主要从事质谱关键技术研究，包括：

1. 超高分辨飞行时间质谱关键技术研究

基于离子光学理论，建立和完善离子光学仿真方法，研究影响飞行时间质谱分辨的关键因素，研究超高分辨的多次反射飞行时间质谱。

2. 流场-电场耦合下离子操控方法的研究

研究离子从常压至真空过程流场-电场共存条件下离子运动规律，实现离子的碰撞冷却、捕获、囚禁、解离、激发这些离子操控，为离子传输认识和质谱设计提供指导。

3. 飞行时间二次离子质谱原位表征技术研究

硕士1名

070302-分析化学

质谱技术；质谱分析；离子光学；质谱仪器

2008-09--2014-07   中国科学院大学   理学博士
2004-09--2008-07   郑州大学物理工程学院   学士

   

[1] Wan, Ningbo, Jiang, Jichun, Hu, Fan, Chen, Ping, Zhu, Kaixin, Deng, Dehui, Xie, Yuanyuan, Wu, Chenxin, Hua, Lei, Li, Haiyang. Nonuniform Electric Field-Enhanced In-Source Declustering in High-Pressure Photoionization/Photoionization-Induced Chemical Ionization Mass Spectrometry for Operando Catalytic Reaction Monitoring. ANALYTICAL CHEMISTRY[J]. 2021, 93(4): 2207-2214, https://www.webofscience.com/wos/woscc/full-record/WOS:000618089100042.
[2] Cao Yixue, Chen Ping, Hua Lei, Wang Weiguo, Chen Yi, Wen yuxuan, Xie Yuanyuan, Li Haiyang. A Strategy for Simultaneously Improving Resolution and Sensitivity of Hybrid Quadrupole Ion Trap/Time-of-Flight Mass Spectrometry Using Square Waveform Phase Modulation. Journal of The American Society for Mass Spectrometry[J]. 2021, 33(2): 322-327, [3] Jiang Jichun, Hua Lei, Xie yuanyuan, Cao yixue, Wen yuxuan, Chen Ping, Li Haiyang. High Mass Resolution Multirefle ction Time-of-Flight Secondary Ion Mass Spectrometer. Journal of the American Society for mass spectrometry[J]. 2021, 32: 1196-1204, [4] Xie, Yuanyuan, Li, Qingyun, Hua, Lei, Chen, Ping, Hu, Fan, Wan, Ningbo, Li, Haiyang. Highly selective and sensitive online measurement of trace exhaled HCN by acetone -assisted negative photoionization time-of-flight mass spectrometry with in -source CID. ANALYTICA CHIMICA ACTA[J]. 2020, 1111: 31-39, http://dx.doi.org/10.1016/j.aca.2020.03.035.
[5] 韩丰磊, 钟黄蓉, 李婷, 李梦雨, 李金旭, 陈平, 李海洋. 便携式飞行时间质谱仪的研制及其在石化污水系统挥发性有机物监测中的应用. 质谱学报[J]. 2020, 41(5): 427-434, http://lib.cqvip.com/Qikan/Article/Detail?id=7102834786.
[6] 陈平, 花磊, 谢园园, 蒋吉春, 侯可勇, 李海洋. 射频增强-VUV灯单光子/化学电离复合离子源研究. 质谱学报[J]. 2020, 41(2): 168-174, http://lib.cqvip.com/Qikan/Article/Detail?id=7101128823.
[7] 何梦琦, 花磊, 李庆运, 侯可勇, 陈平, 柴硕, 李海洋. 甲苯增强高气压光电离-飞行时间质谱高灵敏快速测量酚类化合物. 分析化学. 2019, 47(3): 447-454, http://lib.cqvip.com/Qikan/Article/Detail?id=7001410839.
[8] He MengQi, Hua Lei, Li QingYun, Hou KeYong, Chen Ping, Chai Shuo, Li HaiYang. Toluene Enhanced-High Pressure Photoionization-Time-of-Flight Mass Spectrometry for Highly Sensitive and Rapid Detection of Phenolic Compounds. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2019, 47(3): 447-454, [9] 韩笑笑, 李金旭, 蒋吉春, 吴称心, 陈平, 张智平, 侯可勇, 李海洋. 电冷阱富集-光电离移动质谱快速检测痕量挥发性有机物. 分析化学[J]. 2018, 46(5): 642-649, http://lib.cqvip.com/Qikan/Article/Detail?id=7000639720.
