基本信息
曾庆斌 男 硕导 中国科学院精密测量科学与技术创新研究院
电子邮件： zqingbin08@163.com
通信地址： 湖北省武汉市武昌区小洪山西30号
邮政编码：
电子邮件： zqingbin08@163.com
通信地址： 湖北省武汉市武昌区小洪山西30号
邮政编码：
招生信息
招生专业
070302-分析化学
招生方向
超灵敏磁共振分子探针与分子影像
教育背景
2012-09--2017-06 中国科学院大学 博士学位
2008-09--2012-06 华中师范大学 学士学位
2008-09--2012-06 华中师范大学 学士学位
工作经历
工作简历
2020-12~现在, 中国科学院精密测量科学与技术创新研究院, 副研究员
2017-07~2020-11,中国科学院精密测量科学与技术创新研究院, 博士后
2017-07~2020-11,中国科学院精密测量科学与技术创新研究院, 博士后
专利与奖励
奖励信息
（1） 中国分析测试协会科学技术奖青年奖, 其他, 2017
专利成果
[1] 郭茜旎, 王珍, 曾庆斌, 孙献平, 周欣. 一种多组分金属有机框架材料及其在制备Hyper-CEST信号增强试剂中的应用. CN202211628161.6, 2022-12-16.
[2] 郭茜旎, 乐曲儿, 曾庆斌, 孙献平, 周欣. 一种微孔水的制备方法及其在制备惰性气体磁共振信号增强试剂中的应用. CN202211494290.0., 2022-11-25.
[3] 郭茜旎, 杨鑫鑫, 曾庆斌, 周欣. 一种超极化129Xe MRI的可显影介入导丝及其制备方法. CN202211486304.4, 2022-11-24.
[4] 周欣, 郭茜旎, 肖忠宇, 曾庆斌. 一种超极化129Xe 磁共振分子探针及其制备方法. CN202210211056.6, 2022-03-04.
[5] 周欣, 曾庆斌, 郭茜旎, 王珍, 孙献平. 一种多组分金属有机框架材料及其应用. CN202111651962.X, 2021-12-30.
[6] 周欣, 乐曲儿, 曾庆斌, 郭茜旎, 孙献平. 一种硫化铜与金属有机框架复合纳米材料的应用. CN202111613615.8, 2021-12-27.
[7] 周欣, 曾庆斌, 郭茜旎, 孙献平, 刘买利. 一种沸石咪唑骨架材料在磁共振成像中的应用. 中国: CN108578715A, 2018-09-28.
[8] 周欣, 曾庆斌, 郭茜旎, 袁亚平, 孙献平, 刘买利. 一种多功能穴番‑卟啉化合物及其合成方法和应用. CN: CN107880061A, 2018-04-06.
[2] 郭茜旎, 乐曲儿, 曾庆斌, 孙献平, 周欣. 一种微孔水的制备方法及其在制备惰性气体磁共振信号增强试剂中的应用. CN202211494290.0., 2022-11-25.
[3] 郭茜旎, 杨鑫鑫, 曾庆斌, 周欣. 一种超极化129Xe MRI的可显影介入导丝及其制备方法. CN202211486304.4, 2022-11-24.
[4] 周欣, 郭茜旎, 肖忠宇, 曾庆斌. 一种超极化129Xe 磁共振分子探针及其制备方法. CN202210211056.6, 2022-03-04.
[5] 周欣, 曾庆斌, 郭茜旎, 王珍, 孙献平. 一种多组分金属有机框架材料及其应用. CN202111651962.X, 2021-12-30.
[6] 周欣, 乐曲儿, 曾庆斌, 郭茜旎, 孙献平. 一种硫化铜与金属有机框架复合纳米材料的应用. CN202111613615.8, 2021-12-27.
[7] 周欣, 曾庆斌, 郭茜旎, 孙献平, 刘买利. 一种沸石咪唑骨架材料在磁共振成像中的应用. 中国: CN108578715A, 2018-09-28.
[8] 周欣, 曾庆斌, 郭茜旎, 袁亚平, 孙献平, 刘买利. 一种多功能穴番‑卟啉化合物及其合成方法和应用. CN: CN107880061A, 2018-04-06.
出版信息
发表论文
[1] Analytical Chemistry. 2024, 第 3 作者
[2] Yue, Quer, Zeng, Qingbin, Guo, Qianni, Zhao, Xiuchao, Yuan, Yaping, Yang, Yuqi, Jiang, Weiping, Zhou, Xin. Pitaya-Inspired Metal-Organic Framework Nanozyme for Multimodal Imaging-Guided Synergistic Cuproptosis, Nanocatalytic Therapy, and Photothermal Therapy. ADVANCED HEALTHCARE MATERIALS[J]. 2024, 第 2 作者13(32): http://dx.doi.org/10.1002/adhm.202402915.
