膜蛋白（离子通道）的结构功能及其天然药物研究

   

100706-药理学
100701-药物化学
071010-生物化学与分子生物学

离子通道天然活性分子的发现、机理及成药性研究
离子通道结构功能研究

2009-05--2010-04   美国伊利诺伊斯大学芝加哥分校   访问学生
2005-09--2011-01   中国科学院昆明植物研究所   博士学位
2001-09--2005-07   广东中山大学   学士学位

博士研究生

理学博士；专业：药物化学

2024-02~现在, 中国科学院昆明植物研究所, 研究员（专题组组长）
2020-07~2024-02,中国科学院昆明植物研究所, 副研究员（专题组组长）
2019-01~2020-06,中国科学院昆明动物研究所, 副研究员
2016-03~2017-03,美国贝勒医学院, 博士后
2013-11~2018-12,中国科学院昆明动物研究所, 助理研究员
2011-05~2013-10,云南生物谷灯盏花花药业有限公司和中国科学院昆明植物研究所, 企业联合培养博士后

2023-12-01-2028-11-30,沈阳药科大学硕士研究生联合培养导师, 硕士生导师
2021-12-31-今,SCI期刊Natural Products and Bioprospecting青年编委, 论文审稿

   

（ 1 ） 环维黄杨星D在制药中的应用, 发明专利, 2025, 第 1 作者, 专利号: ZL202211579148.6.

（ 2 ） 黄杨生物碱Buxusemine H和Buxusemine L 在制药中的应用, 发明专利, 2025, 第 1 作者, 专利号: ZL202311495241.3

（ 3 ） 酰基间苯三酚类衍生物及其药物组合物和应用, 发明专利, 2020, 第 2 作者, 专利号: CN111170967A

（ 4 ） 去芳化异戊烯基酰基间苯三酚类衍生物及其药物组合物和应用, 发明专利, 2020, 第 2 作者, 专利号: CN111056935A

（ 5 ） 石松生物碱lycoplanineA及其药物组合物与其制备方法和应用, 专利授权, 2017, 第 4 作者, 专利号: CN107365316A

（ 6 ） 蜘蛛香环烯醚萜部位在制备N-型钙通道抑制剂中的应用, 发明专利, 2015, 第 3 作者, 专利号: CN104721180A

（ 7 ） 去芳化异戊烯基酰化间苯三酚杂萜类化合物及其药物组合物和应用, 发明专利, 2020, 第 2 作者, 专利号: CN111233886A

   

