071007-遗传学
090801-水产养殖

鱼类抗病免疫机制研究，鱼类分子遗传育种

2005-09--2010-06   中国科学院水生生物研究所   学生/研究生博士
2001-09--2005-06   湖北大学   学生/本科学士

   

2010-07~2013-05,中国科学院水生生物研究所, 副研究员
2005-09~2010-06,中国科学院水生生物研究所, 学生/研究生博士
2001-09~2005-06,湖北大学, 学生/本科学士

   

（1） 优秀创新奖, 研究所（学校）, 2021

   

（1） Screening of Genes Related to Sex Determination and Differentiation in Mandarin Fish (Siniperca chuatsi), INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 通讯作者
（2） The cadmium decontamination and disposal of the harvested cadmium accumulator Amaranthus hypochondriacus L., CHEMOSPHERE, 2022, 第 5 作者
（3） Krüppel-like factor 2a (KLF2A) suppresses GCRV replication by upregulating serpinc1 expression in Ctenopharyngodon idellus kidney (CIK) cells, FISH AND SHELLFISH IMMUNOLOGY, 2022, 第 9 作者
（4） Grass carp SERPINA1 inhibits GCRV infection through degrading CF2, FRONTIERS IN IMMUNOLOGY, 2022, 第 3 作者
（5） Multi-Omics Sequencing Provides Insights Into Age-Dependent Susceptibility of Grass Carp (Ctenopharyngodon idellus) to Reovirus, FRONTIERS IN IMMUNOLOGY, 2021, 第 7 作者
（6） Genome-wide identification, evolution of Kr & uuml;ppel-like factors (klfs) and their expressions during GCRV challenge in grass carp (Ctenopharyngodon idella), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 通讯作者
（7） A rapid method of sex-specific marker discovery based on NGS and determination of the XX / XY sex-determination system in Channa maculata, AQUACULTURE, 2020, 通讯作者
（8） A rapid method of sex-marker discovery based on NGS and determination of the XX / XY sex-determination type in Channa maculata, aquaculture, 2020, 
（9） Characterization and expression of galectin-3 in grass carp (Ctenopharyngodon idella), DEVELOPMENTALANDCOMPARATIVEIMMUNOLOGY, 2020, 第 2 作者
（10） Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection, BIOMOLECULES, 2020, 第 3 作者
（11） Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 2 作者
（12） Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 2 作者
（13） Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation, FISH AND SHELLFISH IMMUNOLOGY, 2019, 第 3 作者
（14） Characterisation and function of TRIM23 in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 5 作者
（15） Cloning and characterization of the LEF/TCF gene family in grass carp (Ctenopharyngodon idella) and their expression profiles in response to grass carp reovirus infection, FISH & SHELLFISH IMMUNOLOGY, 2019, 第 2 作者
（16） Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 5 作者
（17） Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
（18） Deep sequencing of small RNAs from 11 tissues of grass carp Ctenopharyngodon idella and discovery of sex-related microRNAs, JOURNAL OF FISH BIOLOGY, 2019, 第 2 作者
（19） Identification, expression and functional characterisation of CYP1A in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 4 作者
（20） Grass carp ATG5 and ATG12 promote autophagy but down-regulate the transcriptional expression levels of IFN-I signaling pathway, FISH & SHELLFISH IMMUNOLOGY, 2019, 第 5 作者
（21） Molecular characterization and functional activity of Prx1 in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 3 作者
（22） Expression and localization of grass carp pkc-theta (protein kinase C theta) gene after its activation, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
（23） Full-Length Transcriptome Sequencing and the Discovery of New Transcripts in the Unfertilized Eggs of Zebrafish ( Danio rerio ), G3: GENES, 2019, 通讯作者
（24） Different responses in one-year-old and three-year-old grass carp reveal the mechanism of age restriction of GCRV infection, FISH & SHELLFISH IMMUNOLOGY, 2019, 第 5 作者
（25） Molecular cloning and preliminary functional analysis of six RING-between-ring (RBR) genes in grass carp (Ctenopharyngodon idellus), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 3 作者
（26） Investigating the Role of BATF3 in Grass Carp (Ctenopharyngodon idella) Immune Modulation: A Fundamental Functional Analysis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 第 2 作者
（27） Identification and molecular characterization of peroxiredoxin 2 in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 2 作者
（28） Molecular characterization, tissue distribution and functional analysis of galectin 1-like 2 in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2019, 第 3 作者
（29） Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 6 作者
（30） Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2018, 第 5 作者
（31） Transcriptomics Sequencing Provides Insights into Understanding the Mechanism of Grass Carp Reovirus Infection, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 4 作者
（32） ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 5 作者
（33） Molecular cloning and functional characterisation of NLRX1 in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2018, 第 4 作者
（34） Changes in gene and genotype frequencies during the development of the grass carp Ctenopharyngodon idella, JOURNAL OF FISH BIOLOGY, 2018, 第 5 作者
（35） Selection of growth-related genes and dominant genotypes in transgenic Yellow River carp Cyprinus carpio L., FUNCTIONAL & INTEGRATIVE GENOMICS, 2018, 第 2 作者
（36） An NGS-based approach for the identification of sex-specific markers in snakehead (Channa argus), ONCOTARGET, 2017, 第 4 作者
（37） Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 第 5 作者
（38） Computational identification of Y-linked markers and genes in the grass carp genome by using a pool-and-sequence method, SCIENTIFIC REPORTS, 2017, 第 2 作者
（39） Molecular cloning of the MARCH family in grass carp (Ctenopharyngodon idellus) and their response to grass carp reovirus challenge, FISH & SHELLFISH IMMUNOLOGY, 2017, 第 2 作者
（40） Differences in responses of grass carp to different types of grass carp reovirus (GCRV) and the mechanism of hemorrhage revealed by transcriptome sequencing, BMC GENOMICS, 2017, 第 6 作者
（41） Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis, ONCOTARGET, 2017, 第 5 作者