[10] Han XiaoXiao, Li JinXu, Jiang JiChun, Wu ChenXin, Chen Ping, Zhang ZhiPing, Hou KeYong, Li HaiYang. Rapid Detection of Trace Volatile Organic Compounds By Electric Driven Cryo-Trap Movable Mass Spectrometer. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2018, 46(5): 642-649, http://cas-ir.dicp.ac.cn/handle/321008/166286.
[11] Wang, Yan, Jiang, Jichun, Hua, Lei, Hou, Keyong, Xie, Yuanyuan, Chen, Ping, Liu, Wei, Li, Qingyun, Wang, Shuang, Li, Haiyang. High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis. ANALYTICAL CHEMISTRY[J]. 2016, 88(18): 9047-9055, http://www.corc.org.cn/handle/1471x/2375910.
[12] Jiang, Jichun, Wang, Yan, Hou, Keyong, Hua, Lei, Chen, Ping, Liu, Wei, Xie, Yuanyuan, Li, Haiyang. Photoionization-Generated Dibromomethane Cation Chemical Ionization Source for Time-of-Flight Mass Spectrometry and Its Application on Sensitive Detection of Volatile Sulfur Compounds. ANALYTICAL CHEMISTRY[J]. 2016, 88(10): 5028-5032, http://cas-ir.dicp.ac.cn/handle/321008/170936.
[13] Xie, Yuanyuan, Chen, Ping, Hua, Lei, Hou, Keyong, Wang, Yongchao, Wang, Haiyan, Li, Haiyang. Rapid Identification and Quantification of Linear Olefin Isomers by Online Ozonolysis-Single Photon Ionization Time-of-Flight Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY[J]. 2016, 27(1): 144-152, http://cas-ir.dicp.ac.cn/handle/321008/148174.
[14] Hua, Lei, Hou, Keyong, Chen, Ping, Xie, Yuanyuan, Jiang, Jichun, Wang, Yan, Wang, Weiguo, Li, Haiyang. Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds. ANALYTICAL CHEMISTRY[J]. 2015, 87(4): 2427-2433, http://cas-ir.dicp.ac.cn/handle/321008/146001.
[15] 谢园园, 花磊, 陈平, 侯可勇, 蒋吉春, 王艳, 李海洋. 气相色谱-单光子电离飞行时间质谱的联用及在柴油组分表征中的应用. 色谱[J]. 2015, 33(2): 188-194, http://lib.cqvip.com/Qikan/Article/Detail?id=663642548.
[16] 窦健, 花磊, 侯可勇, 蒋蕾, 谢园园, 赵无垛, 陈平, 王卫国, 田地, 李海洋. 连续测量大气·OH的化学电离飞行时间质谱仪的研制. 环境科学. 2014, 1688-1693, http://lib.cqvip.com/Qikan/Article/Detail?id=72747590504849524853484948.
[17] 苏明扬, 侯可勇, 黄泽健, 江游, 陈文东, 陈平, 蒋吉春, 赵无垛, 裴克梅, 李海洋. 非接触热解析封闭式低温等离子体电离源质谱法快速分析3种农药残留”；分析化学. Chinese Journal of Analytical Chemistry分析化学[J]. 2014, 42(1): 384-, http://cas-ir.dicp.ac.cn/handle/321008/143953.
[18] 窦健, 花磊, 侯可勇, 蒋蕾, 谢园园, 赵无垛, 陈平, 王卫国, 田地, 李海洋. 连续测量大气·OH的化学电离飞行时间质谱仪的研制. 环境科学[J]. 2014, 35(5): 1688-1693, [19] 苏明扬, 侯可勇, 黄泽健, 江游, 陈文东, 陈平, 蒋吉春, 赵无垛, 裴克梅, 李海洋. 非接触热解析封闭式低温等离子体电离源质谱法快速分析3种农药残留. 分析化学[J]. 2014, 42(3): 384-389, http://lib.cqvip.com/Qikan/Article/Detail?id=49149742.
