基本信息
高璞  男  博导  中国科学院生物物理研究所
电子邮件: gaopu@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
071011-生物物理学
071009-细胞生物学
招生方向
结构免疫学;病原与宿主相互作用;晶体学和冷冻电镜;

教育背景

2005-09--2011-01   中国科学院生物物理研究所   博士
2001-09--2005-07   山东大学   学士

工作经历

   
工作简历
2016-09~现在, 中国科学院生物物理研究所, 课题组长
2011-06~2016-07,美国纪念斯隆-凯特琳癌症中心, 博士后/研究助理

专利与奖励

   
奖励信息
(1) 国家自然基金委优秀青年基金, 其他, 2019
(2) 中源协和生命医学创新突破奖, 其他, 2019
(3) 中国晶体学会青年科技奖, 其他, 2018
(4) Pathway to Independence Award (K99/R00), 其他, 2016
(5) 海外高层次人才引进计划(青年项目), 其他, 2016
(6) CRI Irvington Postdoctoral Fellowship Award, 其他, 2014
(7) MSKCC Postdoctoral Research Award, 其他, 2013
(8) 优秀博士毕业论文, 其他, 2011
(9) David Blow Visiting Scholarship, 其他, 2009
专利成果
[1] Patel, Dinshaw J., Tuschl, Thomas, Ascano, Jr., Manuel, Wu, Yang, Liu, Yizhou, Barchet, Winfried, Hartmann, Gunther, Zillinger, Thomas, Jones, Roger, Gaffney, Barbara L., Gao, Pu, 高璞. Compositions and methods for altering second messenger signaling. US: US11014956(B2), 2021-05-25.

[2] Patel, Dinshaw J., Tuschl, Thomas, Jones, Roger, Hartmann, Gunther, Barchet, Winfried, Zillinger, Thomas, Wang, Weiyi, Gao, Pu, Deng, Liang, Ascano, Jr., Manuel, 高璞. STING crystals and modulators. US: US10176292(B2), 2019-01-08.

