基本信息
胡蕴菲  女  博导  中国科学院精密测量科学与技术创新研究院
电子邮件: huyunfei@wipm.ac.cn
通信地址: 湖北省武汉市武昌区小洪山西30号中国科学院精密测量科学与技术创新研究院波谱楼
邮政编码:

招生信息

   
招生专业
070302-分析化学
招生方向
生物大分子核磁共振

教育背景

2005-09--2010-07   北京大学   博士
2001-09--2005-07   北京大学   学士

工作经历

   
工作简历
2019-06~现在, 中国科学院武汉精密测量科学与技术创新研究院, 研究员
2018-06~2019-06,苏州大学, 教授
2012-07~2018-06,北京大学, 副研究员
2010-07~2012-07,北京大学, 博士后

出版信息

   
发表论文
[1] Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W. Hildebrand, Chunlai Chen, Brian K. Kobilka. Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-18, http://dx.doi.org/10.1038/s41467-023-37233-1.
[2] Jun Xu, Qinggong Wang, Harald Hübner, Yunfei Hu, Xiaogang Niu, Haoqing Wang, Shoji Maeda, Asuka Inoue, Yuyong Tao, Peter Gmeiner, Yang Du, Changwen Jin, Brian K. Kobilka. Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-16, http://dx.doi.org/10.1038/s41467-022-35726-z.
[3] Wang, Jiannan, Lin, Yaling, Yang, Ju, Zhang, Qiang, Liu, Maili, Hu, Yunfei, Dong, Xu. Solution structure of the DNA binding domain of Arabidopsis transcription factor WRKY11. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2023, 653: 133-139, http://dx.doi.org/10.1016/j.bbrc.2023.02.072.
[4] Hu, Yunfei, Cheng, Kai, He, Lichun, Zhang, Xu, Jiang, Bin, Jiang, Ling, Li, Conggang, Wang, Guan, Yang, Yunhuang, Liu, Maili. NMR-Based Methods for Protein Analysis. ANALYTICAL CHEMISTRY[J]. 2021, 93(4): 1866-1879, https://www.webofscience.com/wos/woscc/full-record/WOS:000618089100003.
[5] Jiannan Wang, Yaling Lin, Qinjun Zhu, Jingfeng Zhang, Maili Liu, Yunfei Hu. NMR assignments and characterization of the DNA-binding domain of Arabidopsis transcription factor WRKY11: Dedicated to Professor Xiuwen Han on the occasion of her 80th birthday. MAGNETIC RESONANCE LETTERS. 2021, 1(2): 112-120, [6] Xiuyan Ma, Yunfei Hu, Hossein Batebi, Jie Heng, Jun Xu, Xiangyu Liu, Xiaogang Niu, Hongwei Li, Peter W Hildebrand, Changwen Jin, Brian K Kobilka. Analysis of β 2 AR-G s and β 2 AR-G i complex formation by NMR spectroscopy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020, 117(37): 23096-23105, [7] Jia, Moye, Wu, Bo, Yang, Ziyu, Chen, Chunlai, Zhao, Meiping, Hou, Xianhui, Niu, Xiaogang, Jin, Changwen, Hu, Yunfei. Conformational Dynamics of the Periplasmic Chaperone SurA. BIOCHEMISTRY[J]. 2020, 59(35): 3235-3246, https://www.webofscience.com/wos/woscc/full-record/WOS:000570010100006.
[8] Niu Xiaogang, Ma Shuaipeng, Hu Yunfei, Jin Changwen. Backbone 1H, 13C and 15N resonance assignments of the proteasome lid subunit Rpn12 from Saccharomyces cerevisiae. Biomol. NMR Assign.[J]. 2020, [9] Hu, Yunfei, Li, Conggang, He, Lichun, Jin, Changwen, Liu, Maili. Mechanisms of Chaperones as Active Assistant/Protector for Proteins: Insights from NMR Studies. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 38(4): 406-413, http://lib.cqvip.com/Qikan/Article/Detail?id=7101969870.
[10] Xu, Jun, Hu, Yunfei, Kaindl, Jonas, Risel, Philipp, Huebner, Harald, Maeda, Shoji, Niu, Xiaogang, Li, Hongwei, Gmeiner, Peter, Jin, Changwen, Kobilka, Brian K. Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy. MOLECULAR CELL[J]. 2019, 75(1): 53-+, http://dx.doi.org/10.1016/j.molcel.2019.04.028.
[11] Yu, XingChi, Hu, Yunfei, Ding, Jienv, Li, Hongwei, Jin, Changwen. Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(9): 3192-3206, http://dx.doi.org/10.1074/jbc.RA118.006398.
[12] Zhang Wenbo, Zhao Cong, Hu Yunfei, Jin Changwen. NMR 1H, 13C, 15N Backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5. Biomol. NMR Assign.[J]. 2019, [13] Jia Moye, Hu Yunfei, Jin Changwen. 1H, 13C and 15N resonance assignments of the second peptidyl-prolyl isomerase domain of chaperone SurA from Escherichia coli. Biomol. NMR Assign.[J]. 2019, [14] Zhang, Wenbo, Zhao, Cong, Hu, Yunfei, Jin, Changwen. Solution structure of the N-terminal domain of proteasome lid subunit Rpn5. BIOCHEMICALANDBIOPHYSICALRESEARCHCOMMUNICATIONS[J]. 2018, 504(1): 225-230, http://dx.doi.org/10.1016/j.bbrc.2018.08.159.
