Research Areas
Visible Light-Promoted Synthetic Organic Chemistry
Iron Photocatalysis
Total Synthesis of Complex Natural Products
Education
Sep. 2003 – Jun. 2008: Ph. D. in Organic Chemistry, Zhejiang University
Advisor: Prof. Wei-Min Dai
Sep. 1999 – Jun. 2003: B. S. in Chemistry, Zhejiang University
Advisor: Prof. Wei-Min Dai
Experience
Jul. 2017 – Present: Professor, Shanghai Institute of Organic Chemistry
Jun. 2016 – Jun. 2017: Associate Research Scholar, Princeton University
Jul. 2012 – May. 2016: Postdoctoral Research Associate, Princeton University (With Prof. David W.C. MacMillan)
Nov. 2010 – May 2012: Group Leader, Shanghai Hengrui Pharmaceuticals Co. Ltd.
Jul. 2010 – Oct. 2010: Research Associate, The Hong Kong University of Science and Technology, Hong Kong
(With Prof. Wei-Min Dai)
Jul. 2008 – Jun. 2010: Research Associate, The Scripps Research Institute
(With Prof. K. C. Nicolaou)
Publications
[1] Amy Y. Chan, Atanu Ghosh, Jonathan T. Yarranton, Jack Twilton, Jian Jin, Daniela M. Arias-Rotondo, Holt A. Sakai, James K. McCusker, David W. C. MacMillan. Exploiting the Marcus inverted region for first-row transition metal–based photoredox catalysis. Science[J]. 2023, 382(6667): 191-197, https://www.science.org/doi/10.1126/science.adj0612.
[2] Han, Dongyang, Sun, Jie, Jin, Jian. Picolinamide Ligands: Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Bromocyclopropane and Beyond. Chemistry – An Asian Journal[J]. 2023, 18(2): e202201132-, https://doi.org/10.1002/asia.202201132.
[3] Sun, Jie, Liu, Zhenjiang, Jin, Jian. Modular Synthesis of Triarylamines and Poly(triarylamine)s through a Radical Mechanism. European Journal of Organic Chemistry[J]. 2023, 26(13): e202300081-, http://dx.doi.org/10.1002/ejoc.202300081.
[4] Su, Mincong, Huang, Xia, Lei, Chuanhu, Jin, Jian. Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent. Organic Letters[J]. 2022, 24(1): 354-358, https://doi.org/10.1021/acs.orglett.1c04018.
[5] Hu, Kunjun, Gao, Yunlong, Jin, Jian. Nickel-Catalyzed N-Arylation of Diarylamines for Triarylamine Synthesis. Organometallics[J]. 2022, 41(5): 509-513, https://doi.org/10.1021/acs.organomet.2c00025.
[6] Li, Sasa, Huang, Xia, Gao, Yunlong, Jin, Jian. Oxalamide/Amide Ligands: Enhanced and Copper-Catalyzed C-N Cross-Coupling for Triarylamine Synthesis. ORGANIC LETTERS[J]. 2022, 24(31): 5817-5824, https://doi.org/10.1021/acs.orglett.2c02364.
[7] Li, Sasa, Su, Mincong, Sun, Jie, Hu, Kunjun, Jin, Jian. Visible Light-Promoted Magnesium, Iron, and Nickel Catalysis Enabling C(sp(3))-H Lactonization of 2-Alkylbenzoic Acids. ORGANIC LETTERS[J]. 2021, 23(15): 5842-5847, https://doi.org/10.1021/acs.orglett.1c01984.
[8] Xu, Chang, Shen, Fangqi, Feng, Gaofeng, Jin, Jian. Visible-Light-Induced alpha-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes. ORGANIC LETTERS[J]. 2021, 23(10): 3913-3918, https://doi.org/10.1021/acs.orglett.1c00984.
[9] Han, Dongyang, Li, Sasa, Xia, Siqi, Su, Mincong, Jin, Jian. Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2020, 26(54): 12349-12354, https://doi.org/10.1002/chem.202002800.
