071009-细胞生物学

生殖生物学
发育生物学

1995-09--2001-08   中科院昆明动物研究所   博士研究生

   

2009-05~现在, 中科院昆明动物研究所, 研究员，学科组长
2005-06~2009-03,美国NIH, 博士后
2003-03~2005-06,美国Temple University, 博士后
2001-08~2003-03,中科院昆明动物研究所, 助理研究员
1995-09~2001-08,中科院昆明动物研究所, 博士研究生

   

（ 1 ） 一种建立可持续传代的树鼩精原干细胞细胞系的方法, 2019, 第 1 作者, 专利号: 201610460383X

   

（1） Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells, STEM CELL REPORTS, 2023, 第 6 作者
（2） Lnc956 -TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis, SCIENCE ADVANCES, 2023, 通讯作者
（3） Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway, SCIENCE ADVANCES, 2023, 第 5 作者
（4） Current understanding of genomic stability maintenance in pluripotent stem cells, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 第 1 作者
（5） Depletion of giant ANK2 in monkeys causes drastic brain volume loss, CELL DISCOVERY, 2021, 通讯作者
（6） A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability, NATURE COMMUNICATIONS, 2021, 通讯作者
（7） Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia, SCIENCE ADVANCES, 2020, 通讯作者
（8） KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells, PLOS BIOLOGY, 2019, 通讯作者
（9） In vitro culture of cynomolgus monkey embryos beyond early gastrulation, SCIENCE, 2019, 通讯作者
（10） Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys, NATURE COMMUNICATIONS, 2019, 第 13 作者
（11） mouseembryonicstemcellshaveincreasedcapacityforreplicationforkrestartdrivenbythespecificfiliaflopedproteincomplex, CELL RESEARCH, 2018, 通讯作者
（12） Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos, GENOME RESEARCH, 2018, 通讯作者
（13） Long-term propagation of tree shrew spermatogonial stem cells (SSCs) in culture and the successful generation of transgenic offspring, Cell Research, 2017, 通讯作者
（14） Transcriptome analyses of rhesus monkey pre-implantation embryos reveal a reduced capacity for DNA double strand break repair in primate oocytes and early embryos, GENOME RESEARCH, 2017, 通讯作者
（15） Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice., MOLECULAR HUMAN REPRODUCTION, 2016, 通讯作者
（16） Germ stem cells are active in postnatal mouse ovary under physiological conditions, MHRBASICSCIENCEOFREPRODUCTIVEMEDICINE, 2016, 第 5 作者
（17） Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability, CELL STEM CELL, 2015, 通讯作者
（18） mRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential regulators of rosette neural stem cells, DNA Research, 2014, 通讯作者
（19） PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes., JOURNAL OF CELL SCIENCE, 2013, 通讯作者
（20） Maternal control of early mouse development, DEVELOPMENT, 2010, 第 2 作者
（21） Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embyrogenesis, PNAS, 2009, 第 1 作者
（22） Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos, DEVELOPMENT, 2008, 第 2 作者
（23） Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos., MOLECULAR HUMAN REPRODUCTION, 2007, 第 1 作者
（24） Effects of in vitro maturation of monkey oocytes on their developmental capacity, ANIMAL REPRODUCTION SCIENCE, 2007, 
（25） Expression and downregulation of WNT signaling pathway genes in rhesus monkey oocytes and embryos., MOLECULAR REPRODUCTION AND DEVELOPMENT, 2006, 
（26） Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos., BIOLOGY OF REPRODUCTION, 2005, 
（27） Effects of follicle size and oocyte maturation conditions on maternal message RNA regulation and gene expression in rhesus monkey oocytes and embryos, Biol Reprod, 2005, 第 1 作者
（28） Expression of Genes Encoding Chromatin Regulatory Factors in Developing Rhesus Monkey Oocytes and Preimplantation Stage Embryos: Possible Roles in Genome Activation1, BIOLOGY OF REPRODUCTION, 2004, 第 1 作者
（29） Effect of Glycerol and Dimethyl Sulfoxide on cyropreservation of rhesus monkey (Macaca mulatta) sperm, Am J Primatol, 2004, 第 1 作者
（30） The primate embryo gene expression resource: A novel resource to facilitate rapid analysis of gene expression patterns in non-human primate oocytes and preimplantation stage embryos, BIOLOGY OF REPRODUCTION, 2004, 
（31） Estradiol and progesterone improve in-vitro?Yang JF, Ding CH, Ji WZ. 2003. 17 cytoplasmic maturation of oocytes from unstimulated prepubertal and adult rhesus monkeys, Hum Reprod, 2003, 第 1 作者
（32） Amino acid requirements for maturation of rhesus monkey (Macacca mulatta) oocytes in culture, REPRODUCTION, 2002, 
（33） 纤溶酶原激活因子与猕猴精子运动力的关系及其在附睾和附性腺中的表达调节, 动物学研究, 2002, 第 1 作者
（34） Energy substrate requirement for in vitro maturation of oocytes from unstimulated adult rhesus monkeys., MOLECULAR REPRODUCTION AND DEVELOPMENT, 2001, 
（35） 猕猴精浆纤溶酶原激活因子的来源及在精子获能中的作用, 生理学报, 2001, 第 1 作者
（36） Maturation of rhesus monkey oocytes in chemically defined culture media and their functional assessmental by IVF and embryo development, Hum Reprod, 2001, 第 1 作者
（37） Effect of age and breeding season on the developmental capacity of oocytes from unstimulated and FSH-stimulated rhesus monkeys, 2001, 第 1 作者
（38） Cryopreservation of rhesus monkey (Macaca mulatta) spermatozoa and their functional assessment by in vitro fertilization., Cryobiology, 2000, 第 1 作者

（ 1 ） 猕猴繁殖生物学, reproduction and breeding of rhesus monkey, 科学出版社, 2013-01, 第 5 作者

   

（ 1 ） 阿尔茨海默症（AD）转基因树鼩模型的创建及有效性评价, 负责人, 国家任务, 2018-01--2021-12
（ 2 ） 多能干细胞高效调控DNA复制压力反应的关键lncRNA鉴定与功能分析, 负责人, 国家任务, 2020-01--2024-12
（ 3 ） 猴精原干细胞系的建立及基于精原干细胞研发猴高效基因敲入新技术, 负责人, 国家任务, 2022-01--2025-12
（ 4 ） 灵长类多能干细胞基因组稳态调控网络及增强策略, 负责人, 国家任务, 2021-12--2026-06