（42） Deep Illumina sequencing reveals conserved and novel microRNAs in grass carp in response to grass carp reovirus infection, BMC GENOMICS, 2017, 第 5 作者
（43） 一种新型草鱼呼肠孤病毒人工感染方法, PRELIMINARY STUDY ON A NEW METHOD OF GCRV ARTIFICIAL INFECTION, 水生生物学报, 2016, 第 6 作者
（44） Cloning and characterization of Bax1 and Bax2 genes of Ctenopharyngodon idellus and evaluation of transcript expression in response to grass carp reovirus infection, FISH PHYSIOLOGY AND BIOCHEMISTRY, 2016, 第 5 作者
（45） 草鱼Noxa基因克隆及其应答GCRV入侵的表达响应, CLONING OF GRASS CARP NOXA AND ITS EXPRESSION PROFILES IN RESPONSE TO GCRV INFECTION, 水生生物学报, 2016, 第 4 作者
（46） Differential expression of two C-type lectins in grass carp Ctenopharyngodon idella and their response to grass carp reovirus, JOURNAL OF FISH BIOLOGY, 2016, 
（47） 草鱼NF-κB2和IκBα基因的组织分布及对GCRV病毒感染的应答分析, Tissue distribution of NF-κB2 and IκBα gene and their response to GCRV infection in grass carp, 南昌大学学报：理科版, 2016, 第 4 作者
（48） Characterization, expression analysis and localization pattern of toll-like receptor 1 (tlr1) and toll-like receptor 2 (tlr2) genes in grass carp Ctenopharyngodon idella, JOURNAL OF FISH BIOLOGY, 2016, 
（49） Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.), DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2015, 第 6 作者
（50） Characterizations of four Toll-like receptor 4s in grass carp and their response to GCRV and LPS stimulation, Journal of fish biology, 2015, 
（51） The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation, NATURE GENETICS, 2015, 第 8 作者
（52） LG24 and sex chromosomes, ONCOTARGET, 2015, 第 1 作者
（53） 鱼类和哺乳类TLR4基因结构和功能的保守与进化, CONSERVATIVE AND EVOLUTION OF TLR4＇S GENE STRUCTURE AND FUNCTION IN FISH AND MAMMALIAN, 水生生物学报, 2015, 第 2 作者
（54） Genetic variations of body weight and GCRV resistance in a random mating population of grass carp, ONCOTARGET, 2015, 
（55） Expression pattern and transcriptional regulatory mechanism of noxa gene in grass carp (Ctenopharyngodon idella), FISH & SHELLFISH IMMUNOLOGY, 2015, 第 7 作者
（56） 草鱼CD81基因的克隆及功能分析, MOLECULAR CLONING AND PRIMARY FUNCTIONAL ANALYSIS OF CD81 IN GRASS CARP, 水生生物学报, 2015, 第 2 作者
（57） RNA-seq profiles from grass carp tissues after reovirus (GCRV) infection based on singular and modular enrichment analyses, MOLECULARIMMUNOLOGY, 2014, 第 2 作者
（58） Efficient Knockout of Transplanted Green Fluorescent Protein Gene in Medaka Using TALENs, MARINE BIOTECHNOLOGY, 2014, 第 4 作者
（59） Cloning and preliminary functional studies of the JAM-A gene in grass carp (Ctenopharyngodon idellus), FISH & SHELLFISH IMMUNOLOGY, 2013, 第 3 作者
（60） Transgenic Common Carp Do Not Have the Ability to Expand Populations, PLOS ONE, 2013, 第 3 作者
（61） Cloning and preliminary functional studies of the JAM-A gene in grass carp (Ctenopharyngodon idellus), FISH AND SHELLFISH IMMUNOLOGY, 2013, 第 3 作者
（62） Transgenic Common Carp Do Not Have the Ability to Expand Populations, PLOS ONE, 2013, 
（63） 草鱼（AG）微卫星标记克隆及特征分析, CLONING AND CHARACTERIZATION OF (AG)-MICROSATELLITES IN GRASS CARP (CTENOPHARYNGODON IDELLUS), 水生生物学报, 2012, 第 5 作者
（64） Identification, characterization and the interaction of Tollip and IRAK-1 in grass carp (Ctenopharyngodon idellus), FISH & SHELLFISH IMMUNOLOGY, 2012, 第 1 作者
（65） Isolation and analysis of a novel grass carp toll-like receptor 4 (tlr4) gene cluster involved in the response to grass carp reovirus, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 第 1 作者
（66） Cloning and characterization of the grass carp (Ctenopharyngodon idella) Toll-like receptor 22 gene, a fish-specific gene, FISH & SHELLFISH IMMUNOLOGY, 2012, 第 2 作者
（67） Transcriptome analysis of head kidney in grass carp and discovery of immune-related genes, BMC VETERINARY RESEARCH, 2012, 第 3 作者
（68） 草鱼Ⅰ型微卫星标记的发掘及其多态性检测, IDENTIFICATION OF TYPEⅠMICROSATELLITE MARKERS AND THEIR POLYMORPHISM IN GRASS CARP (CTENOPHARYNGODON IDELLUS), 水生生物学报, 2011, 第 3 作者
（69） Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease, FISH & SHELLFISH IMMUNOLOGY, 2010, 第 1 作者
（70） Identification and characterization of common carp ( Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease, FISH AND SHELLFISH IMMUNOLOGY, 2010, 第 1 作者
（71） 鲤、草鱼几个免疫相关基因的初步研究, Study of several immune-related genes in common carp (Cyprinus carpio L.) and grass carp (Ctenopharyngodon idellus), 2010, 第 1 作者
（72） Structure, organization and expression of common carp ( Cyprinus carpio L.) NKEF-B gene, FISH AND SHELLFISH IMMUNOLOGY, 2009, 第 1 作者
（73） Structure, organization and expression of common carp (Cyprinus carpio L.) NKEF-B gene, FISH & SHELLFISH IMMUNOLOGY, 2009, 第 1 作者
（74） Structure, organization and expression of common carp (Cyprinus carpio L.) SLP-76 gene, FISH & SHELLFISH IMMUNOLOGY, 2008, 第 1 作者
（75） Structure, organization and expression of common carp ( Cyprinus carpio L.) SLP-76 gene, FISH AND SHELLFISH IMMUNOLOGY, 2008, 第 1 作者
（76） Construction of a subtractive cDNA library from the internal organs of Trionyx sinensis experimentally infected by Aeromonas hydrophila, ACTA HYDROBIOLOGICA SINICA, 2007, 第 2 作者
（77） 转“全鱼”GH基因鲤鱼胸腺发育差异表达基因的筛选与鉴定, Identification of thymus development relative genes in ＂all fish＂ GH transgenic common carp (Cyprinus carpio L. ) by suppression subtractive hybridization, 高技术通讯, 2007, 第 2 作者
（78） 乌鳢（Channa argus）干扰素刺激基因Viperin和ISG15及其启动子的克隆与特征分析, 自然科学进展, 2007, 第 3 作者
（79） Cloning and characterization of interferon stimulated genes Viperin and ISG15, and their promoters from snakehead Channa argus, Cloning and characterization of interferon stimulated genes Viperin and ISG15, and their promoters from snakehead Channa argus, PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, 2007, 第 3 作者
（80） 嗜水气单胞菌感染的中华鳖主要器官差减cDNA文库的构建, 水生生物学报, 2007, 第 2 作者
（81） miR-2188-5p promotes GCRV replication by the targeted degradation of klf2a in Ctenopharyngodon idellus, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 第 10 作者

