复杂体系高选择性分离分析

多肽探针的设计、合成、筛选与应用

生物分子动态相互作用研究

   

博士

1984北京师范大学化学系  理学学士

1997中国科学院化学研究所  理学硕士

2005中国科学院研究生院  理学博士

1993-1995日本多肽研究所

1999.12-2000.1 日本大阪大学蛋白质研究所

   

1984-1986 北京师范大学化学系  助教

1986-今  中国科学院化学研究所，助研、副研、研究员、博士生导师

中国色谱学会理事

北京色谱学会常务理事

中国仪器仪表学会分析仪器学会理事

Biomedical Chromatography 杂志编委

   

[1] 赵睿, 瑙甘, 李永明, 金钰龙, 黄嫣嫣. 一种二价靶向多肽探针及其制备方法. CN: CN110456053A, 2019-11-15.

[2] 赵睿, 金钰龙, 黄嫣嫣. 缀合物及其制备方法和用途. CN: CN106334194B, 2019-08-16.

[3] 赵睿, 何佳媛, 黄嫣嫣, 桂诗浪, 金钰龙. 一种检测人癌细胞的亲和肽及其应用. CN: CN108623658A, 2018-10-09.

[4] 黄嫣嫣, 朱媛媛, 金钰龙, 桂诗浪, 赵睿. 一种双靶向多肽-药物偶联物及其制备方法与抗肿瘤应用. CN: CN108578708A, 2018-09-28.

[5] 黄嫣嫣, 于洋, 金钰龙, 赵睿. 人血清白蛋白特异性识别多肽及其应用. CN: CN108341853A, 2018-07-31.

[6] 赵睿, 谢云峰, 黄嫣嫣, 刘国诠. 一种检测水样中铅离子的方法. CN: CN103185737A, 2013-07-03.

[7] 赵睿, 刘吉众, 黄嫣嫣, 刘国诠. 双孔微米级聚甲基丙烯酸环氧丙酯-甲基丙烯酸乙二醇双酯交联微球及其制备方法. CN: CN102617804A, 2012-08-01.

[8] 赵睿, 王蔚芝, 黄嫣嫣, 刘吉众, 刘国诠. 一种阵列式连续流动微流控芯片装置及其制作方法与应用. CN: CN102527306A, 2012-07-04.

[9] 赵睿, 罗佳, 章群丹, 刘国诠. 一种检测人β干扰素的生物传感器及其专用多肽. CN: CN101221185B, 2011-08-10.

[10] 赵睿, 黄嫣嫣, 周柔丽. 检测人癌细胞的多肽及其应用. CN: CN101781357A, 2010-07-21.

[11] 刘国诠, 毛建军, 赵睿, 上官棣华. 一种夹心型液芯波导结构检测池. CN: CN101000299A, 2007-07-18.

[12] 刘国诠, 刘阳, 赵睿. 以磺胺二甲嘧啶为配基的亲和色谱填料. 中国: CN1308067, 2007-04-04.

[13] 刘国诠, 喻昕, 赵睿. 烷基醚型高效液相色谱反相填料及其制备方法. CN: CN1108525C, 2003-05-14.

[14] 赵睿, 赵莹歆, 刘国诠. 一种高效亲和色谱填料及其制备方法. CN: CN1354365A, 2002-06-19.

[15] 刘国诠, 喻昕, 赵睿. 一种酯型高效液相色谱反相填料及其制备方法. CN: CN1283525A, 2001-02-14.

   

