1. Cancer metabolism and novel targets discovery

2. Cancer associated oncogenic signaling

3. Genetic basis of human rare diseases

1999-2001 Liaoning University Biotechnology B.S. 

2001-2004 Jilin University Biocehmisty and Molecular biology M.S.

2004-2007 China Medical University Cell Biology Ph.D.

   

2007.11-2010.1 Boston University, School of Medicine postdoctoral fellow

2010.1-2012.12 Havard Medical School, Dana-Farber Cancer Institute postdoctoral fellow

2012.12-2014.9 Havard Medical School, Brigham & Women Hospital postdoctoral fellow

2014.10-present Dalian institue of Chemical Physics,  principal investigator

1. Ling Tang, Jun Zeng, Pengyu Geng, Yang Wang, Mingju Sun, Chengnan Fang, Changsong Wang, Jiao Wang, Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane Yu, Peng Gao, Enyou Li, Zhengping Zhuang, Guowang Xu*, Yang Liu*. Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma. Clin Cancer Res. 2018 Jan 15;24(2):474-485. (*Corresponding author)

2. Yang Wang, Xiafei Hong, Jiao Wang, Guowang Xu, David J. Kwiatkowski*, Yang Liu*.  Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth. Oncogene. 2017 Feb 9;36(6):756-765 (*Corresponding author)

3. Jian He, Mingju Sun, Enyou Li, Yingyong Hou, Matthew J. Shepard, Di Chen, Karel Pacak, Changsong Wang, Lei Guo, Zhengping Zhuang*, Yang Liu*. Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma. Oncotarget. 2017; 8:103968-103974. (*Corresponding author)

4. He J, Liu Y*. Serum TGF-β1: A Potential Biomarker for Early Detection of Hepatocellular Carcinoma. EBioMedicine. 2016 Oct;12:4-5。 (Invited comments)

5. Wang X, Yang F, Zhang Y, Xu G, Liu Y*, Tian J*, Gao P*. Evaluation and optimization of sample preparation methods for metabolic profiling analysis of Escherichia coli. Electrophoresis. 2015 Jan 16. doi: 10.1002/elps.201400567. (*corresponding author)

6.Liu Y, David J. Kwiatkowski. Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. Mol Cancer Ther, 2015 Jan;14(1):174-82

7. Wen Y^#, Liu Y^#, Xu Y^#, Zhao Y^#, Hua R, Wang K, Sun M, Li Y, Yang S, Zhang XJ, Kruse R, Cichon S, Betz RC, Nothen MM, van Steensel MA, van Geel M, Steijlen PM, Hohl D, Huber M, Dunnill GS, Kennedy C, Messenger A, Munro CS, Terrinoni A, Hovnanian A, Bodemer C, de Prost Y, Paller AS, Irvine AD, Sinclair R, Green J, Shang D, Liu Q, Luo Y, Jiang L, Chen HD, Lo WH, McLean WH, He CD, Zhang X. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet. 2009 Feb; 41(2):228-33 (*Equal Contribution)

8. Zhou Fei^#,  Liu Y^# ,Zhen Yan, Daiming Fan, Alice Alexandra, Jing-Hua Yang. Targeting dsRNA for a rapid and broad antiviral prophylaxis. FASEB J. 2011, Feb 25(5):1767-74 (*Equal contribution)

9. Liu Y, Quang P, Braggio E, Ngo H, Badalian-Very G, Flores L, Zhang Y, Sacco A, Maiso P, Azab AK, Azab F, Carrasco R, Rollins BJ, Roccaro AM, Ghobrial IM. Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma. PLoS One. 2013 Jun 13;8(6):e66982

10. Li C, Liu X, Liu Y, Zhang E, Medepalli K, Masuda K, Li N, Wikenheiser-Brokamp KA, Osterburg A, Borchers MT, Kopras EJ, Plas DR, Sun J, Franz DN, Capal JK, Mays M, Sun Y, Kwiatkowski DJ, Alayev A, Holz MK, Krueger DA, Siroky BJ, Yu JJ. Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Mol Cancer Res. 2017 Oct;15(10):1318-1330

11. Giannikou K, Malinowska IA, Pugh TJ, Yan R, Tseng YY, Oh C, Kim J, Tyburczy ME, Chekaluk Y, Liu Y, Alesi N, Finlay GA, Wu CL, Signoretti S, Meyerson M, Getz G, Boehm JS, Henske EP, Kwiatkowski DJ. Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development. PLoS Genet. 2016 Aug 5;12(8):

