基本信息
丛志奇  男  博导  中国科学院青岛生物能源与过程研究所
电子邮件: congzq@qibebt.ac.cn
通信地址: 山东省青岛市崂山区松岭路189号
邮政编码:

研究领域

1. 基于金属酶结构的人工酶催化体系的理性设计

2. 低碳分子酶催化

3. 生物质酶催化转化

4. 酶制剂污染物处理

招生信息

招收生物化学与分子生物学、化学生物学、化学工程与生物工程、绿色催化化学、环境微生物学及相关专业的博、硕士研究生。

招生专业
071010-生物化学与分子生物学
071005-微生物学
070322-生物无机化学
招生方向
酶学与酶工程,蛋白质结构与功能,低碳分子酶催化
酶制剂污染物处理
酶模拟与仿生催化

教育背景

2006-04--2009-03   日本熊本大学   理学博士
2005-10--2006-03   日本熊本大学   日本政府奖学金留学生
1999-08--2002-06   延边大学   理学硕士
1995-08--1999-07   延边大学   学士
学历

博士研究生学历

学位

博士

工作经历

   
工作简历
2013-04~2016-04,日本名古屋大学/JST/CREST, 研究员
2009-04~2013-03,日本分子科学研究所, IMS Fellow/研究员
2002-07~2005-09,延边大学, 助教

专利与奖励

   
奖励信息
(1) 四面体杂志年度十佳审稿人, 其他, 2012
(2) 日本政府奖学金, 国家级, 2005
专利成果
[1] 丛志奇, 陈杰, 刘传飞. 一种催化乙苯等烷基苯及衍生物羟化的突变体及其应用. CN: CN113106074A, 2021-07-13.

[2] 丛志奇, 赵盼霞, 陈杰, 刘传飞, 马娜娜. 一种催化苯乙烯及其衍生物制备手性有机化合物的方法. CN: CN113106139A, 2021-07-13.

[3] 丛志奇, 陈杰, 陈置丰, 刘传飞. 一种协同选择性催化甲苯及类似物羟化的突变体及其应用. CN: CN113106073A, 2021-07-13.

[4] 丛志奇, 陈杰, 马娜娜, 陈置丰. 一种激活酶催化反应的双功能小分子化合物及其应用. CN: CN110128364A, 2019-08-16.

[5] 尹炳柱, 张春波, 丛志奇. 新型二介晶结构液晶化合物及合成方法. 中国: CN1810924, 2006-08-02.