[1] Han Gao, Jian Chen, Yanyan Huang, Rui Zhao. Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease. TALANTA. 2024, 268: http://dx.doi.org/10.1016/j.talanta.2023.125311.
[2] Li, Yongming, Gao, Han, Jin, Yulong, Zhao, Rui, Huang, Yanyan. Peptide-derived coordination frameworks for biomimetic and selective separation. ANALYTICAL AND BIOANALYTICAL CHEMISTRYnull. 2023, 415(18): 4079-4092, http://dx.doi.org/10.1007/s00216-023-04761-0.
[3] Huang, Yanyan, Zhang, Guanxin, Zhao, Rui, Zhang, Deqing. Tetraphenylethene-Based cis/trans Isomers for Targeted Fluorescence Sensing and Biomedical Applications. CHEMISTRY-A EUROPEAN JOURNAL. 2023, http://dx.doi.org/10.1002/chem.202300539.
[4] Huang, Yanyan, Zhan, Chi, Yang, Yang, Wang, Lingna, Zhong, Huifei, Yu, Yang, Zhang, XiSha, Li, Cheng, Jin, Yulong, Zhang, Guanxin, Zhao, Rui, Zhang, Deqing. Tuning Proapoptotic Activity of a Phosphoric-Acid-Tethered Tetraphenylethene by Visible-Light-Triggered Isomerization and Switchable Protein Interactions for Cancer Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, e202208378-, [5] Jin, Yulong, Xu, Kun, Huang, Yanyan, Zhong, Huifei, Zhao, Rui. Activity-Based Probe for Ratiometric Fluorescence Imaging of Caspase-3 in Living Cells. ANALYTICAL CHEMISTRY[J]. 2021, 93(4): 2045-2052, https://www.webofscience.com/wos/woscc/full-record/WOS:000618089100023.
[6] Zhong, Huifei, Li, Yongming, Huang, Yanyan, Zhao, Rui. Metal-organic frameworks as advanced materials for sample preparation of bioactive peptides. ANALYTICAL METHODSnull. 2021, 13(7): 862-873, https://www.webofscience.com/wos/woscc/full-record/WOS:000621568400002.
[7] Hou, Huiqing, Jin, Yulong, Xu, Kun, Sheng, Le, Huang, Yanyan, Zhao, Rui. Selective recognition of a cyclic peptide hormone in human plasma by hydrazone bond-oriented surface imprinted nanoparticles. ANALYTICA CHIMICA ACTA[J]. 2021, 1154: http://dx.doi.org/10.1016/j.aca.2021.338301.
[8] Xu Kun, Jin Yulong, Huang Yanyan, Zhao Rui. Monitoring chemical synthesis of human atrial natriuretic peptide by ultra high performance liquid chromatography-mass spectrometry analysis. CHINESE JOURNAL OF CHROMATOGRAPHY[J]. 2020, 38(3): 324-331, [9] Huang, Yanyan, Zhang, Guanxin, Zhao, Rui, Zhang, Deqing. Aggregation-Induced Emission Luminogens for Mitochondria-Targeted Cancer Therapy. CHEMMEDCHEMnull. 2020, 15(23): 2220-2227, https://www.doi.org/10.1002/cmdc.202000632.
[10] Huang, Yanyan, You, Xue, Wang, Lingna, Zhang, Guanxin, Gui, Shilang, Jin, Yulong, Zhao, Rui, Zhang, Deqing. Pyridinium-Substituted Tetraphenylethylenes Functionalized with Alkyl Chains as Autophagy Modulators for Cancer Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(25): 10042-10051, http://dx.doi.org/10.1002/anie.202001906.
[11] Gui, Shilang, Huang, Yanyan, Zhu, Yuanyuan, Jin, Yulong, Zhao, Rui. Biomimetic Sensing System for Tracing Pb2+ Distribution in Living Cells Based on the Metal-Peptide Supramolecular Assembly. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(6): 5804-5811, http://dx.doi.org/10.1021/acsami.8b19076.
[12] Li, Yongming, Zhong, Huifei, Huang, Yanyan, Zhao, Rui. Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging. MOLECULESnull. 2019, 24(24): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000507299600171.
