1001J6-再生医学

生殖医学、细胞生物学

1996-09--1997-11   香港大学玛丽医院   妇产科访问学者
1993-09--1996-08   北医大第三医院   博士学位
1987-09--1990-07   北医大第三医院   医学硕士学位
1981-09--1987-07   北京医科大学医学系   学士学位

   

2012-05~现在, 北京大学第三医院, 院长
2003-03~2018-07,北京大学第三医院, 生殖医学中心主任
2002-09~2003-08,美国斯坦福大学, 博士后研究
2000-10~2018-07,北京大学第三医院, 妇产科主任
1996-09~1997-11,香港大学玛丽医院, 妇产科访问学者
1993-09~1996-08,北医大第三医院, 博士学位
1987-09~1990-07,北医大第三医院, 医学硕士学位
1981-09~1987-07,北京医科大学医学系, 学士学位

2018-12-13-今,中国女医师协会, 会长
2018-11-03-今,中华医学会妇产科学分会第十二届委员会, 副主任委员
2016-05-01-今,第七届教育部科学技术委员会学部, 委员
2015-12-01-今,中国医师协会生殖医学专业委员会, 主任委员
2012-02-24-今,《生殖与避孕》杂志、《中华生殖与避孕》杂志, 主编
2012-02-24-2015-08-31,中华医学会生殖医学分会, 主任委员
2010-06-30-今,Seminars in Reproductive Medicine, Editorial Board Membe

北京大学研究生课程
生殖医学前沿讲座
医学发展概论--辅助生殖技术的研究
卵巢早衰
多囊卵巢综合征
医学导论-妇产科学

   

（1） 第十一届谈家桢生命科学临床医学奖, , 部委级, 2018
（2） 生殖细胞发育的表观遗传调控机制及体外干预方法研究（中华医学科技奖）, 一等奖, 省级, 2018
（3） 配子胚胎发育研究与生育力改善新方法的应用, 二等奖, 国家级, 2017
（4） 卵母细胞成熟与胚胎发育的分子机制研究(北京市科学技术奖), 一等奖, 部委级, 2016
（5） 全国杰出人才科技奖(中国科协), 部委级, 2016
（6） 北京市名师奖, 部委级, 2016
（7） 难治性不孕不育诊治问题的临床研究(教育部高校科学进步奖), 一等奖, 部委级, 2015
（8） 不孕症病因及治疗方法的临床研与应用, 二等奖, 国家级, 2011
（9） 人类辅助生殖和精子库的关键技术, 二等奖, 国家级, 2009

（ 1 ） 一种快速鉴定生殖冷冻用玻璃化液的方法及其装置, 2019, 第 2 作者, 专利号: ZL2018103465348

（ 2 ） 一种避光保温型抗冻试剂包装盒, 2018, 第 4 作者, 专利号: ZL 2018 2 0174286.9

（ 3 ） 一种胚胎玻璃化冷冻操作专用皿, 2018, 第 1 作者, 专利号: ZL 2018 2 0174947.8

（ 4 ） 一种来自人辅助生殖发育胚胎发育早期出生安全性预测的试剂盒, 2016, 第 1 作者, 专利号: ZL201510003430.3

（ 5 ） 一种多通道减胎针, 2015, 第 1 作者, 专利号: ZL200810119992.4

（ 6 ） 一种21-三体综合征产前筛查试剂盒, 2011, 第 2 作者, 专利号: ZL200910083599.9

（ 7 ） 一种子宫内膜刮除器, 2009, 第 1 作者, 专利号: ZL200820123202.5

（ 8 ） 一种生物材料玻璃化冷冻载体, 2009, 第 1 作者, 专利号: ZL200820123203.X

（ 9 ） 一种生物材料玻璃化冷冻载体及其制备方法, 2009, 第 1 作者, 专利号: ZL200810119992.4

   

