071005-微生物学

极端微生物遗传与生理及环境适应性

   

2017-10~2019-05,中国科学院微生物研究所, 副研究员
2010-07~2017-09,中国科学院微生物研究所, 助理研究员

   

（1） Post-transcriptional regulation is involved in the cold-active methanol-based methanogenic pathway of a psychrophilic methanogen, Environmental Microbiology, 2021, 第 1 作者
（2） A newly identified duplex RNA unwinding activity of archaeal RNase J depends on processive exoribonucleolysis coupled steric occlusion by its structural archaeal loops, RNA Biology, 2020, 通讯作者
（3） Comprehensive analysis of the pre-ribosomal RNA maturation pathway in a methanoarchaeon exposes the conserved circularization and linearization mode in archaea, RNA Biology, 2020, 第 1 作者
（4） The conserved ribonuclease aCPSF1 triggers genome-wide transcription termination of Archaea via a 3'-end cleavage mode, Nucleic Acids Research, 2020, 第 1 作者
（5） Characterization of the Methanomicrobial Archaeal RNase Zs for Processing the CCA-Containing tRNA Precursors, Frontiers in Microbiology, 2020, 通讯作者
（6） The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis, PLoS Genetics, 2019, 第 1 作者
（7） Genome-wide mRNA processing in methanogenic archaea reveals post-transcriptional regulation of ribosomal protein synthesis, Nucleic Acids Research, 2017, 通讯作者
（8） New molecular insights into an archaeal RNase J reveal a conserved processive exoribonucleolysis mechanism of the RNase J family, Molecular Microbiology, 2017, 通讯作者
（9） Conserved TRAM Domain Functions as an Archaeal Cold Shock Protein via RNA Chaperone Activity, Frontiers in Microbiology, 2017, 通讯作者
（10） Global mapping transcriptional start sites revealed both transcriptional and post-transcriptional regulation of cold adaptation in the methanogenic archaeon Methanolobus psychrophilus, Scientific Reports, 2015, 第 1 作者
（11） Characterization of an Archaeal Two-Component System That Regulates Methanogenesis in Methanosaeta harundinacea, PLOS one, 2015, 第 1 作者
（12） Mechanism for Stabilizing mRNAs Involved in Methanol-Dependent Methanogenesis of Cold-Adaptive Methanosarcina mazei zm-15, Applied and Environmental Microbiology, 2014, 第 2 作者
（13） Acyl homoserine lactone-based quorum sensing in a methanogenic archaeon, The ISME Journal, 2012, 第 4 作者
（14） Identification and Characterization of the Cognate Anti- Sigma Factor and Specific Promoter Elements of a T. tengcongensis ECF Sigma Factor, PLOS one, 2012, 第 2 作者
（15） Functional evaluation of four putative DNA-binding regions in Thermoanaerobacter tengcongensis reverse gyrase, Extremophiles, 2011, 第 1 作者
（16） Two Distantly Homologous DnaG Primases from Thermoanaerobacter tengcongensis Exhibit Distinct Initiation Specificities and Priming Activities, JOURNAL OF BACTERIOLOGY, 2010, 第 1 作者
（17） Mechanism for the TtDnaA–Tt-oriC cooperative interaction at high temperature and duplex opening at an unusual AT-rich region in Thermoanaerobacter tengcongensis, Nucleic Acids Research, 2007, 第 3 作者

   

（ 1 ） 古菌RNA加工流转关键酶生理生化功能及分子机制, 负责人, 国家任务, 2017-01--2020-12
（ 2 ） 青藏高原湿地低温甲烷代谢途径及其功能产甲烷菌的温度适应机制, 参与, 国家任务, 2018-01--2021-12
（ 3 ） 低温甲烷古菌对冷胁迫的转录后响应机制, 参与, 国家任务, 2015-01--2019-12
（ 4 ） 活性污泥人工多细胞体系构建与应用, 参与, 国家任务, 2020-01--2024-12
（ 5 ） 极端微生物底盘细胞的设计与构建, 参与, 国家任务, 2020-07--2025-06