[20] 花磊, 侯可勇, 陈平, 蒋吉春, 王艳, 李海洋. The application of single photon ionization time of flight mass spectrometry in breath analysis. the 8th international conference on breath research & cancer diagnosisnull. 2014, 13-, http://159.226.238.44/handle/321008/119950.
[21] 蒋蕾, 刘巍, 窦健, 花磊, 侯可勇, 谢园园, 陈平, 王卫国, 田地, 李海洋. 自动富集-单光子电离质谱在线测量氯酚的研究. 质谱学报. 2014, 35(6): 488-494, http://lib.cqvip.com/Qikan/Article/Detail?id=663100951.
[22] Xie, Yuanyuan, Hua, Lei, Hou, Keyong, Chen, Ping, Zhao, Wuduo, Chen, Wendong, Ju, Bangyu, Li, Haiyang. Long-Term Real-Time Monitoring Catalytic Synthesis of Ammonia in a Microreactor by VUV-Lamp-Based Charge-Transfer Ionization Time-of-Flight Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2014, 86(15): 7681-7687, http://cas-ir.dicp.ac.cn/handle/321008/143969.
[23] 窦健, 花磊, 侯可勇, 蒋蕾, 谢园园, 赵无垛, 陈平, 王卫国, 田地, 李海洋. 连续测量大气•；OH的化学电离飞行时间质谱仪的研制. 环境科学[J]. 2014, 35(1): 1688-, http://cas-ir.dicp.ac.cn/handle/321008/143952.
[24] Su MingYang, Hou KeYong, Huang ZeJian, Jiang You, Chen WenDong, Chen Ping, Jiang JiChun, Zhao WuDuo, Pei KeMei, Li HaiYang. Rapid Analysis of Three Kinds of Pesticide Residues by Non-contact Thermal Desorbing and Closing Low Temperature Plasma Ionization Mass Spectrometry. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2014, 42(3): 384-389, http://cas-ir.dicp.ac.cn/handle/321008/145793.
[25] Chen, Ping, Hou, Keyong, Hua, Lei, Xie, Yuanyuan, Zhao, Wuduo, Chen, Wendong, Chen, Chuang, Li, Haiyang. Quasi-Trapping Chemical Ionization Source Based on a Commercial VUV Lamp for Time-of-Flight Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2014, 86(3): 1332-1336, http://cas-ir.dicp.ac.cn/handle/321008/143968.
[26] Li FangLong, Hou KeYong, Chen WenDong, Chen Ping, Zhao WuDuo, Cui HuaPeng, Hua Lei, Xie YuanYuan, Pei KeMei, Li HaiYang. Single Photon Ionization/Photoelectron Ionization-Membrane Introduction Mass Spectrometry for On-line Analysis Ethers Gasoline Additive in Water. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2013, 41(1): 42-48, http://159.226.238.44/handle/321008/137485.
[27] Chen, Wendong, Hou, Keyong, Xiong, Xingchuang, Jiang, You, Zhao, Wuduo, Hua, Lei, Chen, Ping, Xie, Yuanyuan, Wang, Zhenxin, Li, Haiyang. Non-contact halogen lamp heating assisted LTP ionization miniature rectilinear ion trap: a platform for rapid, on-site explosives analysis. ANALYST[J]. 2013, 138(17): 5068-5073, http://www.irgrid.ac.cn/handle/1471x/858191.
