0710Z1-基因组学
1001Z1-精准医学
0710J3-生物信息学

基因组大数据与精准医学研究
细胞分化的表观遗传调控网络
基因组学成果转化与应用

1996-09--1999-07   第一军医大学   人体解剖学和组织胚胎学博士
1992-09--1995-07   第一军医大学   免疫学硕士
1986-09--1992-07   第一军医大学   临床医学本科

2009-01~现在, 中国科学院北京基因组研究所研究员，博士生导师
2000-05~2009-01,美国华盛顿大学医学院, 博士后、讲师、研究助理教授

2012-12-31-今,《发育医学电子杂志》, 主编
2011-03-31-今,《遗传》, 编委
2010-01-01-今,Genomics Proteomics Bioinformatics, 副主编

基因组学分析技术与原理
基因组学中的核心技术
生物医学大数据
基因组学前沿
基因组学

   

（1） 《基因组学前沿》国科大生命学院优秀课程, 院级, 2013
（2） 中国科学院知识创新工程“****”择优支持, , 院级, 2010
（3） 上海市科学技术进步奖, 三等奖, 省级, 1999
（4） 广东省科学技术进步奖, 二等奖, 省级, 1995

（ 1 ） 用于检测人肝癌细胞标志物的引物和探针及其检测试剂盒, 发明, 2015, 第 1 作者, 专利号: 201310551809.9
（ 2 ） 2. 一种特异性抑制MAGEA1基因表达的小干扰RNA及其应用, 发明, 2018, 第 1 作者, 专利号: ZL201510958851.1
（ 3 ） 4. 一种特异性抑制CTGF基因表达的小干扰RNA及其应用, 发明, 2018, 第 1 作者, 专利号: ZL201510958362.6
（ 4 ） 5. 一种特异性抑制TWIST1基因表达的小干扰RNA及其应用, 发明, 2018, 第 1 作者, 专利号: ZL201510959113.9

   