[3] Qingbin Zeng, Qianni Guo, Yaping Yuan, Lei Zhang, Weiping Jiang, Yuqi Yang, Xin Zhou. Protocol for detecting substrates in living cells by targeted molecular probes through hyperpolarized 129Xe MRI. STAR PROTOCOLS. 2022, 第 1 作者3(3): http://dx.doi.org/10.1016/j.xpro.2022.101499.
[4] Qingbin Zeng, Qianni Guo, Yaping Yuan, Baolong Wang, Meiju Sui, Xin Lou, LouisS Bouchard, Xin Zhou. Ultrasensitive molecular building block for biothiol NMR detection at picomolar concentrations. ISCIENCE[J]. 2021, 第 1 作者24(12): 103515,
[5] Zhao, Longhui, Guo, Qianni, Yuan, Chenlu, Li, Sha, Yuan, Yaping, Zeng, Qingbin, Zhang, Xu, Ye, Chaohui, Zhou, Xin. Photosensitive MRI biosensor for BCRP-Targeted uptake and light-induced inhibition of tumor cells. TALANTA[J]. 2021, 第 6 作者233: 122501, https://www.sciencedirect.com/science/article/pii/S0039914021004227?via%3Dihub.
[6] Zeng, Qingbin, Bie, Binglin, Guo, Qianni, Yuan, Yaping, Han, Qi, Han, Xiaocang, Chen, Mingwei, Zhang, Xu, Yang, Yunhuang, Liu, Maili, Liu, Pan, Deng, Hexiang, Zhou, Xin. Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 1 作者117(30): 17558-17563, https://www.pnas.org/doi/10.1073/pnas.2004121117.
[7] Zeng, Qingbin, Guo, Qianni, Yuan, Yaping, Zhang, Xiaoxiao, Jiang, Weiping, Xiao, Sa, Zhang, Bin, Lou, Xin, Ye, Chaohui, Liu, Maili, Bouchard, Louis-S., Zhou, Xin. A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy. ACS APPLIED BIO MATERIALS[J]. 2020, 第 1 作者3(3): 1779-1786, https://pubs.acs.org/doi/10.1021/acsabm.9b01080.
[8] Ren, Lili, Chen, Shizhen, Jiang, Weiping, Zeng, Qingbin, Zhang, Xu, Xiao, Long, McMahon, Michael T, Xin, Lou, Zhou, Xin. Efficient temperature-feedback liposome for F-19 MRI signal enhancement. CHEMICAL COMMUNICATIONS[J]. 2020, 第 4 作者56(92): 14427-14430, http://xlink.rsc.org/?DOI=D0CC05809B.
[9] Zhang, Xiaoxiao, Yuan, Yaping, Li, Sha, Zeng, Qingbin, Guo, Qianni, Liu, Na, Yang, Minghui, Yang, Yunhuang, Liu, Maili, McMahon, Michael T, Zhou, Xin. Free-base porphyrins as CEST MRI contrast agents with highly upfield shifted labile protons. MAGNETIC RESONANCE IN MEDICINE[J]. 2019, 第 4 作者82(2): 577-585, https://www.webofscience.com/wos/woscc/full-record/WOS:000471308300006.
[10] Zhang, Bin, Guo, Qianni, Luo, Qing, Zhang, Xiaoxiao, Zeng, QingBin, Zhao, Longhui, Yuan, Yaping, Jiang, Weiping, Yang, Yunhuang, Liu, Maili, Ye, Chaohui, Zhou, Xin. An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor. CHEMICAL COMMUNICATIONS[J]. 2018, 第 5 作者54(97): http://xlink.rsc.org/?DOI=C8CC07822J.
[11] Yang, Shengjun, Zeng, Qingbin, Guo, Qianni, Chen, Shizhen, Liu, Hongbin, Liu, Maili, McMahon, Michael T, Zhou, Xin. Detection and differentiation of Cys, Hcy and GSH mixtures by F-19 NMR probe. TALANTA[J]. 2018, 第 2 作者184: 513-519, https://www.webofscience.com/wos/woscc/full-record/WOS:000432234900066.
[12] Zeng, Qingbin, Guo, Qianni, Yuan, Yaping, Yang, Yuqi, Zhang, Bin, Ren, Lili, Zhang, Xiaoxiao, Luo, Qing, Liu, Maili, Bouchard, LouisS, Zhou, Xin. Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized Xe-129 Magnetofluorescent Biosensor. ANALYTICAL CHEMISTRY[J]. 2017, 第 1 作者89(4): 2288-2295, https://pubs.acs.org/doi/10.1021/acs.analchem.6b03742.