出版信息

   
发表论文
[1] Siyu Di, Shengxian Fan, Fengjie Jiang, Zhiqi Cong, Angel T Martnez, Ana Gutirrez. A Unique P450 Peroxygenase System Facilitated by a Dual-Functional Small Molecule: Concept, Application, and Perspective. Antioxidants. 2022, 11(3): [2] Zhang, Xuan, Jiang, Yiping, Chen, Qianqian, Dong, Sheng, Feng, Yingang, Cong, Zhiqi, Shaik, Sason, Wang, Binju. H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450. ACS CATALYSIS[J]. 2021, 11(14): 8774-8785, [3] Zhao, Panxia, Chen, Jie, Ma, Nana, Chen, Jingfei, Qin, Xiangquan, Liu, Chuanfei, Yao, Fuquan, Yao, Lishan, Jin, Longyi, Cong, Zhiqi. Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases dagger. CHEMICAL SCIENCE[J]. 2021, 12(18): 6307-6314, http://dx.doi.org/10.1039/d1sc00317h.
[4] Ma, Nana, Fang, Wenhan, Liu, Chuanfei, Qin, Xiangquan, Wang, Xiling, Jin, Longyi, Wang, Binju, Cong, Zhiqi. Switching an Artificial P450 Peroxygenase into Peroxidase via Mechanism-Guided Protein Engineering. ACS CATALYSIS[J]. 2021, 11(14): 8449-8455, [5] Mahor, Durga, Cong, Zhiqi, Weissenborn, Martin J, Hollmann, Frank, Zhang, Wuyuan. Valorization of Small Alkanes by Biocatalytic Oxyfunctionalization. CHEMSUSCHEM. 2021, [6] Jiang, Yihui, Wang, Chunlan, Ma, Nana, Chen, Jie, Liu, Chuanfei, Wang, Fang, Xu, Jiakun, Cong, Zhiqi. Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system. CATALYSIS SCIENCE & TECHNOLOGY[J]. 2020, 10(5): 1219-1223, https://www.webofscience.com/wos/woscc/full-record/WOS:000536775400030.
[7] Wang, Xiling, Chen, Jie, Ma, Nana, Cong, Zhiqi. Selective Hydroxylation of Alkanes Catalyzed by Cytochrome P450 Enzymes. ACTA CHIMICA SINICAnull. 2020, 78(6): 490-503, http://dx.doi.org/10.6023/A20030086.
[8] 王曦翎, 陈杰, 马娜娜, 丛志奇. 细胞色素P450酶催化的烷烃选择性羟化. 化学学报[J]. 2020, 78(6): 490-503, http://lib.cqvip.com/Qikan/Article/Detail?id=7102530884.
[9] 丛志奇. 细胞色素P450酶催化的烷烃选择行羟化. 化学学报. 2020, [10] Xu Jiakun, Wang Chunlan, Cong Zhiqi. Strategies for substrate-regulated P450 catalysis: from substrate engineering to co-catalysis.. Chemistry (Weinheim an der Bergstrasse, Germany). 2019, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDD7021155414D5D362CBB1B5E61D21BE4&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[11] Ariyasu, Shinya, Kodama, Yusaku, Kasai, Chie, Cong, Zhiqi, Stanfield, Joshua Kyle, Aiba, Yuichiro, Watanabe, Yoshihito, Shoji, Osami. Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes. CHEMCATCHEM[J]. 2019, 11(19): 4709-4714, https://www.webofscience.com/wos/woscc/full-record/WOS:000483567200001.
[12] Chen, Jie, Kong, Fanhui, Ma, Nana, Zhao, Panxia, Liu, Chuanfei, Wang, Xiling, Cong, Zhiqi. Peroxide-Driven Hydroxylation of Small Alkanes Catalyzed by an Artificial P450BM3 Peroxygenase System. ACS CATALYSIS[J]. 2019, 9(8): 7350-7355, https://www.webofscience.com/wos/woscc/full-record/WOS:000480503700077.
[13] Xu, Jiakun, Wang, Chunlan, Cong, Zhiqi. Strategies for Substrate-Regulated P450 Catalysis: From Substrate Engineering to Co-catalysis. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2019, 25(28): 6853-6863, [14] 丛志奇. Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3 driven by dual-functional small molecule. Journal of Porphyrins and Phthalocyanines. 2018, [15] 马娜娜. Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase.. Angewandte Chemie (International ed. in English). 2018, [16] Ma, Nana, Chen, Zhifeng, Chen, Jie, Chen, Jingfei, Wang, Cong, Zhou, Haifeng, Yao, Lishan, Shoji, Osami, Watanabe, Yoshihito, Cong, Zhiqi. Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(26): 7628-7633, https://www.webofscience.com/wos/woscc/full-record/WOS:000435766800004.
[17] Chen, Zhifeng, Chen, Jie, Ma, Nana, Zho, Haifeng, Cong, Zhiqi. Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3 driven by dual-functional small molecules. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2018, 22(9-10): 831-836, http://ir.qibebt.ac.cn/handle/337004/12205.
