1. 抗血小板药物改性及其纳米逆转剂开发；

2. 疾病治疗微纳机器人；

3. 肿瘤脉管系统调控，提升纳米药物肿瘤富集。

1. 083100-生物医学工程

2. 0710J1-纳米科学与技术

多学科交叉（生物学，药学，材料学，化学，医学）

2021-07~现在, 中国科学院大学, 副教授
2018-07~2021-07,国家纳米科学中心, 博士后（博新计划）

申请专利：

1.一种脂质体-聚合物载药纳米粒子及其制备方法和应用，申请号：CN201610676323.1；

2.一种肿瘤血管梗塞剂多肽、基因、表达载体及其应用 ，申请号：CN201410652608.2；

3.一种多肽药物偶联物及其制备方法和应用，申请号：CN201810213841.9；

4.一种仿生细胞膜-内核纳米粒子及其制备方法和应用，申请号：CN202111406976.5；

5.抗血小板药物及制备方法、抗血小板药物捕获剂，申请号：202211327015.X；

6.联硒透明质酸水凝胶及其制备方法与应用，申请号：CN202210794607.6。

获得奖励：

• 2018中国科学十大进展（研制出用于肿瘤治疗的智能型DNA纳米机器人）

• 中国药学会科学技术进步二等奖

• 吉林大学优秀博士学位论文

• 吉林大学优秀毕业研究生

• 2018年中科院第一届“率先杯”未来科技创新大赛优胜奖

• 2020年北京市自然科学奖一等奖

[1]  Junchao Xu^#, Na Yan^#, Chunling Wang, Chao Gao, Xuexiang Han, Chengzhi Yang, Jiaqi Xu, Kun Wang, Michael J. Mitchell, Yinlong Zhang*, Guangjun Nie*. Platelet-mimicking nanosponges for functional reversal of antiplatelet agents. Circulation Research，2023, 132: 339-354

[2]  Jiaqi Xu, Junchao Xu, Tongfei Shi, Yinlong Zhang*, Fangman Chen, Chao Yang, Xinjing Guo, Guangna Liu, Dan Shao*, Kam W Leong*, Guangjun Nie*. Probiotic-inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the gut microbiome. Advanced Materials, 2022, 35(3), 2207890.

[3]  Jiaqi Xu^#, Tianjiao Chu^#, Tingting Yu, Naishi Li, Chunling Wang, Chen Li, Yinlong Zhang*, Huan Meng*, Guangjun Nie*. Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS Scavenging to Relieve Colitis. ACS Nano, 2022, 16(8), 13037-13048.

[4]    Junchao Xu^#, Kaiwei Wan^#, Hui Wang, Xinghua Shi, Jing Wang, Yi Zhong, Chao Gao, Yinlong Zhang*, and Guangjun Nie*. Polyethylenimine–Poly(lactic-co-glycolic acid)2 Nanoparticles Show an Innate Targeting Ability to the Submandibular Salivary Gland via the Muscarinic 3 Receptor. ACS central science, 2021, 7: 1938–1948.

[5]     Yinlong Zhang^#, Xuexiang Han^#, Guangjun Nie*. Responsive and activable nanomedicines for remodeling the tumor microenvironment. Nature Protocols, 2021. 16. 405–430.

[6]       Suping Li^#, Yinlong Zhang^# , Shih-Hsin Ho, Bozhao Li, Meifang Wang, Xiongwei Deng, Na Yang, Guangna Liu, Zefang Lu, Junchao Xu, Quanwei Shi1, Jing-Yan Han, Lirong Zhang, Yan Wu*, Yuliang Zhao*, Guangjun Nie*. Combining tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles. Nature Biomedical Engineering, 2020. 4: 732-742 

[7]     Huan Min^#, Jing Wang^#, Yingqiu Qi^#, Yinlong Zhang * , Xuexiang Han, Ying Xu, Junchao Xu, Yao Li, Long Chen, Keman Cheng, Guangna Liu, Na Yang, Yiye Li,* and Guangjun Nie*. Biomimetic Metal–Organic Framework Nanoparticles for Cooperatively Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy. Advanced Materials, 2019, 31(15), 1808200.  

[8]     Guangna Liu^#, Xiao Zhao^#, Yinlong Zhang*, Junchao Xu, Jiaqi Xu, Yao Li, Huan Min, Jian Shi, Ying Zhao, Jingyan Wei, Jing Wang,* and Guangjun Nie*. Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity. Advanced Materials, 2019, 1900795.

[9]     Junchao Xu^#, Yinlong Zhang* ,  Jiaqi Xu, Guangna Liu, Chunzhi Di, Xiao Zhao, Xiang Li, Yao Li, Ningbo Pang, Chengzhi Yang, Yanyi Li, Bozhao Li, Zefang Lu, Meifang Wang, Kesheng Dai, Rong Yan, Suping Li*, and Guangjun Nie*. Engineered Nanoplatelets for Targeted Delivery of Plasminogen Activators to Reverse Thrombus in Multiple Mouse Thrombosis Models. Advanced Materials, 2019, 1905145.

[10]     Suping Li ^#, Qiao Jiang ^#, Shaoli Liu ^#, Yinlong Zhang ^# , Yanhua Tian, Chen Song, Jing Wang,Yiguo Zou, Gregory J Anderson, Jing-Yan Han, Yung Chang, Yan Liu, Chen Zhang, Liang Chen, Guangbiao Zhou, Guangjun Nie*, Hao Yan*, Baoquan Ding* , Yuliang Zhao*. A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Nature Biotechnology, 2018, 36: 258~264.

[11]     Suping Li ^#, Yinlong Zhang^# , Jing Wang, Ying Zhao, Tianjiao Ji, Xiao Zhao, Yanping Ding, Xiaozheng Zhao, Ruifang Zhao, Feng Li, Xiao Yang, Shaoli Liu, Zhaofei Liu , Jianhao Lai,Andrew K. Whittaker, Gregory J. Anderson, Jingyan Wei and Guangjun Nie*. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. Nature Biomedical Engineering, 2017, 1(8): 667-679.

1.  入选2022年中国科学院青年创新促进会会员

2.  中国科学院基础前沿科学研究计划“从0到1”原始创新项目，肿瘤富集增强型智能纳米药物的设计及对肿瘤微环境调控研究，ZDBS-LY-SLH039，2019.09-2024.09，主持

3.  博士后创新人才支持计划，基于血小板膜结构的仿生纳米载体的构建及抗肿瘤机制研究，BX20180083， 2018.08-2020.08，主持

4.  国家自然科学基金青年项目，工程化纳米血小板载带组织纤溶酶原激活物用于血栓治疗，31900992，     2020.01-2022.12，主持

5.  第64批中国博士后科学基金面上一等，仿生纳米载体的工程化改造及功能化修饰研究，2018M640100，  2018.07-2020.12，主持