研究组主要研究方向为新酶设计和酵母基因组工程。将从原子水平研究蛋白质进化的基本原理，解析自然界创造蛋白质的基本规律，从而指导新的蛋白质功能元件的理性设计与开发；在此基础上，从原子经济性角度设计新的生物合成途径，降低生物合成的成本，提高酵母细胞工厂的生产能力。

   

071005-微生物学
071021-生物信息学
071022-基因组学

酵母基因组工程
进化生物学
合成生物学

2003-09--2008-07   中国科学院昆明动物研究所   博士
1999-09--2003-07   武汉工业学院   学士

研究生

博士

2008年09月-2012年08月，美国康奈尔大学营养科学系，博士后；

2012年09月至今，中国科学院天津工业生物技术研究所，研究员。

[1] 张学礼, 陈晶, 程健, 江会锋, 樊飞宇, 戴住波. 盾叶薯蓣来源的薯蓣皂素合成相关蛋白及编码基因与应用. CN: CN112708602B, 2022-04-05.
[2] 江会锋, 逯晓云, 刘玉万, 初斋林, 崔博, 卢丽娜. 一种生物合成木糖的方法. CN: CN113699195A, 2021-11-26.
[3] 江会锋, 刘晓楠, 程健, 卢丽娜. 黄酮-O-甲基转移酶及其在汉黄芩素、异汉黄芩素和苏荠苧黄酮合成中的应用. CN: CN113373125A, 2021-09-10.
[4] 江会锋, 郭丹, 刘玉万, 彭凯, 卢丽娜. 一种聚糖酶及其在川芎嗪生物合成中的应用. CN: CN113136377A, 2021-07-20.
[5] 江会锋, 刘晓楠, 程健, 卢丽娜. 黄酮-8-羟化酶及其在8-羟基黄酮化合物合成中的应用. CN: CN113046333A, 2021-06-29.
[6] 江会锋, 逯晓云, 卢丽娜. 核苷转移酶的新功能及应用. CN: CN112746063A, 2021-05-04.
[7] 江会锋, 彭凯, 逯晓云, 阮江星, 王千, 卢丽娜. 一种末端脱氧核糖核苷转移酶变体及其应用. CN: CN110331136A, 2019-10-15.
[8] 江会锋, 丁文涛, 刘玉万, 杨一群. 一种L-赤藓酮糖和赤藓糖醇生产方法. CN: CN109971803A, 2019-07-05.
[9] 江会锋, 逯晓云, 徐占梅, 王杰. 一种丙烯酸的生物合成方法及应用. CN: CN109722456A, 2019-05-07.
[10] 江会锋, 逯晓云, 刘玉万, 杨一群, 卢丽娜, 杨晟, 缑俊冉. 催化甲醛合成羟基乙醛和/或1,3-二羟基丙酮的酶及其应用. CN: CN108713060A, 2018-10-26.
[11] 江会锋, 缑俊冉, 杨晟, 逯晓云, 刘玉万, 卢丽娜. 催化甲酸合成甲醛CAR酶的制备及其应用. CN: CN108624628A, 2018-10-09.
[12] 江会锋, 杨晟, 缑俊冉, 逯晓云, 刘玉万, 卢丽娜. 催化甲酸合成甲醛酶的制备及其应用. CN: CN108624627A, 2018-10-09.
[13] 江会锋, 徐占梅, 刘玉万, 燕志慧, 卢丽娜. 具有催化DHAP或D-G3P合成丙烯酸功能的酶及其应用. CN: CN108624571A, 2018-10-09.
[14] 江会锋, 程晓志, 逯晓云, 刘玉万, 卢丽娜. 用于催化N-乙酰-D-色氨酸水解生成D-色氨酸的新酶. CN: CN108624577A, 2018-10-09.
[15] 江会锋, 杨一群, 刘玉万, 卢丽娜, 马延和. 一种利用生物酶合成1,3-丙二醇的方法. CN: CN108048494A, 2018-05-18.
[16] 江会锋, 刘玉万, 逯晓云, 杨晟, 缑俊冉, 杨一群, 卢丽娜. 催化甲醛合成羟基乙醛的酶及其应用. CN: CN106916794A, 2017-07-04.
[17] 马红武, 杨雪, 袁倩倩, 江会锋. 利用乙醇醛合成乙酰辅酶A及其衍生产品的新途径. CN: CN106755172A, 2017-05-31.
[18] 江会锋, 刘晓楠, 丁文涛, 程健, 段立津, 阮江星, 卢丽娜. 黄酮‑6‑羟化酶及其在灯盏乙素合成中的应用. CN: CN106318920A, 2017-01-11.
[19] 江会锋, 刘玉万, 逯晓云, 燕志慧, 马延和. 具有催化甲醛合成1,3-二羟基丙酮功能的酶及其制备方法. CN: CN105132400A, 2015-12-09.
[20] 江会锋, 刘莹, 燕志慧, 逯晓云, 刘玉万, 马延和. 一种具有催化DMA合成DMAPP功能的酶及其应用. CN: CN104762275A, 2015-07-08.
[21] 江会锋, 阮江星, 丁文涛, 许则滩, 马永硕, 卢丽娜, 董扬, 马延和. 一种将多个外源基因同时克隆到微生物基因组的方法. CN: CN104404077A, 2015-03-11.
[22] 江会锋, 丁文涛, 刘莹, 卢丽娜, 董扬, 马延和. 一种灯盏花糖基转移酶、制备方法及其应用. CN: CN104357419A, 2015-02-18.