[1] Ding Dong, Shuqin Quan, Mingkun Wu, Shuzong Du, Hui Yan, Ye Gong, Minghua Qiu, Xingrong Peng, Yin Nian. Ganomycin C, a Ganoderma Meroterpenoid, Alleviates Pain and Absence Seizures in Mice by Targeting Cav3.1 and Cav3.2 Low-Voltage-Gated Calcium Channels. Phytotherapy Research[J]. 2025, 第 9 作者  通讯作者  null(null): https://onlinelibrary.wiley.com/doi/10.1002/ptr.8486.
[2] Hu Yali, Dong Ding, Zhao Jianjun, Hu Kun , Kong Lingmei, Hu Yunxia, Li Xingren, Li Songyu, Nian Yin, Xu Gang. 5-Methylated Polyprenylated Acylphloroglucinols Derivatives as Low-Voltage-Gated Ca2+ Channels Inhibitors. Organic Chemistry Frontiers[J]. 2025, 第 9 作者  通讯作者  null(null): 
[3] Gong Ye, Liu Rui, Zha Hongjing, Dong Ding, Lu Nihong, Yan Hui, Wan Luosheng, Nian, Yin. Analgesic Buxus alkaloids with enhanced selectivity for the low voltage-gated calcium channel Cav3.2 over Cav3.1 through a new binding mode.. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2024, 第 8 作者  通讯作者  63(1): e202313461, https://onlinelibrary.wiley.com/doi/10.1002/anie.202313461.
[4] Zhao Jianjun, Du Shuzong, Hu Kun, Hu Yali, Xia Fan, Ye Yansong, Yang Jian, Nian Yin, Xu Gang. Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides. CHINESE CHEMICAL LETTERS[J]. 2023, 第 8 作者  通讯作者  34(4): 107737, http://dx.doi.org/10.1016/j.cclet.2022.08.017.
[5] Ye YanSong, Liu Rui, Jiang NaNa, Li SongYu, Nian Yin, Xu Gang. Caged polycyclic polyprenylated acylphloroglucinols as Ca(v)3.2 low voltage-gated Ca2+ channel inhibitors from Hypericum curvisepalum. CHEMICAL COMMUNICATIONS[J]. 2022, 第 5 作者  通讯作者  58(94): 13135-13138, http://dx.doi.org/10.1039/d2cc05396a.
[6] Xia Fan, Du Shuzong, Wu Mingkun, Liu Rui, Ye Yansong, Yang Jian, Xu Gang, Nian Yin. Icetexane diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and analgesic effect of their Semi-synthesized derivatives. BIOORGANIC CHEMISTRY[J]. 2022, 第 8 作者  通讯作者  128: http://dx.doi.org/10.1016/j.bioorg.2022.106059.
[7] Su Deyuan, Gong Ye, Li Songyu, Yang Jian, Nian Yin. Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels. FRONTIERS IN PHARMACOLOGY[J]. 2022, 第 5 作者  通讯作者  13: http://dx.doi.org/10.3389/fphar.2022.1081697.
[8] Hu Guilin, Dong Ding, Du Shuzong, Peng Xingrong, Wu Mingkun, Shi Qiangqiang, Hu Kun, Hong Defu, Wang Xiaoyuan, Zhou Lin, Nian Yin, Qiu Minghua. Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel. FOOD CHEMISTRY[J]. 2022, 第 11 作者  通讯作者  376: http://dx.doi.org/10.1016/j.foodchem.2021.131923.
[9] Xia Fan, Du Shuzong, Wu Mingkun, Liu Rui, Ye Yansong, Yang Jian, Xu Gang, Nian Yin. Icetexane Diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and Analgesic Effect of Their Semi-synthesized Derivatives. BIOORGANIC CHEMISTRY[J]. 2022, 第 8 作者  通讯作者  http://dx.doi.org/10.1016/j.bioorg.2022.106059.
[10] Hu, GuiLin, Peng, XingRong, Gao, Ya, Wang, XiaoYuan, Hong, DeFu, Nian, Yin, Qiu, MingHua. New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase. FOOD CHEMISTRY[J]. 2021, 第 6 作者  通讯作者  345(null): http://dx.doi.org/10.1016/j.foodchem.2020.128823.
[11] Zhan, Rui, Du, ShuZong, Duan, ZhiHang, Nian, Yin, Chen, YeGao. Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris. TETRAHEDRON LETTERS[J]. 2020, 第 4 作者  通讯作者  61(1): http://dx.doi.org/10.1016/j.tetlet.2019.151354.
[12] Wang Lie, Qian Hongwu, Nian Yin, Han Yimo, Ren Zhenning, Zhang Hanzhi, Hu Liya, Prasad, B V Venkataram, Laganowsky, Arthur, Yan Nieng, Zhou Ming. Structure and mechanism of human diacylglycerol O-acyltransferase 1. NATURE[J]. 2020, 第 3 作者581(7808): 329-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255049/.
[13] Ye, YanSong, Li, WenYan, Du, ShuZong, Yang, Jian, Nian, Yin, Xu, Gang. Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 第 5 作者  通讯作者  63(4): 1709-1716, https://www.webofscience.com/wos/woscc/full-record/WOS:000517673100018.
