General

Prof. De-Sheng Pei 

Ph.D. supervisor and Professor of Chongqing Insitute of Green and Intelligent Technology (CIGIT), Chinese Academy of Sciences (CAS)

Recipient of the "Leading Talents in Scientific and Technological Innovation Program of Chongqing"

Dean of the Research Center for Environment and Health, CIGIT,CAS



Email:peids@cigit.ac.cn
Address:No. 266 Fangzheng Avenue,Shuitu Hi-tech Industrial Park, Shuitu Town, Beibei District, Chongqing

Postal: 400714

Research Areas

(1).Desheng Pei, Ph.D, professor,  the recipient of  of Project Chinese Academy of Sciences (CAS) and Science and Technology Innovation Leader of Chongqing. He is the dean of Research Center for Environment and Health (RCEH), Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences (CIGIT, CAS). 

(2).Research Interests: Development of novel monitoring methods on environmental pollutants; the mechanisms of toxicology and carcinogenesis of environmental pollutants. 

(3). A postdoctoral position is available in the laboratory of Dr. Pei. Interested candidates please contact Dr. Pei: peids@cigit.ac.cn.

Education

09/2003-6/2006: Ph.D., Institute of Hydrobiology, Chinese Academy of Sciences
09/2000-06/2003: Master, Southwest University

Experiences

08/2012-present:  Professor, Chongqing Insitute of Green and Intelligent Technology, Chinese Academy of Sciences, China

02/2011-02/2013:  Research Fellow, Dana-Farber Cancer Institute of Harvard Medical School, Harvard University, Boston, Massachusetts, USA

02/2009-02/2011: Senior Postdoctoral Research Associate (Grade 10), Northeastern University, Boston, Massachusetts, USA

06/2006-02/2009: Assistant Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China.

09/1996-09/2000: Biology Leading Teacher, Nanhe High Middle School, YingShan, Hubei., China


Publications

In Peer-viewed Journals (*Corresponding author):

68. T.Y Suman#, Jia PP#, Li WG#, Junaid M, Xin GY, Wang Y, Pei DS*. Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis. Journal of Hazardous Materials. 2020,DOI: 10.1016/j.jhazmat.2020.123220.
67. Hamid N, Junaid M, Manzoor R, Jia PP, Pei DS*. Prioritizing Phthalate Esters (PAEs) using experimental in vitro/vivo toxicity assays and computational in silico approaches. Journal of Hazardous Materials. 2020, 398:122851, DOI: 10.1016/j.jhazmat.2020.122851.
66. Wang Y, Hamid N, Deng S, Jia PP, Pei DS*. Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma). Journal of Hazardous Materials. 2020, 397:122795, DOI: 10.1016/j.jhazmat.2020.122795.