[13] Zhu, Yuanyuan, Huang, Yanyan, Jin, Yulong, Gui, Shilang, Zhao, Rui. Peptide-Guided System with Programmable Subcellular Translocation for Targeted Therapy and Bypassing Multidrug Resistance. ANALYTICAL CHEMISTRY[J]. 2019, 91(3): 1880-1886, http://dx.doi.org/10.1021/acs.analchem.8b03598.
[14] Huang YanYan, Zhao Rui. Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2019, 47(10): 1629-1638, [15] Huang YanYan, Zhao Rui. Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2019, 47(10): 1629-1638, https://www.webofscience.com/wos/woscc/full-record/WOS:000489332700019.
[16] Gui, Shilang, Huang, Yanyan, Hu, Fang, Jin, Yulong, Zhang, Guanxin, Zhang, Deqing, Zhao, Rui. Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling. ANALYTICAL CHEMISTRY[J]. 2018, 90(16): 9708-9715, http://dx.doi.org/10.1021/acs.analchem.8b00059.
[17] Lian, Xizhen, Huang, Yanyan, Zhu, Yuanyuan, Fang, Yu, Zhao, Rui, Joseph, Elizabeth, Li, Jialuo, Pellois, JeanPhilippe, Zhou, HongCai. Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(20): 5725-5730, http://dx.doi.org/10.1002/anie.201801378.
[18] Jin, Yulong, Xie, Yunfeng, Wu, Kui, Huang, Yanyan, Wang, Fuyi, Zhao, Rui. Probing the Dynamic Interaction between Damaged DNA and a Cellular Responsive Protein Using a Piezoelectric Mass Biosensor. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(10): 8490-8497, http://dx.doi.org/10.1021/acsami.6b15077.
[19] Su, Liming, Jin, Yulong, Huang, Yanyan, Zhao, Rui. Surface-imprinted magnetic nanoparticles for the selective enrichment and fast separation of fluoroquinolones in human serum. JOURNAL OF SEPARATION SCIENCE[J]. 2017, 40(10): 2269-2277, http://dx.doi.org/10.1002/jssc.201700080.
[20] 赵睿. Well-defined magnetic surface imprinted nanoparticles for selective enrichment of 2,4-dichlorophenoxyacetic acid in real samples. Talanta. 2017, [21] He, Jiayuan, Gui, Shilang, Huang, Yanyan, Hu, Fang, Jin, Yulong, Yu, Yang, Zhang, Guanxin, Zhang, Deqing, Zhao, Rui. Rapid, sensitive, and in-solution screening of peptide probes for targeted imaging of live cancer cells based on peptide recognition-induced emission. CHEMICAL COMMUNICATIONS[J]. 2017, 53(80): 11091-11094, http://dx.doi.org/10.1039/c7cc06485c.
[22] Sheng, Le, Jin, Yulong, He, Yonghuan, Huang, Yanyan, Yan, Liushui, Zhao, Rui. Well-defined magnetic surface imprinted nanoparticles for selective enrichment of 2,4-dichlorophenoxyacetic acid in real samples. TALANTA[J]. 2017, 174: 725-732, http://dx.doi.org/10.1016/j.talanta.2017.07.002.
[23] 赵睿. Surface-imprinted magnetic nanoparticles for the selective enrichment and fast separation of fluoroquinolones in human serum. Journal of Separation Science. 2017, [24] 瑙甘, 金钰龙, 黄嫣嫣, 赵睿. 脑啡肽的固相合成与LC-MS/MS分离鉴定. 分析测试学报[J]. 2017, 36(2): 190-195, http://lib.cqvip.com/Qikan/Article/Detail?id=671405442.
[25] Yu, Yang, Huang, Yanyan, Jin, Yulong, Zhao, Rui. Dual-targeting peptide probe for sequence- and structure-sensitive sensing of serum albumin. BIOSENSORS & BIOELECTRONICS[J]. 2017, 94: 657-662, http://dx.doi.org/10.1016/j.bios.2017.03.067.
[26] Zhao Rui, Jin Yulong, Yu Yang, Huang Yanyan. Dual-targeting peptide probe for sequence- and structure-sensitive sensing of serum albumin. BIOSENSORS & BIOELECTRONICS[J]. 2017, 94: 657-662, http://ir.iccas.ac.cn/handle/121111/38504.
[27] Huang, Yanyan, Zhang, Guanxin, Hu, Fang, Jin, Yulong, Zhao, Rui, Zhang, Deqing. Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells in vitro and in vivo by varying counter anions. CHEMICAL SCIENCE[J]. 2016, 7(12): 7013-7019, http://dx.doi.org/10.1039/c6sc02395a.
