Title:Professor
Phone:+86 871 65176320
E-mail:ybchen@mail.kiz.ac.cn
Address:Kunming Institute of Zoology, the Chinese Academy of Sciences.
No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Zip Code:650223
Research Areas
Education
2000/09-2005/07 Doctor of Philosophy, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1996/09-2000/07 Bachelor of Science, Wuhan University
Experience
Work Experience
2012/05-present, Kunming Institute of Zoology, Chinese Academy of Sciences
2010/12-2012/05, Texas Southwestern Medical Center, Instructor
2005/12-2010/11, Texas Southwestern Medical Center, Postdoc
Publications
Papers
1.Xu PF#, Jiang LP#, Yang Y#, Wu MG, Liu BY, Shi YL, Shen QS, Jiang XL, He YM, Cheng DT, Xiong QX, Yang ZZ, Duan LC, Lin J, Zhao S, Shi P, Yang CP*, Chen YB*,(2020)PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.Theranostics. 10(8): 3767-3778.
2.Shi, Y.L., # Fan,S.Q., # Wu,M.G., # Zuo,Z.X., Li, X.Y., Jiang, L.P., Shen, Q.S., Xu, P.F., Zeng, L., Zhou, Y.C., Huang, Y.C., Yang, Z.Z., Zhou, J.M., Gao, J., Zhou, H., Xu, S.H., Ji, H.B., Shi, P., Wu, D.D.,* Yang, C.P., *Chen, Y.B.,*(2019).YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.Nature communications10:4892
3.Wu,D.D.,* Yang, C.P.,# Wang,M.S.,# Dong,K.Z.,# Yan, D.W., # Hao,Z.Q.,#,Fan, S.Q., Chu ,S.Z., Shen,Q.S., Jiang,L.P., Li,Y. , Zeng,L., Liu, H.Q., Xie,H.B., Ma,Y.F. , Kong, X.Y., Yang,S.L. , Dong,X.X. , Ali Esmailizadeh Koshkoiyeh, David M Irwin, Xiao,X., Li,M., Dong,Y., Wang,W., Shi, P., Li,H.P., Ma, Y.H., * Gou,X.,*Chen,Y.B., * Zhang,Y.P., *(2019)Convergent genomic signatures of high altitude adaptation among domestic mammals National Science Review doi: http://dx.doi.org/10.1101/743955.
4.Yang, C.P.,# Li, X.Y,# Wu, Y.,# Shen, Q.S,# Zeng, Y., Xiong, Q.X., Wei, M.P, Chen, C.H., Liu, J.W., Huo, Y.X., Li, K.Q., Xue, G., Yao, Y.G., Zhang, C., Li, M., Chen, Y.B.,* Luo, X.J.* (2018). Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nature communications 9, 838.
5. Jiang, L.P., Fan, S.Q., Xiong, Q.X., Zhou, Y.C., Yang, Z.Z., Li, G.F., Huang, Y.C., Wu, M.G., Shen, Q.S., Liu, K., Yang, C.P.,* Chen, Y.B.* (2018). GRK5 functions as an oncogenic factor in non-small-cell lung cancer. Cell death & disease 9, 295.
6.Li, Q.G#., He, Y.H#., Wu, H#., Yang, C.P#., Pu, S.Y., Fan, S.Q., Jiang, L.P., Shen, Q.S., Wang, X.X., Chen, X.Q., Yu, Q., Li, Y., Sun, C., Wang, X., Zhou, J., Li, H.P., Chen, Y.B*., Kong, Q.P*. (2017). A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers. Theranostics 7, 2888-2899.
7.Yin, L#., Jiang, L.P#., Shen, Q.S#., Xiong, Q.X#., Zhuo, X., Zhang, L.L., Yu, H.J., Guo, X., Luo, Y., Dong, J*., Kong, Q.P*., Yang, C.P*., Chen, Y.B*. (2017). NCAPH plays important roles in human colon cancer. Cell death & disease 8, e2680.
