Cell Death Differ. 2004; 11:354-356
Yuan L, Liu JG, Hoja MR, Wilbertz J, Nordqvist K, Hoog C. Female germ cell
aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science. 2002; 296:1115-8
发表论文
[1] Yang Ling, Zhang Ying, Yuan Li. Loss of a Centrosomal Protein, Centlein, Promotes Cell Cycle Progression. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2019, 第 3 作者 通讯作者 46(7): 689-698, [2] Yongliang Shang, Jie Yan, Wenhao Tang, Chao Liu, Sai Xiao, Yueshuai Guo, Li Yuan, Liang Chen, Hui Jiang, Xuejiang Guo, Jie Qiao, Wei Li. Mechanistic insights into acephalic spermatozoa syndrome–associated mutations in the human SUN5 gene. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2018, 293(7): 2395-2407, http://dx.doi.org/10.1074/jbc.RA117.000861.[3] Shang, Yongliang, Zhu, Fuxi, Wang, Lina, Ouyang, YingChun, Dong, MingZhe, Liu, Chao, Zhao, Haichao, Cui, Xiuhong, Ma, Dongyuan, Zhang, Zhiguo, Yang, Xiaoyu, Guo, Yueshuai, Liu, Feng, Yuan, Li, Gao, Fei, Guo, Xuejiang, Sun, QingYuan, Cao, Yunxia, Li, Wei. Essential role for SUN5 in anchoring sperm head to the tail. ELIFE[J]. 2017, 第 14 作者6: https://doaj.org/article/69cbd51f21454f31b2adf8f2316beff1.[4] Kong, Lingjun, Yin, Huilong, Yuan, Li. Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 3 作者 通讯作者 489(4): 497-502, [5] Gao Xuan, Wang Youxin, Lang Minglin, Yuan Li, Reece Albert Stuart, Wang Wei. Contribution of Genetic Polymorphisms and Haplotypes in DRD2 , BDNF , and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. OMICS: A JOURNAL OF INTEGRATIVE BIOLOGY[J]. 2017, 第 4 作者[6] Yin Huilong, Zheng Lu, Liu Weixiao, Zhang Dachuan, Li Wei, Yuan Li. Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion. BBA - MOLECULAR CELL RESEARCH[J]. 2017, 第 6 作者1864(4): 645-654, http://dx.doi.org/10.1016/j.bbamcr.2017.01.007.[7] Jing, Zhenli, Yin, Huilong, Wang, Pan, Gao, Juntao, Yuan, Li. Centlein, a novel microtubule-associated protein stabilizing microtubules and involved in neurite formation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 第 5 作者 通讯作者 472(2): 360-365, https://www.webofscience.com/wos/woscc/full-record/WOS:000373251300011.[8] YUAN LI. Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertilit. American Journal of Human Genetics. 2016, 第 1 作者[9] Lai, Qingxuan, Wang, Ting, Guo, Qingqing, Zhang, Yuxiang, Wang, Youxin, Yuan, Li, Ling, Rui, He, Yan, Wang, Wei. Positive correlation between the expression of hEag1 and HIF-1 alpha in breast cancers: an observational study. BMJ OPEN[J]. 2014, 第 6 作者4(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000336976900044.[10] Fang, Guoliang, Zhang, Dachuan, Yin, Huilong, Zheng, Lu, Bi, Xiaolin, Yuan, Li. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. JOURNAL OF CELL SCIENCE[J]. 2014, 第 6 作者127(8): 1631-1639, http://ir.ihep.ac.cn/handle/311005/225070.[11] 尹会龙, 袁莉. GST-β-catenin-His双标签融合蛋白的原核表达、纯化及鉴定. 中国科学院研究生院学报[J]. 2012, 29(6): 847-852, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4678328&detailType=1.
科研活动
指导学生
现指导学生
房国梁 博士研究生 071007-遗传学
来庆璇 博士研究生 071007-遗传学
张大川 博士研究生 071007-遗传学
高璇 博士研究生 071007-遗传学
景珍丽 硕士研究生 071007-遗传学
尹会龙 博士研究生 071007-遗传学
汪俊彦 硕士研究生 085238-生物工程
郑璐 博士研究生 071010-生物化学与分子生物学
孔令军 硕士研究生 071010-生物化学与分子生物学