[28] Yu, Yang, Huang, Yanyan, Hu, Fang, Jin, Yulong, Zhang, Guanxin, Zhang, Deqing, Zhao, Rui. Self-Assembled Nanostructures Based on Activatable Red Fluorescent Dye for Site-Specific Protein Probing and Conformational Transition Detection. ANALYTICAL CHEMISTRY[J]. 2016, 88(12): 6374-6381, http://dx.doi.org/10.1021/acs.analchem.6b00774.
[29] Zhang, Ning, Hou, Jian, Chen, Suming, Xiong, Caiqiao, Liu, Huihui, Jin, Yulong, Wang, Jianing, He, Qing, Zhao, Rui, Nie, Zongxiu. Rapidly Probing Antibacterial Activity of Graphene Oxide by Mass Spectrometry-based Metabolite Fingerprinting. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000378078300001.
[30] 侯会卿, 苏黎明, 黄嫣嫣, 金钰龙, 赵睿. 表面分子印迹材料和技术在分离分析中的应用进展. 色谱[J]. 2016, 34(12): 1206-1214, http://lib.cqvip.com/Qikan/Article/Detail?id=672065930.
[31] Huang, Yanyan, Jin, Yulong, Zhao, Rui. Rational design and functional evolution of targeted peptides for bioanalytical applications. SCIENCE CHINA-CHEMISTRY[J]. 2016, 59(10): 1250-1257, https://www.webofscience.com/wos/woscc/full-record/WOS:000385060400004.
[32] Yang Yang, Huang Yanyan, Zhang Guanxin, Zhao Rui, Zhang Deqing. A New Fluorometric Turn-on Assay for Carboxylesterase and Inhibitor Screening Based on Aggregation Induced Emission Behavior of Tetraphenylethylene Molecules. ACTA CHIMICA SINICA[J]. 2016, 74(11): 871-876, https://www.webofscience.com/wos/woscc/full-record/WOS:000392462100003.
[33] 杨阳, 黄嫣嫣, 张关心, 赵睿, 张德清. 新型四苯乙烯衍生物的设计合成及其在羧酸酯酶活性分析中的应用. 化学学报[J]. 2016, 74(11): 871-876, http://lib.cqvip.com/Qikan/Article/Detail?id=670802902.
[34] Jin, Yulong, Huang, Yanyan, Yang, Hua, Liu, Guoquan, Zhao, Rui. A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells. CHEMICAL COMMUNICATIONS[J]. 2015, 51(77): 14454-14457, http://dx.doi.org/10.1039/c5cc05184c.
[35] Huang, Yanyan, Zhang, Qundan, Liu, Guoquan, Zhao, Rui. A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition. CHEMICAL COMMUNICATIONS[J]. 2015, 51(30): 6601-6604, http://dx.doi.org/10.1039/c5cc00885a.
[36] Gui, Shilang, Huang, Yanyan, Hu, Fang, Jin, Yulong, Zhang, Guanxin, Yan, Liushui, Zhang, Deqing, Zhao, Rui. Fluorescence Turn-On Chemosensor for Highly Selective and Sensitive Detection and Bioimaging of Al3+ in Living Cells Based on Ion-Induced Aggregation. ANALYTICAL CHEMISTRY[J]. 2015, 87(3): 1470-1474, http://dx.doi.org/10.1021/ac504153c.
[37] 黄嫣嫣, 赵睿. 靶向多肽识别与高选择性分离分析. 色谱[J]. 2015, 33(5): 447-448, http://lib.cqvip.com/Qikan/Article/Detail?id=664653165.
[38] Hu, Fang, Huang, Yanyan, Zhang, Guanxin, Zhao, Rui, Zhang, Deqing. A highly selective fluorescence turn-on detection of hydrogen peroxide and D-glucose based on the aggregation/deaggregation of a modified tetraphenylethylene. TETRAHEDRON LETTERS[J]. 2014, 55(8): 1471-1474, http://dx.doi.org/10.1016/j.tetlet.2014.01.056.
[39] Xie, Yunfeng, Jin, Yulong, Huang, Yanyan, Liu, Guoquan, Zhao, Rui. Highly selective piezoelectric sensor for lead(II) based on the lead-catalyzed release of gold nanoparticles from a self-assembled nanosurface. MICROCHIMICA ACTA[J]. 2014, 181(13-14): 1521-1527, http://ir.iccas.ac.cn/handle/121111/27235.
[40] He, Yonghuan, Huang, Yanyan, Jin, Yulong, Liu, Xiangjun, Liu, Guoquan, Zhao, Rui. Well-Defined Nanostructured Surface-Imprinted Polymers for Highly Selective Magnetic Separation of Fluoroquinolones in Human Urine. ACS APPLIED MATERIALS & INTERFACES[J]. 2014, 6(12): 9634-9642, http://ir.iccas.ac.cn/handle/121111/27233.