（1） Single-cell multiomics sequencing and analyses of human colorectal cancer. Science, Science, 2018, 通讯作者
（2） Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis, Cell Stem Cell, 2018, 通讯作者
（3） A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex, Nature, 2018, 通讯作者
（4） Elevated CD14++CD16+ Monocytes in Hyperhomocysteinemia-Associated Insulin Resistance in Polycystic Ovary Syndrome, Reprod Sci, 2018, 通讯作者
（5） Poly(ADP-ribose) mediates asymmetric division of mouse oocyte, Cell Research, 2018, 通讯作者
（6） Dual role for the unfolded protein response in the ovary: adaption and apoptosis, PROTEIN & CELL, 2017, 通讯作者
（7） Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients with Polycystic Ovary Syndrome, Reprod Sci, 2017, 通讯作者
（8） Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions, Cell Stem Cell, 2017, 通讯作者
（9） DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cell, Cell Research, 2017, 通讯作者
（10） Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial, JAMA, 2017, 通讯作者
（11） Chemokine Receptor Type 4 Regulates Migration and Invasion of Trophectoderm Cell in the Human Blastocyst, BIOLOGY OF REPRODUCTION, 2016, 通讯作者
（12） High-fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS, REPRODUCTION, 2016, 通讯作者
（13） Bone mesenchymal stem cells improve pregnancy outcome by inducing maternal tolerance to the allogeneic fetus in abortion-prone matings in mouse, PLACENTA, 2016, 通讯作者
（14） Anti-Mullerian hormone for prediction of ovarian response in Chinese infertile women undergoing IVF/ICSI cycles: a prospective, multi-centre, observational study, REPRODUCTIVE BIOMEDICINE ONLINE, 2016, 通讯作者
（15） Clinical Performance of APTIMA Human Papillomavirus (HPV) 16 18/45 mRNA Genotyping Testing for the Detection of Cervical Intraepithelial Neoplasia 3 (CIN3) or Cancer in a Select Group of Chinese Women, PATHOLOGY & ONCOLOGY RESEARCH, 2016, 通讯作者
（16） TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis, SCIENTIFIC REPORTS, 2016, 通讯作者
（17） Human single follicle growth in vitro from cryopreserved ovarian tissue after slow freezing or vitrification, HUMAN REPRODUCTION, 2016, 通讯作者
（18） Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes, HUMAN REPRODUCTION, 2016, 通讯作者
（19） Epigenomic Landscape of Human Fetal Brain, Heart, and Liver, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 通讯作者
（20） Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy, JOURNAL OF GENETICS AND GENOMICS, 2016, 通讯作者
（21） Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis, CELL CYCLE, 2016, 通讯作者
（22） Identification of a human subcortical maternal complex, MOLECULAR HUMAN REPRODUCTION, 2015, 通讯作者
（23） Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation, CELL TRANSPLANTATION, 2015, 通讯作者
（24） Basic fibroblast growth factor promotes macaque follicle development in vitro, REPRODUCTION, 2015, 通讯作者
（25） Increased Incidence of Mitochondrial Cytochrome C Oxidase 1 Gene Mutations in Patients with Primary Ovarian Insufficiency, PLOS ONE, 2015, 通讯作者
（26） Effect of Local Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor on Subcutaneously Allotransplanted Ovarian Tissue in Ovariectomized Mice, PLOS ONE, 2015, 通讯作者
（27） Identification and Characterization of Xlr5c as a Novel Nuclear Localization Protein in Mouse Germ Cells, PLOS ONE, 2015, 通讯作者
（28） Impaired Oocyte Quality Induced by Dehydroepiandrosterone Is Partially Rescued by Metformin Treatment, PLOS ONE, 2015, 通讯作者
（29） Altered amphiregulin expression induced by diverse luteinizing hormone receptor reactivity in granulosa cells affects IVF outcomes, REPRODUCTIVE BIOMEDICINE ONLINE, 2015, 通讯作者
（30） Mesenchymal Stem Cells Facilitate In Vitro Development of Human Preantral Follicle, REPRODUCTIVE SCIENCES, 2015, 通讯作者
（31） Homeodomain interacting protein kinase2 is downregulated through the peroxisome proliferator-activated receptor gamma signaling pathway in an insulin-resistant population, JOURNAL OF DIABETES INVESTIGATION, 2015, 通讯作者
（32） Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2015, 通讯作者
（33） Chromosomal characteristics at cleavage and blastocyst stages from the same embryos, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2015, 通讯作者
（34） The transcriptome and DNA methylome landscapes of human primordial germ cells, Cell, 2015, 通讯作者
（35） Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation, Cell Research, 2015, 通讯作者
（36） Tracing the expression of circular RNAs in human pre-implantation embryos, GENOME BIOLOGY, 2015, 通讯作者
