基本信息
王晓辉  男  博导  中国科学院长春应用化学研究所
电子邮件: xiaohui.wang@ciac.ac.cn
通信地址: 吉林省长春市人民大街5625号
邮政编码: 130022

招生信息

   
招生专业
070304-物理化学(含:化学物理)
070321-化学生物学
070322-生物无机化学
招生方向
天然免疫;神经免疫药理学
药物成瘾;慢性疼痛
生物材料;生物化工;化学进化

教育背景

2004-09--2010-01 中国科学院长春应用化学研究所 理学博士
2000-09--2004-06 北京工商大学 工学学士

工作经历

   
工作简历
2015-02--今 中国科学院长春应用化学研究所 研究员/药物化学生物学课题组长
2010-02--2015-02 美国科罗拉多大学博尔德分校 Research Associate
社会兼职
2015-07--今 吉林省药学会药理专业委员会,委员

出版信息

   
发表论文
(1) A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells,Dalton Trans. ,2015,第2作者
(2) Caspases come together,Trends Immunol. ,2015,第1作者
(3) DAT is not all that cocaine reward and reinforcement requires Toll like receptor 4 signaling.,Mol. Psychiatry ,2015,第2作者
(4) Structure activity relationships of (+)-naltrexone-inspired Toll-like receptor 4 (TLR4) antagonists,J. Med. Chem. ,2015,第1作者
(5) Activation of adult rat CNS endothelial cells by opioid-induced TLR4 signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae,Neuroscience ,2015,第4作者
(6) Targeting the Toll of drug abuse: the translational potential of Toll-like receptor 4., CNS Neurol. Disord. Drug Targets,2015,第3作者
(7) A Lysin-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. ,Nat. Commun. ,2015,第2作者
(8) In vivo veritas plus naltrexone actions define translational importance,Trends Pharmacol. Sci. ,2014,第2作者
(9) Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain,FASEB J,2013,第1作者
(10) Targeting the lateral interactions of transmembrane domain 5 of Epstein–Barr virus latent membrane protein 1,Biochim. Biophys. Acta-Biomembranes ,2013,第1作者
(11) Targeting Toll-like receptors with small molecule agents,Chem. Soc. Rev. ,2013,第1作者
(12) Selection, synthesis, and antiinflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitor,Bioorg. Med. Chem. ,2013,第3作者
(13) Discovery of small molecule inhibitors of the TLR1-TLR2 complex,,Angew. Chem. Int. Edit. ,2012,第2作者
(14) Morphine activates neuroinflammataion in a parallel manner to endotoxin,Proc. Natl. Acad. Sci. USA,2012,第1作者
(15) Toll-like receptors as the therapeutic targets of autoimmune connective tissue diseases,Pharmacol. Ther. ,2012,第1作者
(16) Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1,PLoS One,2012,第1作者
(17) Opioid activation of Toll-Like receptor 4 contributes to drug reinforcement,J. Neurosci. ,2012,第4作者
(18) Small molecule inhibitors of the TLR3/dsRNA complex,J. Am. Chem. Soc. ,2011,第2作者
(19) Microwave assisted one-step green synthesis of multicolor photoluminescent carbon dots without surface passivation reagents, J. Mater. Chem. ,2011,第1作者
(20) Multicolor luminescent carbon nanoparticles: synthesis, supramolecular assembly with porphyrin, intrinsic peroxidase-like catalytic activity and application,Nano Res.,2011,第1作者
(21) Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe,,Biosens. Bioelectron. ,2011,第1作者
(22) Small interfering RNA for effective cancer therapies,Mini. Rev. Med. Chem. ,2011,第1作者
(23) Label-free colorimetric detection of single nucleotide polymorphism by using single-walled carbon nanotube intrinsic peroxidase-like activity,Chem. Eur. J. ,2010,第1作者
(24) A rapid and sensitive “add-mix-measure” assay for multiple proteinases based on one gold nanoparticle–peptide–fluorophore conjugate,Biosens. Bioelectron. ,2010,第1作者
(25) Ultrasensitive and selective detection of a prognostic indicator in early-stage cancer using graphene oxide and carbon nanotubes,Adv. Funct. Mater.,2010,第1作者
发表著作
(1) 第十二章 药物滥用,Drug abuse in Microglia in Health and Disease (Sierra, A.; Tremblay, M. E. Ed.),Springer-Verlag,2014-09,第1作者

科研活动

   
科研项目
(1) 华南肿瘤重点实验室开放课题,主持,部委级,2015-06--2016-05
(2) 天然药物活性组分与药效国家重点实验室开放课,主持,部委级,2015-06--2017-05
(3) 药物化学生物学重点实验室开放课题,主持,部委级,2015-05--2017-04
(4) 启动经费,主持,研究所(学校)级,2015-02--2017-02