[13] Yang, Yuqi, Chen, Shizhen, Liu, Lianhua, Li, Sha, Zeng, Qingbin, Zhao, Xiuchao, Li, Haidong, Zhang, Zhiying, Bouchard, Louis-S., Liu, Maili, Zhou, Xin. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 第 5 作者9(28): 23400-23408, https://www.webofscience.com/wos/woscc/full-record/WOS:000406172700014.
[14] Guo, Qianni, Zeng, Qingbin, Jiang, Weiping, Luo, Qing, Zhang, Xu, Bouchard, Louis-S., Liu, Maili, Zhou, Xin. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe. CHEMISTRY – A EUROPEAN JOURNAL[J]. 2016, 第 2 作者22(12): 3967-3970, http://dx.doi.org/10.1002/chem.201600193.
[15] Guo, Qianni, Zeng, Qingbin, Zhang, Xiaoxiao, Zhou, Xin. Highly sensitive detection of mercury (II) in aqueous media by tetraphenylporphyrin with a metal ion receptor. SUPRAMOLECULAR CHEMISTRY[J]. 2014, 第 2 作者26(10-12): 836-842, http://ir.wipm.ac.cn/handle/112942/1398.
[16] 曾庆斌, 郭茜旎, 罗晴, 吴光耀, 周欣. 锰对比剂在MRI中的应用. 磁共振成像[J]. 2014, 第 1 作者5(4): 315, http://lib.cqvip.com/Qikan/Article/Detail?id=661908143.
[2] Yue, Quer, Zeng, Qingbin, Guo, Qianni, Zhao, Xiuchao, Yuan, Yaping, Yang, Yuqi, Jiang, Weiping, Zhou, Xin. Pitaya-Inspired Metal-Organic Framework Nanozyme for Multimodal Imaging-Guided Synergistic Cuproptosis, Nanocatalytic Therapy, and Photothermal Therapy. ADVANCED HEALTHCARE MATERIALS[J]. 2024, 第 2 作者13(32): http://dx.doi.org/10.1002/adhm.202402915.
[3] Qingbin Zeng, Qianni Guo, Yaping Yuan, Lei Zhang, Weiping Jiang, Yuqi Yang, Xin Zhou. Protocol for detecting substrates in living cells by targeted molecular probes through hyperpolarized 129Xe MRI. STAR PROTOCOLS. 2022, 第 1 作者3(3): http://dx.doi.org/10.1016/j.xpro.2022.101499.
[4] Qingbin Zeng, Qianni Guo, Yaping Yuan, Baolong Wang, Meiju Sui, Xin Lou, LouisS Bouchard, Xin Zhou. Ultrasensitive molecular building block for biothiol NMR detection at picomolar concentrations. ISCIENCE[J]. 2021, 第 1 作者24(12): 103515,
[5] Zhao, Longhui, Guo, Qianni, Yuan, Chenlu, Li, Sha, Yuan, Yaping, Zeng, Qingbin, Zhang, Xu, Ye, Chaohui, Zhou, Xin. Photosensitive MRI biosensor for BCRP-Targeted uptake and light-induced inhibition of tumor cells. TALANTA[J]. 2021, 第 6 作者233: 122501, https://www.sciencedirect.com/science/article/pii/S0039914021004227?via%3Dihub.
[6] Zeng, Qingbin, Bie, Binglin, Guo, Qianni, Yuan, Yaping, Han, Qi, Han, Xiaocang, Chen, Mingwei, Zhang, Xu, Yang, Yunhuang, Liu, Maili, Liu, Pan, Deng, Hexiang, Zhou, Xin. Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 1 作者117(30): 17558-17563, https://www.pnas.org/doi/10.1073/pnas.2004121117.
[7] Zeng, Qingbin, Guo, Qianni, Yuan, Yaping, Zhang, Xiaoxiao, Jiang, Weiping, Xiao, Sa, Zhang, Bin, Lou, Xin, Ye, Chaohui, Liu, Maili, Bouchard, Louis-S., Zhou, Xin. A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy. ACS APPLIED BIO MATERIALS[J]. 2020, 第 1 作者3(3): 1779-1786, https://pubs.acs.org/doi/10.1021/acsabm.9b01080.
[8] Ren, Lili, Chen, Shizhen, Jiang, Weiping, Zeng, Qingbin, Zhang, Xu, Xiao, Long, McMahon, Michael T, Xin, Lou, Zhou, Xin. Efficient temperature-feedback liposome for F-19 MRI signal enhancement. CHEMICAL COMMUNICATIONS[J]. 2020, 第 4 作者56(92): 14427-14430, http://xlink.rsc.org/?DOI=D0CC05809B.
