070302-分析化学

微流控生物芯片
质谱
蛋白质组学

2010-09--2011-12   加拿大国家科学院-生物科学研究所（NRC-IBS）   国家公派访问学者
2006-09--2012-06   华中科技大学生命科学与技术学院   博士

   

2017-10~现在, 中国科学院武汉物理与数学研究所, 副研究员
2016-04~2017-10,中国科学院武汉物理与数学研究所, 助理研究员
2012-07~2016-04,中国科学院水生生物研究所, 工程师

   

[1] 李颖, 李涛, 胡锐, 杨运煌, 周欣, 刘买利. 一种快速可视化的溶血性大肠杆菌O157：H7检测方法. CN: CN110286216B, 2021-10-15.

[2] 李颖, 李涛, 杨运煌, 胡锐, 刘买利. 一种新型的核酸检测方法. CN: CN112080549A, 2020-12-15.

[3] 胡锐, 杨运煌, 蒋滨, 刘买利. 一种液质联用分析内毒素类脂A的方法. CN: CN107807185B, 2020-09-29.

[4] 李颖, 杨运煌, 胡锐. 一种用于现场诊断的酶联免疫吸附检测装置及方法. CN: CN109839502B, 2020-09-11.

[5] 李颖, 杨运煌, 胡锐, 周欣, 刘买利. 一种用于生化反应条件筛选的三维浓度梯度阵列装置及应用. CN: CN110193384B, 2020-06-19.

[6] 胡锐, 杨运煌, 张许, 刘买利. 一种毛细管电泳的质谱联用定量分析血清中磷脂酰胆碱的方法及应用. CN: CN108020592B, 2019-10-08.

[7] 李颖, 杨运煌, 胡锐. 一种全血过滤装置. CN: CN109806632A, 2019-05-28.

[8] 杨运煌, 胡锐, 朱江, 刘买利. 一种超声破碎仪. 中国: CN206858589U, 2018.01.09.

[9] 胡锐, 杨运煌, 朱江, 刘买利. 一种控温涡旋仪. CN: CN207042370U, 2018-02-27.

[10] 朱江, 杨运煌, 胡锐, 刘买利. 一种杀菌摇床. CN: CN206853583U, 2018-01-09.

[11] 杨运煌, 胡锐, 朱江, 刘买利. 一种冻干用离心管. 中国: CN206853712U, 2018-01-09.

   