[1] Wang, Guoliang, Wu, Song, Xiong, Zhuang, Qu, Hongzhu, Fang, Xiangdong, Bao, Yiming. CROST: a comprehensive repository of spatial transcriptomics. NUCLEIC ACIDS RESEARCH. 2023, http://dx.doi.org/10.1093/nar/gkad782.
[2] 葛令乔, 渠鸿竹, 方向东. 大型队列数据资源及其研究方法综述. 中国卫生信息管理杂志. 2023, 20(3): 475-481, http://lib.cqvip.com/Qikan/Article/Detail?id=7109903055.
[3] 时文睿, 渠鸿竹, 方向东. 痛风的多组学研究进展. 遗传[J]. 2023, 45(8): 643-657, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7542676&detailType=1.
[4] Cui, Yunlong, Li, Hongfeng, Liu, Pengfei, Wang, Hailong, Zhang, Zhenzhen, Qu, Hongzhu, Tian, Caijuan, Fang, Xiangdong. DeteX: A highly accurate software for detecting SNV and InDel in single and paired NGS data in cancer research. FRONTIERS IN GENETICS[J]. 2023, 13: http://dx.doi.org/10.3389/fgene.2022.1118183.
[5] Fenglong Yang, Jialin Qian, Hongzhu Qu, Xiangdong Fang. DNA methylation-based age prediction with bloodstains using pyrosequencing and random forest regression. Electrophoresis[J]. 2023, [6] Zhao, Xuetong, Sui, Yang, Ruan, Xiuyan, Wang, Xinyue, He, Kunlun, Dong, Wei, Qu, Hongzhu, Fang, Xiangdong. A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features. CLINICAL EPIGENETICS[J]. 2022, 14(1): http://dx.doi.org/10.1186/s13148-022-01232-8.
[7] Tingting Jin, Zhaojun Zhang, Yuanyuan Han, Di Li, Juan Liu, Minmin Jiang, Ryo Kurita, Yukio Nakamura, Fangfang Hu, Xiangdong Fang, Shengwen Huang, Zhaolin Sun. ANTXR1 Regulates Erythroid Cell Proliferation and Differentiation through wnt β -Catenin Signaling Pathway In Vitro and in Hematopoietic Stem Cell. DISEASE MARKERS[J]. 2022, 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440811/.
[8] Tingting Jin, Zhaojun Zhang, Yuanyuan Han, Di Li, Juan Liu, Minmin Jiang, Junwei Zhu, Ryo Kurita, Yukio Nakamura, Fangfang Hu, Yongjie Xu, Xiangdong Fang, Shengwen Huang, Zhaolin Sun. Transmembrane Protein ANTXR1 Regulates γ -Globin Expression by Targeting the Wnt β -Catenin Signaling Pathway. JOURNAL OF IMMUNOLOGY RESEARCH[J]. 2022, 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356848/.
[9] Han, Yuanyuan, Huang, Ling, Zhou, Man, Tan, Xiaoyu, Gong, Shangjin, Zhang, Zhaojun, Jin, Tingting, Fang, Xiangdong, Jia, Yankai, Huang, S W. Comparison of transcriptome profiles of nucleated red blood cells in cord blood between preterm and full-term neonates. HEMATOLOGY[J]. 2022, 27(1): 263-273, http://dx.doi.org/10.1080/16078454.2022.2029255.
[10] Liu, Bing, Wang, Chen, Fang, Zhanjie, Bai, Jing, Qian, Ying, Ma, Yuanyuan, Ruan, Xiuyan, Yan, Shi, Li, Shaolei, Wang, Yaqi, Dong, Bin, Yang, Xin, Li, Meng, Xia, Xuefeng, Qu, Hongzhu, Fang, Xiangdong, Wu, Nan. Single-cell RNA sequencing reveals the cellular and molecular changes that contribute to the progression of lung adenocarcinoma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 10: http://dx.doi.org/10.3389/fcell.2022.927300.
[11] Han, Yuanyuan, Tan, Xiaoyu, Jin, Tingting, Zhao, Siqi, Hu, Li, Zhang, Wei, Kurita, Ryo, Nakamura, Yukio, Liu, Juan, Li, Di, Zhang, Zhaojun, Fang, Xiangdong, Huang, Shengwen. CRISPR/Cas9-based multiplex genome editing of BCL11A and HBG efficiently induces fetal hemoglobin expression. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2022, 918: http://dx.doi.org/10.1016/j.ejphar.2022.174788.
[12] Zan He, Zijuan Xin, Qiong Yang, Chen Wang, Meng Li, Wei Rao, Zhimin Du, Jia Bai, Zixuan Guo, Xiuyan Ruan, Zhaojun Zhang, Xiangdong Fang, Hua Zhao. Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments. ELIFE[J]. 2022, 11: https://doaj.org/article/3abf992fbf1c4a5b8f4e309104741c37.
[13] Xin, Zijuan, Zhang, Wei, Gong, Shangjin, Zhu, Junwei, Li, Yanming, Zhang, Zhaojun, Fang, Xiangdong. Mapping Human Pluripotent Stem Cell-derived Erythroid Differentiation by Single-cell Transcriptome Analysis. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2021, 19(3): 358-376, http://dx.doi.org/10.1016/j.gpb.2021.03.009.
