王柳 女 硕导 中国科学院动物研究所
电子邮件： wangliu@ioz.ac.cn
通信地址： 北京市朝阳区北辰西路1号院5号
邮政编码： 100101
电子邮件： wangliu@ioz.ac.cn
通信地址： 北京市朝阳区北辰西路1号院5号
邮政编码： 100101
招生信息
招生专业
086000-生物与医药
招生方向
干细胞临床转化
工作经历
社会兼职
2015-07-11-今,中国细胞生物学学会干细胞生物学分会会员,
教授课程
胚胎工程
专利与奖励
奖励信息
（1） 中华医学科技奖, 三等奖, 部委级, 2017（2） 中国科学院杰出科技成就奖, , 院级, 2013
出版信息
发表论文
[1] Tingting Gao, Xiyuan Zhao, Jie Hao, Yao Tian, Huike Ma, Wenjing Liu, Bin An, Faguo Sun, Shasha Liu, Baojie Guo, Shuaishuai Niu, Zhongwen Li, Chenxin Wang, Yukai Wang, Guihai Feng, Liu Wang, Wei Li, Jun Wu, Meijin Guo, Qi Zhou, Qi Gu. A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells. MATERIALS TODAY BIO[J]. 2023, 20:100662: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196860/.[2] Yalong Wang, Hanqing Lin, Lianzheng Zhao, Fan Hong, Jie Hao, Zhen Zhang, Weiqi Sheng, Linhong Song, ChuXia Deng, Bing Zhao, Jiani Cao, Lei Wang, Liu Wang, Lingmin Liang, Wenli Kelly Chen, Chunping Yu, Zhijian Sun, Yingying Yang, Changlin Wang, Yong Zhang, Qiyuan Li, Ka Li, Aijin Ma, Tongbiao Zhao, Guoqiang Hua, YeGuang Chen. Standard:Human intestinal organoids. CELL REGENERATION[J]. 2023, 12(1): 1-5, https://doaj.org/article/99a3ab1fa2af47958a73f133d678bdec.[3] YuKai Wang et al. Human midbrain dopaminergic progenitors. Cell Prolif[J]. 2023, [4] Baojie Guo et al. High-Strength Cell Sheets and Vigorous Hydrogels from Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells. ACS Appl Mater Interfaces[J]. 2023, [5] Chen, Ling, Li, Zhongwen, Wei, Wumei, An, Bin, Tian, Yao, Liu, Wenjing, Niu, Shuaishuai, Wang, Yukai, Wang, Liu, Li, Wei, Hao, Jie, Wu, Jun. Human embryonic stem cell-derived immunity-and-matrix regulatory cells promote intrahepatic cell renewal to rescue acute liver failure. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2023, 662: 104-113, http://dx.doi.org/10.1016/j.bbrc.2023.04.051.[6] YuKai Wang et al. Human neural stem cells. Cell Prolif[J]. 2023, [7] Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wang. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. NEURAL REGENERATION RESEARCH. 2023, 19(2): 458-464, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503631/.[8] Liangjiang Huang, Song Zhang, Jun Wu, Baojie Guo, Tingting Gao, Sayed Zulfiqar Ali Shah, Bo Huang, Yajie Li, Bo Zhu, Jiaqi Fan, Liu Wang, Yani Xiao, Wenjing Liu, Yao Tian, Zhengyu Fang, Yingying Lv, Lingfeng Xie, Sheng Yao, Gaotan Ke, Xiaolin Huang, Ying Huang, Yujuan Li, Yi Jia, Zhongwen Li, Guihai Feng, Yan Huo, Wei Li, Qi Zhou, Jie Hao, Baoyang Hu, Hong Chen. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023, 8: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618459/.[9] Hanqing Lin, Yalong Wang, Chunyan Cheng, Yuxin Qian, Jie Hao, Zhen Zhang, Weiqi Sheng, Linhong Song, ChuXia Deng, Bing Zhao, Jiani Cao, Lei Wang, Liu Wang, Lingmin Liang, Wenli Kelly Chen, Chunping Yu, Zhijian Sun, Yingying Yang, Changlin Wang, Yong Zhang, Qiyuan Li, Ka Li, Aijin Ma, Tongbiao Zhao, YeGuang Chen, Guoqiang Hua. Standard:Human intestinal cancer organoids. CELL REGENERATION[J]. 