[1] Hu, Rui, Li, Ying, Yang, Yunhuang, Liu, Maili. Mass spectrometry-based strategies for single-cell metabolomics. MASS SPECTROMETRY REVIEWSnull. 2023, 42(1): 67-94, [2] Yu Wang, Mingkun Yang, Feng Ge, Bin Jiang, Rui Hu, Xin Zhou, Yunhuang Yang, Maili Liu. Lysine Succinylation of VBS Contributes to Sclerotia Development and Aflatoxin Biosynthesis in Aspergillus flavus. MOLECULAR & CELLULAR PROTEOMICS[J]. 2023, 22(2): http://dx.doi.org/10.1016/j.mcpro.2022.100490.
[3] Ting He, Yao Nie, Tingting Yan, Jiang Zhu, Xiaoling He, Ying Li, Qi Zhang, Xiaoqian Tang, Rui Hu, Yunhuang Yang, Maili Liu. Enhancing the detection sensitivity of nanobody against aflatoxin B1 through structure-guided modification. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2022, 194: 188-197, [4] Zheyu Li, Yue Xiong, Shuangli Li, Jiang Zhu, Rui Hu, Ying Li, Yunhuang Yang, Maili Liu. A fast microfluidic mixer enabling rapid preparation of homogeneous PEG and bicelle media for RDC in NMR analysis. CHEMICAL ENGINEERING JOURNAL[J]. 2022, 431: [5] Xiaoling He, Yao Nie, Heng Zhou, Rui Hu, Ying Li, Ting He, Jiang Zhu, Yunhuang Yang, Maili Liu. Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(23): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657803/.
[6] Li, Tao, Hu, Rui, Xia, Jianbo, Xu, Zhichen, Chen, Dongjuan, Xi, Jinou, Liu, BiFeng, Zhu, Jiang, Li, Ying, Yang, Yunhuang, Liu, Maili. G-triplex: A new type of CRISPR-Cas12a reporter enabling highly sensitive nucleic acid detection. BIOSENSORS & BIOELECTRONICS[J]. 2021, 187: http://dx.doi.org/10.1016/j.bios.2021.113292.
[7] Li, Tao, Zhang, Zhaowei, Wang, Yu, Li, Ying, Zhu, Jiang, Hu, Rui, Yang, Yunhuang, Liu, Maili. Quantitative Proteomic Analysis for High- and Low-Aflatoxin-Yield Aspergillus flavus Strains Isolated From Natural Environments. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.741875.
[8] Hu, Rui, Li, Tao, Yang, Yunhuang, Tian, Yuan, Zhang, Limin, Hu, S. NMR-Based Metabolomics in Cancer Research. CANCER METABOLOMICS: METHODS AND APPLICATIONS[J]. 2021, 1280: 201-218, http://dx.doi.org/10.1007/978-3-030-51652-9_14.
[9] Li, Ying, Li, Tao, Liu, BiFeng, Hu, Rui, Zhu, Jiang, He, Ting, Zhou, Xin, Li, Conggang, Yang, Yunhuang, Liu, Maili. CRISPR-Cas12a trans-cleaves DNA G-quadruplexes. CHEMICAL COMMUNICATIONS[J]. 2020, 56(83): 12526-12529, https://www.webofscience.com/wos/woscc/full-record/WOS:000583607100040.
[10] Nie, Yao, Li, Shuangli, Zhu, Jiang, Hu, Rui, Liu, Maili, He, Ting, Yang, Yunhuang. Chemical shift assignments of a camelid nanobody against aflatoxin B-1. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2019, 13(1): 75-78, https://www.webofscience.com/wos/woscc/full-record/WOS:000463649500016.
[11] Rui Hu, Chao Liu, Jie Xuan, Youzhi Xu, Tao Li, BiFeng Liu, Ying Li, Yunhuang Yang. 3D Hydrodynamic Flow Focusing-based Micromixer Enables High-Resolution Imaging for Studying the Early Folding Kinetics of G-Quadruplex. SENSORS & ACTUATORS: B. CHEMICAL. 2019, 293: 312-320, http://dx.doi.org/10.1016/j.snb.2019.05.026.
[12] Hu, Rui, Liu, Chao, Xuan, Jie, Xu, Youzhi, Li, Tao, Liu, BiFeng, Li, Ying, Yang, Yunhuang. 3D hydrodynamic flow focusing-based micromixer enables high-resolution imaging for studying the early folding kinetics of G-quadruplex. SENSORS AND ACTUATORS B-CHEMICAL[J]. 2019, 293: 312-320, http://dx.doi.org/10.1016/j.snb.2019.05.026.
[13] Hu, Rui, He, Ting, Zhang, Zhaowei, Yang, Yunhuang, Liu, Maili. Safety analysis of edible oil products via Raman spectroscopy. TALANTA[J]. 2019, 191: 324-332, http://dx.doi.org/10.1016/j.talanta.2018.08.074.
[14] He, Ting, Li, Shuangli, Hu, Rui, Ramelot, Theresa A, Kennedy, Michael A, Yang, Yunhuang, Zhu, Jiang, Liu, Maili. Chemical shift assignments of Mb1858 (24-155), a FHA domain-containing protein from Mycobacterium bovis. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2018, 12(1): 1-4, http://dx.doi.org/10.1007/s12104-017-9769-0.
[15] He, Ting, Zhu, Jiang, Nie, Yao, Hu, Rui, Wang, Ting, Li, Peiwu, Zhang, Qi, Yang, Yunhuang. Nanobody Technology for Mycotoxin Detection: Current Status and Prospects. TOXINS[J]. 2018, 10(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000435198800011.
[16] 聂瑶, 李双利, 李涛, 朱江, 胡锐, 蒋滨, 张许, 杨运煌, 刘买利. 溶液中蛋白质寡聚态的表征分析. 中国科学化学[J]. 2017, 47(12): 1450-, http://lib.cqvip.com/Qikan/Article/Detail?id=74668875504849554950484948.
[17] Liang Chunjie, Hu Rui, Ramelot Theresa A, Kennedy Michael A, Li Xuegang, Yang Yunhuang, Zhu Jiang, Liu Maili. Chemical shift assignments of polyketide cyclase_like protein CGL2373 from Corynebacterium glutamicum. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2017, [18] Hu, Rui, Liu, Pian, Chen, Pu, Wu, Liang, Wang, Yao, Feng, Xiaojun, Liu, BiFeng. Encapsulation of single cells into monodisperse droplets by fluorescence-activated droplet formation on a microfluidic chip. TALANTA[J]. 2016, 153: 253-259, http://dx.doi.org/10.1016/j.talanta.2016.03.013.
[19] Hu, Xiaofeng, Hu, Rui, Zhang, Zhaowei, Li, Peiwu, Zhang, Qi, Wang, Min. Development of a multiple immunoaffinity column for simultaneous determination of multiple mycotoxins in feeds using UPLC-MS/MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2016, 408(22): 6027-6036, https://www.webofscience.com/wos/woscc/full-record/WOS:000382681400010.
[20] Ou, Gaozhi, Hu, Rui, Zhang, Liangxiao, Li, Peiwu, Luo, Xinjian, Zhang, Zhaowei. Advanced detection methods for traceability of origin and authenticity of olive oils. ANALYTICAL METHODS[J]. 2015, 7(14): 5731-5739, http://www.irgrid.ac.cn/handle/1471x/981937.
[21] Hu Rui. Advanced detection methods for adulteration of olive oil. Analytical methods. 2015, [22] 汪艳, 胡锐, 刘伟, 乔志仙, 李婷婷. 流式细胞分选技术的质量控制. 中国科技期刊数据库 科研[J]. 2015, 252-253, http://lib.cqvip.com/Qikan/Article/Detail?id=1000000034179.
[23] Wang, Xixian, Hu, Rui, Ge, Anle, Hu, Liang, Wang, Shanshan, Feng, Xiaojun, Du, Wei, Liu, BiFeng. Highly efficient microfluidic sorting device for synchronizing developmental stages of C. elegans based on deflecting electrotaxis. LAB ON A CHIP[J]. 2015, 15(11): 2513-2521, http://www.irgrid.ac.cn/handle/1471x/981936.
[24] Yan, An, Wu, Minjie, Yan, Limei, Hu, Rui, Ali, Imran, Gan, Yinbo. AtEXP2 Is Involved in Seed Germination and Abiotic Stress Response in Arabidopsis. PLOS ONE[J]. 2014, 9(1): http://www.irgrid.ac.cn/handle/1471x/852659.
[25] Li, Chong, Yan, Hui, Zhang, GuoFeng, Gong, WenLiang, Chen, Tao, Hu, Rui, Aldred, Matthew P, Zhu, MingQiang. Photocontrolled Intramolecular Charge/Energy Transfer and Fluorescence Switching of Tetraphenylethene-Dithienylethene-Perylenemonoimide Triad with Donor-Bridge-Acceptor Structure. CHEMISTRY-AN ASIAN JOURNAL[J]. 2014, 9(1): 104-109, http://www.irgrid.ac.cn/handle/1471x/852660.
[26] 肖媛, 刘伟, 汪艳, 左艳霞, 胡锐, 李婷婷, 崔宗斌. 生物样品的扫描电镜制样干燥方法. 实验室研究与探索[J]. 2013, 32(5): 45-53, http://lib.cqvip.com/Qikan/Article/Detail?id=46156948.
[27] Liang Chunjie, Zhu Jiang, Hu Rui, Ramelot Theresa A., Kennedy Michael A., Liu Maili, Yang Yunhuang. Solution NMR structure of RHE_CH02687 from Rhizobium etli: a novel flavonoid-binding protein. PROTEINS. 85(5): 951-956, https://www.webofscience.com/wos/woscc/full-record/WOS:000399380400014.

