071007-遗传学

鱼类环境基因组学

2007-09--2010-12   中国科学院水生生物研究所   博士
2002-09--2005-06   西南农业大学   硕士
1998-09--2002-06   西南农业大学   学士

   

2015-12~2016-12,University of California, San Francisco, 访问学者
2013-12~现在, 中国科学院水生生物研究所, 副研究员
2011-01~2013-12,中国科学院水生生物研究所, 助理研究员
2005-07~2007-08,信阳农业高等专科学校, 助教

   

[1] 龙勇, 刘冉, 宋桂丽, 李青, 崔宗斌. 一株吉富罗非鱼脑神经细胞系、转染方法、培养方法及其应用. CN: [[[CN111690613A]]], [[["2020-09-22"]]].
[2] 宋桂丽, 龙勇. 一种罗非鱼受精卵的人工孵化装置. CN: CN214801686U, 2021-11-23.
[3] 崔宗斌, 周同, 周波兰, 龙勇, 宋桂丽, 李青, 朱作言. 一种鱼类皮肤粘液腺生物反应器的制备方法及其应用. CN: CN110628818A, 2019-12-31.
[4] 宋桂丽, 刘春艳, 龙勇, 李青, 崔宗斌. 斑马鱼神经组织特异性增强子及其克隆和应用. CN: CN105087578A, 2015-11-25.

   