[14] 方向东. 中国人类遗传资源与生物大数据. 遗传. 2021, [15] 王昕玥, 渠鸿竹, 方向东. 组学大数据和医学人工智能. 遗传[J]. 2021, 43(10): 930-937, [16] He, Zan, Xin, Zijuan, Peng, Yongfei, Zhao, Hua, Fang, Xiangdong. Construction of competing endogenous RNA interaction network as prognostic markers in metastatic melanoma. PEERJ[J]. 2021, 9: http://dx.doi.org/10.7717/peerj.12143.
[17] Ren, Yunxiao, Zhu, Junwei, Han, Yuanyuan, Li, Pin, Wu, Jing, Qu, Hongzhu, Zhang, Zhaojun, Fang, Xiangdong. Regulatory association of long noncoding RNAs and chromatin accessibility facilitates erythroid differentiation. BLOOD ADVANCES[J]. 2021, 5(23): 5396-5409, http://dx.doi.org/10.1182/bloodadvances.2021005167.
[18] Bi, F, Qian, Y, Song, L, Qu, H, Zheng, J, Fang, X, He, T, Yan, H. Genome sequencing of pancreatic cancer: differential expression by location. BRITISH JOURNAL OF SURGERYnull. 2021, 108(2): E67-E68, http://dx.doi.org/10.1093/bjs/znaa063.
[19] Yang, Yadong, Zhang, Tao, Xiao, Rudan, Hao, Xiaopeng, Zhang, Huiqiang, Qu, Hongzhu, Xie, Bingbing, Wang, Tao, Fang, Xiangdong. Platform-independent approach for cancer detection from gene expression profiles of peripheral blood cells. BRIEFINGS IN BIOINFORMATICS[J]. 2020, 21(3): 1006-1015, https://www.webofscience.com/wos/woscc/full-record/WOS:000537509700020.
[20] X Wang, L Sun, N He, Z An, R Yu, C Li, Y Li, Y Li, X Liu, X Fang, J Zhao. Increased expression of CXCL2 in ACPA‐positive rheumatoid arthritis and its role in osteoclastogenesis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY[J]. 2020, 203(2): 194-208, [21] Hongzhu Qu, Hongxing Lei, Xiangdong Fang. Big Data and the Brain: Peeking at the Future. 基因组蛋白质组与生物信息学报:英文版[J]. 2019, 17(4): 333-336, http://dx.doi.org/10.1016/j.gpb.2019.11.003.
[22] 任云晓, 肖茹丹, 娄晓敏, 方向东. 基因编辑技术及其在基因治疗中的应用. 遗传[J]. 2019, 41(1): 18-28, http://lib.cqvip.com/Qikan/Article/Detail?id=7001148373.
[23] Yadong Yang, Yang Sui, Bingbing Xie, Hongzhu Qu, Xiangdong Fang. GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis. GENOMICS[J]. 2019, 17(4): 465-471, http://lib.cqvip.com/Qikan/Article/Detail?id=7101029400.
[24] Zhou, Xia, Yang, Yadong, Ma, Pengcheng, Wang, Na, Yang, Dong, Tu, Qiu, Sun, Bin, Xiang, Tingxiu, Zhao, Xudong, Hou, Zongliu, Fang, Xiangdong. TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway. JOURNAL OF NEURO-ONCOLOGY[J]. 2019, 145(2): 211-222, http://dx.doi.org/10.1007/s11060-019-03301-0.
[25] Xie, Fang, Yu, Haisheng S, Wang, Rui, Wang, Dong, Li, Yanming M, Wen, Haiying Y, Du, Jiangbo B, Ba, Wei, Meng, Xianfu F, Yang, Jie, Lin, Biwen W, Li, Hengjin J, Li, Chengxin X, Zhang, Liguo G, Fang, Xiangdong D, Zhao, Hua. Photodynamic Therapy for Genital Warts Causes Activation of Local Immunity. JOURNAL OF CUTANEOUS MEDICINE AND SURGERY[J]. 2019, 23(4): 370-379, https://www.webofscience.com/wos/woscc/full-record/WOS:000477683700003.
[26] Yang, Qiong, Deng, Youhui, Xu, Yuanyuan, Ding, Nan, Wang, Chen, Zhao, Xuetong, Lou, Xiaomin, Li, Yongjun, Zhao, Hua, Fang, Xiangdong. Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression. GENE[J]. 2019, 716: http://dx.doi.org/10.1016/j.gene.2019.144010.
[27] Qu Hongzhu. GliomaDB: a Web Server for Integrating Glioma Omics Data and Interactive Analysis.. Genomics Proteomics & Bioinformatics. 2018, [28] 任岚, 肖茹丹, 张倩, 娄晓敏, 张昭军, 方向东. KLF1和KLF9对K562细胞红系分化的协同调控作用. 遗传[J]. 2018, 40(11): 998-1006, http://lib.cqvip.com/Qikan/Article/Detail?id=7000931358.
[29] 肖茹丹, 任云晓, 张昭军, 方向东. 基因编辑在镰状细胞贫血症治疗中的研究进展. 发育医学电子杂志[J]. 2018, 6(3): 141-148, http://lib.cqvip.com/Qikan/Article/Detail?id=675956593.
[30] 赵学彤, 杨亚东, 渠鸿竹, 方向东. 组学时代下机器学习方法在临床决策支持中的应用. 遗传[J]. 2018, 40(9): 693-703, http://lib.cqvip.com/Qikan/Article/Detail?id=7000827522.
[31] Fang Xiangdong. MOBCdb: a comprehensive database for integrating multi-omics data on breast cancer for precision medicine.. Breast Cancer Res Treat. 2018, [32] Fang Xiangdong. Research progress on liquid biopsy in oncology and its clinical applications.. Hereditas. 2017, [33] Li, Yanming, Zhang, Qian, Du, Zhenglin, Lu, ZhiChao, Liu, Shuge, Zhang, Lu, Ding, Nan, Bao, Binghao, Yang, Yadong, Xiong, Qian, Wang, Hai, Zhang, Zhaojun, Qu, Hongzhu, Jia, Haibo, Fang, Xiangdong. MicroRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB. BRITISH JOURNAL OF HAEMATOLOGY[J]. 2017, 176(1): 50-64, https://www.webofscience.com/wos/woscc/full-record/WOS:000393611900007.