[18] Dr. Osami Shoji, Sota Yanagisawa, Joshua Kyle Stanfield, Kazuto Suzuki, Dr. Zhiqi Cong, Dr. Hiroshi Sugimoto, Prof. Dr. Yoshitsugu Shiro, Prof. Dr. Yoshihito Watanabe. Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives. Angewandte Chemie International Edition. 2017, https://www.webofscience.com/wos/woscc/full-record/WOS:000434546000005.
[19] 丛志奇. 过氧化氢驱动的细胞色素犘450酶研究进展. 生物资源. 2017, [20] 王曦翎, 陈杰, 陈置丰, 周海峰, 丛志奇. 过氧化氢驱动的细胞色素P450酶研究进展. 生物资源. 2017, 39(2): 75-84, http://lib.cqvip.com/Qikan/Article/Detail?id=672189261.
[21] 丛志奇. Activation of Wild-type Cytochrome P450BM3 by the Next Generation Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence. ACS Catal.. 2015, [22] Kawakami, Norifumi, Cong, Zhiqi, Shoji, Osami, Watanabe, Yoshihito. Highly efficient hydroxylation of gaseous alkanes at reduced temperature catalyzed by cytochrome P450BM3 assisted by decoy molecules. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2015, 19(1-3): 329-334, https://www.webofscience.com/wos/woscc/full-record/WOS:000352644100030.
[23] Cong Zhiqi, Kinemuchi Haruki, Kurahashi Takuya, Fujii Hiroshi. Factors affecting hydrogen-tunneling contribution in hydroxylation reactions promoted by oxoiron(IV) porphyrin π-cation radical complexes.. Inorganic chemistry. 2014, [24] 丛志奇. Synthesis, Charaterization and Reactivity of Hypochloritoiron(III) Porphyrin Complexes.. J. Am. Chem. Soc.. 2012, [25] Cong Zhiqi, Kurahashi Takuya, Fujii Hiroshi. Formation of iron(III) meso-chloro-isoporphyrin as a reactive chlorinating agent from oxoiron(IV) porphyrin π-cation radical.. Journal of the American Chemical Society. 2012, [26] 丛志奇. Oxidation of Chloride Ion and Subsequent Chlorination of Organic Compounds by Oxoiron(IV) Porphyrin π-Cation Radical Complexes.. Angew. Chem. Int. Ed.. 2011, [27] 张春波, 黄哲钢, 丛志奇, 尹炳柱. 含胆甾烯基结构的手性二介晶结构液晶化合物. 液晶与显示[J]. 2005, 20(5): 375-383, http://lib.cqvip.com/Qikan/Article/Detail?id=20261930.
[28] Chen, T, Liu, WJ, Cong, ZQ, Yin, BZ. Synthesis of novel dithia-crown ether annulated tetrathiafulvalene derivatives. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2005, 25(5): 570-575, https://www.webofscience.com/wos/woscc/full-record/WOS:000228850100014.
[29] 张晓鹏, 丛志奇, 尹炳柱, 吴峰. 带取代卓酮基的中性生色氮杂15-完-5-丁烷的合成及其络合性质的研究. 延边大学学报. 自然科学版[J]. 2005, 31(1): 31-34, [30] 陈铁, 刘武军, 丛志奇, 尹炳柱. 新品研发辑要——新型四硫富瓦烯硫杂冠醚衍生物的合成. 化工中间体. 2005, 58-58, http://lib.cqvip.com/Qikan/Article/Detail?id=20048155.
[31] 张晓鹏, 丛志奇, 尹炳柱, 吴峰. 带取代革酮基的中性生色氮杂15-冠-5-醚的合成及其络合性质的研究. 延边大学学报:自然科学版. 2005, 31(1): 31-34, http://lib.cqvip.com/Qikan/Article/Detail?id=15100311.
[32] Yin, BZ, Wen, QW, Chen, T, Liu, WJ, Cong, ZQ, Jin, LY, Wada, T, Saigo, K. Synthesis of nanoscale octathia 36-crown-12 annulated tetrathiafulvalene tetramers. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2005, 25(2): 188-192, https://www.webofscience.com/wos/woscc/full-record/WOS:000226796200008.
[33] Yin, BZ, Wen, QW, Chen, T, Liu, WJ, Cong, ZQ, Jin, LY, Wada, T, Saigo, K. Synthesis of nanoscale octathia 36-crown-12 annulated tetrathiafulvalene tetramers. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2005, 25(2): 188-192, https://www.webofscience.com/wos/woscc/full-record/WOS:000226796200008.
[34] 陈铁, 燕小梅, 丛志奇, 金龙一, 尹炳柱. 含TTF的氮硫杂冠醚的合成. 延边大学学报:自然科学版[J]. 2003, 29(3): 231-232, http://lib.cqvip.com/Qikan/Article/Detail?id=8419275.
[35] 尹炳柱, 丛志奇. 2,6—二氨基—1,3二氮杂Ao的简便合成. 化学试剂[J]. 2003, 25(1): 55-55, http://lib.cqvip.com/Qikan/Article/Detail?id=7455393.
[36] 丛志奇, 陈铁, 尹炳柱, 许桂花. 2—芳胺基—5—芳偶氮基草酮化合物的合成. 延边大学学报:自然科学版[J]. 2003, 29(2): 107-110,156, http://lib.cqvip.com/Qikan/Article/Detail?id=8044272.
[37] 丛志奇, 尹炳柱, 金龙一, 陈铁. 2-氯(上艹下卓)酮与Meldrum's acid的反应研究. 化学试剂[J]. 2003, 25(6): 321-322,366, [38] 丛志奇, 胡永才. 2-酰胺基-6-芳偶氮基-1,3-二氮杂Ao的合成. 延边大学学报:自然科学版. 2002, 28(4): 280-284, http://lib.cqvip.com/Qikan/Article/Detail?id=7471846.
[39] 丛志奇, 陈铁, 尹炳柱, 胡永才. 2-酰胺基-6-芳偶氮基-1,3-二氮杂薁的合成. 延边大学学报. 自然科学版[J]. 2002, 28(4): 282-284, 