65. Pu SY, Hamid N, Ren YW, Pei DS*. Effects of phthalate acid esters on zebrafish larvae: Development and skeletal morphogenesis. Chemosphere. 2019, DOI:10.1016/j.chemosphere.2019.125808.
64. Keerthiga Rajendiran, Zizhen Zhao, Pei DS*, Ailing Fu*. Antimicrobial Activity and Mechanism of Functionalized Quantum Dots. Polymers. 2019, 11, 1670.
63. Hamid N, Junaid M, Pei DS*. Individual and combined mechanistic toxicity of Sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China. Journal of Hazardous Materials. 2019, 382:121106.
62. Niu AP, Song LY, Xiong YH, Lu CJ, Junaid M, Pei DS*. Impact of water quality on the microbial diversity in the surface water along the Three Gorge Reservoir (TGR), China. Ecotoxicology and Environmental Safety. 2019, 181:412-418
61. Jia PP, Sun T, Junaid M, Xiong YH, Wang YQ, Liu L, Pu SY, Pei DS*. Chronic exposure to graphene oxide (GO) induced inflammation and differentially disturbed intestinal microbiota in zebrafish. Environmental Science-Nano. 2019, 6:2452-2469.
60. Junaid M, Wang Y, Hamid N, Deng S, Li WG, Pei DS*. Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: a toxicity estimation to confirmation approach. Journal of Hazardous Materials. 2019, 380: 120828.
59. Gu QL, Yang XJ, Li Q, Long Y, Song GL, Pei DS, Hackett B.P, Chen J, Peng JR, Cui ZB*. Asymmetrical cleavages of Sleeping Beauty transposons generate multiple excised transposon fragments during transposition. BioRxiv. 2019, DOI:10.1101/659086
58. Pei DS*, Jia PP, Luo JJ, Liu W, Strauss RP*. AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Cell Death & Disease. 2019, 10:348.
57. Bian WP#, Chen YL#, Luo JJ, Wang C, Xie S, Pei DS*. Knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system. ACS Synthetic Biology. 2019,621-632.
56. Deng S#, Fu A#, Junaid M, Wang Y, Yin Q, Fu C, Liu L, Su DS, Bian WP, Pei DS*.Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish. Biomaterials. 2019, 206:61-72 
55. Hamid N, Junaid M, Ali MS, Zahid M, Pei DS*. Status of air quality with potential linkage to the metrological conditions in three major cities of Pakistan. American Journal of Environmental Sciences, 2019, 15(2): 42-54.
54. Dong WJ, Wang F, Fang ML, Wu J, Wang SY, Li M, Yang JF, Chernick M, Hinton⁠ D, Pei DS, Chen HX, Zheng N, Mu JL, Xie LT, Dong W. Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China. Ecotoxicology and Environmental Safety. 2019, 173:339-346
53. Huo F, Liang WF, Tang YR, Zhang W, Liu XH, Pei DS, Wang HB, Jia WJ, Jia PP, Yang F. Full-color carbon dots with multiple red-emission tuning: on/off sensors, in vitro and in vivo multicolor bioimaging. Journal of Materials Science. 2019, DOI: 10.1007/s10853-019-03370-6
52. Jia PP, Sun T, Junaid M, Yang L, Ma YB, Cui ZS, Wei DP, Shi HF, Pei DS*. Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo. Environmental Pollution. 2019, 247: 595-606.

51. Yi Liu, Muhammad Junaid, Naima Hamid, Chun-Di Chen,De-Sheng Pei. Environmental Concerns and Toxicogenetic Endpoints of Priority Substances (PSs) and Contaminants of Emerging Concerns (CECs): A Comprehensive Review. American Journal of Environmental Sciences, 2018.

50. Muhammad Junaid, Pan-Pan Jia, Yu-Mei Tang, Wen-Xu Xiong, Hai-Yang Huang, Phyllis R. Strauss, Wei-Guo Li, De-Sheng Pei. Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China. Environmental Pollution. 2018, DOI: 10.1016/j.envpol.2018.07.067. 

49. Jiang XF, Lu CJ, Tang MJ, Yang ZB, Jia WJ, Ma YB, Jia PP, Pei DS*, Wang HB*. Nanotoxicity of Silver Nanoparticles on HEK293T Cells: A Combined Study Using Biomechanical and Biological Techniques. ACS Omega, 2018, 3 (6), pp 6770–6778.

48. Liu Y, Junaid M, Wang Y, Tang YM, Bian WP, Xiong WX, Huang HY, Chen CD, Pei DS*. New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: a toxicity estimation to confirmation approach. Aquatic Toxicology. 2018, 201:151-161.

47. Deng S, Jia PP, Zhang JH, Junaid M, Niu A, Ma YB, Fu A*, Pei DS*. Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). Journal of Hazardous Materials. 2018, 357: 146-158.

46. Ma YB, Lu CJ, Junaid M, Jia PP, Yang L, Zhang JH, Pei DS*. Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish. Chemosphere. 2018,207: 320-328.

45. Luo JJ, Bian WP, Liu Y, Huang HY, Yin Q, Yang XJ*, Pei DS*. CRISPR/Cas9 based genome engineering of zebrafish using a seamless integration strategy. The FASEB Journal. 2018, DOI:10.1096/fj.201800077RR

44. Ma YB, Song LY*, Lei Y, Jia PP, Lu CJ, Wu JF, Xi CW, Strauss P, Pei DS*. Sex dependent effects of silver nanoparticles on the zebrafish gut microbiota. Environmental Science-Nano. 2018, DOI: 10.1039/C7EN00740J. 

43. Zhao YT, Wang X, Ren YW*, Pei DS*. Mesh-embedded polysulfone (PSU)/sulfonated polysulfone (sPSU) supported thin film composite membranes for forward osmosis. ACS Applied Materials & Interfaces. 2018, 10 (3):2918–2928.

