Research on cell signal pathway transduction, tumorigenesis and stem cell function, and screening of new drugs for treating tumors or improving stem cell function

‍‍2001/09--2007/03   Ph.D.; Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences‍‍
1997/09--2001/07 ‍‍  B.S.; East China Normal University‍‍

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‍‍2018-03-present  Professor;Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan,China
2012/05-2018/03  Associate professor;‍‍Kunming Institute of Zoology,‍‍Chinese Academy of Sciences,Yunnan,China
2006/12-2012/05  Ph.D.;Southwest Texas Medical Research Center,Texas,USA

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‍‍‍‍（1） PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation, Theranostics, 2020-02, corresponding author
（2） Convergent genomic signatures of high altitude adaptation among domestic mammals, National Science Review, 2019-12, first author

（3） YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression, Nature Communications, 2019-10, corresponding author

（4） GRK5 functions as an oncogenic factor in non-small-cell lung cancer, Cell Death and Disease, 2018,  corresponding author

（5） Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes, Nature Communications, 2018, first author

（6） A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers, Theranostics, 2017, first author

（7） Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis), Zoological Research, 2017, corresponding author

（8） NCAPH plays important roles in human colon cancer, Cell Death and Disease, 2017, corresponding author

（9） Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation, Nature Genetics, 2016, first author

（10） Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties, RSC Advances, 2015, corresponding author

（11） Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation, Phytochemistry, 2015, third author

（12） ApoE Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells, J Neurotrauma, 2015, fourth author

（13） Indole Alkaloids with New Skeleton Activating Neural Stem Cells, Organic Letters, 2014, First author

（14） Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation, Tetrahedron, 2014, fifth author

（15） Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2, Cell Research, 2012, first author

（16） Coupling Hippocampal Neurogenesis to Brain pH through Proneurogenic Small Molecules That Regulate Proton Sensing G Protein-Coupled Receptors, ACS Chemical Neuroscience, 2012, sixth author

（17） ApoE is required for maintenance of the dentate gyrus neural progenitor pool, DEVELOPMENT AND STEM CELLS, 2011, first author

（18） Developmental Profiling of Postnatal Dentate Gyrus Progenitors Provides Evidence For Dynamic Cell-Autonomous Regulation, HIPPOCAMPUS, 2009,second author 

（19） Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury, J Cereb Blood Flow Metab, 2008,fourth author 
（20） Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo, Nucleic Acids Research, 2006, first author
（21） Def1p Is Involved in Telomere Maintenance in Budding Yeast, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, second author

（22） Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast, Biochem. J, 2005, third author

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(1) Use of human NCAPH gene, invention, 2019, 2nd author, patent number: 201710034315.1

(2) Use of human GRK5 gene, invention, 2019, 2nd author, patent number: 201810034552.2

(3) New uses of human GLT8D1 gene, Invention, 2018, 1st author, Patent number: 201810131431.x

(4) Use of AKR1C1 protein inhibitor, Invention, 2018, 2nd author, Patent number: 201811412945.9

(5) Use of human YTHDF1 gene, Invention, 2018, 2nd author, Patent number: 201811412949.7

(6) Use of human NCAPH gene, invention, 2019, 2nd author, patent number: 201910923512.8

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(1) The function and molecular mechanism of GLT8D1 in neurological diseases. 2019 Youth Conference of the Chinese Academy of Sciences.10-17-2019

(2) Plateau Adaptation and Plateau-Related Diseases. Yunnan Individualized Superculture Industry Conference. 03-20-2019

(3) The application of interdisciplinary in the excavation of tumor markers. The 2018 Annual Conference of the Youth Innovation Promotion Association of the Chinese Academy of Sciences and the "Youth Promotion Conference". 11-07-2018

(4) Research on the mechanism of hypoxia adaptation to tumorigenesis and development in the plateau. Southwest Youth Scientist Forum.09-13-2017

(5) Experience and progress of screening new molecules that affect tumorigenesis and development using hypoxia-adapted evolutionary biological methods.Hunan Cancer Hospital Academic Exchange.04-11-2017

(6) Research on the mechanism of hypoxic adaptation and tumorigenesis and development of plateau. The annual meeting of the Youth Innovation Promotion Association.11-16-2016

Baiyang Liu, PhD student

(1) Outstanding Youth of Yunnan Province, Yunnan Province, Provincial, 2019

(2) Yunnan Science and Technology Progress Award, Third Prize, Provincial, 2018

(3) Reserve candidates for academic and technical leaders of young and middle-aged people in Yunnan Province, Provincial, 2018

(4) Top Ten Talents of Yunnan Province for Ten Thousand People Program,, Provincial, 2018

(5) "Academic Interdisciplinary and Innovation Award" of the 2018 Annual Conference of the Youth Innovation Promotion Association of the Chinese Academy of Sciences, college level, 2018

(6) Health Science and Technology Achievement Award of Yunnan Province, Provincial, 2017

(7) Advanced Individual, Youth Innovation Promotion Association, Chinese Academy of Sciences, College Level, 2016

(8) Young and middle-aged academic and technical reserve candidates in Kunming, prefecture-level, 2016