基本信息
胡宝洋 男 博导 动物研究所
电子邮件:byhu@ioz.ac.cn
通信地址:北京市朝阳区北辰西路1号院5号C107
邮政编码:100101

招生信息

   
招生专业
071009-细胞生物学
071008-发育生物学
071006-神经生物学
招生方向
干细胞与再生医学
神经干细胞与神经修复
干细胞生物学

教育背景

1999-07--2004-07 复旦大学 博士
1990-07--1995-07 济宁医学院 学士

工作经历

   
工作简历
2011-02--今 中国科学院动物研究所 研究员
2009-04--2010-09 University of Wisconsin-Madison Assistant Scientist
2005-10--2009-03 University of Wisconsin-Madison Research Associate
2004-07--2005-10 济宁医学院 教师
1995-07--1999-07 济宁医学院 教师

教授课程

干细胞研究进展系列讲座

专利与奖励

   

出版信息

   
发表论文
[1] An, Ni A A, Zhang, Jie, Mo, Fan, Luan, Xuke, Tian, Lu, Shen, Qing Sunny, Li, Xiangshang, Li, Chunqiong, Zhou, Fanqi, Zhang, Boya, Ji, Mingjun, Qi, Jianhuan, Zhou, WeiZhen, Ding, Wanqiu, Chen, JiaYu, Yu, Jia, Zhang, Li, Shu, Shaokun, Hu, Baoyang, Li, ChuanYun. De novo genes with an lncRNA origin encode unique human brain developmental functionality. NATURE ECOLOGY & EVOLUTION. 2023, 7(2): 264-278, http://dx.doi.org/10.1038/s41559-022-01925-6.
[2] Qi, Jianhuan, Mo, Fan, An, Ni A, Mi, Tingwei, Wang, Jiaxin, Qi, JunTian, Li, Xiangshang, Zhang, Boya, Xia, Longkuo, Lu, Yingfei, Sun, Gaoying, Wang, Xinyue, Li, ChuanYun, Hu, Baoyang. A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding. ADVANCED SCIENCE[J]. 2023, 10(7): [3] Sun, Gaoying, Tang, Mingming, Wang, Xinyue, Li, Da, Liu, Wenwen, Qi, Jianhuan, Wang, Haibo, Hu, Baoyang. Generation of human otic neuronal organoids using pluripotent stem cells. CELL PROLIFERATION. 2023, http://dx.doi.org/10.1111/cpr.13434.
[4] Xia, Longkuo, Qi, Jianhuan, Tang, Mingming, Liu, Jing, Zhang, Da, Zhu, Yanbing, Hu, Baoyang. Continual Deletion of Spinal Microglia Reforms Astrocyte Scar Favoring Axonal Regeneration. FRONTIERS IN PHARMACOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fphar.2022.881195.
[5] Sun, Yun, Feng, Lin, Liang, Lingmin, Stacey, Glyn N, Wang, Chaoqun, Wang, Yukai, Hu, Baoyang. Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment. STEM CELLS TRANSLATIONAL MEDICINE[J]. 2021, 10(Suppl 2): S31-S40, http://dx.doi.org/10.1002/sctm.20-0522.
[6] Liu, Jing, Hou, Zongren, Wu, Jun, Liu, Kailun, Li, Da, Gao, Tingting, Liu, Wenjing, An, Bin, Sun, Yun, Mo, Fan, Wang, Liu, Wang, Yukai, Hao, Jie, Hu, Baoyang. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. CELLPROLIFERATION[J]. 2021, 54(8): http://dx.doi.org/10.1111/cpr.13085.
[7] Sun, Han, Liu, Jing, Lv, Fengting, Liu, Libing, Gu, Qi, Hu, Baoyang, Wang, Shu. Selective reaction of conjugated polymers with basic proteins for broad-spectrum antivirulence therapy. NPG ASIA MATERIALS[J]. 2021, 13(1): http://dx.doi.org/10.1038/s41427-020-00252-1.
[8] Wu, Jun, Hu, Zhongjie, Wang, Liu, Tan, Yuanqing, Hou, Wei, Li, Zhongwen, Gao, Tingting, Fan, Jiaqi, Guo, Baojie, Dai, Huaping, Li, Wei, Hao, Jie, Jin, Ronghua, Hu, Baoyang. First case of COVID-19 infused with hESC derived immunity- and matrix-regulatory cells. CELL PROLIFERATION. 2020, 53(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645847/.
[9] Wu, Jun, Song, Dingyun, Li, Zhongwen, Guo, Baojie, Xiao, Yani, Liu, Wenjing, Liang, Lingmin, Feng, Chunjing, Gao, Tingting, Chen, Yanxia, Li, Ying, Wang, Zai, Wen, Jianyan, Yang, Shengnan, Liu, Peipei, Wang, Lei, Wang, Yukai, Peng, Liang, Stacey, Glyn Nigel, Hu, Zheng, Feng, Guihai, Li, Wei, Huo, Yan, Jin, Ronghua, ShyhChang, Ng, Zhou, Qi, Wang, Liu, Hu, Baoyang, Dai, Huaping, Hao, Jie. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. CELL RESEARCH[J]. 2020, 30(9): 794-809, http://lib.cqvip.com/Qikan/Article/Detail?id=7103057039.