[41] Huang, Yanyan, Hu, Fang, Zhao, Rui, Zhang, Guanxin, Yang, Hua, Zhang, Deqing. Tetraphenylethylene Conjugated with a Specific Peptide as a Fluorescence Turn-On Bioprobe for the Highly Specific Detection and Tracing of Tumor Markers in Live Cancer Cells. CHEMISTRYAEUROPEANJOURNAL[J]. 2014, 20(1): 158-164, http://dx.doi.org/10.1002/chem.201303679.
[42] Hu, Fang, Huang, Yanyan, Zhang, Guanxin, Zhao, Rui, Yang, Hua, Zhang, Deqing. Targeted Bioimaging and Photodynamic Therapy of Cancer Cells with an Activatable Red Fluorescent Bioprobe. ANALYTICAL CHEMISTRY[J]. 2014, 86(15): 7987-7995, http://dx.doi.org/10.1021/ac502103t.
[43] Liu, Yongliang, He, Yonghuan, Jin, Yulong, Huang, Yanyan, Liu, Guoquan, Zhao, Rui. Preparation of monodispersed macroporous core-shell molecularly imprinted particles and their application in the determination of 2,4-dichlorophenoxyacetic acid. JOURNAL OF CHROMATOGRAPHY A[J]. 2014, 1323(1): 11-17, http://dx.doi.org/10.1016/j.chroma.2013.11.002.
[44] Wang, Weizhi, Huang, Yanyan, Jin, Yulong, Liu, Guoquan, Chen, Yi, Ma, Huimin, Zhao, Rui. A tetra-layer microfluidic system for peptide affinity screening through integrated sample injection. ANALYST[J]. 2013, 138(10): 2890-2896, https://www.webofscience.com/wos/woscc/full-record/WOS:000317867400017.
[45] 金钰龙, 黄嫣嫣, 刘国诠, 赵睿. 基于纳米金增敏的石英晶体微天平传感器用于铜离子的快速；高选择性检测. ANALYST[J]. 2013, 138(1): 5479-5485, http://ir.iccas.ac.cn/handle/121111/27228.
[46] 王蔚芝, 黄嫣嫣, 金钰龙, 刘国诠, 陈义, 马会民, 赵睿. 基于集成化进样的多层3D微流控芯片系统及其在多肽筛选检测中的应用. ANALYST[J]. 2013, 138(1): 2890-2896, http://ir.iccas.ac.cn/handle/121111/27227.
[47] Jin, Yulong, Huang, Yanyan, Liu, Guoquan, Zhao, Rui. Gold nanoparticle-sensitized quartz crystal microbalance sensor for rapid and highly selective determination of Cu(II) ions. ANALYST[J]. 2013, 138(18): 5479-5485, https://www.webofscience.com/wos/woscc/full-record/WOS:000323115200040.
[48] 刘吉众, 黄嫣嫣, 杨博, 常建华, 刘国诠, 赵睿. 高亲水性强阳离子交换色谱填料的制备及其在蛋白质分析中的应用. 色谱[J]. 2013, 31(4): 310-316, http://lib.cqvip.com/Qikan/Article/Detail?id=45614432.
[49] 黄嫣嫣, 赵睿. Highly selective analysis of proteins based on targetable peptide probes. 分析测试学报[J]. 2012, 31(9): 1184-1190, http://ir.iccas.ac.cn/handle/121111/5325.
[50] Zhi-Bing Shi, Dan Zhao, 黄嫣嫣, Yun Du, Xiang-Rong Cao, Zhu-Nan Gong, 赵睿, 李建新. Discovery, Synthesis, and Evaluation of Small-Molecule Signal Transducer and Activator of Transcription 3 Inhibitors. CHEMICAL AND PHARMACEUTICAL BULLETIN[J]. 2012, 60(12): 1574-1580, http://www.irgrid.ac.cn/handle/1471x/898305.
[51] 黄嫣嫣, 赵睿. Highly selective analysis of proteins based on targetable peptide probes. 分析测试学报[J]. 2012, 31(9): 1184-1190, http://ir.iccas.ac.cn/handle/121111/5325.
[52] Liu, Yongliang, Huang, Yanyan, Liu, Jizhong, Wang, Weizhi, Liu, Guoquan, Zhao, Rui. Superparamagnetic surface molecularly imprinted nanoparticles for water-soluble pefloxacin mesylate prepared via surface initiated atom transfer radical polymerization and its application in egg sample analysis. JOURNAL OF CHROMATOGRAPHY A[J]. 2012, 1246: 15-21, http://dx.doi.org/10.1016/j.chroma.2012.01.045.
[53] Jin, Yulong, Huang, Yanyan, Xie, Yunfeng, Hu, Wenbing, Wang, Fuyi, Liu, Guoquan, Zhao, Rui. Cyclic interconversion of methionine containing peptide between oxidized and reduced phases monitored by reversed-phase HPLC and ESI-MS/MS. TALANTA[J]. 2012, 89: 531-536, http://dx.doi.org/10.1016/j.talanta.2011.12.070.
