基本信息
路中华  男  博导  中国科学院深圳先进技术研究院
电子邮件: zh.lu@siat.ac.cn
通信地址: 深圳市南山区学苑大道1068号
邮政编码: 518055

研究领域

1. 脑疾病动物模型的构建和表型解析;

2. 嗜神经病毒环路示踪工具的开发和应用;

3. 脑疾病干预技术的开发。

招生信息

   
招生专业
071006-神经生物学
071007-遗传学
071008-发育生物学
招生方向
神经精神疾病,神经科学技术
发育性神经疾病
神经分子遗传学

教育背景

2002-08--2007-09   杜克大学   博士
1999-09--2002-07   北京大学   硕士
1995-09--1999-07   山东大学   学士

工作经历

   
工作简历
2008-09~2016-06,弗雷德哈钦森癌症研究中心/霍华德休斯医学研究所, 博士后

教授课程

神经生理学

出版信息

   
发表论文
[1] Hu, Yu, Li, Jiamin, Zhu, Yuyuan, Li, Mengqi, Lin, Jianbang, Yang, Lixin, Wang, Chuan, Lu, Zhonghua. Development and characterization of an Otp conditional loss of function allele. GENESIS[J]. 2020, 58(9): [2] Chen, Qian, Deister, Christopher A, Gao, Xian, Guo, Baolin, LynnJones, Taylor, Chen, Naiyan, Wells, Michael F, Liu, Runpeng, Goard, Michael J, Dimidschstein, Jordane, Feng, Shijing, Shi, Yiwu, Liao, Weiping, Lu, Zhonghua, Fishell, Gord, Moore, Christopher I, Feng, Guoping. Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD. NATURE NEUROSCIENCE[J]. 2020, 23(4): 520-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000517738700001.
[3] Yingting Zhang, Zhihao Fang, Hongyu Lu, Yaqing Li, Zulqarnain Baloch, Yongxiang Liu, Shihua Yang, Zhonghua Lu, Chenhui Ding. A blastocyst biopsy approach for preimplantation genetic diagnosis technique that affects the expression of SNAP-α in mice. Reproductive Biology. 2020, 20(3): 417-423, http://dx.doi.org/10.1016/j.repbio.2020.03.010.
[4] Zhou, Yang, Sharma, Jitendra, Ke, Qiong, Landman, Rogier, Yuan, Jingli, Chen, Hong, Hayden, David S, Fisher, John W, III, Jiang, Minqing, Menegas, William, Aida, Tomomi, Yan, Ting, Zou, Ying, Xu, Dongdong, Parmar, Shivangi, Hyman, Julia B, FanucciKiss, Adrian, Meisner, Olivia, Wang, Dongqing, Huang, Yan, Li, Yaqing, Bai, Yanyang, Ji, Wenjing, Lai, Xinqiang, Li, Weiqiang, Huang, Lihua, Lu, Zhonghua, Wang, Liping, Anteraper, Sheeba A, Sur, Mriganka, Zhou, Huihui, Xiang, Andy Peng, Desimone, Robert, Feng, Guoping, Yang, Shihua. Atypical behaviour and connectivity in SHANK3-mutant macaques. NATURE[J]. 2019, 570(7761): 326-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000472145700056.
[5] Li, Jiamin, Liu, Taian, Dong, Yun, Kondoh, Kunio, Lu, Zhonghua. Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses. NEUROSCIENCE BULLETINnull. 2019, 35(5): 909-920, http://lib.cqvip.com/Qikan/Article/Detail?id=7003104026.
[6] Huang, Yubin, Xu, Zhen, Xiong, Shanshan, Sun, Fangfang, Qin, Guangrong, Hu, Guanglei, Wang, Jingjing, Zhao, Lei, Liang, YuXiang, Wu, Tianzhun, Lu, Zhonghua, Humayun, Mark S, So, KwokFai, Pan, Yihang, Li, Ningning, Yuan, TiFei, Rao, Yanxia, Peng, Bo. Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. NATURE NEUROSCIENCE[J]. 2018, 21(4): 530-+, http://ir.siat.ac.cn:8080/handle/172644/14268.
[7] Liu, Taian, Shi, Yujian, Chan, Matthew T, V, Peng, Gang, Zhang, Quan, Sun, Xiao, Zhu, Zeyao, Xie, Yuxin, Sham, Kathy W Y, Li, Jianzhen, Liu, Xiaodong, Ho, Idy H T, Gin, Tony, Lu, Zhonghua, Wu, William K K, Cheng, Christopher H K. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. TRANSLATIONAL PSYCHIATRY[J]. 2018, 8(1): http://ir.siat.ac.cn:8080/handle/172644/13879.
[8] Li, Lei, Feng, Xiaolong, Zhou, Zheng, Zhang, Huiqi, Shi, Qianqian, Lei, Zhuogui, Shen, Peilei, Yang, Qingning, Zhao, Binghao, Chen, Shuran, Li, Lin, Zhang, Yulin, Wen, Pengjie, Lu, Zhonghua, Li, Xiang, Xu, Fuqiang, Wang, Liping. Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection. CURRENT BIOLOGY[J]. 2018, 28(6): 859-+, http://ir.siat.ac.cn:8080/handle/172644/13863.
[9] Kondoh, Kunio, Lu, Zhonghua, Ye, Xiaolan, Olson, David P, Lowell, Bradford B, Buck, Linda B. A specific area of olfactory cortex involved in stress hormone responses to predator odours. NATURE[J]. 2016, 532(7597): 103-+, [10] Yoon, Kyounghye, Ragoczy, Tobias, Lu, Zhonghua, Kondoh, Kunio, Kuang, Donghui, Groudine, Mark, Buck, Linda B. Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 112(18): E2403-E2409, https://www.webofscience.com/wos/woscc/full-record/WOS:000353953800020.
[11] Hanchate, Naresh K, Kondoh, Kunio, Lu, Zhonghua, Kuang, Donghui, Ye, Xiaolan, Qiu, Xiaojie, Pachter, Lior, Trapnell, Cole, Buck, Linda B. Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis. SCIENCE[J]. 2015, 350(6265): 1251-1255, https://www.webofscience.com/wos/woscc/full-record/WOS:000365700500077.
发表著作
(1) The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology, Nova, 2010-01, 第 5 作者

科研活动

   
科研项目
( 1 ) 神经网络示踪新技术及其在嗅觉神经环路特异受体探查中的应用, 主持, 国家级, 2017-01--2018-12
( 2 ) 脑疾病分子标记物筛查的神经网络示踪技术研究, 参与, 省级, 2016-07--2019-06
( 3 ) 非人灵长类逆向示踪AAV病毒的改造及在神经环路解析中的应用, 主持, 国家级, 2019-01--2022-12
( 4 ) 大脑应激神经环路的发育和功能研究, 主持, 省级, 2017-06--2020-06
( 5 ) SHANK3突变自闭症模型猴的构建和表型分析, 主持, 国家级, 2020-01--2024-12
参与会议
(1)Tracing Based Molecular Characterization of Olfactory Neural Circuits   2016-07-29

指导学生

现指导学生

李嘉敏  硕士研究生  071006-神经生物学  

林剑邦  硕士研究生  085238-生物工程  

王静怡  博士研究生  071006-神经生物学  

张誉竞  硕士研究生  071006-神经生物学