（1） Cancer metabolomics, Springer, 2020-03, 第 1 作者

   

（ 1 ） 基于蛋白质液晶化定向排列芯片的RDC核磁样品制备新方法研究, 主持, 国家级, 2018-01--2020-12
（ 2 ） 生物磁共振波谱分析中的原子标记和非标记方法研究, 参与, 国家级, 2018-01--2022-12
（ 3 ） 蛋白质机器动态结构的核磁共振研究方法及应用, 参与, 国家级, 2016-07--2021-06
（ 4 ） 用于微量蛋白质研究的微流控芯片核磁检测系统研制, 参与, 部委级, 2018-01--2022-12
（ 5 ） 活体小动物磷脂特异性磁共振谱仪系统研制, 参与, 部委级, 2017-01--2021-12
（ 6 ） 2017年湖北省青年科技晨光计划, 主持, 省级, 2018-01--2018-12
（ 7 ） 人类发育与疾病调控蛋白TGIF1的结构与生物学功能的NMR研究, 主持, 市地级, 2017-01--2018-12
（ 8 ） 肺癌的超高灵敏谱学与成像新技术研究, 参与, 国家级, 2019-09--2024-08
（ 9 ） 细胞中重要调控蛋白质的发现和原 位相互作用的分析新方法, 参与, 国家级, 2020-01--2024-12

（1）Ultra-Sensitive Point-of-Care Detection of PSA Using an Enzymeand Equipment-Free Microfluidic Platform   2019-10-11
（2）Hydrogen-deuterium exchange mass spectrometry characterizes the DNA binding interface and conformational change of protein   中国化学会第13届全国分析化学年会   2018-06-14
（3）氢氘交换质谱技术表征TGIF1-HD与DNA的结合   中国化学会第31届学术年会   2018-05-05
（4）Phosphorylated c-Met Recognition of SHIP2-SH2 Revealed by NMR Spectroscopy   第59届实验核磁共振会议   2018-04-29