[1] Hu, Han, Long, Yong, Song, Guili, Chen, Shaoxiong, Xu, Zhicheng, Li, Qing, Wu, Zhengli. Dysfunction of Prkcaa Links Social Behavior Defects with Disturbed Circadian Rhythm in Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 24(4): http://dx.doi.org/10.3390/ijms24043849.
[2] Juhong Xie, Long, Yong. Identification of male-specific DNA markers and generation of genetically all-female offspring using natural pseudomales in Amur catfish (Silurus asotus). Aquaculture[J]. 2023, [3] Liu, Ran, Liu, Renyan, Song, Guili, Li, Qing, Cui, Zongbin, Long, Yong. Mitochondria Dysfunction and Cell Apoptosis Limit Resistance of Nile Tilapia (Oreochromis niloticus) to Lethal Cold Stress. ANIMALS[J]. 2022, 12(18): [4] Liu, Renyan, Long, Yong, Liu, Ran, Song, Guili, Li, Qing, Yan, Huawei, Cui, Zongbin. Understanding the Function and Mechanism of Zebrafish Tmem39b in Regulating Cold Resistance. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 23(19): http://dx.doi.org/10.3390/ijms231911442.
[5] Li, Fengyang, Long, Yong, Xie, Juhong, Ren, Jing, Zhou, Tong, Song, Guili, Li, Qing, Cui, Zongbin. Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(11): http://dx.doi.org/10.3390/ijms22115551.
[6] Ren, Jing, Long, Yong, Liu, Ran, Song, Guili, Li, Qing, Cui, Zongbin. Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(6): https://doaj.org/article/229b1caf6ef942778fd1d6c0a6028ffa.
[7] Lu, Xing, Long, Yong, Li, Xixi, Zhang, Lang, Li, Qing, Wen, Hua, Zhong, Shan, Cui, Zongbin. Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923114/.
[8] Zhou, Tong, Zhou, Bolan, Zhao, Yasong, Li, Qing, Song, Guili, Zhu, Zuoyan, Long, Yong, Cui, Zongbin. Development of a Mucus Gland Bioreactor in Loach Paramisgurnus dabryanus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(2): http://dx.doi.org/10.3390/ijms22020687.
[9] Long, Yong, Liu, Ran, Song, Guili, Li, Qing, Cui, Zongbin. Establishment and characterization of a cold-sensitive neural cell line from the brain of tilapia (Oreochromis niloticus). JOURNAL OF FISH BIOLOGY[J]. 2021, 98(3): 842-854, http://dx.doi.org/10.1111/jfb.14637.
[10] Long, Yong, Li, Xixi, Li, Fengyang, Ge, Guodong, Liu, Ran, Song, Guili, Li, Qing, Qiao, Zhigang, Cui, Zongbin. Transcriptional Programs Underlying Cold Acclimation of Common Carp (Cyprinus carpioL.). FRONTIERS IN GENETICS[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538616/.
[11] Yan, Junjun, Long, Yong, Zhou, Tong, Ren, Jing, Li, Qing, Song, Guili, Cui, Zongbin. Dynamic Phosphoproteome Profiling of Zebrafish Embryonic Fibroblasts during Cold Acclimation. PROTEOMICS[J]. 2020, 20(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000506064600001.
[12] Shen, Fangfang, Long, Yong, Li, Fengyang, Ge, Guodong, Song, Guili, Li, Qing, Qiao, Zhigang, Cui, Zongbin. De novo transcriptome assembly and sex-biased gene expression in the gonads of Amur catfish (Silurus asotus). GENOMICS[J]. 2020, 112(3): 2603-2614, http://dx.doi.org/10.1016/j.ygeno.2020.01.026.
[13] Ge, Guodong, Long, Yong, Shi, Lianyu, Ren, Jing, Yan, Junjun, Li, Chitao, Li, Qing, Cui, Zongbin. Transcriptomic profiling revealed key signaling pathways for cold tolerance and acclimation of two carp species. BMC GENOMICS[J]. 2020, 21(1): http://dx.doi.org/10.1186/s12864-020-06946-8.
[14] Vozdek, Roman, Long, Yong, Ma, Dengke K. The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury. SCIENCE SIGNALING[J]. 2018, 11(550): http://dx.doi.org/10.1126/scisignal.aat0138.
[15] Wei Jiang. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans. ELIFE SCIENCES PUBLICATIONS, LTD. 2018, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201910289023843ZK.
[16] Jiang, Wei, Wei, Yuehua, Long, Yong, Owen, Arthur, Wang, Bingying, Wu, Xuebing, Luo, Shuo, Dang, Yongjun, Ma, Dengke K. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans. ELIFE[J]. 2018, 7: https://doaj.org/article/d57a8eae22bf44a185594635bba730c7.
[17] Yan, Junjun, Gao, Qiang, Cui, Zongbin, Yang, Guoliang, Long, Yong. Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter. PEERJ[J]. 2018, 6: http://202.127.146.157/handle/2RYDP1HH/5852.
[18] Wu, DongMei, Ma, LiangPeng, Song, GuiLi, Long, Yong, Liu, HanXiao, Liu, Yang, Ping, Jie. Steroidogenic factor-1 hypermethylation in maternal rat blood could serve as a biomarker for intrauterine growth retardation. ONCOTARGET[J]. 2017, 8(56): 96139-96153, https://www.webofscience.com/wos/woscc/full-record/WOS:000414937900086.
[19] Li, Zhouquan, Long, Yong, Zhong, Liqiao, Song, Guili, Zhang, Xiaohua, Yuan, Li, Cui, Zongbin, Dai, Heping. RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. JOURNAL OF APPLIED TOXICOLOGY[J]. 2016, 36(1): 94-104, http://dx.doi.org/10.1002/jat.3147.
[20] Zhou, Bolan, Long, Yong, Song, Guili, Li, Qing, Cui, Zongbin. Molecular characterization of the lgals1 gene in large scale loach Paramisgurnus dabryanus. GENE[J]. 2016, 577(1): 65-74, http://dx.doi.org/10.1016/j.gene.2015.11.025.
[21] Long, Yong, Yan, Junjun, Song, Guili, Li, Xiaohui, Li, Xixi, Li, Qing, Cui, Zongbin. Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. BMC GENOMICS[J]. 2015, 16(1): http://www.irgrid.ac.cn/handle/1471x/978676.
[22] Feng, Guohui, Long, Yong, Peng, Jinrong, Li, Qing, Cui, Zongbin. Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish. BMC GENOMICS[J]. 2015, 16(1): http://www.irgrid.ac.cn/handle/1471x/1012143.