8. Yu, L#*., Wang, G.D#., Ruan, J#, Chen, Y.B#., Yang, C.P#., Cao, X#., Wu, H#, Liu, Y.H#., Du, Z.L#., Wang, X.P#., Yang, J#., Chen, S.C#., Zhong, L., Wang, L., Wang, X., Hu, J.Y., Fang, L., Bai, B., Wang, K.L., Zhang, J.G., Yang, Y.Q., Zhang, C.L., Long, Y.C., Li, H.S., Yang, J.Y., Irwin, D., Ryder, O., Li, Y., Wu, S.F., Wu, C.I*., Zhang, Y.P*. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nature Genetics. Aug;48(8):947-52. (#Co-first author, *Co-correspondence author)
9.Yan Y.M ,Wang X.L , Luo Q , Jiang L.P, Yang C.P, Hou B., Zuo Z.L*., Chen Y.B*, Cheng YX*, Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry. 2015, 114:155-162.
10. Yang X.W, Yang C.P, Jiang L.P, Qin X.J, Liu Y.P, Shen Q.S, Chen Y.B*, Luo X.D*, Indole Alkaloids with New Skeleton Activating Neural Stem Cells. Organic Letters. 2014, Oct 29 doi:10.1021/ol5029223.
11. Tang J.J , Zhang L, Jiang L.P, Di L, Yan Y.M, Tu Z.C, Yang C.P, Zuo Z.L, Hou B, Xia H.L, Chen Y.B*, Cheng Y.X*. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation. Tetrahedron, 2014, http://dx.doi.org/10.1016/j.tet.2014.09.095
12. Chen, Y.B*, Jiang, J*. (2013) Decoding the phosphorylation code in Hedgehog signal transduction. Cell Research 23, 186-200.
13.Yang, C.P., Chen, W.L., Chen, Y.B*., Jiang, J*. (2012) Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Research 22, 1593-1604.
14.Chen, Y.B., Sasai, N., Ma, G.Q., Yue, T., Jia, J.H., Briscoe, J., Jiang, J*. (2011) Sonic hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of Smoothened. PLoS Biol 9(6), e1001083. DOI:10.1371
15. Chen, Y.B., Li, S., Tong, C., Zhao, Y., Wang, B., Liu, Y., Jia, J.H., Jiang, J*. (2010) G protein coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and -independent mechanisms in Drosophila. Genes Dev 24, 2054 - 2067.
16. Zhang, Q#., Shi, Q#., Chen, Y.B#., Yue, T., Li, S., Wang, B., and Jiang, J*. (2009) Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc Natl Acad Sci U S A 106, 21191-21196
17. Chen, Y. B., Yang, C. P., Li, R. X., Zeng, R., and Zhou, J. Q. (2005) Def1p Is Involved in Telomere Maintenance in Budding Yeast. J Biol Chem 280, 24784-24791.
Patents
(1)Use of human NCAPH gene, invention, 2019, first author, patent number: 201710034315.1
(2)Use of human GLT8D1 gene, Invention, 2018, second author, patent number: 201810131431.X
(3)Use of human GRK5 gene, invention, 2019, first author, patent number: 201810034552.2
(4)Use of AKR1C1 protein inhibitor, Invention, 2018, first author, patent number: 201811412945.9
(5)Use of human YTHDF1 gene, Invention, 2018, first author, patent number: 201811412949.7
(6)Use of human NCAPH gene, invention, 2019, first author, patent number: 201910923512.8
Research Interests
Mechanism of tumorigenesis, maintenance of stem cell pluripotency, screening new drugs of antitumor and improving stem cell function, etc.
Students
Jiang Liping, Ph.D., 071009-Cell Biology
Shen Qiushu, Ph.D., 100104-Pathology and Pathophysiology
Shi Yulin, PhD candidate, 100104-Pathology and Pathophysiology
Nie Zhi, PhD candidate, 100104-Pathology and Pathophysiology
Liu Kun, PhD candidate, 100104-pathology and pathophysiology
Yun Chu, Postgraduate, 100104-Pathology and Pathophysiology
Han Yanfei, Postgraduate, 100104-Pathology and Pathophysiology
He Yaomei, PhD candidate, 100104-Pathology and Pathophysiology
Zhai Haoqing, Postgraduate, 071009-Cell Biology
Liu Peisheng, Postgraduate, 071009-Cell Biology
staff member:
Dr. Yang Cuiping, Professor, cuipingyang@mail.kiz.ac.cn
Dr. Jiang Liping, Assistant Professor, jiangliping@mail.kiz.ac.cn
Liu Weili, Secretary, liuweili@mail.kiz.ac.cn