2023, 12(1): 1-6, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307733/.[10] Liang, Lingmin, Tian, Yao, Feng, Lin, Wang, Chaoqun, Feng, Guihai, Stacey, Glyn Nigel, ShyhChang, Ng, Wu, Jun, Hu, Baoyang, Li, Wei, Hao, Jie, Wang, Liu, Wang, Yukai. Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. STEM CELL RESEARCH & THERAPY[J]. 2022, 13(1): http://dx.doi.org/10.1186/s13287-022-03104-7.[11] ZhengQuan He, XueWei Yuan, ZongBao Lu, YuHuan Li, YuFei Li, Xin Liu, Liu Wang, Ying Zhang, Qi Zhou, Wei Li. Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts. FUNDAMENTAL RESEARCH[J]. 2022, 2(1): 37-47, [12] Zhao, Yilong, Wu, Jun, Li, Da, Liu, Jing, Chen, Weiqi, Hou, Zongren, Liu, Kailun, Jiang, Lingling, Chen, Xiaowei, Wang, Liu, Hu, Baoyang, Zong, Fangrong, Wang, Yukai, Wang, Yilong. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. CELL PROLIFERATION[J]. 2022, 55(5): http://dx.doi.org/10.1111/cpr.13223.[13] Xing, Dan, Wang, Kai, Wu, Jun, Zhao, Yu, Liu, Wei, Li, Jiao Jiao, Gao, Tingting, Yan, Deng, Wang, Liu, Hao, Jie, Lin, Jianhao. Clinical-Grade Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Ameliorate the Progression of Osteoarthritis in a Rat Model. MOLECULES[J]. 2021, 26(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865331/.[14] Li, Xia, Wang, Yiming, Ma, Ruoyu, Liu, Xin, Song, Biaobiao, Duan, Yongchao, Guo, Jia, Feng, Guihai, Cui, Tongtong, Wang, Liu, Hao, Jie, Wang, Hongmei, Gu, Qi. Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro. BIOMEDICAL MATERIALS[J]. 2021, 16(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000625107600001.[15] Zhang, Bowen, Wu, Xumin, Zi, Guicheng, He, Lijuan, Wang, Sihan, Chen, Lin, Fan, Zeng, Nan, Xue, Xi, Jiafei, Yue, Wen, Wang, Lei, Wang, Liu, Hao, Jie, Pei, Xuetao, Li, Yanhua. Large-scale generation of megakaryocytes from human embryonic stem cells using transgene-free and stepwise defined suspension culture conditions. CELL PROLIFERATION[J]. 2021, 54(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016648/.[16] Li, ShiYing, Liu, Yong, Wang, Lei, Wang, Fang, Zhao, TongTao, Li, QiYou, Xu, HaiWei, Meng, XiaoHong, Hao, Jie, Zhou, Qi, Wang, Liu, Yin, ZhengQin. A phase I clinical trial of human embryonic stem cell-derived retinal pigment epithelial cells for early-stage Stargardt macular degeneration: 5-years' follow-up. CELL PROLIFERATION[J]. 2021, 54(9): http://dx.doi.org/10.1111/cpr.13100.[17] Liu, Jing, Hou, Zongren, Wu, Jun, Liu, Kailun, Li, Da, Gao, Tingting, Liu, Wenjing, An, Bin, Sun, Yun, Mo, Fan, Wang, Liu, Wang, Yukai, Hao, Jie, Hu, Baoyang. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. CELL PROLIFERATION[J]. 2021, 54(8): http://dx.doi.org/10.1111/cpr.13085.