   

[1] Wu, Ranran, Li, Fei, Cui, Xinyu, Li, Zehua, Ma, Chunling, Jiang, Huifeng, Zhang, Lingling, Zhang, YiHeng P Job, Zhao, Tongxin, Zhang, Yanping, Li, Yin, Chen, Hui, Zhu, Zhiguang. Enzymatic Electrosynthesis of Glycine from CO2 and NH3. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, http://dx.doi.org/10.1002/anie.202218387.
[2] 蔡韬, 刘玉万, 朱蕾蕾, 苏浩, 王钰, 王国坤, 张玲玲, 朱之光, 盛翔, 毕昌昊, 马红武, 田朝光, 张学礼, 吴洽庆, 孙媛霞, 江会锋, 马延和. 二氧化碳人工生物转化. 生物工程学报[J]. 2022, 38(11): 4101-4114, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545586.
[3] Wang, Yina, Liu, Xiaonan, Chen, Bihuan, Liu, Wei, Guo, Zhaokuan, Liu, Xiangyu, Zhu, Xiaoxi, Liu, Jiayu, Zhang, Jin, Li, Jing, Zhang, Lei, Gao, Yadi, Zhang, Guanghui, Wang, Yan, Choudhary, M Iqbal, Yang, Shengchao, Jiang, Huifeng. Metabolic engineering of Yarrowia lipolytica for scutellarin production. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2022, 7(3): 958-964, http://lib.cqvip.com/Qikan/Article/Detail?id=7108197527.
[4] 毕慧萍, 刘晓楠, 李清艳, 程健, 庄以彬, 王冬, 戴住波, 江会锋, 刘涛, 张学礼. 植物天然产物微生物重组合成研究进展. 生物工程学报[J]. 2022, 38(11): 4263-4282, http://lib.cqvip.com/Qikan/Article/Detail?id=7108545595.
[5] Liu, Yuwan, Jiang, Huifeng. Directed Evolution of Propionyl-CoA Carboxylase for Succinate Biosynthesis. TRENDS IN BIOTECHNOLOGY. 2021, 39(4): 330-331, http://dx.doi.org/10.1016/j.tibtech.2021.02.006.
[6] 王千, 白杰, 江会锋. 合成生物学酶改造设计技术的研究进展. 生命科学[J]. 2021, 33(12): 1493-1501, http://lib.cqvip.com/Qikan/Article/Detail?id=7106780132.
[7] Bi, Xupeng, Wang, Kun, Yang, Liandong, Pan, Hailin, Jiang, Haifeng, Wei, Qiwei, Fang, Miaoquan, Yu, Hao, Zhu, Chenglong, Cai, Yiran, He, Yuming, Gan, Xiaoni, Zeng, Honghui, Yu, Daqi, Zhu, Youan, Jiang, Huifeng, Qiu, Qiang, Yang, Huanming, Zhang, Yong E, Wang, Wen, Zhu, Min, He, Shunping, Zhang, Guojie. Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes. CELL[J]. 2021, 184(5): 1377-1391, http://dx.doi.org/10.1016/j.cell.2021.01.046.
[8] Yang, Qiaoyu, Guo, Xiaoxian, Liu, Yuwan, Jiang, Huifeng. Biocatalytic C-C Bond Formation for One Carbon Resource Utilization. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918591/.
[9] Xu, Ning, Liu, Yuwan, Jiang, Huifeng, Liu, Jun, Ma, Yanhe. Combining protein and metabolic engineering to construct efficient microbial cell factories. CURRENT OPINION IN BIOTECHNOLOGYnull. 2020, 66: 27-35, http://dx.doi.org/10.1016/j.copbio.2020.06.001.
[10] 李德茂, 曾艳, 周桔, 王钦宏, 孙际宾, 江会锋, 马延和. 生物制造食品原料市场准入政策比较及对我国的建议. 中国科学院院刊[J]. 2020, 35(8): 1041-1052, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=KYYX202008015&v=MDY5MDhITkhNcDQ5RVlZUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSN3FlWnVkdUZ5bmxWYnJKTGpUU2RyRzQ=.
[11] Jian Cheng, Jing Chen, Xiaonan Liu, Xiangchen Li, Weixiong Zhang, Zhubo Dai, Lina Lu, Xiang Zhou, Jing Cai, Xueli Zhang, Huifeng Jiang, Yanhe Ma. The origin and evolution of the diosgenin biosynthetic pathway in yam. PLANT COMMUNICATIONS. 2020, 2(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816074/.