[14] Ye, YanSong, Du, ShuZong, Jiang, NaNa, Xu, HongXi, Yang, Jian, Fu, WenWei, Nian, Yin, Xu, Gang. Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors. ORGANIC LETTERS[J]. 2020, 第 7 作者  通讯作者  22(16): 6339-6343, http://dx.doi.org/10.1021/acs.orglett.0c02170.
[15] Jiang, NaNa, Du, ShuZong, Ye, YanSong, Yan, Hui, Yang, XingWei, Yang, Jian, Nian, Yin, Xu, Gang. Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Ca(v)3.1 T-type calcium channel inhibitor from Hypericum henryi. TETRAHEDRON LETTERS[J]. 2019, 第 7 作者  通讯作者  60(45): https://www.webofscience.com/wos/woscc/full-record/WOS:000495490500006.
[16] Xia, Fan, Li, WenYan, Yang, XingWei, Yang, Jian, Li, Xian, Nian, Yin, Xu, Gang. Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii. ORGANIC LETTERS[J]. 2019, 第 6 作者  通讯作者  21(14): 5670-5674, https://www.webofscience.com/wos/woscc/full-record/WOS:000476957200062.
[17] Zhou, Jun, Dong, Fa-Wu, Jiang, He-Hai, Yang, Liu, Gong, Ye, Zi, Cheng-Ting, Yang, Dan, Ye, Chen-Jun, Li, Huan, Yang, Jian, Nian, Yin, Hu, Jiang-Miao. Valepotriates From the Roots and Rhizomes of Valeriana jatamansi Jones as Novel N-Type Calcium Channel Antagonists. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2018, 第 11 作者222: 208-216, http://www.irgrid.ac.cn/handle/1471x/1781692.
[18] Nian, Yin, Lu, NiHong, Liu, XiaoLing, Li, DaShan, Zhou, Lin, Qiu, MingHua. Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis. RSCADVANCES[J]. 2018, 第 1 作者8(14): 7832-7838, https://www.webofscience.com/wos/woscc/full-record/WOS:000425647000058.
[19] Ren, Zhenning, Lee, Jumin, Moosa, Mahdi Muhammad, Nian, Yin, Hu, Liya, Xu, Zhichun, McCoy, Jason G, Ferreon, Allan Chris M, Im, Wonpil, Zhou, Ming. Structure of an EIIC sugar transporter trapped in an inward-facing conformation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 第 4 作者115(23): 5962-5967, http://dx.doi.org/10.1073/pnas.1800647115.
[20] Jiang, HeHai, Dong, Wu, Zhou, Jun, Hu, JiangMiao, Yang, Jian, Nian, Yin. Ca(v)2.2 and Ca(v)3.1 calcium channel inhibitors from Valeriana jatamansi Jones. RSC ADVANCES[J]. 2017, 第 6 作者  通讯作者  7(72): 45878-45884, https://www.webofscience.com/wos/woscc/full-record/WOS:000412147000075.
[21] Nian, Yin, Yan, Hui, Li, XiaoNian, Zhou, Lin, Qiu, MingHua. Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida. RSC ADVANCES[J]. 2017, 第 1 作者7(61): 38557-38564, http://dx.doi.org/10.1039/c7ra07275a.
[22] Kong, Yanjie, Li, Fubin, Nian, Yin, Zhou, Zhongmei, Yang, Runxiang, Qiu, MingHua, Chen, Ceshi. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway. THERANOSTICS[J]. 2016, 第 3 作者6(6): 875-886, http://www.irgrid.ac.cn/handle/1471x/1109578.
[23] Nian, Yin, Yang, Jing, Liu, TongYang, Luo, Ying, Zhang, JiHong, Qiu, MingHua. New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis. SCIENTIFIC REPORTS[J]. 2015, 第 1 作者5: http://www.irgrid.ac.cn/handle/1471x/959063.
[24] Yin Nian, HaiYanWang, Lin Zhou, Jia Su, Yan Li, MingHua Qiu. Cytotoxic Cycloartane Triterpenes of the TraditionalChinese Medicine "Shengma" (Cimicifuga dahurica). PLANTA MED[J]. 2013, 第 1 作者79: 60–69, http://ir.kib.ac.cn/handle/151853/52984.
[25] Nian, Yin, Zhu, Hui, Tang, WenRu, Luo, Yin, Du, Jiang, Qiu, MingHua. Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 第 1 作者76(5): 896-902, http://www.irgrid.ac.cn/handle/1471x/660284.
[26] Nian, Yin, Wang, HaiYan, Su, Jia, Zhou, Lin, Qiu, MingHua. A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L. FITOTERAPIA[J]. 2012, 第 1 作者83(2): 293-297, http://www.irgrid.ac.cn/handle/1471x/448456.
[27] Fang, ZhongZe, Nian, Yin, Li, Wei, Wu, JingJing, Ge, GuangBo, Dong, PeiPei, Zhang, YanYan, Qiu, MingHua, Liu, Lei, Yang, Ling. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway. PHYTOTHERAPY RESEARCH[J]. 2011, 第 2 作者25(1): 17-24, http://dx.doi.org/10.1002/ptr.3222.
[28] Yin Nian, HaiYan Wang, Lin Zhou, Jia Su, Yan Li, MingHua Qiu. Cytotoxic Cycloartane Triterpenes of Traditional Chinese Medicine "Shengma" (Cimicifugadahurica). PLANTA MED[J]. 第 1 作者1-51, http://ir.kib.ac.cn/handle/151853/53141.