[54] Shi, ZhiBing, Zhao, Dan, Huang, YanYan, Du, Yun, Cao, XiangRong, Gong, ZhuNan, Zhao, Rui, Li, JianXin. Discovery, Synthesis, and Evaluation of Small-Molecule Signal Transducer and Activator of Transcription 3 Inhibitors. CHEMICAL & PHARMACEUTICAL BULLETIN[J]. 2012, 60(12): 1574-1580, http://www.irgrid.ac.cn/handle/1471x/898305.
[55] Huang, Yanyan, Zhao, Rui, Fu, Yabin, Zhang, Qundan, Xiong, Shaoxiang, Li, Li, Zhou, Rouli, Liu, Guoquan, Chen, Yi. Highly Specific Targeting and Imaging of Live Cancer Cells by Using a Peptide Probe Developed from Rationally Designed Peptides. CHEMBIOCHEM[J]. 2011, 12(8): 1209-1215, http://dx.doi.org/10.1002/cbic.201100031.
[56] Huang, Yanyan, Xiong, Shaoxiang, Liu, Guoquan, Zhao, Rui. A rapid and highly selective colorimetric method for direct detection of tryptophan in proteins via DMSO acceleration. CHEMICAL COMMUNICATIONS[J]. 2011, 47(29): 8319-8321, http://dx.doi.org/10.1039/c1cc12303c.
[57] Xie, Yunfeng, Huang, Yanyan, Wang, Weizhi, Liu, Guoquan, Zhao, Rui. Dynamic interaction between melamine and cyanuric acid in artificial urine investigated by quartz crystal microbalance. ANALYST[J]. 2011, 136(12): 2482-2488, http://dx.doi.org/10.1039/c1an15119c.
[58] 黄嫣嫣, 赵睿, 付雅斌, 章群丹, 熊少祥, 李莉, 周柔丽, 刘国诠, 陈义. Highly specific targeting and imaging of live cancer cells using a peptide probe developed from rationally designed peptides. CHEMBIOCHEM[J]. 2011, 12(8): 1209-1215, http://ir.iccas.ac.cn/handle/121111/5408.
[59] Liu, Jizhong, Wang, Weizhi, Xie, Yunfeng, Huang, Yanyan, Liu, Yongliang, Liu, Xiangjun, Zhao, Rui, Liu, Guoquan, Chen, Yi. A novel polychloromethylstyrene coated superparamagnetic surface molecularly imprinted core-shell nanoparticle for bisphenol A. JOURNAL OF MATERIALS CHEMISTRY[J]. 2011, 21(25): 9232-9238, http://dx.doi.org/10.1039/c1jm10227c.
[60] Wang, Weizhi, Huang, Yanyan, Liu, Jizhong, Xie, Yunfeng, Zhao, Rui, Xiong, Shaoxiang, Liu, Guoquan, Chen, Yi, Ma, Huimin. Integrated SPPS on continuous-flow radial microfluidic chip. LAB ON A CHIP[J]. 2011, 11(5): 929-935, http://dx.doi.org/10.1039/c0lc00542h.
[61] Wang, Cheng, Chen, Qun, Sun, Fei, Zhang, Deqing, Zhang, Guanxin, Huang, Yanyan, Zhao, Rui, Zhu, Daoben. Multistimuli Responsive Organogels Based on a New Gelator Featuring Tetrathiafulvalene and Azobenzene Groups: Reversible Tuning of the Gel-Sol Transition by Redox Reactions and Light Irradiation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(9): 3092-3096, https://www.webofscience.com/wos/woscc/full-record/WOS:000275660500047.
[62] 赵睿. “全国生物医药色谱学术交流会（2010）”会议简报. 色谱[J]. 2010, 28(5): 525-526, http://lib.cqvip.com/Qikan/Article/Detail?id=34062031.
[63] 黄嫣嫣, 罗佳, 赵睿. 多肽型QCM生物传感器的构建及应用. 分析化学[J]. 2009, 37(A03): 1007-, http://lib.cqvip.com/Qikan/Article/Detail?id=32785586.
[64] Cheng, Xiaohong, Liu, Xiangjun, Bing, Tao, Zhao, Rui, Xiong, Shaoxiang, Shangguan, Dihua. Specific DNA G-Quadruplexes Bind to Ethanolamines. BIOPOLYMERS[J]. 2009, 91(10): 874-883, http://www.corc.org.cn/handle/1471x/2400173.
[65] Peng, Lihua, Zhang, Guanxin, Zhang, Deqing, Xiang, Junfeng, Zhao, Rui, Wang, Yilin, Zhu, Daoben. A Fluorescence "Turn-On" Ensemble for Acetylcholinesterase Activity Assay and Inhibitor Screening. ORGANIC LETTERS[J]. 2009, 11(17): 4014-4017, http://dx.doi.org/10.1021/ol9016723.