[12] 初斋林, 逯晓云, 刘玉万, 崔博, 靖美东, 江会锋. 生物催化甲醛生成L-木糖. 生物工程学报[J]. 2020, 36(5): 942-948, http://lib.cqvip.com/Qikan/Article/Detail?id=7101937144.
[13] Liu, Xiaonan, Zhu, Xiaoxi, Wang, Hui, Liu, Tian, Cheng, Jian, Jiang, Huifeng. Discovery and modification of cytochrome P450 for plant natural products biosynthesis. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2020, 5(3): 187-199, http://lib.cqvip.com/Qikan/Article/Detail?id=7103845003.
[14] Jian Cheng, Jing Chen, Xiaonan Liu, Xiangchen Li, Weixiong Zhang, Zhubo Dai, Lina Lu, Xiang Zhou, Jing Cai, Xueli Zhang, Huifeng Jiang, Yanhe Ma. The origin and evolution of diosgenin biosynthetic pathway in Yam. PLANT COMMUNICATIONS[J]. 2020, http://dx.doi.org/10.1016/j.xplc.2020.100079.
[15] 王杰, 逯晓云, 刁爱坡, 江会锋. 一种高效的多点组合突变克隆构建方法. 生物工程学报[J]. 2020, 36(2): 309-319, http://lib.cqvip.com/Qikan/Article/Detail?id=7101105924.
[16] Li, Xiangchen, Cheng, Jian, Liu, Xiaonan, Guo, Xiaoxian, Liu, Yuqian, Fan, Wenjing, Lu, Lina, Ma, Yanhe, Liu, Tao, Tao, Shiheng, Jiang, Huifeng. Origin and Evolution of Fusidane-Type Antibiotics Biosynthetic Pathway through Multiple Horizontal Gene Transfers. GENOME BIOLOGY AND EVOLUTION[J]. 2020, 12(10): 1830-1840, http://dx.doi.org/10.1093/gbe/evaa163.
[17] Peng, Kai, Guo, Dan, Lou, Qianqian, Lu, Xiaoyun, Cheng, Jian, Qiao, Jing, Lu, Lina, Cai, Tao, Liu, Yuwan, Jiang, Huifeng. Synthesis of Ligustrazine from Acetaldehyde by a Combined Biological-Chemical Approach. ACS SYNTHETIC BIOLOGY[J]. 2020, 9(11): 2902-2908, https://www.webofscience.com/wos/woscc/full-record/WOS:000592986800003.
[18] 江会锋. 合成生物技术助力可持续发展. 生物技术通报[J]. 2020, 36(4): 6-7, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=SWJT202004001&v=MDczMDJDVVI3cWVadWR1RnlubVZiL0lOanJCZXJHNEhOSE1xNDlGWllSOGVYMUx1eFlTN0RoMVQzcVRyV00xRnI=.
[19] 江会锋, 刘玉万, 杨巧玉. 生物固碳途径研究进展. 微生物学杂志[J]. 2020, 40(2): 1-9, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=WSWX202002002&v=MjI5MzhSOGVYMUx1eFlTN0RoMVQzcVRyV00xRnJDVVI3cWVaK1J2RmkzaFdyM0xNajdjZHJHNEhOSE1yWTlGWm8=.
[20] Li, Tianzhen, Tang, Zijing, Wei, Hongli, Tan, Zijian, Liu, Pi, Li, Jinlong, Zheng, Yingying, Lin, Jianping, Liu, Weidong, Jiang, Huifeng, Liu, Haifeng, Zhu, Leilei, Ma, Yanhe. Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediates. GREEN CHEMISTRY[J]. 2020, 22(20): 6809-6814, https://www.webofscience.com/wos/woscc/full-record/WOS:000579757000011.
[21] 彭凯, 逯晓云, 程健, 刘莹, 江会锋, 郭晓贤. DNA合成、组装与纠错技术研究进展. 合成生物学[J]. 2020, 1(6): 697-708, http://lib.cqvip.com/Qikan/Article/Detail?id=7103713718.
[22] 王杰, 逯晓云, 刁爱坡, 江会锋. 一种高效的多点组合突变克隆构建方法（英文）. 生物工程学报. 2020, 309-319, [[["https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=SHWU202002014&v=MTE5NTJyWTlFWUlSOGVYMUx1eFlTN0RoMVQzcVRyV00xRnJDVVI3cWVadWR1RnlublU3N0pOaVhjZTdHNEhOSE0="]]].
[23] Liu, Xiaonan, Cheng, Jian, Zhu, Xiaoxi, Zhang, Guanghui, Yang, Shengchao, Guo, Xiaoxian, Jiang, Huifeng, Ma, Yanhe. De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae. ACS SYNTHETIC BIOLOGY[J]. 2020, 9(11): 3042-3051, https://www.webofscience.com/wos/woscc/full-record/WOS:000592986800018.