   

（ 1 ） 草鱼JAM-A基因克隆及其功能研究, 负责人, 国家任务, 2012-01--2014-12
（ 2 ） 草鱼出血病抗性相关基因的功能研究, 参与, 国家任务, 2012-01--2016-12
（ 3 ） 草鱼生长与抗病性状的遗传分析, 参与, 国家任务, 2009-01--2013-12
（ 4 ） 草鱼重要经济性状相关基因的克隆及功能验证, 参与, 国家任务, 2011-01--2015-12
（ 5 ） 草鱼抗出血病品种的分子模块设计与培育, 参与, 国家任务, 2013-08--2017-12
（ 6 ） 草鱼呼肠孤病毒受体筛选及其育种潜力评估, 负责人, 国家任务, 2016-01--2019-12
（ 7 ） 转基因黄河鲤的基因组选育, 参与, 国家任务, 2017-01--2020-12
（ 8 ） 吉鲤的生产性试验及规模化养殖示范, 参与, 中国科学院计划, 2017-01--2018-12
（ 9 ） 鳢性别控制技术研究及新种质创制, 负责人, 国家任务, 2019-01--2022-12
（ 10 ） 稀有鮈鲫突变基因位点筛选及抗出血病功能验证, 负责人, 国家任务, 2020-01--2023-12
（ 11 ） 鳜鱼抗病品系的基因组选育, 参与, 地方任务, 2022-07--2024-12
（ 12 ） 大口黑鲈抗病育种关键技术研究, 参与, 地方任务, 2021-06--2023-12