[18] Wu, Jun, Hu, Zhongjie, Wang, Liu, Tan, Yuanqing, Hou, Wei, Li, Zhongwen, Gao, Tingting, Fan, Jiaqi, Guo, Baojie, Dai, Huaping, Li, Wei, Hao, Jie, Jin, Ronghua, Hu, Baoyang. First case of COVID-19 infused with hESC derived immunity- and matrix-regulatory cells. CELL PROLIFERATION[J]. 2020, 53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645847/.[19] Wu, Jun, Song, Dingyun, Li, Zhongwen, Guo, Baojie, Xiao, Yani, Liu, Wenjing, Liang, Lingmin, Feng, Chunjing, Gao, Tingting, Chen, Yanxia, Li, Ying, Wang, Zai, Wen, Jianyan, Yang, Shengnan, Liu, Peipei, Wang, Lei, Wang, Yukai, Peng, Liang, Stacey, Glyn Nigel, Hu, Zheng, Feng, Guihai, Li, Wei, Huo, Yan, Jin, Ronghua, ShyhChang, Ng, Zhou, Qi, Wang, Liu, Hu, Baoyang, Dai, Huaping, Hao, Jie. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. CELL RESEARCH[J]. 2020, 30(9): 794-809, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6805741&detailType=1.[20] Xing, Dan, Wu, Jun, Wang, Bin, Liu, Wei, Liu, Wenjing, Zhao, Yu, Wang, Liu, Li, Jiao Jiao, Liu, Aifeng, Zhou, Qi, Hao, Jie, Lin, Jianhao. Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES[J]. 2020, 23(6): 778-787, https://www.webofscience.com/wos/woscc/full-record/WOS:000527271400001.[21] Hao, Jie, Ma, Aijin, Wang, Lei, Cao, Jiani, Chen, Si, Wang, Liu, Fu, Boqiang, Zhou, Jiaxi, Pei, Xuetao, Zhang, Yu, Xiang, Peng, Hu, Shijun, Li, Qiyuan, Zhang, Yong, Xia, Yingjie, Zhu, Huanxin, Stacey, Glyn, Zhou, Qi, Zhao, Tongbiao. General requirements for stem cells. CELL PROLIFERATION[J]. 2020, 53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705904/.[22] Hao, Jie, Cao, Jiani, Wang, Lei, Ma, Aijin, Chen, Si, Ding, Jinfeng, Wang, Liu, Fu, Boqiang, Zhang, Yu, Pei, Xuetao, Xiang, Peng, Li, Qiyuan, Zhang, Yong, Zhou, Jiaxi, Hu, Shijun, Yu, Junying, Wei, Jun, Zhu, Huanxin, Stacey, Glyn, Zhao, Tongbiao, Zhou, Qi. Requirements for human embryonic stem cells. CELL PROLIFERATION[J]. 2020, 53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705896/.[23] Wu, Jun, Zhou, Xing, Tan, Yuanqing, Wang, Liu, Li, Tianda, Li, Zhongwen, Gao, Tingting, Fan, Jiaqi, Guo, Baojie, Li, Wei, Hao, Jie, Wang, Xianguang, Hu, Baoyang. Phase 1 trial for treatment of COVID-19 patients with pulmonary fibrosis using hESC-IMRCs. CELL PROLIFERATION. 2020, 53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645925/.[24] Kobold, Sabine, Guhr, Anke, Mah, Nancy, Bultjer, Nils, Seltmann, Stefanie, Wulczyn, Andrea E M Seiler, Stacey, Glyn, Jie, Hao, Liu, Wang, Loser, Peter, Kurtz, Andreas. A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells. STEM CELL REPORTS[J]. 2020, 15(2): 546-555, http://dx.doi.org/10.1016/j.stemcr.2020.06.014.[25] Zhongwen Li, Jun Wu, Lei Wang, Weifang Han, Juan Yu, Xin Liu, Yukai Wang, Ying Zhang, Guihai Feng, Wei Li, Glyn Nigel Stacey, Qi Gu, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. Correction: Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. CELL DEATH & DISEASE. 