42. Luo JJ, Su DS, Xie SL, Liu Y, Liu P, Yang XJ*, Pei DS*. Hypersensitive assessment of aryl hydrocarbon receptor 

transcriptional activity using a novel truncated cyp1a promoter in zebrafish. The FASEB Journal. 2017.

41. Wang C, Chen YL, Bian WP, Qi KL, Xie SL, Zou JX*, Pei DS*. Deletion of mstna and mstnb impairs immune system 

and affects growth performance in zebrafish. Fish & Shellfish Immunology. 2018, 72: 572-580.

40. Xie SL, Junaid M, Bian WP, Luo JJ, Syed HJ, Wang Chao, Xiong WX, Ma YB, Niu A, Yang XJ, Zou JX*, Pei DS*

Generation and application of a novel transgenic zebrafish line Tg(cyp1a:mCherry) as an in vivo assay to sensitively 

monitor PAHs and TCDD in the environment. Journal of Hazardous Materials. 2017, 344: 723-732.

39. Ma YB, Jia PP, Junaid M, Yang L, Lu CJ, Pei DS*. Reproductive effects linked to DNA methylation in male zebrafish 

chronically exposure to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate. Environmental Pollution

2017, DOI: 10.1016/j.envpol.2017.11.025.

38. Junaid M, Syed HJ, Abbasi N, Hashmi ZM, Malik NR*, Pei DS*. Status of indoor air pollution (IAP) through particulate 

matter (PM) emissions and associated health concerns in South Asia. Chemosphere. 2017, DOI: 10.1016/j.chemosphere.

2017.10.097.

37. Jia PP, Junaid M, Ma YB, Ahmad F, Jia YF, Li WG*, Pei DS*. Role of Human DNA2 (hDNA2) as a Potential Target for 

Cancer and other Diseases: A Systematic Review. DNA Repair. 2017, 59: 9-19.

36. Lu CJ, Jiang XF, Junaid M, Ma YB, Jia PP, Wang HB*,  Pei DS*. Graphene oxide nanosheets induce DNA damage and

 activate the base excision repair (BER) signaling pathway both in vitro and in vivo. Chemosphere. 2017, 184:795-805

35. Junaid M, Hashmi M, Tang Y, Malik RN*, Pei DS*. Potential health risk of heavy metals in the leather manufacturing 

industries in Sialkot, Pakistan. Scientific Reports. 2017, doi:10.1038/s41598-017-09075-7.

34. Zhou A, Xie S, Wang Z, Junaid M, Fan L, Wang C, Ye Q, Chen Y, Pei DS, Zou J. Molecular cloning, characterization and expression analysis of heat shock protein 90 in albino northern snakehead Channa argus. Gene. 2017 pii: S0378-1119(17)30291-3. 

33. Jing-Hui Zhang, Tai Sun#, Aping Niu#, Yu-Mei Tang, Shun Deng, Wei Luo, Qun Xu*, Dapeng Wei*, Pei DS*. 

Perturbation effect of reduced graphene oxide quantum dots (rGOQDs) on aryl hydrocarbon receptor (AhR) pathway in 

zebrafish. Biomaterials. 2017, 133:49-49.

32. Muhammad Junaid, Riffat Naseem Malik*, Pei DS*. Health hazards of child labor in the leather products and surgical 

instrument manufacturing industries of Sialkot, Pakistan. Environmental Pollution. 2017, 226: 198-211.

31.Tang YM, Junaid M, Niu A, Deng S, Pei DS*. Diverse toxicological risks of PAHs in surface water with an impounding 

level of 175m in the Three Gorges Reservoir Area, China. Science of the Total Environment. 2016, doi:10.1016/j.

scitotenv.2016.12.064.

30. Zhang JH, Niu A, Li J, Fu JW, Xu Q*, Pei DS*. In vivo characterization of hair and skin derived carbon quantum dots 

with high quantum yield as long-term bioprobes in zebrafish. Scientific Reports. 2016, 6:37860. doi: 10.1038/srep37860.

29. Li J, Niu A, Lu CJ, Zhang JH, Junaid M, Strauss PR, Xiao P, Wang X, Ren YW, Pei DS*. A novel forward osmosis 

system in landfill leachate treatment for removing polycyclic aromatic hydrocarbons and for direct fertigation. 