[24] Jiang, Chunmei, Liu, Xiaonan, Chen, Xianqing, Cai, Yi, Zhuang, Yibin, Liu, Tian, Zhu, Xiaoxi, Wang, Hui, Liu, Yuwan, Jiang, Huifeng, Wang, Wen. Raising the production of phloretin by alleviation of by-product of chalcone synthase in the engineered yeast. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(11): 1734-1743, http://lib.cqvip.com/Qikan/Article/Detail?id=7104062134.
[25] Wei, Liang, Wang, Qian, Xu, Ning, Cheng, Jian, Zhou, Wei, Han, Guoqiang, Jiang, Huifeng, Liu, Jun, Ma, Yanhe. Combining Protein and Metabolic Engineering Strategies for High-Level Production of O-Acetylhomoserine in Escherichia coli. ACS SYNTHETIC BIOLOGY[J]. 2019, 8(5): 1153-1167, [26] Xiaoyun Lu, Yuwan Liu, Yiqun Yang, Shanshan Wang, Qian Wang, Xiya Wang, Zhihui Yan, Jian Cheng, Cui Liu, Xue Yang, Hao Luo, Sheng Yang, Junran Gou, Luzhen Ye, Lina Lu, Zhidan Zhang, Yu Guo, Yan Nie, Jianping Lin, Sheng Li, Chaoguang Tian, Tao Cai, Bingzhao Zhuo, Hongwu Ma, Wen Wang, Yanhe Ma, Yongjun Liu, Yin Li, Huifeng Jiang. Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-10, https://doaj.org/article/1a13a3c2908242da81c5fcbabe166587.
[27] Zong, Zhiyou, Li, Qiyu, Hong, Zhangyong, Fu, Haohao, Cai, Wensheng, Chipot, Christophe, Jiang, Huifeng, Zhang, Dongyuan, Chen, Shulin, Shao, Xueguang. Lysine Mutation of the Claw-Arm-Like Loop Accelerates Catalysis by Cellobiohydrolases. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(36): 14451-14459, [28] Tiukova, Ievgeniia A, Jiang, Huifeng, Dainat, Jacques, Hoeppner, Marc P, Lantz, Henrik, Piskur, Jure, Sandgren, Mats, Nielsen, Jens, Gu, Zhenglong, Passoth, Volkmar. Assembly and Analysis of the Genome Sequence of the Yeast Brettanomyces naardenensis CBS 7540. MICROORGANISMS[J]. 2019, 7(11): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000502273600012.
[29] Yang, Xue, Yuan, Qianqian, Luo, Hao, Li, Feiran, Mao, Yufeng, Zhao, Xin, Du, Jiawei, Li, Peishun, Ju, Xiaozhi, Zheng, Yangyang, Chen, Yang, Liu, Yuwan, Jiang, Huifeng, Yao, Yonghong, Ma, Hongwu, Ma, Yanhe. Systematic design and in vitro validation of novel one-carbon assimilation pathways. METABOLIC ENGINEERING[J]. 2019, 56: 142-153, http://dx.doi.org/10.1016/j.ymben.2019.09.001.
[30] Liu, Xiaonan, Cheng, Jian, Zhang, Guanghui, Ding, Wentao, Duan, Lijin, Yang, Jing, Kui, Ling, Cheng, Xiaozhi, Ruan, Jiangxing, Fan, Wei, Chen, Junwen, Long, Guangqiang, Zhao, Yan, Cai, Jing, Wang, Wen, Ma, Yanhe, Dong, Yang, Yang, Shengchao, Jiang, Huifeng. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/92caa47494d0490abeaced8635892682.
[31] 崔博, 卓炳照, 逯晓云, 王文, 肖冬光, 江会锋. 酶法催化甲醛合成木酮糖. 生物工程学报[J]. 2018, 34(7): 1128-1136, http://lib.cqvip.com/Qikan/Article/Detail?id=675668565.