[66] Liu, Xiangjun, Liu, Jizhong, Huang, Yanyan, Zhao, Rui, Liu, Guoquan, Chen, Yi. Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly iniprinted polymer. JOURNAL OF CHROMATOGRAPHY A[J]. 2009, 1216(44): 7533-7538, https://www.webofscience.com/wos/woscc/full-record/WOS:000271250500030.
[67] 赵睿, 刘祥军. 拟模板分子印迹聚合物的制备与应用研究. 分析化学[J]. 2009, 37(A02): 471-, http://lib.cqvip.com/Qikan/Article/Detail?id=32784442.
[68] Huang, Yanyan, Zhao, Rui, Luo, Jia, Xiong, Shaoxiang, Shangguan, Dihua, Zhang, Hangwu, Liu, Guoquan, Chen, Yi. Design, synthesis and screening of antisense peptide based combinatorial peptide libraries towards an aromatic region of SARS-CoV. JOURNAL OF MOLECULAR RECOGNITION[J]. 2008, 21(2): 122-131, https://www.webofscience.com/wos/woscc/full-record/WOS:000255105800006.
[69] Zhang, Qundan, Huang, Yanyan, Zhao, Rui, Liu, Guoquan, Chen, Yi. In situ growth of nanogold on quartz crystal microbalance and its application in the interaction between heparin and antithrombin III. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2008, 319(1): 94-99, http://dx.doi.org/10.1016/j.jcis.2007.11.039.
[70] Zhang, Qundan, Huang, Yanyan, Zhao, Rui, Liu, Guoquan, Chen, Yi. Determining binding sites of drugs on human serum albumin using FIA-QCM. BIOSENSORS & BIOELECTRONICS[J]. 2008, 24(1): 48-54, http://dx.doi.org/10.1016/j.bios.2008.03.009.
[71] Jia, Luo, YanYan, Huang, ShaoXiang, Xiong, GuoQuan, Liu, Rui, Zhao. Study on peptide-peptide interaction using high-performance affinity chromatography and quartz crystal microbalance biosensor. CHINESE SCIENCE BULLETIN[J]. 2007, 52(10): 1311-1319, http://lib.cqvip.com/Qikan/Article/Detail?id=24544988.
[72] Luo, Jia, Zhang, Qundan, Huang, Yanyan, Liu, Guoquan, Zhao, Rui. Quartz crystal microbalance biosensor for recombinant human interferon-beta detection based on antisense peptide approach. ANALYTICA CHIMICA ACTA[J]. 2007, 590(1): 91-97, https://www.webofscience.com/wos/woscc/full-record/WOS:000246098400011.
[73] Liu, Xiangjun, Chen, Zhiyong, Zhao, Rui, Shangguan, Dihua, Liu, Guoquan, Chen, Yi. Uniform-sized molecularly imprinted polymer for metsulfuron-methyl by one-step swelling and polymerization method. TALANTA[J]. 2007, 71(3): 1205-1210, http://dx.doi.org/10.1016/j.talanta.2006.06.021.
[74] Liu XiangJun, Liu JiZhong, Zhao Rui, Liu GuoQuan, Chen Yi. Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE[J]. 2007, 28(10): 1878-1880, https://www.webofscience.com/wos/woscc/full-record/WOS:000250324400017.
[75] Wen, Guoyong, Zhang, Deqing, Huang, Yanyan, Zhao, Rui, Zhu, Lingyun, Shuai, Zhigang, Zhu, Daoben. New heterocyclic tetrathiafulvalene compounds with an azobenzene moiety: Photomodulation of the electron-donating ability of the tetrathiafulvalene moiety. JOURNAL OF ORGANIC CHEMISTRY[J]. 2007, 72(16): 6247-6250, https://www.webofscience.com/wos/woscc/full-record/WOS:000248344400038.
[76] 赵睿, 刘国诠, 陈义, 刘祥军, 刘吉众. 三甲氧基苄啶分子印迹整体柱的制备及色谱性能. 高等学校化学学报[J]. 2007, 28(10): 1878-1880, http://lib.cqvip.com/Qikan/Article/Detail?id=25586336.
[77] Ji, Dongmei, Zhao, Rui, Huang, Zhengxi, Xia, Andong. Energy migration within BODIPY dimer studied by single molecule spectroscopy. JOURNAL OF LUMINESCENCE[J]. 2007, 122: 253-255, http://dx.doi.org/10.1016/j.jlumin.2006.01.128.
[78] Liu, Xiangjun, Ouyan, Canbin, Zhao, Rui, Shangguan, Dihua, Chen, Yi, Liu, Guoquan. Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase. ANALYTICA CHIMICA ACTA[J]. 2006, 571(2): 235-241, http://dx.doi.org/10.1016/j.aca.2006.05.005.