Chemosphere. 2016, 168:112-121. DOI: 10.1016/j.chemosphere.2016.10.048.

28. Chun-Jiao Lu, Dan Luo, Muhammad Junaid, Jin-Jing Duan, Shi-Min Ding, Ao-Xue Dai, Tuan-Wu Cao and Pei DS*

The status of pollutants in the three gorges reservoir area, china and its ecological health assessment. American Journal 

of Environmental Sciences, 2016, DOI: 10.3844/ajessp.2016.

27. Xie SL, Bian WP, Wang C, Junaid M, Zou J*, Pei DS*. A novel technique based on in vitro oocyte injection to improve 

CRISPR/Cas9 gene editing in zebrafish. Scientific Reports. 2016, DOI: 10.1038/srep34555

26. Junaid M, Hashmi MZ*, Malik RN*, Pei DS*. Toxicity and oxidative stress induced by chromium in workers exposed 

from different occupational settings around the globe: A review. Environ Sci Pollut Res Int. 2016, DOI: 10.1007/s11356

-016-7463-x.

25. Zhang Y, Chen Y, Fu Y, Ying C, Feng Y, Huang Q, Wang C, Pei DS*, Wang D*. Monitoring tetracycline through a solid-

state nanopore sensor. Scientific Reports2016, 6:27959. doi: 10.1038/srep27959.

24. Jia PP, Ma YB, Lu C, Mirza Z, Zhang W, Jia YF, Li WG*, Pei DS*. The Effects of Disturbance on Hypothalamus-Pituitary

-Thyroid (HPT) Axis in Zebrafish Larvaeafter Exposure to DEHP. PLoS One. 2016, 11(5):e0155762.

23. Niu A, Ren YW, Yang L, Xie SL, Jia PP, Zhang JH, Wang X, Li J, Pei DS*. Toxicological characterization of a novel

 wastewater treatment process using  EDTA-Na2Zn as draw solution (DS) for the efficient treatment of MBR-treated landfill

 leachate. Chemosphere. 2016, 155:100-8.

22. Lu CJ, Duan JJ, Junaid M, Cao TW, Ding SM, Pei DS*. Recent status of fishes in the Yangtze River and its ecological

 health assessment. American Journal of Environmental Sciences, 2016, 12(2): 86-93

21. Bian WP, Pei DS*. Zebrafish model for safety and toxicity testing of nutraceuticals. In Nutraceuticals: Efficacy, 

Safety and Toxicity. Gupta, R.C., Ed.; Elsevier Science & Technology, San Diego, USA. 2016, 333 (Chapter 25).

20. He SX, Fang SX, Liu XH, Zhang W, Xie WY, Zhang H, Wei DP, Fu WL. Pei DS. Investigation of a genetic algorithm

 based cubic spline smoothing for baseline correction of Raman spectra. Chemometrics and Intelligent Laboratory 

Systems. 2016, 152:1-9.

19. Dai YJ, Jia YF, Chen N, Bian WP, Li QK, Ma YB, Chen YL, Pei DS*. Zebrafish as a model system to study toxicology.

 Environ Toxicol Chem. 2014, 33(1): 11-17.

18. Pei DS, Luther, Wang WC, Paw B, Stewart RA and George RE. Distinct Neuroblastoma-associated Alterations of 

PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. Plos Genetics,2013, 9(6):e1003533. 

17. Pei DS, Yang XJ, Liu W, Guikema J, Schrader C, Strauss P*. A Novel Regulatory Circuit in Base Excision Repair

 Involving AP endonuclease 1, Creb1 and DNA polymerase ß. Nucleic Acids Res. 2011, 39(8):3156-65. 

16. Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei DS, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z,

 Barker K, Moreau L, Webber H, Wang W,  Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson

 SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE*. The ALK(F1174L) Mutation Potentiates the Oncogenic 

Activity of MYCN in Neuroblastoma. Cancer Cell. 2012, 22(1):117-30. 