[32] Ding, Wentao, Cheng, Jian, Guo, Dan, Mao, Ling, Li, Jingwei, Lu, Lina, Zhang, Yunxin, Yang, Jiangke, Jiang, Huifeng. Engineering the 5 ' UTR-Mediated Regulation of Protein Abundance in Yeast Using Nucleotide Sequence Activity Relationships. ACS SYNTHETIC BIOLOGY[J]. 2018, 7(12): 2709-2714, https://www.webofscience.com/wos/woscc/full-record/WOS:000454568100001.
[33] Ruan, Jiangxing, Cheng, Jian, Zhang, Tongcun, Jiang, Huifeng. Mitochondrial genome evolution in the Saccharomyces sensu stricto complex. PLOS ONE[J]. 2017, 12(8): http://dx.doi.org/10.1371/journal.pone.0183035.
[34] Duan, Lijin, Ding, Wentao, Liu, Xiaonan, Cheng, Xiaozhi, Cai, Jing, Hua, Erbing, Jiang, Huifeng. Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae. MICROBIAL CELL FACTORIES[J]. 2017, 16(1): https://doaj.org/article/1bda44e50e4a4b38bd4ebf76d5858aa8.
[35] 王千, 程健, 江会锋. 新基因起源：从自然进化到人工设计. 生物工程学报[J]. 2017, 33(3): 324-330, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5948618&detailType=1.
[36] Liu, Xiaonan, Ding, Wentao, Jiang, Huifeng. Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production. MICROBIAL CELL FACTORIES[J]. 2017, 16(1): https://doaj.org/article/530fd2f4364548aba99eff1729c391b7.
[37] Cheng, Jian, Guo, Xiaoxian, Cai, Pengli, Cheng, Xiaozhi, Piskur, Jure, Ma, Yanhe, Jiang, Huifeng, Gu, Zhenglong. Parallel Evolution of Chromatin Structure Underlying Metabolic Adaptation. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(11): 2870-2878, https://www.webofscience.com/wos/woscc/full-record/WOS:000416178700010.
[38] Li, Siwei, Ding, Wentao, Zhang, Xueli, Jiang, Huifeng, Bi, Changhao. Development of a modularized two-step (M2S) chromosome integration technique for integration of multiple transcription units in Saccharomyces cerevisiae. BIOTECHNOLOGY FOR BIOFUELS[J]. 2016, 9(1): http://dx.doi.org/10.1186/s13068-016-0645-4.
[39] Min, HanYi, Qiao, PengPeng, Asan, Yan, ZhiHui, Jiang, HuiFeng, Zhu, YaPing, Du, HuiQian, Li, Qin, Wang, JiaWei, Zhang, Jie, Sun, Jun, Yi, Xin, Yang, Ling. Targeted Genes Sequencing Identified a Novel 15 bp Deletion on GJA8 in a Chinese Family with Autosomal Dominant Congenital Cataracts. CHINESE MEDICAL JOURNAL[J]. 2016, 129(7): 860-+, http://lib.cqvip.com/Qikan/Article/Detail?id=668370609.
[40] Liu, Ying, Yan, Zhihui, Lu, Xiaoyun, Xiao, Dongguang, Jiang, Huifeng. Improving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis. SCIENTIFIC REPORTS[J]. 2016, 6: http://124.16.173.210/handle/834782/2240.
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（ 1 ） 布鲁塞尔德克酵母核小体图谱与有氧发酵途径的进化, 主持, 国家级, 2014-01--2016-12
（ 2 ） 中科院****, 主持, 部委级, 2014-01--2016-12
（ 3 ） 灯盏乙素合成途径发掘, 主持, 院级, 2014-03--2017-03
（ 4 ） 工业微生物基因组数据整合及分析平台开发, 主持, 国家级, 2014-01--2016-12
（ 5 ） 固氮与相关抗逆线路的集成优化, 主持, 国家级, 2015-01--2016-12
（ 6 ） 基于翻译组学的酵母有氧发酵途径翻译调控的进化机制研究, 主持, 国家级, 2015-01--2018-12
（ 7 ） 色氨酸拆分全细胞催化工艺, 主持, 院级, 2015-06--2016-06
（ 8 ） 电能高效固碳的人工生物体系创建, 主持, 部委级, 2016-01--2018-12

（1）Synthesis of plant natural products by synthetic biology in yeast   江会锋   2016-03-29

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