[15] Wenbo Zhang, Xiaogang Niu, Jienv Ding, Yunfei Hu, Changwen Jin. Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000447591000105.
[16] Niu, Xiaogang, Ding, Jienv, Zhang, Wenbo, Li, Qianwen, Hu, Yunfei, Jin, Changwen. Residue selective N-15 CEST and CPMG experiments for studies of millisecond timescale protein dynamics. JOURNAL OF MAGNETIC RESONANCE[J]. 2018, 293: 47-55, https://www.webofscience.com/wos/woscc/full-record/WOS:000441226500007.
[17] Yu, XingChi, Yang, Chengfeng, Ding, Jienv, Niu, Xiaogang, Hu, Yunfei, Jin, Changwen. Characterizations of the Interactions between Escherichia coil Periplasmic Chaperone HdeA and Its Native Substrates during Acid Stress. BIOCHEMISTRY[J]. 2017, 56(43): 5748-5757, https://www.webofscience.com/wos/woscc/full-record/WOS:000414383400006.
[18] Hu Yunfei, He Peng, Wu Yujie, Jin Changwen. 枯草芽孢杆菌双精氨酸转运系统TatAy蛋白的溶液结构. 波谱学杂志[J]. 2015, 32(2): 291-307, http://lib.cqvip.com/Qikan/Article/Detail?id=665102161.
[19] Hu, Yunfei, Wu, Yujie, Li, Qianwen, Zhang, Wenbo, Jin, Changwen. Solution Structure of Yeast Rpn9 INSIGHTS INTO PROTEASOME LID ASSEMBLY. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2015, 290(11): 6878-6889, http://dx.doi.org/10.1074/jbc.M114.626762.
[20] Ding, Jienv, Yang, Chengfeng, Niu, Xiaogang, Hu, Yunfei, Jin, Changwen. HdeB chaperone activity is coupled to its intrinsic dynamic properties. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000365088400001.
[21] Ye, Qian, Fu, Wenyu, Hu, Yunfei, Jin, Changwen. Long-chain flavodoxin FldB from Escherichia coli. JOURNAL OF BIOMOLECULAR NMR[J]. 2014, 60(4): 283-288, https://www.webofscience.com/wos/woscc/full-record/WOS:000348423800008.
[22] Zhang, Yi, Wang, Lei, Hu, Yunfei, Jin, Changwen. Solution structure of the TatB component of the twin-arginine translocation system. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES[J]. 2014, 1838(7): 1881-1888, https://www.webofscience.com/wos/woscc/full-record/WOS:000336695300022.
[23] Ye, Qian, Hu, Yunfei, Jin, Changwen. Conformational Dynamics of Escherichia coli Flavodoxins in Apo- and Holo-States by Solution NMR Spectroscopy. PLOS ONE[J]. 2014, 9(8): https://doaj.org/article/39cd72b352164ace94dfb36720694b4b.
[24] Wu, Yujie, Hu, Yunfei, Jin, Changwen. H-1, C-13 and N-15 resonance assignments of Rpn9, a regulatory subunit of 26S proteasome from Saccharomyces cerevisiae. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2014, 8(2): 307-311, http://dx.doi.org/10.1007/s12104-013-9506-2.
[25] Wu, Yujie, Hu, Yunfei, Jin, Changwen. H-1, C-13 and N-15 resonance assignments of the VWA domain of Saccharomyces cerevisiae Rpn10, a regulatory subunit of 26S proteasome. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2014, 8(2): 391-394, http://dx.doi.org/10.1007/s12104-013-9525-z.
[26] Zhang, Yi, Hu, Yunfei, Li, Hongwei, Jin, Changwen. Structural Basis for TatA Oligomerization: An NMR Study of Escherichia coli TatA Dimeric Structure. PLOS ONE[J]. 2014, 9(8): http://dx.doi.org/10.1371/journal.pone.0103157.
[27] Ye, Qian, Hu, Yunfei, Jin, Changwen. H-1, C-13 and N-15 resonance assignments of the apo and holo states of flavodoxin YqcA from Escherichia coli. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2014, 8(2): 269-273, https://www.webofscience.com/wos/woscc/full-record/WOS:000342080900011.
[28] Liu, Tingting, Liu, Zixu, Song, Chuanjun, Hu, Yunfei, Han, Zhifu, She, Ji, Fan, Fangfang, Wang, Jiawei, Jin, Changwen, Chang, Junbiao, Zhou, JianMin, Chai, Jijie. Chitin-Induced Dimerization Activates a Plant Immune Receptor. SCIENCE[J]. 2012, 336(6085): 1160-1164, http://dx.doi.org/10.1126/science.1218867.