15. Pei DS, Strauss P*. Zebrafish as a model system to study DNA damage and repair. Mutat Res-Fund Mol M. 2013,

 743-744:151-9

14. Snow B, Estabrook T, Pei DS, Strauss PR. DNA repair regulates chromatin structure and key transcription factors.

 The FASEB Journal. 2013, 27, 771.1

13. Pei DS, Sun YH, Chen SP, Wang YP, Hu W, Zhu ZY*. Identification and characterization of a novel gene differentially

 expressed in fish cross-subfamily cloned embryos. BMC Dev Biol, 2008, 18; 8:29.

12. Pei DS, Sun YH, Zhu ZY*. Construction of cytoplasmic molecular markers distinguishing Danio rerio from Gobiocypris

 rarus at high identity domains based on MP-PCR strategy and Sybr Green I detection. Mol Biol Rep. 35(1):45-50, 2008.

11. Pei DS, Sun YH, Long Y, Zhu ZY*. Inhibition of no tail (ntl) gene expression in zebrafish by external guide sequence

 (EGS) technique. Mol Biol Rep. 35(2):139-43, 2008.

10. Pei DS, Sun YH, Long Y, Zhu ZY*. Identification of a novel gene K23 over-expressed in fish cross-subfamily cloned

 embryos. Mol Biol Rep. 36(6):1375-80, 2008.

9. Pei DS, Sun YH, Chen SP, Wang YP, Hu W, Zhu ZY*. Zebrafish GAPDH can be used as a reference gene for

 expression analysis in cross-subfamily cloned embryos.Anal Biochem. 363(2):291-3, 2007.

8. Pei DS, Sun YH, Chen SP, Wang YP, Hu W, Zhu ZY*. Identification of differentially expressed genes from the cross

-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology. 68(9):

1282-91, 2007.

7. Chen CH, Sun YH, Pei DS, Zhu ZY*. Comparative expression of zebrafish lats1 and lats2 and their implication in

 gastrulation movements.Dev Dyn, 238(11):2850-9,2009.

6. Zhong S, Wang YP, Pei DS, Luo DJ, Liao LJ, Zhu ZY*. A one-year investigation of the relationship between serum

 GH levels and the growth of F4 transgenic and non-transgenic common carp Cyprinus carpio. J Fish Biol. 75 (5): 

1092-1100, 2009

5. Pei DS, Sun YH, Chen SP, Wang YP, Zhu ZY*. Cloning and characterization of cytochrome c oxidase subunit I

 (COXI) in Gobiocypris rarus. Mitochondr DNA / DNA Seq.18(1):1-8, 2007.

4. Liu J, Sun YH, Wang YW, Wang N, Pei DS, Wang YP, Hu W, Zhu ZY*. Identification of differential transcript profiles

 between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA

-AFLP. Theriogenology. 70(9): 1525-1535, 2008. 

3. Hu W*,Pei DS*, Dai J, Chen SP, Sun YH, Wang YP, Zhu ZY*. Conversion of RAPD markers to SCAR markers and its

 application between zebrafish and Chinese rare minnow.Chinese High Technology Letters, 9(16):959-963, 2006. (*Co- first author) 

2. Pei DS, Cai PZ*, Li MY, Xiang YW, Yan WZ, Zhang ZX, Hou L, Zhang ZY,Pei Y. Screening of RAPD Markers for Sterility

 Gene of Nucleo2cytoplasmic Interaction in Mitochondrial DNA of Rice. Acta Agronomica Sinica, 29 (6): 899-902, 2003.

1. Pei DS, Xiang YW, Li MY, Cai PZ*, Zhang ZX, Yan WZ, Hou L, Pei Y. Analysis of RAPD Markers About Sterility Gene

 in Cytoplasm-Nucleolus Interacting Type Rice Mitochondrial DNA. Acta Genetica Sinica, 30 (4): 357-363, 2003.

Research Interests

Developing novel monitoring methods on environmental pollutants; study on mechanisms of toxicology and carcinogenesis of environmental pollutants.

PhD and Master Students

已指导学生

唐宇梅  硕士研究生  085229-环境工程  

赵运涛  博士研究生  083001-环境科学  

刘怡  硕士研究生  085229-环境工程  

贾盼盼  博士研究生  083002-环境工程  

王燕  硕士研究生  085229-环境工程  

现指导学生

刘立  博士研究生  083002-环境工程  

张睿  硕士研究生  085229-环境工程  

贾煌杰  硕士研究生  085700-资源与环境  

任学峰  硕士研究生  085700-资源与环境