[10] Zhongwen Li, Jun Wu, Lei Wang, Weifang Han, Juan Yu, Xin Liu, Yukai Wang, Ying Zhang, Guihai Feng, Wei Li, Glyn Nigel Stacey, Qi Gu, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. Correction: Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. CELL DEATH & DISEASE. 2020, 11(1): [11] Wang, Lei, Wu, Wei, Gu, Qi, Liu, Zengping, Li, Qiyou, Li, Zhongwen, Fang, Jinhui, Liu, Wenjing, Wu, Jun, Zhang, Ying, Wang, Liu, Xu, Haiwei, Li, Wei, Hu, Baoyang, Zhou, Qi, Yin, Zhengqin, Hao, Jie. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. PROTEIN & CELL[J]. 2019, 10(6): 455-460, http://lib.cqvip.com/Qikan/Article/Detail?id=7002265647.
[12] Xu Yanpeng, Qiu Yang, Zhang Boya, Chen Guilai, Chen Qi, Wang Miao, Mo Fan, Xu Jiuyue, Wu Jin, Zhang Rongrong, Cheng Mengli, Zhang Nana, Lyu Bao, Zhu Wenliang, Wu Menghua, Ye Qing, Zhang Da, Man Jianghong, Li Xiaofeng, Cui Jie, Xu Zhiheng, Hu Baoyang, Zhou Xi, Qin Chengfeng. Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. CELL RESEARCH[J]. 2019, 29(4): 265-273, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6474850&detailType=1.
[13] Wenliang Zhu, Boya Zhang, Mengqi Li, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou, Wei Li, Baoyang Hu. Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-18, https://doaj.org/article/fe289d2c0c864031a37e09fb8593c020.
[14] Zhang, Weiqi, Wan, Haifeng, Feng, Guihai, Qu, Jing, Wang, Jiaqiang, Jing, Yaobin, Ren, Ruotong, Liu, Zunpeng, Zhang, Linlin, Chen, Zhiguo, Wang, Shuyan, Zhao, Yong, Wang, Zhaoxia, Yuan, Yun, Zhou, Qi, Li, Wei, Liu, GuangHui, Hu, Baoyang. SIRT6 deficiency results in developmental retardation cynomolgus monkeys. NATURE[J]. 2018, 560(7720): 661-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000443218600053.
[15] Jiang, Yuan, Yan, Long, Xia, Longkuo, Lu, Xiaoyin, Zhu, Wenliang, Ding, Dewen, Du, Mingxia, Zhang, Da, Wang, Hongmei, Hu, Baoyang. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(50): 19317-19329, http://dx.doi.org/10.1074/jbc.RA118.005498.
[16] Wu, Menghua, Zhang, Da, Bi, Chunying, Mi, Tingwei, Zhu, Wenliang, Xia, Longkuo, Teng, Zhaoqian, Hu, Baoyang, Wu, Yihui. A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. STEM CELL REPORTS[J]. 2018, 11(3): 635-650, http://dx.doi.org/10.1016/j.stemcr.2018.08.005.
[17] Xia Li, Ruoyu Ma, Qi Gu, Lingmin Liang, Lei Wang, Ying Zhang, Xianning Wang, Xin Liu, Zhongwen Li, Jinhui Fang, Jun Wu, Yukai Wang, Wei Li, Baoyang Hu, Liu Wang, Qi Zhou, Jie Hao. A fully defined static suspension culture system for large-scale human embryonic stem cell production. CELL DEATH AND DISEASE[J]. 2018, 9(9): 1-9, https://doaj.org/article/517fbb632f3142c385073e2f1824afd8.
[18] Chen, Guilai, Zhang, Da, Zhang, Linlin, Feng, Guihai, Zhang, Boya, Wu, Yihui, Li, Wei, Zhang, Ying, Hu, Baoyang. RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 501(1): 259-265, http://dx.doi.org/10.1016/j.bbrc.2018.04.231.
[19] Boya Zhang, Yangzhige He, Yanpeng Xu, Fan Mo, Tingwei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, Chengfeng Qin, Baoyang Hu, Guomin Zhou. Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. CELL DEATH AND DISEASE[J]. 2018, 9(7): 1-10, https://doaj.org/article/52a061027b714c9184fec9199e231068.