（37） Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors, Hum Reprod Updat, 2015, 通讯作者
（38） Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome, FREE RADICAL BIOLOGY AND MEDICINE, 2015, 通讯作者
（39） Up-Regulated Expression of WNT5a Increases Inflammation and Oxidative Stress via PI3K/AKT/NF-kappa B Signaling in the Granulosa Cells of PCOS Patients, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 通讯作者
（40） L-proline: a highly effective cryoprotectant for mouse oocyte vitrification, SCIENTIFIC REPORTS, 2015, 通讯作者
（41） Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome, SCIENTIFIC REPORTS, 2015, 通讯作者
（42） Statistical Approach to Decreasing the Error Rate of Noninvasive Prenatal Aneuploid Detection caused by Maternal Copy Number Variation, SCIENTIFIC REPORTS, 2015, 通讯作者
（43） Chromosome microduplication in somatic cells decreases the genetic stability of human reprogrammed somatic cells and results in pluripotent stem cells, SCIENTIFIC REPORTS, 2015, 通讯作者
（44） Aberrant expression of maternal Plk1 and Dctn3 results in the developmental failure of human in-vivo- and in-vitro-matured oocytes, SCIENTIFIC REPORTS, 2015, 通讯作者
（45） Association of serum levels of typical organic pollutants with polycystic ovary syndrome (PCOS): a case-control study, HUMAN REPRODUCTION, 2015, 通讯作者
（46） Effect of embryo culture media on percentage of males at birth, HUMAN REPRODUCTION, 2015, 通讯作者
（47） Ascorbic acid improves pluripotency of human parthenogenetic embryonic stem cells through modifying imprinted gene expression in the Dlk1-Dio3 region, STEM CELL RESEARCH & THERAPY, 2015, 通讯作者
（48） Validation of a next-generat on sequencing based protocol for 24-chromosome aneuploidy screening of blastocysts, FERTILITY AND STERILITY, 2015, 通讯作者
（49） Influence of embryo culture medium on incidence of ectopic pregnancy in in vitro fertilization, FERTILITY AND STERILITY, 2015, 通讯作者
（50） Value of transferring embryos that show no evidence of fertilization at the time of fertilization assessment, FERTILITY AND STERILITY, 2015, 通讯作者
（51） The construction of an interfacial valve-based microfluidic chip for thermotaxis evaluation of human sperm, BIOMICROFLUIDICS, 2014, 通讯作者
（52） Gonadotropin-Mediated Dynamic Alterations During Bovine Oocyte Maturation In Vitro, BIOLOGY OF REPRODUCTION, 2014, 通讯作者
（53） Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases, ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 通讯作者
（54） Serologic autoimmunologic parameters in women with primary ovarian insufficiency, BMC IMMUNOLOGY, 2014, 通讯作者
（55） ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions, REPRODUCTION FERTILITY AND DEVELOPMENT, 2014, 通讯作者
（56） Impact of gonadotropins on oocyte maturation, fertilisation and developmental competence in vitro, REPRODUCTION FERTILITY AND DEVELOPMENT, 2014, 通讯作者
（57） Metabolic heterogeneity of follicular amino acids in polycystic ovary syndrome is affected by obesity and related to pregnancy outcome, BMC PREGNANCY AND CHILDBIRTH, 2014, 通讯作者
（58） Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study, BMC ENDOCRINE DISORDERS, 2014, 通讯作者
（59） Fertility preservation: challenges and opportunities, Lancet（第一及通讯作者）, 2014, 第 1 作者
（60） The DNA methylation landscape of human early embryos, Nature, 2014, 通讯作者
（61） Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain, GENOME BIOLOGY, 2014, 通讯作者
（62） The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects, MOLECULAR ASPECTS OF MEDICINE, 2014, 第 1 作者
（63） Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 通讯作者
（64） Validation of multiple annealing and looping-based amplification cycle sequencing for 24-chromosome aneuploidy screening of cleavage-stage embryos, FERTILITY AND STERILITY, 2014, 通讯作者
（65） Effect of ABO blood type on ovarian reserve in Chinese women, FERTILITY AND STERILITY, 2014, 通讯作者
（66） Up-regulation of heme oxygenase-1 expression modulates reactive oxygen species level during the cryopreservation of human seminiferous tubules, FERTILITY AND STERILITY, 2014, 通讯作者
（67） The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5, HUMAN REPRODUCTION, 2014, 通讯作者
（68） Basic fibroblast growth factor promotes the development of human ovarian early follicles during growth in vitro, HUMAN REPRODUCTION, 2014, 通讯作者
（69） SLX2 interacting with BLOS2 is differentially expressed during mouse oocyte meiotic maturation, CELL CYCLE, 2014, 通讯作者
（70） Genome Analyses of Single Human Oocytes, Cell, 2013, 通讯作者
（71） Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 通讯作者