[34] Fang Xiangdong. The mechanism and clinical significance of long noncoding RNA-mediated gene expression via nuclear architecture.. Hereditas. 2017, [35] Yanqing Wang, Fuhai Song, Junwei Zhu, Sisi Zhang, Yadong Yang, Tingting Chen, Bixia Tang, Lili Dong, Nan Ding, Qian Zhang, Zhouxian Bai, Xunong Dong, Huanxin Chen, Mingyuan Sun, Shuang Zhai, Yubin Sun, Lei Yu, Li Lan, Jingfa Xiao, Xiangdong Fang, Hongxing Lei, Zhang Zhang, Wenming Zhao. GSA: Genome Sequence Archive. 基因组蛋白质组与生物信息学报：英文版[J]. 2017, 15(1): 14-18, http://lib.cqvip.com/Qikan/Article/Detail?id=671499521.
[36] Ding, Nan, Zhang, Zhaojun, Yang, Wenyu, Ren, Lan, Zhang, Yingchi, Zhang, Jingliao, Li, Zhanqi, Zhang, Peihong, Zhu, Xiaofan, Chen, Xiaojuan, Fang, Xiangdong. Transcriptome Analysis of Monozygotic Twin Brothers with Childhood Primary Myelofibrosis. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2017, 15(1): 37-48, http://lib.cqvip.com/Qikan/Article/Detail?id=671499523.
[37] Wang, Dong, Wang, Junyun, Ding, Nan, Li, Yongjun, Yang, Yaran, Fang, Xiangdong, Zhao, Hua. MAGE-A1 promotes melanoma proliferation and migration through C-JUN activation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 473(4): 959-965, [38] Qian Zhang, Nan Ding, Lu Zhang, Xuetong Zhao, Yadong Yang, Hongzhu Qu, Xiangdong Fang. Biological Databases for Hematology Research. 基因组蛋白质组与生物信息学报：英文版[J]. 2016, 14(6): 333-337, http://lib.cqvip.com/Qikan/Article/Detail?id=671109324.
[39] Wan, Yang, Zhang, Qian, Zhang, Zhaojun, Song, Binfeng, Wang, Xiaomin, Zhang, Yingchi, Jia, Qiong, Cheng, Tao, Zhu, Xiaofan, Leung, Anskar YuHung, Yuan, Weiping, Jia, Haibo, Fang, Xiangdong. Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. BMC MEDICAL GENOMICS[J]. 2016, 9: http://dx.doi.org/10.1186/s12920-016-0174-9.
[40] Ding, Nan, Xi, Jiafei, Li, Yanming, Xie, Xiaoyan, Shi, Jian, Zhang, Zhaojun, Li, Yanhua, Fang, Fang, Wang, Sihan, Yue, Wen, Pei, Xuetao, Fang, Xiangdong. Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during human erythroid differentiation. FRONTIERS OF MEDICINE[J]. 2016, 10(3): 297-310, http://lib.cqvip.com/Qikan/Article/Detail?id=669944401.
[41] Wang, Junyun, Ding, Nan, Li, Yongjun, Cheng, Hua, Wang, Dong, Yang, Qiong, Deng, Youhui, Yang, Yaran, Li, Yanming, Ruan, Xiuyan, Xie, Fang, Zhao, Hua, Fang, Xiangdong. Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells. ONCOTARGET[J]. 2015, 6(24): 20636-20649, http://dx.doi.org/10.18632/oncotarget.4114.
[42] Hu, Yang, Xiong, Qian, Yang, Yadong, Wang, Hai, Shu, Chang, Xu, Wei, Fang, Xiangdong, Hu, Songnian. Integrated analysis of gene expression and microRNA regulation in three leukemia-related lymphoblastic cell lines. GENE[J]. 2015, 564(1): 39-52, http://dx.doi.org/10.1016/j.gene.2015.03.039.
[43] Wang, Hai, Li, Yanming, Wang, Sifeng, Zhang, Qian, Zheng, Jiawen, Yang, Yadong, Qi, Heyuan, Qu, Hongzhu, Zhang, Zhaojun, Liu, Feng, Fang, Xiangdong. Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2015, 460(4): 923-930, https://www.webofscience.com/wos/woscc/full-record/WOS:000356980900006.
[44] Fang Xiangdong. Regulation of ALAS2 by miR-218 during iron metabolism and erythroid differentiation.. INTJMOLSCI. 2015, [45] Song, Binfeng, Zhang, Qian, Zhang, Zhaojun, Wan, Yang, Jia, Qiong, Wang, Xiaomin, Zhu, Xiaofan, Leung, Anskar YuHung, Cheng, Tao, Fang, Xiangdong, Yuan, Weiping, Jia, Haibo. Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency. BMC GENOMICS[J]. 2014, 15(1): http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201706294092197ZK.
