071006-神经生物学
071009-细胞生物学
071010-生物化学与分子生物学

大脑进化发育，神经突触发育和功能调控

2003-09--2011-01   中国科学学院上海生物化学与细胞生物学研究所   博士学位
1999-09--2003-07   南开大学生命科学学院   学士学位

   

2017-08~现在, 中国科学学院昆明动物所, 研究员
2011-08~2017-07,美国加州大学旧金山分校分子细胞药理系, 博士后
2003-09~2011-01,中国科学学院上海生物化学与细胞生物学研究所, 博士学位
1999-09~2003-07,南开大学生命科学学院, 学士学位

   

（1） Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules, CELL, 2023, 第 15 作者
（2） Correlative Assembly of Subsynaptic Nanoscale Organizations During Development, Frontiers in Synaptic Neuroscience, 2022, 通讯作者
（3） Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human, Molecular Psychiatry, 2022, 第 16 作者
（4） Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory, Molecular Psychiatry, 2022, 第11作者
（5） The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, TRANSLATIONAL PSYCHIATRY, 2022, 通讯作者
（6） KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor, MOLECULAR PSYCHIATRY, 2022, 第11作者
（7） RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission, SCIENCE ADVANCES, 2022, 通讯作者
（8） A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 16 作者
（9） Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci, EBIOMEDICINE, 2019, 通讯作者
（10） Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, NATIONAL SCIENCE REVIEW, 2019, 第 20 作者
（11） Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain, NATURE COMMUNICATIONS, 2018, 通讯作者
（12） LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 通讯作者
（13） Postsynaptic delta 1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 3 作者
（14） A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons, NEUROPHARMACOLOGY, 2017, 第 1 作者
（15） Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 1 作者
（16） Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 2 作者
（17） Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1, ELIFE, 2015, 第 1 作者
（18） ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models, STEM CELL REPORTS, 2015, 第 7 作者
（19） The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways, ELIFE, 2014, 第 7 作者
（20） A Cortical Circuit for Gain Control by Behavioral State, CELL, 2014, 第 4 作者
（21） BMP signaling pathway and spinal cord development, BMP signaling pathway and spinal cord development, 生物学前沿：英文版, 2012, 
（22） AP2 gamma regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning, CELL RESEARCH, 2012, 第 3 作者
（23） Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 第 1 作者
（24） The function of BMP signaling pathway during the central nervous system development, Chinese Journal of Cell Biology, 2009, 第 2 作者
（25） NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development, JOURNAL OF CELL SCIENCE, 2009, 第 4 作者
（26） Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1, DEVELOPMENTAL CELL, 2007, 第 2 作者

   

（ 1 ） 长时程增强（LTP）神经突触后分子机制的研究, 负责人, 国家任务, 2018-01--2018-12
（ 2 ） 红藻氨酸受体（KAR）突触转运机制和功能研究, 负责人, 国家任务, 2019-01--2022-12
（ 3 ） “率先行动”****, 负责人, 中国科学院计划, 2017-09--2019-08
（ 4 ） “****”择优支持, 负责人, 中国科学院计划, 2020-01--2022-12
（ 5 ） ****启动经费, 负责人, 研究所自主部署, 2017-08--2022-07
（ 6 ） 云南省基础研究计划杰出青年项目, 负责人, 地方任务, 2019-07--2022-06
（ 7 ） 云南省基础研究计划重点项目, 负责人, 地方任务, 2019-07--2022-06
（ 8 ） 中国科学院“西部之光”交叉团队项目-重点实验室合作研究专项, 参与, 中国科学院计划, 2020-01--2022-12
（ 9 ） 动物复杂性状的创新与重塑, 负责人, 中国科学院计划, 2021-06--2022-05