2020, 11(1): [26] Li, Zhongwen, Niu, Shuaishuai, Guo, Baojie, Gao, Tingting, Wang, Lei, Wang, Yukai, Wang, Liu, Tan, Yuanqing, Wu, Jun, Hao, Jie. Stem cell therapy for COVID-19, ARDS and pulmonary fibrosis. CELL PROLIFERATIONnull. 2020, 53(12): http://dx.doi.org/10.1111/cpr.12939.[27] Tan, Yuanqing, Wang, Lei, Chen, Gang, Liu, Wenjing, Li, Zhongwen, Wang, Yukai, Wang, Liu, Li, Wei, Wu, Jun, Hao, Jie. Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction. CELL PROLIFERATION[J]. 2020, 53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705924/.[28] Wang, Lei, Wu, Wei, Gu, Qi, Liu, Zengping, Li, Qiyou, Li, Zhongwen, Fang, Jinhui, Liu, Wenjing, Wu, Jun, Zhang, Ying, Wang, Liu, Xu, Haiwei, Li, Wei, Hu, Baoyang, Zhou, Qi, Yin, Zhengqin, Hao, Jie. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. PROTEIN & CELL[J]. 2019, 10(6): 455-460, http://lib.cqvip.com/Qikan/Article/Detail?id=7002265647.[29] Zhongwen Li, Jun Wu, Lei Wang, Weifang Han, Juan Yu, Xin Liu, Yukai Wang, Ying Zhang, Guihai Feng, Wei Li, Glyn Nigel Stacey, Qi Gu, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. CELLDEATHANDDISEASE[J]. 2019, 10(10): 1-14, http://dx.doi.org/10.1038/s41419-019-1967-5.[30] Li, Zhongwen, Wu, Jun, Wang, Lei, Han, Weifang, Yu, Juan, Liu, Xin, Wang, Yukai, Zhang, Ying, Feng, Guihai, Li, Wei, Stacey, Glyn Niger, Gu, Qi, Hu, Baoyang, Wang, Liu, Zhou, Qi, Hao, Jie. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. CELLDEATHDISEASE[J]. 2019, 10(10): http://dx.doi.org/10.1038/s41419-019-1967-5.[31] Lei Wang, Wei Wu, Qi Gu, Zengping Liu, Qiyou Li, Zhongwen Li, Jinhui Fang, Wenjing Liu, Jun Wu, Ying Zhang, Liu Wang, Haiwei Xu, Wei Li, Baoyang Hu, Qi Zhou, Zhengqin Yin, Jie Hao. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. 蛋白质与细胞:英文版. 2019, 10(6): 455-460, http://lib.cqvip.com/Qikan/Article/Detail?id=7002265647.[32] Cui, Tongtong, Jiang, Liyuan, Li, Tianda, Teng, Fei, Feng, Guihai, Wang, Xuepeng, He, Zhengquan, Guo, Lu, Xu, Kai, Mao, Yihuan, Wang, Leyun, Yuan, Xuewei, Wang, Liu, Li, Wei, Zhou, Qi. Derivation of Mouse Haploid Trophoblast Stem Cells. CELL REPORTS[J]. 2019, 26(2): 407-+, http://dx.doi.org/10.1016/j.celrep.2018.12.067.[33] TiANDa Li, Leyun Wang, Xinxin Zhang, Liyuan Jiang, Yufei Li, Junjie Mao, Tongtong Cui, Wei Li, Liu Wang, Qi Zhou. Generation of rat-mouse chimeras by introducing single cells of rat inner cell masses into mouse blastocysts. 遗传学报：英文版[J]. 2018, 45(6): 325-328, http://lib.cqvip.com/Qikan/Article/Detail?id=675742569.[34] Zhang, Minjie, Wang, Liu, An, Ke, Cai, Jun, Li, Guochao, Yang, Caiyun, Liu, Huixian, Du, Fengxia, Han, Xiao, Zhang, Zilong, Zhao, Zitong, Pei, Duanqing, Long, Yuan, Xie, Xin, Zhou, Qi, Sun, Yingli. Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining. CANCER COMMUNICATIONS[J]. 2018, 38(1): 520-541, https://doaj.org/article/0491b03f55c5434caf6dbd40dbf0aa6c.[35] Zhang, Wei, Feng, Guihai, Wang, Libin, Teng, Fei, Wang, Liu, Li, Wei, Zhang, Ying, Zhou, Qi. MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation. JOURNALOFMOLECULARCELLBIOLOGY[J]. 