[23] Liu, Chunyan, Song, Guili, Mao, Lin, Long, Yong, Li, Qing, Cui, Zongbin. Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. PLOS ONE[J]. 2015, 10(10): http://www.irgrid.ac.cn/handle/1471x/991727.
[24] Lu, Xing, Long, Yong, Sun, Rongze, Zhou, Bolan, Lin, Li, Zhong, Shan, Cui, Zongbin. Zebrafish Abcb4 is a potential efflux transporter of microcystin-LR. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY[J]. 2015, 167: 35-42, http://dx.doi.org/10.1016/j.cbpc.2014.08.005.
[25] Liqiao Zhong, Li Yuan, Yu Rao, Zhouquan Li, Qilin Gu, Yong Long, Xiaohua Zhang, Zongbin Cui, Ying Xu, Heping Dai. Investigation of effect of 17α-ethinylestradiol on vigilin expression using an isolated recombinant antibody. AQUATIC TOXICOLOGY. 2014, 156: 1-9, http://dx.doi.org/10.1016/j.aquatox.2014.07.016.
[26] 杨玲, 严军军, 龙勇, 崔宗斌, 鲍传和. 斑马鱼nr1d4a和nr1d4b基因的表达及其对不同环境刺激的响应. 水生生物学报[J]. 2014, 38(1): 100-107, http://lib.cqvip.com/Qikan/Article/Detail?id=48542919.
[27] Lu, Xing, Long, Yong, Lin, Li, Sun, Rongze, Zhong, Shan, Cui, Zongbin. Characterization of Zebrafish Abcc4 as an Efflux Transporter of Organochlorine Pesticides. PLOS ONE[J]. 2014, 9(12): http://www.irgrid.ac.cn/handle/1471x/978696.
[28] Zhong, Liqiao, Yuan, Li, Rao, Yu, Li, Zhouquan, Gu, Qilin, Long, Yong, Zhang, Xiaohua, Cui, Zongbin, Xu, Ying, Dai, Heping. Investigation of effect of 17 alpha-ethinylestradiol on vigilin expression using an isolated recombinant antibody. AQUATIC TOXICOLOGY[J]. 2014, 156: 1-9, http://www.irgrid.ac.cn/handle/1471x/929264.
[29] He, Xiaozhen, Li, Jie, Long, Yong, Song, Guili, Zhou, Peiyong, Liu, Qiuxiang, Zhu, Zuoyan, Cui, Zongbin. Gene transfer and mutagenesis mediated by Sleeping Beauty transposon in Nile tilapia (Oreochromis niloticus). TRANSGENIC RESEARCH[J]. 2013, 22(5): 913-924, http://dx.doi.org/10.1007/s11248-013-9693-8.
[30] Long, Yong, Li, Qing, Zhou, Bolan, Song, Guili, Li, Tao, Cui, Zongbin. De Novo Assembly of Mud Loach (Misgurnus anguillicaudatus) Skin Transcriptome to Identify Putative Genes Involved in Immunity and Epidermal Mucus Secretion. PLOS ONE[J]. 2013, 8(2): http://www.irgrid.ac.cn/handle/1471x/733514.
[31] Long, Yong, Song, Guili, Yan, Junjun, He, Xiaozhen, Li, Qing, Cui, Zongbin. Transcriptomic characterization of cold acclimation in larval zebrafish. BMC GENOMICS[J]. 2013, 14(1): 612-612, http://www.irgrid.ac.cn/handle/1471x/779919.
[32] Song, Guili, Li, Qing, Long, Yong, Gu, Qilin, Hackett, Perry B, Cui, Zongbin. Effective Gene Trapping Mediated by Sleeping Beauty Transposon. PLOS ONE[J]. 2012, 7(8): http://www.irgrid.ac.cn/handle/1471x/533469.
[33] 李林春, 李青, 龙勇, 崔宗斌. 温度刺激对斑马鱼仔鱼基因转录表达的影响. 水生生物学报[J]. 2012, 36(5): 882-891, http://lib.cqvip.com/Qikan/Article/Detail?id=43590027.
[34] Long, Yong, Li, Linchun, Li, Qing, He, Xiaozhen, Cui, Zongbin. Transcriptomic Characterization of Temperature Stress Responses in Larval Zebrafish. PLOS ONE[J]. 2012, 7(5): https://doaj.org/article/d76f6c13310d4c2a827a45ac07714891.
[35] Song, Guili, Li, Qing, Long, Yong, Hackett, Perry B, Cui, Zongbin. Effective Expression-Independent Gene Trapping and Mutagenesis Mediated by Sleeping Beauty Transposon. JOURNAL OF GENETICS AND GENOMICS[J]. 2012, 39(9): 503-520, http://lib.cqvip.com/Qikan/Article/Detail?id=43433735.
[36] Li, Yuanyuan, Li, Qing, Long, Yong, Cui, Zongbin. Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear beta-Catenin in Zebrafish. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(52): 45116-45130, http://www.irgrid.ac.cn/handle/1471x/1759727.
[37] Long, Yong, Li, Qing, Zhong, Shan, Wang, Youhui, Cui, Zongbin. Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY[J]. 2011, 153(4): 381-391, http://dx.doi.org/10.1016/j.cbpc.2011.01.002.
[38] Yong Long, Qing Li, Jie Li, Zongbin Cui. Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART B. 2011, 158(1): 46-55, http://dx.doi.org/10.1016/j.cbpb.2010.09.005.
[39] Yong Long, Qing Li, Youhui Wang, Zongbin Cui. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART C. 2011, 153(3): 310-317, http://dx.doi.org/10.1016/j.cbpc.2010.12.001.
[40] Long, Yong, Li, Qing, Cui, Zongbin. Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish. MOLECULAR BIOLOGY REPORTS[J]. 2011, 38(3): 1703-1711, https://www.webofscience.com/wos/woscc/full-record/WOS:000286941400033.
[41] Long, Yong, Li, Qing, Wang, Youhui, Cui, Zongbin. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY[J]. 2011, 153(3): 310-317, http://dx.doi.org/10.1016/j.cbpc.2010.12.001.
[42] Yong Long, Qing Li, Shan Zhong, Youhui Wang, Zongbin Cui. Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART C. 2011, 153(4): 381-391, http://dx.doi.org/10.1016/j.cbpc.2011.01.002.
[43] Yuanyuan Li, Qing Li, Yong Long, Zongbin Cui. Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear β-Catenin in Zebrafish*. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011, 286(52): 45116-45130, http://dx.doi.org/10.1074/jbc.M111.267328.
[44] Long, Yong, Li, Qing, Li, Jie, Cui, Zongbin. Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY[J]. 2011, 158(1): 46-55, http://dx.doi.org/10.1016/j.cbpb.2010.09.005.
[45] 龙勇. 斑马鱼多药耐药相关蛋白基因的克隆、表达和功能研究. 2010, 129-, http://ir.ihb.ac.cn/handle/342005/11915.
[46] Pei, DeSheng, Sun, YongHua, Long, Yong, Zhu, ZuoYan. Inhibition of no tail (ntl) gene expression in zebrafish by external guide sequence (EGS) technique. MOLECULAR BIOLOGY REPORTS[J]. 2008, 35(2): 139-143, http://ir.ihb.ac.cn/handle/152342/8114.