12. Sacco A, Aujay M, Morgan B, Azab AK, Maiso P, Zhang Y, Liu Y, Azab F, Ngo HT, Issa GC, Quang P, Roccaro AM, Ghobrial IM. Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to anti-tumor activity in Waldesntrom's macroglobulinemia. Clin Cancer Res. 2011 Apr 1;17(7):1753-64  

13. Zhu H, Shang D, Sun M, Choi S, Liu Q, Hao J, Figuera LE, Zhang F, Choy KW, Ao Y, Liu Y, Zhang XL, Yue F, Wang MR, Jin L, Patel PI, Jing T, Zhang X. XLinked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3. Am J Hum Genet. 2011 Jun 10; 88(6):819-26.

14. Azab AK, Azab F, Quang P, Maiso P, Morgan B, Sacco A, Ngo HT, Liu Y, Zhang Y, Roccaro AM, Ghobrial IM. FGFR3 is overexpressed in Waldenstrom macroglobulinemia and its inhibition by Dovitinib induces apoptosis, and overcomes stroma-induced proliferation. Clin Cancer Res. 2011 Jul 1; 17(13):4389-99.

15. Maiso P, Liu Y, Morgan B, Azab A, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A,Ngo H, Azab F, Quang P, Rodig SJ, Lin CP, Roccaro A, Rommel C, Ghobrial IM. Defining the role of TORC1 and TORC2 in multiple myeloma. Blood. 2011 Dec 22;118 (26):6860-70

16. Azab F, Azab AK, Maiso P, Calimeri T, Flores LM, Liu Y, Quang P, Roccaro AM, Sacco A, Ngo HT, Zhang Y, Morgan B, Carrasco R, Ghobrial IM. Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's Macroglobulinemia. Clin Cancer Res. 2012 Jan 1; 18(1):91-104

17. LNA-mediated anti-microRNA-155 silencing in low-grade B cell lymphomas. Zhang Y, Roccaro AM, Rombaoa C, Flores L, Obad S, Fernandes SM, Sacco A, Liu Y, Ngo H, Quang P, Azab AK, Azab F, Maiso P, Reagan M, Brown JR, Thai TH, Kauppinen S, Ghobrial IM. Blood. 2012 Aug 23;120(8):1678-86

18. Zhao C, Du H, Xu L, Wang J, Tang L, Cao Y, Li C, Wang Q, Liu Y, Shan F, Feng J, Xu F, Gao P.

Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects. J Pharm Biomed Anal. 2015 Nov 10;115:48-54. 

19. Ma J, Zhang X, Liu Y, Yu H, Liu L, Shi Y, Li Y, Qin J. Patterning hypoxic multicellular spheroids in a 3D matrix - a promising method for anti-tumor drug screening. Biotechnol J. 2016 Jan;11(1):127-34.

20. Ghobrial IM, Zhang Y, Liu Y, Ngo H, Azab F, Sacco A, Azab A, Maiso P, Morgan B, Quang P, Issa GC, Leleu X, Roccaro AM. Targeting the bone marrow in Waldenstrom macroglobulinemia. Clin Lymphoma Myeloma Leuk. 2011 Jun;11 Suppl 1:S65-9. doi: 10.1016/j.clml.2011.03.022. 

21. Ghobrial IM, Maiso P, Azab A, Liu Y, Zhang Y, Issa G, Azab F, Sacco A, Quang P, Ngo H, Roccaro A. The bone marrow microenvironment in waldenstrom macroglobulinemia. Ther Adv Hematol. 2011 Aug;2(4):267-72.

22. Ghobrial IM, Zhang Y, Liu Y, Ngo H, Azab F, Sacco A, Azab A, Maiso P, Morgan B, Quang P, Issa G, Roccaro A.The bone marrow niche in Waldenström's macroglobulinemia. Clin Lymphoma Myeloma Leuk. 2011 Feb;11(1):118-20. 

23. Sacco A, Maiso P, Azab A, Azab F, Zhang Y, Liu Y, Ngo HT, Morgan B, Quang P, Issa G, Ghobrial IM, Roccaro AM. Key role of microRNAs in Waldenström's macroglobulinemia pathogenesis. Clin Lymphoma Myeloma Leuk. 2011 Feb;11(1):109-11

24. Sacco A, Issa GC, Zhang Y, Liu Y, Maiso P, Ghobrial IM, Roccaro AM. Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology. J Hematol Oncol. 2010 Oct 7;3:38.