[29] Hu, Yunfei, Zhang, Xinxin, Shi, Yunming, Zhou, Yanfeng, Zhang, Wei, Su, XiaoDong, Xia, Bin, Zhao, Jindong, Jin, Changwen. Structures of Anabaena Calcium-binding Protein CcbP INSIGHTS INTO CA(2+) SIGNALING DURING HETEROCYST DIFFERENTIATION. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(14): 12381-12388, http://dx.doi.org/10.1074/jbc.M110.201186.
[30] Peng, Heng, Hu, Yunfei, Zhou, Aiguo, Jin, Changwen, Pan, Weiqing. Solution structure of a Plasmodium falciparum AMA-1/MSP 1 chimeric protein vaccine candidate (PfCP-2.9) for malaria. MALARIA JOURNAL[J]. 2010, 9: http://dx.doi.org/10.1186/1475-2875-9-76.
[31] Hong, Jiang, Hu, Yunfei, Li, Congmin, Jia, Zongchao, Xia, Bin, Jin, Changwen. NMR Characterizations of the Ice Binding Surface of an Antifreeze Protein. PLOS ONE[J]. 2010, 5(12): https://doaj.org/article/5ef0a1efde7741deb4ee6cdaa7d5c58b.
[32] Hu, Yunfei, Zhao, Enwei, Li, Hongwei, Xia, Bin, Jin, Changwen. Solution NMR Structure of the TatA Component of the Twin-Arginine Protein Transport System from Gram-Positive Bacterium Bacillus subtilis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(45): 15942-15944, https://www.webofscience.com/wos/woscc/full-record/WOS:000284202200036.
[33] Shao, Xuan, Lu, Jie, Hu, Yunfei, Xia, Bin, Jin, Changwen. Solution structure of the Escherichia cali HybE reveals a novel fold. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2009, 75(4): 1051-1056, https://www.webofscience.com/wos/woscc/full-record/WOS:000266133600023.
[34] 胡蕴菲, 金长文. 蛋白质溶液结构及动力学的核磁共振研究. 波谱学杂志[J]. 2009, 26(2): 151-172, http://lib.cqvip.com/Qikan/Article/Detail?id=30571518.
[35] Li, You, Hu, Yunfei, Fu, Wenyu, Xia, Bin, Jin, Changwen. Solution structure of the bacterial chemotaxis adaptor protein CheW from Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2007, 360(4): 863-867, https://www.webofscience.com/wos/woscc/full-record/WOS:000248502700026.
[36] Wang, Fei, Yang, Fan, Hu, Yunfei, Wang, Xu, Wang, Xinhe, Jin, Changwen, Ma, Jiyan. Lipid interaction converts prion protein to a PrPSc-like proteinase K-Resistant conformation under physiological conditions. BIOCHEMISTRY[J]. 2007, 46(23): 7045-7053, https://www.webofscience.com/wos/woscc/full-record/WOS:000247141700036.
[37] Li, You, Hu, Yunfei, Zhang, Xinxin, Xu, Huimin, Lescop, Ewen, Xia, Bin, Jin, Changwen. Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2007, 282(15): 11078-11083, http://dx.doi.org/10.1074/jbc.M700970200.
[38] Hu, Yunfei, Li, You, Zhang, Xinxin, Guo, Xianrong, Xia, Bin, Jin, Changwen. Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both apo- and holo-forms - Implications for cofactor binding and electron transfer. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2006, 281(46): 35454-35466, https://www.webofscience.com/wos/woscc/full-record/WOS:000241933700079.
[39] Hu Cuiyun, Yu Caifang, Liu Yanhua, Hou Xianhui, Liu Xiaoyun, Hu Yunfei, Jin Changwen. A Hybrid Mechanism for the Synechocystis Arsenate Reductase Revealed by Structural Snapshots during Arsenate Reduction *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 290(36): 22262-22273, http://dx.doi.org/10.1074/jbc.M115.659896.

科研活动

   
科研项目
( 1 ) 细胞中生物大分子结构与相互作用的谱学测量, 参与, 国家级, 2020-01--2024-12
( 2 ) 肠道菌抗酸性分子伴侣HdeA和HdeB的结构、动力学和活化的分子机理研究, 主持, 国家级, 2014-01--2017-12
( 3 ) 黄素氧还蛋白结构、动力学和功能的核磁共振研究, 主持, 国家级, 2012-01--2012-12
参与会议
(1)Molecular basis for proteasome lid assembly via PCI domains revealed by structures and interactions of yeast Rpn9   第五届海峡两岸磁共振研讨会   2015-01-18
(2)Structures and dynamics of bacterial flavodoxins   太平洋地区国际化学大会   2010-12-15