   

（ 1 ） 靶向离子通道的新颖止疼先导分子智能发掘, 负责人, 研究所自主部署, 2024-11--2027-10
（ 2 ） 离子通道天然活性分子筛选、机制及成药性研究, 负责人, 地方任务, 2024-05--2025-12
（ 3 ） 云南高山植物鸡桑和草珊瑚中美白等功效成分的研究, 负责人, 境内委托项目, 2023-04--2025-12
（ 4 ） 重要天然产物化学成分及生物活性研究, 负责人, 境内委托项目, 2022-03--2025-02
（ 5 ） NYZY01和TTX缓解疼痛作用研究, 负责人, 境内委托项目, 2022-01--2022-12
（ 6 ） 金丝桃属植物中特色间苯三酚类T-型钙通道活性成分的研究, 负责人, 国家任务, 2021-01--2024-12
（ 7 ） 中国科学院西部之光“西部青年学者”项目, 负责人, 中国科学院计划, 2021-01--2023-12
（ 8 ） 云南省杰出青年研究专项, 负责人, 地方任务, 2021-01--2023-12
（ 9 ） 云南省青年拔尖人才专项经费, 负责人, 地方任务, 2021-01--2025-12
（ 10 ） PPAP类天然分子的离子通道活性筛选及作用机制研究, 负责人, 中国科学院计划, 2021-01--2023-12
（ 11 ） 高原动物肠道共生菌次生代谢产物研究, 负责人, 境内委托项目, 2020-10--2022-12
（ 12 ） 灵芝杂萜GMs15抗典型失神癫痫机理研究, 负责人, 地方任务, 2020-09--2023-08
（ 13 ） 优秀人才启动经费, 负责人, 研究所自主部署, 2020-07--2025-06
（ 14 ） 第二次青藏高原综合科学考察研究，“藏药资源的挖掘利用”专题子课题“藏药中特色化学成分的活性研究”, 负责人, 国家任务, 2019-01--2024-12

（1）通过新颖结合模式靶向Cav3.2的黄杨生物碱   中国化学学会第34届学术年会第14分会：天然产物化学   年寅   2024-06-15
（2）黄杨生物碱靶向Cav3.2的新型拮抗机理研究   第十七届全国生化与分子药理学学术会议   2023-10-27
（3）Buxus alkaloids targeting Cav3.2 via a new antagonistic mechanism   第十四届全国天然有机化学学术会议   年寅   2023-09-23
（4）Discovery of Novel Natural Small Molecules Targeting Ion Channels   第十四届生物毒素毒理学术大会   2019-08-16
（5）作用于离子通道天然活性分子的挖掘   第一届中国科学院药物创新研究院“百草”论坛   2019-07-26
（6）Discovery of novel natural small molecules targeting ion channels   2018精准医疗暨离子通道国际论坛   2018-11-14

已指导学生

李松谕  硕士研究生  105500-药学  

伍铭坤  硕士研究生  105500-药学  

马梦蝶  硕士研究生  105500-药学  

现指导学生

向建  硕士研究生  105500-药学  

胡云霞  硕士研究生  078001-药物化学  

过俊奇  硕士研究生  078006-药理学  

孙晓烊  硕士研究生  105500-药学  

王建钦  硕士研究生  078006-药理学