基本信息
卜鹏程  男  博导  中国科学院生物物理研究所
电子邮件: bupc@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:

研究领域

非编码RNA,肿瘤代谢,肠道菌群

招生信息

生物化学与分子生物学、生物信息学、细胞生物学、免疫学


招生专业
071009-细胞生物学
招生方向
非编码RNA与疾病,肿瘤代谢

教育背景

2004-09--2007-07   中科院生物物理研究所   博士
2001-09--2004-07   大连理工大学   硕士
1997-09--2001-07   大连工业大学   学士

工作经历

   
工作简历

2008-2010 美国加州大学伯克利分校, 博士后

2010-2015 美国康奈尔大学,研究助理

2015-2016 美国杜克大学,资深科学家   

2016.09-至今 中科院生物物理研究所,研究员


指导学生

现指导学生

叶高琪  硕士研究生  071010-生物化学与分子生物学  

张丽雯  硕士研究生  071010-生物化学与分子生物学  

王智  硕士研究生  071009-细胞生物学  

乔裕锋  硕士研究生  071009-细胞生物学  

晁珊珊  博士研究生  071009-细胞生物学  

专利与奖励

中组部“青年千人计划”,国家级, 2017

中科院 率先行动“百人计划” B类, 院级, 2016

北京市科学技术奖一等奖 (7/13), 省级, 2014

中科院院长优秀奖,院级, 2007

中科院优秀毕业生,院级,2007

代表性论文

  1. Bu P#, Kaiyuan Chen,..., Shen X#Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metabolism. 2018 27 (1-14). #, Corresponding author.
  2. Chen KY, Srinivasan T, Tung KL,…,  Bu P#, Shen X#. A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol. 2017 13(4):927. #, Corresponding author.
  3. Bu P#, Wang L, Chen K-Y, …, Shen X#.  miR-34a and Numb synergize for asymmetric cell fate determination to  control stem cell proliferation.  Cell Stem Cell. 2016 18(2):189-202. #, Corresponding author.

            Highlighted in Cancer Discovery and AAAS

  1. Wang L*, Bu P*,   Ai Y, et al. A large non-coding RNA  regulates colon cancer stem cell asymmetric division. Elife. *,  Co-first author. 2016; 10.7554/eLife.14620.
  2. Chen HJ,…,Bu P,…et al. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016, doi: 10.1038/nbt.3586
  3. Srinivasan T, Walters J, Bu P,… et al. Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells. Cancer  Res. 2016; DOI: 10.1158/0008-5472.CAN-15-3198.
  4. Srinivasan T, Than EB, Bu P  et al. Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing  intestinal stem cells. Sci Rep. 2016 16;6:26069. doi: 10.1038/srep26069
  5. Bu P#, Wang L, Chen K-Y, …, Shen X#.  miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF-b. Nat commun.  2015 6:6879.  #, Corresponding author.
  6. Sun S, …, Bu P…, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015, 17(12):1546-55
  7. Li J, Ai Y, Wang L, Bu P,… et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2015 Oct 21;76:52-65
  8. Chen, H, …, Bu, P, …, et al.  Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nat Biotechnol. 2015, 33(6):656-60.
  9. Okada  N, …, Bu P…, et al. A  positive feedback between p53 and miR-34 miRNAs mediates  tumor suppression. Genes Dev. 2014 28: 438-450
  10. Bu P, Chen K-Y, Chen JH et al. A microRNA miR-34a-Regulated  Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell. 2013,      12(5):602-625.

             Highlighted in Cell Stem Cell and Biotechniques.

  1. Bu P, Chen K-Y, Lipkin SM, Shen X. Asymmetric division: a marker for cancer stem cells in   early stage tumors? Oncotarget. 2013, 4(7):950-951.
  2. Chen JH Edwards R, Tucci S, Bu P, et al. The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis. J Clin  Invest. 2012, 122(9):3184-96
  3. 15.  Choi YJ, …, Bu P, …, et al. miR-34a miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011, 13(11):1353-60.
  1. Bu P, Zhuang J, Feng J, et al. Visualization of CD146  dimerization and its regulation in living cells. BBA-Mol Cell Res. 2007, 1773(4):513-20.1.      
  2. Bu P, Gao L, Zhuang J, et al. Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation. Mol Caner Ther. 2006, 5(11): 2872-2878