基本信息
王琛  男  博导  国家纳米科学中心
电子邮件: wangch@nanoctr.cn
通信地址: 北京市海淀区中关村北一条11号
邮政编码: 100190

招生信息

   
招生专业
070304-物理化学
0703J1-纳米科学与技术
招生方向
表面物理化学
表面物理化学

教育背景

1986-09--1992-07   美国弗吉尼亚大学   博士
1981-09--1986-07   中国科技大学   学士

工作经历

   
工作简历
2004-06~现在, 国家纳米科学中心, 副主任、主任
1995-07~2004-05,中国科学院化学研究所, 研究员
1994-02~1995-05,华中师范大学, 教授
1992-07~1993-12,美国亚利桑那大学, 博士后
1986-09~1992-07,美国弗吉尼亚大学, 博士
1981-09~1986-07,中国科技大学, 学士

教授课程

纳米科学导论
生物纳米材料
入学教育与交流
纳米生物材料与技术
纳米科学概论
纳米与生物技术前沿讲座
纳米科技前沿讲座
纳米生物医学系列讲座

专利与奖励

   
奖励信息
(1) 教育部科技一等奖, 一等奖, 部委级, 2003
(2) 中国化学会青年化学奖, , 部委级, 1988

出版信息

   
发表论文
(1) Dual-functional extracellular vesicles enable synergistic treatment via m6A reader YTHDF1-targeting epigenetic regulation and chemotherapy, Nano Resaerch, 2023, 通讯作者
(2) A Nucleus-Targeting WT1 Antagonistic Peptide Encapsulated in Polymeric Nanomicelles Combats Refractory Chronic Myeloid Leukemia, PHARMACEUTICS, 2023, 通讯作者
(3) Peptide-based coacervates in therapeutic applications, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 通讯作者
(4) Prominent enhancement of peptide-mediated targeting efficiency for human hepatocellular carcinomas with composition-engineered protein corona on gold nanoparticles, COLLOIDS AND SURFACES A: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2023, 通讯作者
(5) Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide, Nano Research, 2023, 通讯作者
(6) Principles of Amino-Acid-Ribonucleotide Interaction Revealed by Binding Affinities between Homogeneous Oligopeptides and Single-stranded RNA Molecules, Nano Research, 2023, 通讯作者
(7) Principles of Amino-Acid-Nucleotide Interactions Revealed by Binding Affinities between Homogeneous Oligopeptides and Single-Stranded DNA Molecules, CHEMBIOCHEM, 2022, 通讯作者
(8) Heterochirality-Mediated Cross-Strand Nested Hydrophobic Interaction Effects Manifested in Surface-Bound Peptide Assembly Structures, JOURNAL OF PHYSICAL CHEMISTRY B, 2022, 第 8 作者
(9) Machine Learning-Assisted Dual-Marker Detection in Serum Small Extracellular Vesicles for the Diagnosis and Prognosis Prediction of Non-Small Cell Lung Cancer, NANOMATERIALS, 2022, 第 8 作者
(10) A nucleus-targeting peptide antagonist towards EZH2 displays therapeutic efficacy for lung cancer, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 通讯作者
(11) A nucleus-targeting peptide antagonist towards EZH2 displays therapeutic efficacy for lung cancer, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 通讯作者
(12) Peptide-Enabled Targeted Delivery Systems for Therapeutic Applications, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 通讯作者
(13) Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer, JOURNAL OF MATERIALS CHEMISTRY B, 2021, 通讯作者
(14) Anti-fouling peptide functionalization of ultraflexible neural probes for long-term neural activity recordings in the brain, BIOSENSORS & BIOELECTRONICS, 2021, 通讯作者
(15) Quantitative Nanomechanical Analysis of Small Extracellular Vesicles for Tumor Malignancy Indication, ADVANCED SCIENCE, 2021, 通讯作者
(16) Peptide-directed delivery of drug-loaded nanocarriers targeting CD36 overexpressing cells, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2021, 通讯作者
(17) Peptoid Nanosheet-Based Sensing System for the Diagnosis and Surveillance of Amnestic Mild Cognitive Impairment and Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2021, 第 7 作者
(18) Enhanced lymphatic delivery of nanomicelles encapsulating CXCR4-recognizing peptide and doxorubicin for the treatment of breast cancer, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 通讯作者
(19) Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, SCIENCE ADVANCES, 2020, 其他(合作组作者)