[9] Zhang, Xiaoxiao, Yuan, Yaping, Li, Sha, Zeng, Qingbin, Guo, Qianni, Liu, Na, Yang, Minghui, Yang, Yunhuang, Liu, Maili, McMahon, Michael T, Zhou, Xin. Free-base porphyrins as CEST MRI contrast agents with highly upfield shifted labile protons. MAGNETIC RESONANCE IN MEDICINE[J]. 2019, 第 4 作者82(2): 577-585, https://www.webofscience.com/wos/woscc/full-record/WOS:000471308300006.
[10] Zhang, Bin, Guo, Qianni, Luo, Qing, Zhang, Xiaoxiao, Zeng, QingBin, Zhao, Longhui, Yuan, Yaping, Jiang, Weiping, Yang, Yunhuang, Liu, Maili, Ye, Chaohui, Zhou, Xin. An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor. CHEMICAL COMMUNICATIONS[J]. 2018, 第 5 作者54(97): http://xlink.rsc.org/?DOI=C8CC07822J.
[11] Yang, Shengjun, Zeng, Qingbin, Guo, Qianni, Chen, Shizhen, Liu, Hongbin, Liu, Maili, McMahon, Michael T, Zhou, Xin. Detection and differentiation of Cys, Hcy and GSH mixtures by F-19 NMR probe. TALANTA[J]. 2018, 第 2 作者184: 513-519, https://www.webofscience.com/wos/woscc/full-record/WOS:000432234900066.
[12] Zeng, Qingbin, Guo, Qianni, Yuan, Yaping, Yang, Yuqi, Zhang, Bin, Ren, Lili, Zhang, Xiaoxiao, Luo, Qing, Liu, Maili, Bouchard, LouisS, Zhou, Xin. Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized Xe-129 Magnetofluorescent Biosensor. ANALYTICAL CHEMISTRY[J]. 2017, 第 1 作者89(4): 2288-2295, https://pubs.acs.org/doi/10.1021/acs.analchem.6b03742.
[13] Yang, Yuqi, Chen, Shizhen, Liu, Lianhua, Li, Sha, Zeng, Qingbin, Zhao, Xiuchao, Li, Haidong, Zhang, Zhiying, Bouchard, Louis-S., Liu, Maili, Zhou, Xin. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 第 5 作者9(28): 23400-23408, https://www.webofscience.com/wos/woscc/full-record/WOS:000406172700014.
[14] Guo, Qianni, Zeng, Qingbin, Jiang, Weiping, Luo, Qing, Zhang, Xu, Bouchard, Louis-S., Liu, Maili, Zhou, Xin. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe. CHEMISTRY – A EUROPEAN JOURNAL[J]. 2016, 第 2 作者22(12): 3967-3970, http://dx.doi.org/10.1002/chem.201600193.
[15] Guo, Qianni, Zeng, Qingbin, Zhang, Xiaoxiao, Zhou, Xin. Highly sensitive detection of mercury (II) in aqueous media by tetraphenylporphyrin with a metal ion receptor. SUPRAMOLECULAR CHEMISTRY[J]. 2014, 第 2 作者26(10-12): 836-842, http://ir.wipm.ac.cn/handle/112942/1398.
[16] 曾庆斌, 郭茜旎, 罗晴, 吴光耀, 周欣. 锰对比剂在MRI中的应用. 磁共振成像[J]. 2014, 第 1 作者5(4): 315, http://lib.cqvip.com/Qikan/Article/Detail?id=661908143.
科研活动
科研项目
（ 1 ） 荧光标记MOF用于非小细胞肺癌的超灵敏磁共振分子影像传感, 主持, 国家级, 2021-01--2023-12
（ 2 ） 外泌体介导的129Xe/19F双核MRI用于肺癌早期探测及其演进机制的研究, 参与, 国家级, 2019-01--2022-12
（ 3 ） 肺的异构功能性数据获取与智能融合, 参与, 部委级, 2019-09--2029-08
（ 4 ） 肺癌的超高灵敏谱学与成像新技术研究, 参与, 国家级, 2019-09--2024-08
（ 2 ） 外泌体介导的129Xe/19F双核MRI用于肺癌早期探测及其演进机制的研究, 参与, 国家级, 2019-01--2022-12
（ 3 ） 肺的异构功能性数据获取与智能融合, 参与, 部委级, 2019-09--2029-08
（ 4 ） 肺癌的超高灵敏谱学与成像新技术研究, 参与, 国家级, 2019-09--2024-08