出版信息

   
发表论文
[1] Dong Li, Yihong Yang, Chenglin Lv, Yingjie Wang, Xiaoting Chao, Jiafeng Huang, Shashi P. Singh, Ye Yuan, Chengyu Zhang, Jizhong Lou, Pu Gao, Shanjin Huang, Bo Li, Huaqing Cai. GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3. JOURNAL OF CELL BIOLOGY[J]. 2023, [2] Xiong, TianChen, Wei, MingCong, Li, FangXu, Shi, Miao, Gan, Hu, Tang, Zhen, Dong, HongPeng, Liuyu, Tianzi, Gao, Pu, Zhong, Bo, Zhang, ZhiDong, Lin, Dandan. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-33671-5.
[3] Xu, Guangjun, Liu, Chong, Zhou, Sheng, Li, Quanjin, Feng, Yun, Sun, Panpan, Feng, Han, Gao, Yina, Zhu, Jingpeng, Luo, Xiu, Zhan, Qi, Liu, Songqing, Zhu, Shu, Deng, Hongyu, Li, Dong, Gao, Pu. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. MOLECULAR CELL[J]. 2021, 81(13): 2823-+, http://dx.doi.org/10.1016/j.molcel.2021.05.002.
[4] Zhang, Liwen, Zhu, Zijing, Yan, Huiwen, Wang, Wen, Wu, Zhenzhen, Zhang, Fei, Zhang, Qixiang, Shi, Guizhi, Du, Junfeng, Cai, Huiyun, Zhang, Xuanxuan, Hsu, David, Gao, Pu, Piao, Hailong, Chen, Gang, Bu, Pengcheng. Creatine promotes cancer metastasis through activation of Smad2/3. CELL METABOLISM[J]. 2021, 33(6): 1111-+, http://dx.doi.org/10.1016/j.cmet.2021.03.009.
[5] Shen, Chen, Li, Runzhi, Negro, Roberto, Cheng, Jiewei, Vora, Setu M, Fu, TianMin, Wang, Anmin, He, Kaixin, Andreeva, Liudmila, Gao, Pu, Tian, Zhigang, Flavell, Richard A, Zhu, Shu, Wu, Hao. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. CELL[J]. 2021, 184(23): 5759-+, http://dx.doi.org/10.1016/j.cell.2021.09.032.
[6] Sun, Shiyu, Cai, Yueqi, Song, TianZhang, Pu, Yang, Cheng, Lin, Xu, Hairong, Sun, Jing, Meng, Chaoyang, Lin, Yifan, Huang, Haibin, Zhao, Fang, Zhang, Silin, Gao, Yu, Han, JianBao, Feng, XiaoLi, Yu, DanDan, Zhu, Yalan, Gao, Pu, Tang, Haidong, Zhao, Jincun, Zhang, Zheng, Yang, Jiaming, Hu, Zhenxiang, Fu, YangXin, Zheng, YongTang, Peng, Hua. Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2. CELL RESEARCH[J]. 2021, 31(9): 1011-1023, http://dx.doi.org/10.1038/s41422-021-00531-8.
[7] Yong Wang, Qi Zhan, Xinlu Wang, Peipei Li, Songqing Liu, Guangxia Gao, Pu Gao. Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-16587-w.
[8] Feng, Han, Tian, Huabin, Wang, Yong, Zhang, Qixiang, Lin, Ni, Liu, Songqing, Yu, Yang, Deng, Hongyu, Gao, Pu. Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(43): 26719-26727, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604486/.
[9] Gao, Yina, Cao, Duanfang, Zhu, Jingpeng, Feng, Han, Luo, Xiu, Liu, Songqing, Yan, XiaoXue, Zhang, Xinzheng, Gao, Pu. Structural insights into assembly, operation and inhibition of a type I restriction-modification system. NATURE MICROBIOLOGY[J]. 2020, 5(9): 1107-+, [10] Luo, Xiu, Wang, Xinlu, Gao, Yina, Zhu, Jingpeng, Liu, Songqing, Gao, Guangxia, Gao, Pu. Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein. CELL REPORTS[J]. 2020, 30(1): 46-+, http://dx.doi.org/10.1016/j.celrep.2019.11.116.
[11] Zhu, Yalan, Gao, Ang, Zhan, Qi, Wang, Yong, Feng, Han, Liu, Songqing, Gao, Guangxia, Serganov, Alexander, Gao, Pu. Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. MOLECULAR CELL[J]. 2019, 74(2): 296-+, http://dx.doi.org/10.1016/j.molcel.2019.01.038.
[12] Lama, Lodoe, Adura, Carolina, Xie, Wei, Tomita, Daisuke, Kamei, Taku, Kuryavyi, Vitaly, Gogakos, Tasos, Steinberg, Joshua I, Miller, Michael, RamosEspiritu, Lavoisier, Asano, Yasutomi, Hashizume, Shogo, Aida, Jumpei, Imaeda, Toshihiro, Okamoto, Rei, Jennings, Andy J, Michino, Mayako, Kuroita, Takanobu, Stamford, Andrew, Gao, Pu, Meinke, Peter, Glickman, J Fraser, Patel, Dinshaw J, Tuschl, Thomas. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. NATURE COMMUNICATIONS[J]. 2019, 10(1): http://dx.doi.org/10.1038/s41467-019-08620-4.
[13] Xinlu Wang, Yifang Xuan, Yuling Han, Xiang Ding, Kai Ye, Fuquan Yang, Pu Gao, Stephen P Goff, Guangxia Gao. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed −1 Ribosomal Frameshifting. CELL[J]. 2019, 176(3): 625-635.e14, [14] Wang, Yong, Shi, Miao, Feng, Han, Zhu, Yalan, Liu, Songqing, Gao, Ang, Gao, Pu. Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. CELL[J]. 2018, 173(5): 1231-+, http://dx.doi.org/10.1016/j.cell.2018.04.023.
[15] Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J Patel, J Fraser Glickman, Manuel Ascano. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/a1c22f6c069f4297bb2ed0aef032466c.
[16] Liu, YanPing, Tang, Qun, Zhang, JieZhong, Tian, LiFei, Gao, Pu, Yan, XiaoXue. Structural basis underlying complex assembly and conformational transition of the type I R-M system. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(42): 11151-11156, https://www.webofscience.com/wos/woscc/full-record/WOS:000413237900051.
[17] Wang, Yong, Feng, Han, Zhu, Yalan, Gao, Pu. Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes. PROTEIN & CELL[J]. 2017, 8(4): 308-312, http://lib.cqvip.com/Qikan/Article/Detail?id=671854434.
[18] Ren, Aiming, Vusurovic, Nikola, Gebetsberger, Jennifer, Gao, Pu, Juen, Michael, Kreutz, Christoph, Micura, Ronald, Patel, Dinshaw J. Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage. NATURE CHEMICAL BIOLOGY[J]. 2016, 12(9): 702-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000382255100011.
[19] Yang, Hui, Gao, Pu, Rajashankar, Kanagalaghatta R, Patel, Dinshaw J. PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. CELL[J]. 2016, 167(7): 1814-+, http://dx.doi.org/10.1016/j.cell.2016.11.053.
[20] Xia, Pengyan, Wang, Shuo, Gao, Pu, Gao, Guangxia, Fan, Zusen. DNA sensor cGAS-mediated immune recognition. PROTEIN & CELL[J]. 2016, 7(11): 777-791, https://doaj.org/article/08e64bcfa6514b819f3e4423a0825201.
[21] Gao, Pu, Yang, Hui, Rajashankar, Kanagalaghatta R, Huang, Zhiwei, Patel, Dinshaw J. Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. CELL RESEARCH[J]. 2016, 26(8): 901-913, https://www.webofscience.com/wos/woscc/full-record/WOS:000380923900008.
[22] Gao, Pu, Patel, Dinshaw J. V-cGAPs: attenuators of 3 ' 3 '-cGAMP signaling. CELL RESEARCH[J]. 2015, 25(5): 529-530, https://www.webofscience.com/wos/woscc/full-record/WOS:000353917500001.
[23] Gao, Pu, Zillinger, Thomas, Wang, Weiyi, Ascano, Manuel, Dai, Peihong, Hartmann, Gunther, Tuschl, Thomas, Deng, Liang, Barchet, Winfried, Patel, Dinshaw J. Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA. CELL REPORTS[J]. 2014, 8(6): 1668-1676, https://doaj.org/article/91ccfc3d80dd4d97962cbfb4d2c79dcd.
[24] Gao Pu. SMARCA3, a chromation-remodeling factor, is required for p11-dependent antidepressant action. Cell[J]. 2013, [25] Gao, Pu, Ascano, Manuel, Zillinger, Thomas, Wang, Weiyi, Dai, Peihong, Serganov, Artem A, Gaffney, Barbara L, Shuman, Stewart, Jones, Roger A, Deng, Liang, Hartmann, Gunther, Barchet, Winfried, Tuschl, Thomas, Patel, Dinshaw J. Structure-Function Analysis of STING Activation by cG(2 ',5 ') pA(3 ',5 ')p and Targeting by Antiviral DMXAA. CELL[J]. 2013, 154(4): 748-762, http://dx.doi.org/10.1016/j.cell.2013.07.023.
[26] Gao, Pu, Ascano, Manuel, Wu, Yang, Barchet, Winfried, Gaffney, Barbara L, Zillinger, Thomas, Serganov, Artem A, Liu, Yizhou, Jones, Roger A, Hartmann, Gunther, Tuschl, Thomas, Patel, Dinshaw J. Cyclic G(2 ',5 ') pA(3 ',5 ')p Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase. CELL[J]. 2013, 153(5): 1094-1107, http://dx.doi.org/10.1016/j.cell.2013.04.046.
[27] Tang, Qun, Gao, Pu, Liu, YanPing, Gao, Ang, An, XiaoMin, Liu, Shun, Yan, XiaoXue, Liang, DongCai. RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(21): 11115-11125, http://www.irgrid.ac.cn/handle/1471x/756910.
[28] Gao, Pu, Tang, Qun, An, XiaoMin, Yan, XiaoXue, Liang, DongCai. Structure of HsdS Subunit from Thermoanaerobacter tengcongensis Sheds Lights on Mechanism of Dynamic Opening and Closing of Type I Methyltransferase. PLOS ONE[J]. 2011, 6(3): http://www.irgrid.ac.cn/handle/1471x/757397.
[29] Shi, Liang, Gao, Pu, Yan, XiaoXue, Liang, DongCai. Crystal structure of a putative methylmalonyl-coenzyme a epimerase from Thermoanaerobacter tengcongensis at 2.0 angstrom resolution. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2009, 77(4): 994-999, http://www.irgrid.ac.cn/handle/1471x/757895.