[20] Li, ZhiKun, Wang, LeYun, Wang, LiBin, Feng, GuiHai, Yuan, XueWei, Liu, Chao, Xu, Kai, Li, YuHuan, Wan, HaiFeng, Zhang, Ying, Li, YuFei, Li, Xin, Li, Wei, Zhou, Qi, Hu, BaoYang. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. CELL STEM CELL[J]. 2018, 23(5): 665-+, http://dx.doi.org/10.1016/j.stem.2018.09.004.
[21] Wang, Xuepeng, Li, Tianda, Cui, Tongtong, Yu, Dawei, Liu, Chao, Jiang, Liyuan, Feng, Guihai, Wang, Lei, Fu, Rui, Zhang, Xinxin, Hao, Jie, Wang, Yukai, Wang, Liu, Zhou, Qi, Li, Wei, Hu, Baoyang. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. CELL RESEARCH[J]. 2018, 28(1): 126-129, https://www.webofscience.com/wos/woscc/full-record/WOS:000423834700012.
[22] Wang, YuKai, Zhu, WanWan, Wu, MengHua, Wu, YiHui, Liu, ZhengXin, Liang, LingMin, Sheng, Chao, Hao, Jie, Wang, Liu, Li, Wei, Zhou, Qi, Hu, BaoYang. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. STEM CELL REPORTS[J]. 2018, 11(1): 171-182, http://dx.doi.org/10.1016/j.stemcr.2018.05.010.
[23] Gu, Qi, Wang, Juan, Wang, Lei, Liu, ZhengXin, Zhu, WanWan, Tan, YuanQing, Han, WeiFang, Wu, Jun, Feng, ChunJing, Fang, JinHui, Liu, Lei, Wang, Liu, Li, Wei, Zhao, XiaoYang, Hu, BaoYang, Hao, Jie, Zhou, Qi. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. STEM CELL REPORTS[J]. 2017, 9(1): 366-380, http://dx.doi.org/10.1016/j.stemcr.2017.04.017.
[24] Qian, Kun, Huang, Hailong, Peterson, Andrew, Hu, Baoyang, Maragakis, Nicholas J, Ming, Guoli, Chen, Hong, Zhang, SuChun. Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo. STEM CELL REPORTS[J]. 2017, 8(4): 843-855, http://dx.doi.org/10.1016/j.stemcr.2017.03.003.
[25] Li Tianda, Feng Guihai, Li Yufei, Wang Mei, Mao Junjie, Wang Jiaqiang, Li Xin, Wang Xuepeng, Qu Bin, Wang Leyun, XinXin Zhang, Wan Haifeng, Cui Tongtong, Wan Cong, Liu Lei, Zhao Xiaoyang, Hu Baoyang, Li Wei, Zhou Qi. Rat Embryonic Stem Cells Produce Fertile Offspring Through Tetraploid Complementation. PNAS[J]. 2017, 114(45): 11974-11979, http://ir.ioz.ac.cn/handle/000000/12809.
[26] Yuan, Ling, Huang, XingYao, Liu, ZhongYu, Zhang, Feng, Zhu, XingLiang, Yu, JiuYang, Ji, Xue, Xu, YanPeng, Li, Guanghui, Li, Cui, Wang, HongJiang, Deng, YongQiang, Wu, Menghua, Cheng, MengLi, Ye, Qing, Xie, DongYang, Li, XiaoFeng, Wang, Xiangxi, Shi, Weifeng, Hu, Baoyang, Shi, PeiYong, Xu, Zhiheng, Qin, ChengFeng. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. SCIENCE[J]. 2017, 358(6365): 933-+, http://dx.doi.org/10.1126/science.aam7120.
[27] Zhang JbrChen SQbrZhang DMbrShi ZXbrLi HbrZhao TBbrHu BYbrZhou QbrJiao JW. Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. CELL REPORTS. 
发表著作
(1) 新生物学年鉴2013,Advances in Biology 2013,科学出版社,2014-01,第1作者
(2) 分子生物学方法-编程与重编程章节:神经特定细胞类型定向分化,Directed differentiation of neural and subtype specific neuronal cells from hESCs. in Reprogramming and Programming of Cell Fate, Methods in Molecular Biology,Humana Press.,2009-07,第1作者
(3) 人胚干细胞实用手册章节:人胚干细胞和运动神经元定向分化,Differentiation of human embryonic stem cells into spinal motor neurons, in Human Embryonic Stem Cells: The Practical Handbook,Wiley Publishing,2007-07,第1作者
(4) 医学发育生物学章节:中枢神经系统发育,Development of Central Nervous System, in Developmental Neurobiology,科学出版社,2004-07,第1作者