[46] Zhao, Hua, Li, Yongjun, Wang, Shaobin, Yang, Yadong, Wang, Junyun, Ruan, Xiuyan, Yang, Yaran, Cai, Kan, Zhang, Bing, Cui, Peng, Yan, Jiangwei, Zhao, Yongliang, Wakeland, Edward K, Li, Quanzhen, Hu, Songnian, Fang, Xiangdong. Whole transcriptome RNA-seq analysis: tumorigenesis and metastasis of melanoma. GENE[J]. 2014, 548(2): 234-243, http://dx.doi.org/10.1016/j.gene.2014.07.038.
[47] Xiong Qian, Yang Yadong, Wang Hai, Li Jie, Wang Shaobin, Li Yanming, Yang Yaran, Cai Kan, Ruan Xiuyan, Yan Jiangwei, Hu Songnian, Fang Xiangdong. Characterization of miRNomes in Acute and Chronic Myeloid Leukemia Cell Lines. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2014, 12(2): 79-91, http://lib.cqvip.com/Qikan/Article/Detail?id=49732685.
[48] Zhang, Zhaojun, Jia, Haibo, Zhang, Qian, Wan, Yang, Zhou, Yang, Jia, Qiong, Zhang, Wanguang, Yuan, Weiping, Cheng, Tao, Zhu, Xiaofan, Fang, Xiangdong. Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing. BMC GENOMICS[J]. 2013, 14(1): 896-896, http://dx.doi.org/10.1186/1471-2164-14-896.
[49] Fang Xiangdong. Dynamic transcriptomes during human erythroid differentiation and development.. Genomics. 2013, [50] Wang, Hai, Hu, Haiyan, Zhang, Qian, Yang, Yadong, Li, Yanming, Hu, Yang, Ruan, Xiuyan, Yang, Yaran, Zhang, Zhaojun, Shu, Chang, Yan, Jiangwei, Wakeland, Edward K, Li, Quanzhen, Hu, Songnian, Fang, Xiangdong. Dynamic transcriptomes of human myeloid leukemia cells. GENOMICS[J]. 2013, 102(4): 250-256, http://dx.doi.org/10.1016/j.ygeno.2013.06.004.
[51] Wang, Y, Zhang, Z, Chi, Y, Zhang, Q, Xu, F, Yang, Z, Meng, L, Yang, S, Yan, S, Mao, A, Zhang, J, Yang, Y, Wang, S, Cui, J, Liang, L, Ji, Y, Han, ZB, Fang, X, Han, Z C. Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation. CELL DEATH & DISEASE[J]. 2013, 4(12): e950-, http://dx.doi.org/10.1038/cddis.2013.480.
[52] Qian Xiong, Zhaojun Zhang, Kai-Hsin Chang, Hongzhu Qu, Hai Wang, Heyuan Qi, Yajuan Li, Xiuyan Ruan, Yaran Yang, Yadong Yang, Yanming Li, Richard Sandstrom, Peter J Sabo, Qiliang Li, George Stamatoyannopoulos, John A Stamatoyannopoulos, Xiangdong Fang. Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors. BMC GENOMICS. 2013, 14(1): http://www.corc.org.cn/handle/1471x/2374296.
[53] Fang Xiangdong. Few de novo single nucleotide variations in exomes of human cord blood induced pluripotent stem cells.. 2013, [54] Chang, KaiHsin, Fang, Xiangdong, Wang, Hao, Huang, Andy, Cao, Hua, Yang, Yadong, Bonig, Halvard, Stamatoyannopoulos, John A, Papayannopoulou, Thalia. Epigenetic Modifications and Chromosome Conformations of the Beta Globin Locus throughout Development. STEM CELL REVIEWS AND REPORTS[J]. 2013, 9(4): 397-407, http://dx.doi.org/10.1007/s12015-012-9355-x.
[55] Li, Yajuan, Wang, Hai, Yang, Bin, Yang, Jichen, Ruan, Xiuyan, Yang, Yadong, Wakeland, Edward K, Li, Quanzhen, Fang, Xiangdong. Influence of Carbon Monoxide on Growth and Apoptosis of Human Umbilical Artery Smooth Muscle Cells and Vein Endothelial Cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2012, 8(10): 1431-1446, https://doaj.org/article/1146a224967c418d98fc8a509440bf38.
[56] Fang, Xiangdong, Yin, Wenxuan, Xiang, Ping, Han, Hemei, Stamatoyannopoulos, George, Li, Qiliang. The Higher Structure of Chromatin in the LCR of the beta-Globin Locus Changes during Development. JOURNAL OF MOLECULAR BIOLOGY[J]. 2009, 394(2): 197-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000271985700003.
[57] Fang Xiangdong. Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of HS3 of the LCR.. J Mol Biol. 2007, [58] Fang Xiangdong. Synergistic and additive properties of the beta-globin LCR revealed by 5'HS3 deletion mutations: Implication for LCR chromatin architecture.. Mol Cell Biol. 2005, [59] Fang, XD, Han, HM, Stamatoyannopoulos, G, Li, QL. Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2004, 279(7): 5444-5449, https://www.webofscience.com/wos/woscc/full-record/WOS:000188776500051.
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（1） 分子诊断与肿瘤个性化治疗原则, 北京: 科学出版社, 2017-01, 第 5 作者
（2） 转录组学与精准医学, 上海：交通大学出版社, 2017-12, 第 1 作者
（3） 微生物组学与精准医学, Microbiome and Precision Medicine, 上海交通大学出版社, 2017-12, 第 5 作者

