Pathogenesis of bacterial pathogens 

Ph.D., Institute of Hydrobiology, Chinese Academy of Sciences, Hydrobiology, 2005.  

B.A., HuaZhong Agricultural University, Aquaculture, 1999. 

2019-     Professor, Institute of Hydrobiology, the Chinese Academy of Sciences 

2011-2018 Associate Professor, Institute of Hydrobiology, the Chinese Academy of Sciences 

2017-2018 Visiting scholar, Imperial College, London.

2008-2010 Assistant Professor, Institute of Hydrobiology, the Chinese Academy of Sciences 

2005-2008 PostDoc, Department of Biology, National University of Singapore

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Selected publications:

1. TianTian He, Ying Zhou, YingLi Liu, DuanYou Li, Pin Nie, AiHua Li*, HaiXia Xie*. Edwardsiella piscicida type III protein EseJ suppresses apoptosis through down regulating type I fimbriae, which stimulate the cleavage of caspase-8. Cellular Microbiology, 2020, 22:e13193. 

2. Qian Zhang, TianTian He, DuanYou Li , Pin Nie*, HaiXia Xie*. The Edwardsiella piscicida type III effector EseJ suppresses expression of type 1 fimbriae, leading to decreased bacterial adherence to host cells. Infection & Immunity, 2019, 87: e00187-19.  

3. YingLi Liu, TianTian He, LuYi Liu, Jia Yi, Pin Nie, HongBing Yu, HaiXia Xie*. The Edwardsiella piscicida type III translocon protein EseC inhibits biofilm formation by sequestering EseE. Applied and Environmental Microbiology, 2019, 85:e02133-18.  

4. LuYi Liu, Pin Nie*, HongBing Yu , HaiXia Xie*. Regulation of type III secretion of translocon and effector proteins by the EsaB/EsaL/EsaM complex in Edwardsiella tarda. Infection & Immunity, 2017, 85:e00322-17. 

5. Jia Yi , ShuiBing Xiao, ZhiXiong Zeng, JinFang Lu, LuYi Liu, Zubair Ahmed Laghari, Pin Nie, HongBing Yu, HaiXia Xie*. EseE of Edwardsiella tarda augments the secretion of translocon protein EseC and the expression of escC-eseE operon.  Infection & Immunity, 2016, 84:2336-2344. 

6. JinFang Lu, WeiNa Wang, GaiLing Wang, HeZhang, YingZhou, ZhiPeng Gao, Pin Nie*, HaiXia Xie*. Edwardsiella tarda EscE (Orf13 protein) is a type III secretion system secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infection & Immunity, 2016, 84:2-10. 

7. ZhiPeng Gao, Pin Nie, JinFang Lu, LuYi Liu, TiaoYi Xiao, Wei Liu, JiaShou Liu*, HaiXia Xie*. Type III secretion system translocon component EseB forms filaments and mediates autoaggregation and biofilm formation in Edwardsiella tarda. Applied and Environmental Microbiology, 2015, 81:6078-6087. 

8. HaiXia Xie, JinFang Lu, Ying Zhou, Jia Yi, Xiu-Jun Yu*, KaYing Leung, Pin Nie*. Identification and functional characterization of the novel Edwardsiella tarda effector EseJ. Infection & Immunity, 2015, 83:1650-1660. 

9. HaiXia Xie, JinFang Lu, Nathalie Rolhion, David W. Holden, Pin Nie*, Ying Zhou, Xiu-Jun Yu*. Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin. Infection & Immunity, 2014, 82:3436-3445.  

10. HaiXia Xie, HongBing Yu, Jun Zheng, Leonard J. Foster, Yu-Keung Mok, Brett B. Finlay, Pin Nie, KaYin Leung*. EseG, an effector of the type III secretion system of Edwardsiella tarda triggers microtubule destabilization. Infection & Immunity 2010, 78:5011-5021. 

Bacterial pathogenesis, Type III secretion system, biofilm, type I fimbriae, Host-pathogen interaction, Immersion vaccine  

已指导学生

易佳  硕士研究生  085238-生物工程  

周瑛  硕士研究生  071004-水生生物学  

张倩  硕士研究生  071004-水生生物学  

刘莹莉  硕士研究生  085238-生物工程  

李端友  硕士研究生  071004-水生生物学  

现指导学生

江修龙  硕士研究生  071004-水生生物学  

孙珊珊  博士研究生  071004-水生生物学  

汤璞玉  硕士研究生  071004-水生生物学  

张淑雅  博士研究生  071004-水生生物学