科研活动

   
科研项目
(1) 人特异性miRNA-F1对人脑发育调控研究,主持,国家级,2015-01--2019-12
(2) 体外定向分化神经干细胞移植及功能整合,参与,国家级,2014-01--2018-12
(3) 神经外胚层细胞R-C化和D-V化的调控网络,主持,国家级,2012-12--2016-12
(4) 人多能干细胞分化神经细胞移植的免疫耐受诱导,主持,院级级,2012-08--2015-12
(5) 干细胞与神经再生,主持,院级级,2012-07--2015-06
(6) 人多能干细胞来源OLIG2+前体细胞向运动神经元的分化调控,主持,国家级,2012-01--2015-12
(7) 灵长类ES和iPS细胞分化为多巴胺神经细胞,参与,国家级,2012-01--2016-12
(8) 干细胞医学转化研究,主持,院级级,2011-02--2013-02

指导学生

已指导学生

曹旭  硕士研究生  085238-生物工程  

现指导学生

王崧  博士研究生  071008-发育生物学  

蒋远  博士研究生  071008-发育生物学  

陈桂来  博士研究生  071008-发育生物学  

杨亚明  硕士研究生  071008-发育生物学  

丁德文  博士研究生  071008-发育生物学  

王毅  博士研究生  071008-发育生物学  

吴孟华  博士研究生  071008-发育生物学  

夏隆阔  硕士研究生  071008-发育生物学  

朱文亮  博士研究生  071008-发育生物学  

莫凡  硕士研究生  071008-发育生物学