   

（ 1 ） 斑马鱼抗寒相关转录因子的基因转移及其作用机制研究, 主持, 国家级, 2012-01--2014-12
（ 2 ） 罗氏沼虾抗病基因工程育种技术研究, 主持, 省级, 2013-01--2015-12
（ 3 ） 即刻早期基因在斑马鱼低温信号传导中的功能与机制研究, 主持, 市地级, 2015-01--2015-12
（ 4 ） 泥鳅皮肤粘液腺生物反应器的技术建立与应用研究, 主持, 市地级, 2012-01--2013-12
（ 5 ） 肝脏发育和再生关键基因的鉴定及遗传调控研究, 主持, 国家级, 2012-01--2016-12
（ 6 ） 从母体外周血中探寻宫内发育迟缓的DNA甲基化生物标志物研究, 主持, 国家级, 2013-01--2016-12
（ 7 ） Fos家族即刻早期基因在斑马鱼低温适应中的功能与机制研究, 主持, 国家级, 2016-01--2019-12
（ 8 ） 钙离子信号系统调控鱼类低温适应的分子机制研究, 主持, 国家级, 2018-01--2021-12
（ 9 ） 罗非鱼抗寒性状的分子基础, 主持, 国家级, 2018-12--2022-12

（1）斑马鱼抗寒相关信号通路的鉴定和功能研究   第十届水产生物技术专业委员会   2020-12-03
（2）即刻早期基因调控斑马鱼低温适应的作用机制研究   第九届水产生物技术专业委员会   2018-10-15
（3）Genetic programs underlying cold acclimation of zebrafish larvae   第十三届国际斑马鱼大会   2018-06-20
（4）Transcriptional regulation of cold acclimation in zebrafish   第十一届国际斑马鱼发育与遗传学大会   Yong Long and Zongbin Cui   2014-06-24

现指导学生

陈艺元  硕士研究生  085238-生物工程  

谢巨洪  硕士研究生  086000-生物与医药