   

（ 1 ） 高通量细胞分选多模式检测仪器在血液干细胞分化研究中的应用, 主持, 国家级, 2011-10--2016-09
（ 2 ） 中国科学院“引进国外杰出人才”择优支持, 主持, 部委级, 2011-01--2012-12
（ 3 ） 肿瘤个体化治疗方法及其相关的基因组和系统生物学研究, 主持, 部委级, 2012-05--2014-12
（ 4 ） 利用高通量组学平台和系统生物学分析技术筛选肿瘤干细胞的特异性标记物和治疗靶点, 主持, 部委级, 2012-06--2015-05
（ 5 ） 肿瘤的个体化RNA干扰治疗, 参与, 国家级, 2012-05--2015-04
（ 6 ） 生物大数据表述索引、搜索与存储访问关键技术研发, 主持, 国家级, 2015-01--2018-12
（ 7 ） 转录因子KLFs调控干细胞红系分化的分子网络机制, 主持, 国家级, 2015-01--2018-12
（ 8 ） 精准医学大数据处理和利用的标准化技术体系建设, 主持, 国家级, 2016-01--2020-12
（ 9 ） 染色质构象调控lncRNA在造血干细胞红系分化中的作用机制研究, 主持, 国家级, 2017-01--2020-12
（ 10 ） 精准医学基础支撑数据库群, 主持, 国家级, 2016-07--2020-12