科研活动

   
科研项目
( 1 ) 基于金属酶催化C-H变换的分子设计(团队科研项目启动基金), 主持, 市地级, 2016-05--2019-04
参与会议
(1)小分子驱动P450单加氧酶选择性氧化气态烷烃   泰山学术论坛-生物无机化学与纳米材料专题   2016-11-04
(2)小分子驱动P450单加氧酶选择氧化气态烷烃   第十六届全国青年催化学术会议   2016-10-21
(3)氯过氧化物酶Hypochlorito-Iron(III) Porophyrin模型中间体的研究   中国化学会第十三届全国生物无机化学会议   2016-10-13
(4)Synergistic Effect of Decoy Molecule andSite-directed Mutation Leading to A P450   CONG, Zhiqi; SHOJI, Osami; KASAI, Chie; SUGIMOTO, Hiroshi; SHIRO, Yoshitsugu; WATANABE, Yoshihito   2016-03-24
(5)Activation of Wild-type Cytochrome P450BM3 by the 2nd-generation of Decoy Molecules: Hydroxylation of Small Alkanes and Mechanism   2015-07-24
(6)Construction of Small Alkane Hydroxylase by P450BM3-decoy Molecule System   Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2015-03-27
(7)Powerful Activation of Cytochrome P450BM3 by Second-Generation Decoy Molecules and the Hydroxylation of Small Alkanes    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-11-15
(8)Arousal of Wild-type Cytochrome P450 by second-generation decoy molecules: toward the hydroxylation of gaseous alkanes   2014-09-24
(9)“Hydroxylation of gaseous alkanes catalyzed by Wild-type Cytochrome P450: Development of Second-Generation Decoy Molecules and Studies of Reaction mechanism based on crystal structure analysis”    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-09-11
(10) “New Generation of Decoy Molecules to Powerfully Activate Cytochrome P450BM3 for Small Alkanes Hydroxylation”    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-03-26
(11) “Synthesis, Charaterization and Reactivity of Hypochlorite-Iron(III) Porphyrin Complexes.”   CONG, Zhiqi; YANAGISAWA, Sachiko; KURAHASHI, Takuya; OGURA, Takashi; FUJII, Hiroshi   2012-11-16
(12) “Synthesis and Chlorinating Reactivity of Iron(III) meso-Chloro-Isoporphyrins.”    CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2012-09-21
(13)“Oxidation of Chloride Ion by Compound I Model Complex and Related Chlorination of Organic Compounds.”   CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2011-11-04
(14) “Hydrogen Tunneling Effect on Alkane Hydroxylation by High-valent Oxoiron porphyrin Model Complexes.”   CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2011-03-26
(15) “Hydrogen Tunneling Effect on Hydrocarbon Hydroxylation by Oxoiron(IV) Porphyrin π-Cation Radical Complexes.”    CONG, Zhiqi; FUJII, Hiroshi   2010-11-10
(16)“Synthesis of Dibenz[b,f]oxepins from 2-(9-Xanthenyl)malonate.”    CONG, Zhiqi; NISHINO, Hiroshi   2008-03-26

合作情况

1. 低碳酶催化,日本名古屋大学渡边研究室

2. 金属酶分子机理与小分子活化,日本奈良女子大学藤井研究室

指导学生

现指导学生

马娜娜  02  63228  

赵盼霞  02  63228