[79] 王磊, 韩慧婉, 余晓, 赵睿, 刘国诠. 微柱液相色谱—电化学法检测鼠纹状体单胺类物质的含量. 高等学校化学学报[J]. 2002, 23(6): 1050-1052, http://lib.cqvip.com/Qikan/Article/Detail?id=6349808.
[80] 喻昕, 刘国诠, 赵睿. 限进介质烷基—二醇基硅胶（ADS）的制备. 色谱[J]. 2001, 19(2): 152-, http://lib.cqvip.com/Qikan/Article/Detail?id=5073314.
[81] 余晓, 刘国诠, 苏天升, 方梅, 熊少祥, 赵睿. 以寡聚组氨酸为配基的高效亲和色谱研究. 高等学校化学学报[J]. 2000, 21(4): 532-, http://lib.cqvip.com/Qikan/Article/Detail?id=4197446.
[82] 喻昕, 赵睿, 刘国诠. 十八烷基醚型高效液相反相色谱填料的制备. 高等学校化学学报[J]. 2000, 21(7): 1043-, http://lib.cqvip.com/Qikan/Article/Detail?id=4417413.
[83] 余晓, 熊少祥, 赵睿, 刘国诠, 赵莹欣, 王光辉, 辛斌. HPLC分离MALDI-TOF-MS鉴定合成多肽的研究. 质谱学报[J]. 2000, 21(4): 73-, http://lib.cqvip.com/Qikan/Article/Detail?id=4653192.
[84] 刘国诠, 王允富, 何秀娟, 乔霞, 赵睿, 喻昕. 利用后凝胶化反应制备低吸附性反相填料. 高等学校化学学报[J]. 2000, 21(3): 383-, http://lib.cqvip.com/Qikan/Article/Detail?id=4110377.
[85] 熊少祥, 韩慧婉, 赵睿, 王光辉, 马会民, 陈义, 刘国诠. 高效液相色谱-激光诱导荧光-增强型电荷耦合器件检测氨基酸的研究. 高等学校化学学报[J]. 2000, 1191-, [86] 赵睿, 韩慧婉, 刘国诠, 方梅, 藏冰, 余晓, 盛力. 一种研究生物大分子与其小分子配基相互作用的毛细管电泳新方法. 分析化学[J]. 2000, 28(8): 925-, http://lib.cqvip.com/Qikan/Article/Detail?id=4511458.
[87] 赵睿, 郭予含, 熊少祥, 苏天升, 刘国诠, 方梅, 余晓. 单分散非多孔交联聚甲基丙烯酸环氧丙酯微球作为亲和色谱载体的研究. 分析化学[J]. 2000, 28(5): 544-, http://lib.cqvip.com/Qikan/Article/Detail?id=4248064.
[88] 喻昕, 赵睿, 刘国诠. 一种新型C18酯型反相高效液相色谱填料的制备. 色谱[J]. 2000, 18(1): 25-, https://www.chrom-china.com/CN/.
[89] 韩慧婉, 赵睿, 陈义, 刘国诠, 舒鸿钧. 操作式条件反射训练对大鼠脑海马区游离氨基酸的影响. 高等学校化学学报[J]. 1999, 20(11): 1703-, http://lib.cqvip.com/Qikan/Article/Detail?id=3661339.
[90] 马会民, 王光辉, 刘国诠, 韩慧婉, 熊少祥, 陈义, 赵睿. 高效毛细管电泳—激光诱导荧光检测生物活性肽的研究. 分析测试学报[J]. 1999, 18(5): 1-, http://lib.cqvip.com/Qikan/Article/Detail?id=3708114.
[91] 赵睿, 刘国诠, 韩慧婉, 秦浚川, 舒鸿钧, 沈倍奋. 家蚕血淋巴液中重组人粒细胞-巨噬细胞集落刺激因子（rhGM-CSF）的制备纯化及鉴定. 高技术通讯. 1999, 9(7): 45-, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=604522&detailType=1.
[92] 陈义, 王光辉, 赵睿, 刘国诠, 熊少祥, 马会民, 韩慧婉. 高效液相色谱—激光诱导荧光—增强型电荷耦合器件检测装置. 分析化学[J]. 1999, 27(10): 1231-, http://lib.cqvip.com/Qikan/Article/Detail?id=3661279.
[93] 赵睿. 超微量生理活性多酞分离分析新方法. 1997, http://ir.iccas.ac.cn/handle/121111/32543.
[94] 何秀娟, 赵睿, 王萍, 吴晓军, 刘国诠, 乔桂娟. 无机基质疏水作用色谱填料的研制及扩试. 色谱[J]. 1997, 15(3): 225-, http://lib.cqvip.com/Qikan/Article/Detail?id=2852397.
[95] 赵睿, 郑秋君, 陈滨, 蒋盘宏, 吴淑华, 许丽锋, 刘国诠, 白东亭. 基因工程β型干扰素的分离纯化. 中华微生物学和免疫学杂志[J]. 1996, 16(6): 452-, http://lib.cqvip.com/Qikan/Article/Detail?id=2402687.
[96] 何秀娟, 张任恩, 赵睿, 鲁青. 痕量神经肽的高效液相色谱. 分析化学[J]. 1992, 20(3): 245-, http://lib.cqvip.com/Qikan/Article/Detail?id=736063.
[97] Zhao, Rui, Liu, Guoquan, Feng, Fangbo, Zhang, Renen. DETERMINATION OF ENKEPHALINS IN FETUS BRAIN TISSUES BY MEANS OF HPLC WITH PRE-COLUMN FLUORESCENCE DERIVATIZATION. ANALYTICAL SCIENCES[J]. 1991, 7: 951-954, https://www.webofscience.com/wos/woscc/full-record/WOS:000209357900258.
[98] Han Gao, Jian Chen, Yanyan Huang, Rui Zhao. Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease. TALANTA. http://dx.doi.org/10.1016/j.talanta.2023.125311.

 

刘永亮 2009级博士研究生 070302-分析化学  80032-化学研究所

谢云峰  2008级博士研究生  070302-分析化学 80032-化学研究所

王蔚芝  2006级硕博连读生  070302-分析化学  80032-化学研究所

刘吉众  2005级硕博连读生  070302-分析化学  80032-化学研究所

黄嫣嫣 2004级硕博连读生 070302-分析化学  80032-化学研究所  

章群丹 2003级硕博连读生 070302-分析化学  80032-化学研究所

刘祥军 2002级硕博连读生 070302-分析化学  80032-化学研究所

罗    佳 2001级硕博连读生 070302-分析化学  80032-化学研究所 

方灿良 1999级硕士研究生 070302-分析化学  80032-化学研究所

翟来良  1998级硕士研究生 070302-分析化学  80032-化学研究所