科研活动

   
科研项目
( 1 ) 2016年“****”青年项目, 主持, 国家级, 2016-09--2019-08
( 2 ) 中科院生物物理所启动经费, 主持, 市地级, 2016-06--2019-05
参与会议
(1)Structure-function studies of cytosolic DNA sensing pathway   2014-11-14
(2)Structure-function studies of cytosolic DNA sensing pathway   2014-08-13
(3)Structure-function studies of cytosolic sensors of dsDNA in metazoans that activate the STING pathway   2011-08-05

指导学生

已指导学生

徐广军  博士研究生  071010-生物化学与分子生物学  

朱亚兰  博士研究生  071010-生物化学与分子生物学  

朱景鹏  博士研究生  071010-生物化学与分子生物学  

现指导学生

石苗  博士研究生  071010-生物化学与分子生物学  

展琪  博士研究生  071010-生物化学与分子生物学  

李佩佩  硕士研究生  071010-生物化学与分子生物学  

孙盼盼  硕士研究生  071011-生物物理学  

蔺妮  博士研究生  071010-生物化学与分子生物学  

张启祥  博士研究生  071010-生物化学与分子生物学  

李肇隆  硕士研究生  071011-生物物理学  

刘可欣  硕士研究生  071010-生物化学与分子生物学  

李权锦  博士研究生  071010-生物化学与分子生物学  

赵春秋  博士研究生  071010-生物化学与分子生物学