(20) Position-coded multivalent peptide-peptide interactions revealed by tryptophan-scanning mutagenesis, JOURNAL OF PEPTIDE SCIENCE, 2020, 通讯作者
(21) Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt‐Based Oxygen Nanogenerator for Multimodal Imaging‐Guided Synergistic Phototherapy, ADVANCED SCIENCE, 2020, 第 10 作者
(22) Peptide-enabled receptor-binding-quantum dots for enhanced detection and migration inhibition of cancer cells, JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2020, 通讯作者
(23) Synthetic CXCR4 Antagonistic Peptide Assembling with Nanoscaled Micelles Combat Acute Myeloid Leukemia, SMALL, 2020, 通讯作者
(24) Peptide conformation and oligomerization characteristics of surface-mediated assemblies revealed by molecular dynamics simulations and scanning tunneling microscopy, RSC ADVANCES, 2019, 通讯作者
(25) Identifying Terminal Assembly Propensity of Amyloidal Peptides by Scanning Tunneling Microscopy, CHEMPHYSCHEM, 2019, 通讯作者
(26) Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer, JOURNAL OF MATERIALS CHEMISTRY B, 2019, 通讯作者
(27) Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma, THERANOSTICS, 2019, 第 7 作者
(28) Principles of Inter-Amino-Acid Recognition Revealedby Binding Energies between Homogeneous Oligopeptides, ACS CENTRAL SCIENCE, 2019, 通讯作者
(29) Peptide-Polyphenol (KLVFF/EGCG) Binary Modulators for Inhibiting Aggregation and Neurotoxicity of Amyloid-beta Peptide, ACS OMEGA, 2019, 通讯作者
(30) On-Surface Crystallization Behaviors of H-Bond Donor-Acceptor Complexes at Liquid/Solid Interfaces, LANGMUIR, 2019, 通讯作者
(31) Steric Dependence of Chirality Effect in Surface-Mediated Peptide Assemblies Identified with Scanning Tunneling Microscopy, NANO LETTERS, 2019, 通讯作者
(32) Modulation of beta-amyloid aggregation by graphene quantum dots, ROYAL SOCIETY OPEN SCIENCE, 2019, 通讯作者
(33) Diagnosis of Invasive Nonfunctional Pituitary Adenomas by Serum Extracellular Vesicles, ANALYTICAL CHEMISTRY, 2019, 第 5 作者
(34) Nrp-1 receptor targeting peptide-functionalized TPGS micellar nanosystems to deliver 10-hydroxycampothecin for enhanced cancer chemotherapy, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 第 6 作者
(35) 二维过渡金属硫化物纳米复合材料的模拟酶特性及应用, Two-dimentional Transition-metal Dichalcogenide Nanocomposites as Novel Enzyme Mimics: An Overview, 生物化学与生物物理进展, 2018, 第 3 作者
(36) Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis (vol 7, 2017), SCIENTIFIC REPORTS, 2018, 通讯作者
(37) GO-AgCl/Ag nanocomposites with enhanced visible light-driven catalytic properties for antibacterial and biofilm-disrupting applications, COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 通讯作者
(38) Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy, NANO RESEARCH, 2018, 通讯作者
(39) Probing Molecular Basis for Constructing Interface Bionanostructures, TOPICS IN CATALYSIS, 2018, 通讯作者
(40) Peptide-functionalized carbon dots for sensitive and selective Ca2+ detection, SENSORSANDACTUATORSBCHEMICAL, 2018, 通讯作者
(41) Peptide-Functionalized Nanomaterials for the Efficient Isolation of HER2-Positive Circulating Tumor Cells, ACS APPLIED MATERIALS & INTERFACES, 2017, 通讯作者
(42) Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis, SCIENTIFIC REPORTS, 2017, 通讯作者
(43) Molybdenum Disulfide Nanoparticles as Multifunctional Inhibitors against Alzheimer's Disease, ACS APPLIED MATERIALS & INTERFACES, 2017, 通讯作者
(44) MoS2-Pt3Au1 Nanocomposites with Enhanced Peroxidase-Like Activities for Selective Colorimetric Detection of Phenol, MoS2-Pt3Au1 Nanocomposites with Enhanced Peroxidase-Like Activities for Selective Colorimetric Detection of Phenol, 中国化学:英文版, 2017, 第 8 作者
(45) Antibody-Mimetic Peptoid Nanosheet for Label-Free Serum-Based Diagnosis of Alzheimer's Disease, ADVANCEDMATERIALS, 2017, 通讯作者