（ 1 ） 生殖医学微创手术学, 北京大学医学部出版社, 2012-02, 第 2 作者
（ 2 ） 实用生殖医学, 人民卫生出版社, 2012-03, 第 2 作者
（ 3 ） 生殖内分泌疾病诊断与治疗, 北京大学医学部出版社, 2013-03, 第 2 作者
（ 4 ） 生殖医学临床诊疗常规（中华医学会继续医学教育教材）, 人民军医出版社, 2013-06, 第 1 作者
（ 5 ） 生殖医学实验室技术(“十二五”国家重点图书), 北京大学医学出版社, 2013-12, 第 2 作者
（ 6 ） 生育力保护与生殖储备(“十二五”国家重点图书), 北京大学医学出版社, 2013-12, 第 1 作者
（ 7 ） 妇产科学（第3版）(“十二五”普通高等教育本科国家级规划教材), 北京大学医学出版社, 2013-12, 第 3 作者
（ 8 ） 生殖医学临床指南与专家解读, 人民军医出版社, 2014-06, 第 1 作者
（ 9 ） 妇产科学（第二版）(卫计委“十二五”规划教材), 人民卫生出版社, 2014-06, 第 2 作者
（ 10 ） 辅助生育技术促排卵药物治疗共识专家解读, 人民卫生出版社, 2016-03, 第 1 作者
Human Reproductive and Prenatal Genetics, ACADEMIC PRESS, 2018-08, 第 1 作者
（ 12 ） 生殖内分泌学, Reproductive Endocrinology, 科学出版社, 2019-01, 第 1 作者

   

（ 1 ） 人卵泡体内及体外生长发育的基因表达谱及调控机制的研究, 负责人, 国家任务, 2011-01--2017-12
（ 2 ） 女性生殖细胞发育与生殖遗传疾病, 负责人, 国家任务, 2015-01--2021-12
（ 3 ） 卵极体细胞甲基化与人胚胎发育潜能的关系, 负责人, 地方任务, 2015-01--2018-12
（ 4 ） 基质金属蛋白酶ADAMTS-7在胚胎着床过程中的二条街与功能研究, 负责人, 国家任务, 2013-01--2017-12
（ 5 ） 人类辅助生殖技术质量控制体系建立的相关研究, 负责人, 地方任务, 2014-01--2018-12
（ 6 ） 小鼠四细胞胚胎异质表达基因在胚胎细胞命运决定中的作用及机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 7 ） 面向 2035 我国生殖健康维护与生殖医学发展战略研究, 负责人, 国家任务, 2019-01--2020-12
（ 8 ） 高龄对妊娠结局及子代健康的影响及其机制研究, 负责人, 国家任务, 2018-01--2022-12