已指导学生

张倩  硕士研究生  071022-基因组学  

孙红英  硕士研究生  071022-基因组学  

王海  博士研究生  071007-遗传学  

熊倩  博士研究生  071022-基因组学  

李杰  硕士研究生  085238-生物工程  

亓合媛  博士研究生  071022-基因组学  

王均云  博士研究生  071022-基因组学  

刘淑阁  硕士研究生  071007-遗传学  

邓友辉  硕士研究生  071022-基因组学  

李艳明  博士研究生  071007-遗传学  

郑佳文  硕士研究生  071007-遗传学  

杨琼  博士研究生  071007-遗传学  

丁楠  博士研究生  0710Z1-基因组学  

任岚  硕士研究生  071007-遗传学  

施剑  硕士研究生  071007-遗传学  

梁明珠  博士研究生  071010-生物化学与分子生物学  

董绪浓  硕士研究生  0710Z1-基因组学  

刘彦霞  博士研究生  071010-生物化学与分子生物学  

张璐  硕士研究生  071007-遗传学  

李品  硕士研究生  071007-遗传学  

徐洪凯  硕士研究生  071010-生物化学与分子生物学  

杨玲玲  硕士研究生  071010-生物化学与分子生物学  

贺宁  硕士研究生  071007-遗传学  

杨亚东  博士研究生  0710Z1-基因组学  

谢兵兵  博士研究生  0710J3-生物信息学  

龚春丽  硕士研究生  071010-生物化学与分子生物学  

任云晓  硕士研究生  071007-遗传学  

祝俊伟  硕士研究生  071007-遗传学  

吴森  硕士研究生  085238-生物工程  

钱颖  博士研究生  0710J3-生物信息学  

龚尚瑾  硕士研究生  071007-遗传学  

现指导学生

张苇  博士研究生  071007-遗传学  

张宇星  博士研究生  071010-生物化学与分子生物学  

王晨  博士研究生  0710Z1-基因组学  

张立娟  硕士研究生  071007-遗传学  

彭勇飞  硕士研究生  071007-遗传学  

赵学彤  博士研究生  0710Z1-基因组学  

辛子娟  博士研究生  0710Z1-基因组学  

吴静  硕士研究生  071007-遗传学  

谭肖喻  硕士研究生  071007-遗传学  

陈永森  硕士研究生  071007-遗传学  

赵思琪  博士研究生  0710J3-生物信息学  

隋阳  博士研究生  1001Z1-精准医学