[28] 李芳龙, 侯可勇, 陈文东, 陈平, 赵无垛, 崔华鹏, 花磊, 谢园圆, 裴克梅, 李海洋. 单光子光电子电离-膜进样质谱在线检测水中醚类汽油添加剂. 分析化学[J]. 2013, 41(1): 42-, http://159.226.238.44/handle/321008/119585.
[29] 陈文东, 侯可勇, 陈平, 李芳龙, 赵无垛, 崔华鹏, 花磊, 谢园园, 李海洋. 单光子光电子在线质谱实时分析聚氯乙烯热分解燃烧产物. 环境科学[J]. 2013, 34(1): 34-, http://159.226.238.44/handle/321008/119678.
[30] 李芳龙, 侯可勇, 陈文东, 陈平, 赵无垛, 崔华鹏, 花磊, 谢园园, 裴克梅, 李海洋. 单光子／光电子电离-膜进样质谱法在线检测水中醚类汽油添加剂. 分析化学[J]. 2013, 41(1): 42-48, http://lib.cqvip.com/Qikan/Article/Detail?id=44559864.
[31] Hou, Keyong, Li, Fanglong, Chen, Wendong, Chen, Ping, Xie, Yuanyuan, Zhao, Wuduo, Hua, Lei, Pei, Kemei, Li, Haiyang. An in-source stretched membrane inlet for on-line analysis of VOCs in water with single photon ionization TOFMS. ANALYST[J]. 2013, 138(19): 5826-5831, http://www.irgrid.ac.cn/handle/1471x/858245.
[32] 谢园园, 花磊, 侯可勇, 陈平, 崔华鹏, 赵无垛, 陈文东, 李京华, 李海洋. 单光子电离质谱法在线分析牙膏中的香精物质. 分析化学. 2012, 40(12): 1883-1889, http://lib.cqvip.com/Qikan/Article/Detail?id=44313750.
[33] 曲丕丞, 赵无垛, 王卫国, 陈平, 崔华鹏, 花磊, 侯可勇, 张桂秋, 李海洋. 激光电离碘甲烷中空间电荷对飞行时间质谱峰的影响研究. 质谱学报. 2012, 33(3): 149-154, http://lib.cqvip.com/Qikan/Article/Detail?id=42279672.
[34] Xie YuanYuan, Hua Lei, Hou KeYong, Chen Ping, Cui HuaPeng, Zhao WuDuo, Chen WenDong, Li JingHua, Li HaiYang. On-line Analysis of Flavor Compounds in Toothpastes by Single Photon Ionization Mass Spectrometry. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2012, 40(12): 1883-1889, http://159.226.238.44/handle/321008/142923.
[35] Cui, Huapeng, Hua, Lei, Hou, Keyong, Wu, Jing, Chen, Ping, Xie, Yuanyuan, Wang, Weiguo, Li, Jinghua, Li, Haiyang. Coupling of stir bar sorptive extraction with single photon ionization mass spectrometry for determination of volatile organic compounds in water. ANALYST[J]. 2012, 137(2): 513-518, http://www.irgrid.ac.cn/handle/1471x/721279.
[36] Hua, Lei, Wu, Qinghao, Hou, Keyong, Cui, Huapeng, Chen, Ping, Wang, Weiguo, Li, Jinghua, Li, Haiyang. Single Photon Ionization and Chemical Ionization Combined Ion Source Based on a Vacuum Ultraviolet Lamp for Orthogonal Acceleration Time-of-Flight Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2011, 83(13): 5309-5316, http://159.226.238.44/handle/321008/142800.
[37] Wu QingHao, Hua Lei, Hou KeYong, Cui HunPeng, Chen Ping, Zhao WuDuo, Wang WeiGuo, Li JingHua, Li HaiYang. Characterization and Applications of Combined Single Photon Ionization and Photoelectron Ionization Source. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2011, 39(10): 1465-1469, http://159.226.238.44/handle/321008/142657.