(46) Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression, Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2017, 通讯作者
(47) Fluorine Functionalized Graphene Quantum Dots as Inhibitor against hIAPP Amyloid Aggregation, ACS CHEMICAL NEUROSCIENCE, 2017, 第 4 作者
(48) Versatile graphene-based photothermal nanocomposites for effectively capturing and killing bacteria, and for destroying bacterial biofilms, JOURNAL OF MATERIALS CHEMISTRY B, 2017, 通讯作者
(49) Studies on Composition and Sequence Effects in Surface-Mediated Octapeptide Assemblies by Using Scanning Tunneling Microscopy, JOURNAL OF PHYSICAL CHEMISTRY C, 2017, 通讯作者
(50) Photo-regulation of 2D supramolecular self-assembly: On-surface photochemistry studied by STM, CHINESE CHEMICAL LETTERS, 2017, 通讯作者
(51) Stabilization effect of amino acid side chains in peptide assemblies on graphite studied by scanning tunneling microscopy, CHEMPHYSCHEM, 2017, 通讯作者
(52) Peptide-binding induced inhibition of chemokine cxcl12, RSC ADVANCES, 2017, 通讯作者
(53) Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand, CHINESE JOURNAL OF CHEMISTRY, 2017, 通讯作者
(54) Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand, Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand, 中国化学:英文版, 2017, 第 8 作者
(55) Nano-cage-mediated refolding of insulin by PEG-PE micelle, BIOMATERIALS, 2016, 通讯作者
(56) Host-guest supramolecular chemistry at solid-liquid interface: An important strategy for preparing two-dimensional functional nanostructures, SCIENCE CHINA-CHEMISTRY, 2014, 第 3 作者
(57) Bridging mesoscopic blend structure and property to macroscopic device performance via in situ optoelectronic characterization, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 8 作者
(58) Sequential assembly of metal-free phthalocyanine on few-layer epitaxial graphene mediated by thickness-dependent surface potential, NANO RESEARCH, 2012, 第 9 作者
(59) Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro, PLOS ONE, 2011, 第 9 作者
(60) Construction of tunable supramolecular networks studied by scanning tunneling microscopy, SCIENCE CHINA-CHEMISTRY, 2010, 通讯作者
(61) NiO Thin Film Fabricated by Electrophoretic Deposition and Formaldehyde Gas Sensing Property Thereof, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 第 4 作者
(62) Oxygen Desorption from Single-Walled Carbon Nanotubes by Camera Flash, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 第 7 作者
(63) On the topography multiplicity of non-planar titanyl (IV) phthalocyanine molecules and the STM imaging mechanism, SURFACE SCIENCE, 2008, 通讯作者
(64) Individual water-filled single-walled carbon nanotubes as hydroelectric power converters, ADVANCED MATERIALS, 2008, 第 7 作者
(65) Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy, SMALL, 2008, 第 5 作者
(66) Highly dense and perfectly aligned single-walled carbon nanotubes fabricated by diamond wire drawing dies, NANO LETTERS, 2008, 第 15 作者
(67) Interactions between blood proteins and multiwalled carbon nanotubes in aqueous solution, NEW CARBON MATERIALS, 2007, 第 7 作者
(68) 铁氧化物中电子隧道现象的扫描隧道显微术研究, 物理学报, 1996, 第 1 作者
(69) STM/STS实验中单电子隧道现象的观测, 物理学报, 1996, 第 1 作者
发表著作
( 1 ) 扫描探针显微术应用进展, 无, 化学工业出版社, 2007-07, 第 2 作者
( 2 ) 施普林格纳米技术手册, Springer handbook of nano-technology, 科学出版社, 2009-01, 第 2 作者

科研活动

   
科研项目
( 1 ) 纳米测量技术标准的基础研究, 负责人, 国家任务, 2011-01--2015-01
( 2 ) 与重大慢性疾病诊治相关的纳米技术基础研究, 负责人, 中国科学院计划, 2009-07--2013-12
( 3 ) 自组装功能分子纳米结构研究, 负责人, 国家任务, 2009-02--2012-12
( 4 ) 强电场条件下表面纳米尺度的电润湿性质研究, 负责人, 国家任务, 2009-07--2011-12
( 5 ) 变革性纳米产业制造技术聚焦, 负责人, 中国科学院计划, 2013-07--2017-12
( 6 ) 多肽组装趋势的分子水平研究, 负责人, 国家任务, 2017-01--2020-12
( 7 ) 功能纳米系统的精准构筑原理与测量, 负责人, 中国科学院计划, 2020-01--2024-12