2018, 10(6): 515-526, https://www.webofscience.com/wos/woscc/full-record/WOS:000455316500004.[36] Xia Li, Ruoyu Ma, Qi Gu, Lingmin Liang, Lei Wang, Ying Zhang, Xianning Wang, Xin Liu, Zhongwen Li, Jinhui Fang, Jun Wu, Yukai Wang, Wei Li, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. A fully defined static suspension culture system for large-scale human embryonic stem cell production. 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MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated ceil cycle gene translation. 分子细胞生物学报:英文版[J]. 2018, 10(6): 515-526, http://lib.cqvip.com/Qikan/Article/Detail?id=6100236851.[40] Liu, Yong, Xu, Hai Wei, Wang, Lei, Li, Shi Ying, Zhao, Cong Jian, Hao, Jie, Li, Qi You, Zhao, Tong Tao, Wu, Wei, Wang, Yi, Zhou, Qi, Qian, Cheng, Wang, Liu, Yin, Zheng Qin. Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration. CELL DISCOVERY[J]. 2018, 4(1): https://doaj.org/article/51bdd4145e324bd79e38ac568e73f63f.[41] Tan, Yuanqing, Han, Pengcheng, Gu, Qi, Chen, Gang, Wang, Lei, Ma, Ruoyu, Wu, Jun, Feng, Chunjing, Zhang, Ying, Wang, Liu, Hu, Baoyang, Li, Wei, Hao, Jie, Zhou, Qi. Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE[J]. 2018, 12(1): 153-163, https://www.webofscience.com/wos/woscc/full-record/WOS:000423431200070.[42] Cao, Yun, Sun, Haixiang, Zhu, Hui, Zhu, Xianghong, Tang, Xiaoqiu, Yan, Guijun, Wang, Jingmei, Bai, Donghui, Wang, Juan, Wang, Liu, Zhou, Qi, Wang, Huiyan, Dai, Chengyan, Ding, Lijun, Xu, Biyun, Zhou, Yan, Hao, Jie, Dai, Jianwu, Hu, Yali. Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. STEMCELLRESEARCHTHERAPY[J]. 2018, 9(1): https://doaj.org/article/9e29377fb10c4088bd91b412d3e75b54.[43] Li, Tianda, Wang, Leyun, Zhang, Xinxin, Jiang, Liyuan, Li, Yufei, Mao, Junjie, Cui, Tongtong, Li, Wei, Wang, Liu, Zhou, Qi. Generation of rat-mouse chimeras by introducing single cells of rat inner cell masses into mouse blastocysts. JOURNAL OF GENETICS AND GENOMICS[J]. 2018, 45(6): 325-328, http://lib.cqvip.com/Qikan/Article/Detail?id=675742569.[44] Wang, Xuepeng, Li, Tianda, Cui, Tongtong, Yu, Dawei, Liu, Chao, Jiang, Liyuan, Feng, Guihai, Wang, Lei, Fu, Rui, Zhang, Xinxin, Hao, Jie, Wang, Yukai, Wang, Liu, Zhou, Qi, Li, Wei, Hu, Baoyang. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. CELL RESEARCH[J]. 2018, 28(1): 126-129, https://www.webofscience.com/wos/woscc/full-record/WOS:000423834700012.[45] Wang, YuKai, Zhu, WanWan, Wu, MengHua, Wu, YiHui, Liu, ZhengXin, Liang, LingMin, Sheng, Chao, Hao, Jie, Wang, Liu, Li, Wei, Zhou, Qi, Hu, BaoYang. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. 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发表著作
（1） 《再生医学——理论与技术》书中的《克隆技术与细胞重编程技术》章节, 科学出版社, 2010-05, 第 2 作者（2） 干细胞实验指南, 中央广播电视大学出版社, 2015-07, 第 3 作者
科研活动
参与会议
（1）临床级胚胎干细胞及其应用 中国干细胞第八届年会（2018 •济南） 2018-09-16