[38] 花磊, 吴庆浩, 侯可勇, 崔华鹏, 陈平, 赵无垛, 谢园园, 李海洋. 膜进样-单光子电离/化学电离-质谱仪在线检测水中VOCs. 环境科学. 2011, 32(12): 3628-3634, http://lib.cqvip.com/Qikan/Article/Detail?id=40045497.
[39] 吴庆浩, 花磊, 侯可勇, 崔华鹏, 陈平, 赵无垛, 王卫国, 李京华, 李海洋. 新型单光子电离和光电子电离复合电离源的研究及应用. 分析化学. 2011, 39(10): 1465-1469, http://lib.cqvip.com/Qikan/Article/Detail?id=39474926.
[40] Wu, Qinghao, Fua, Lei, Hou, Keyong, Cui, Huapeng, Chen, Wendong, Chen, Ping, Wang, Weiguo, Li, Jinghua, Li, Haiyang. Vacuum Ultraviolet Lamp Based Magnetic Field Enhanced Photoelectron Ionization and Single Photon Ionization Source for Online Time-of-Flight Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2011, 83(23): 8992-8998, http://www.irgrid.ac.cn/handle/1471x/457185.
[41] 陈平, 侯可勇, 花磊, 崔华鹏, 谢园园, 陈文东, 李海洋. 高分辨SPI/TOFMS的研制及VOCs分子式确定. 现代科学仪器. 2011, 55-58, http://lib.cqvip.com/Qikan/Article/Detail?id=39834232.
[42] Cui HuaPeng, Hou KeYong, Wu QingHao, Hua Lei, Chen Ping, Ju BangYu, Li Lin, Wang ZhenXin, Li JingHua, Li HaiYang. Development and Application of A Membrane Inlet-Single Photon Ionization-Mass Spectrometer for On- line Analysis Volatile Organic Compounds in Water. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2010, 38(5): 760-764, http://159.226.238.44/handle/321008/141819.
[43] Wu, Qinghao, Hua, Lei, Hou, Keyong, Cui, Huapeng, Chen, Ping, Wang, Weiguo, Li, Jinghua, Li, Haiyang. A combined single photon ionization and photoelectron ionization source for orthogonal acceleration time-of-flight mass spectrometer. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY[J]. 2010, 295(1-2): 60-64, http://dx.doi.org/10.1016/j.ijms.2010.06.034.
[44] Cui HuaPeng, Hou KeYong, Wu QingHao, Hua Lei, Chen Ping, Ju BangYu, Li Lin, Wang ZhenXin, Li JingHua, Li HaiYang. Development and Application of A Membrane Inlet-Single Photon Ionization-Mass Spectrometer for On- line Analysis Volatile Organic Compounds in Water. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2010, 38(5): 760-764, http://159.226.238.44/handle/321008/141819.
[45] 吴婧, 崔华鹏, 侯可勇, 吴庆浩, 花磊, 陈平, 赵无垛, 鞠帮玉, 李林, 屈凌波, 李海洋. 在线衍生-膜进样-VUV电离-飞行时间质谱法测定废水中酚类化合物. 质谱学报[J]. 2010, 31(6): 321-325, http://lib.cqvip.com/Qikan/Article/Detail?id=36271323.

   

（ 1 ） 高质量分辨原位液相二次离子质谱系统, 主持, 国家级, 2020-01--2024-12
（ 2 ） 质谱成像冷电子二次电离源技术探索, 主持, 市地级, 2022-01--2023-12
（ 3 ） SF6高压电气设备故障在线诊断关键技术研究, 主持, 省级, 2021-01--2022-12
（ 4 ） 亚纳米深度分辨的高灵敏中性后电离二次离子质谱, 参与, 部委级, 2021-01--2023-12