[10] Xia, Siqi, Hu, Kunjun, Lei, Chuanhu, Jin, Jian. Intramolecular Aromatic C-H Acyloxylation Enabled by Iron Photocatalysis. ORGANIC LETTERS[J]. 2020, 22(4): 1385-1389, https://doi.org/10.1021/acs.orglett.0c00002.
[11] Yin, Dehang, Su, Dengquan, Jin, Jian. Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids. CELL REPORTS PHYSICAL SCIENCE[J]. 2020, 1(8): 100141-, https://doi.org/10.1016/j.xcrp.2020.100141.
[12] Li, Zhenlong, Jin, Jian, Huang, Shahua. Recent Advances in Transition Metal-Catalyzed Cross-Coupling Reactions Directly Promoted by Visible Light. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 40(3): 563-574, https://doi.org/10.6023/cjoc201910031.
[13] Feng, Guangshou, Wang, Xiaofei, Jin, Jian. Decarboxylative C-C and C-N Bond Formation via Ligand-Accelerated Iron Photocatalysis. European Journal of Organic Chemistry[J]. 2019, 2019(39): 6728-6732, https://doi.org/10.1002/ejoc.201901381.
[14] Li, Zhenlong, Wang, Xiaofei, Xia, Siqi, Jin, Jian. Ligand-Accelerated Iron Photocatalysis Enabling Decarboxylative Alkylation of Heteroarenes. ORGANIC LETTERS[J]. 2019, 21(11): 4259-4265, https://doi.org/10.1021/acs.orglett.9b01439.
[15] Zhao, Hong, Li, Zhenlong, Jin, Jian. Green oxidant H2O2 as a hydrogen atom transfer reagent for visible light-mediated Minisci reaction. NEW JOURNAL OF CHEMISTRY[J]. 2019, 43(32): 12533-12537, https://doi.org/10.1039/c9nj03106e.
[16] Yin, Dehang, Jin, Jian. Transition-Metal-Free Dehydrogenative N-N Coupling of Secondary Amines with KI/KIO4. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 2019(33): 5646-5649, https://doi.org/10.1002/ejoc.201900763.
[17] Zhao, Hong, Jin, Jian. Visible Light-Promoted Aliphatic C-H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent. ORGANIC LETTERS[J]. 2019, 21(16): 6179-6184, https://doi.org/10.1021/acs.orglett.9b01635.
[18] Jin, Jian, MacMillan, David W C. Direct alpha-Arylation of Ethers through the Combination of Photoredox-Mediated C-H Functionalization and the Minisci Reaction. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(5): 1565-1569, https://doi.org/10.1002/anie.201410432.
[19] Jin, Jian, MacMillan, David W C. Alcohols as alkylating agents in heteroarene C-H functionalization. NATURE[J]. 2015, 525(7567): 87-90, https://doi.org/10.1038/nature14885.
[20] Wu, Dongdong, Li, Huoming, Jin, Jian, Wu, Jinlong, Dai, WeiMin. Total Synthesis of Amphidinolide T3 Using Ring-Closing Metathesis and Asymmetric Dihydroxylation Strategy. SYNLETT[J]. 2011, 895-898, https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0030-1259706.
[21] Nicolaou, K C, Aversa, Robert J, Jin, Jian, Rivas, Fatima. Synthesis of the ABCDEFG Ring System of Maitotoxin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(19): 6855-6861, https://doi.org/10.1021/ja102260q.
[22] Dai, WeiMin, Chen, Yile, Jin, Jian, Wu, Jinlong, Lou, Jianshu, He, Qiaojun. Total synthesis of amphidinolide X and its 12Z-isomer by formation of the C12-C13 trisubstituted double bond via ring-closing metathesis. SYNLETT[J]. 2008, 1737-1741, https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2008-1077885.
[23] Jin, Jian, Chen, Yile, Li, Yannian, Wu, Jinlong, Dai, WeiMin. Total synthesis of amphidinolide y by formation of trisubstituted (E)-double bond via ring-closing metathesis of densely functionalized alkenes. ORGANIC LETTERS[J]. 2007, 9(13): 2585-2588, https://doi.org/10.1021/ol0710360.
[24] Chen, Yile, Jin, Jian, Wu, Jinlong, Dai, WeiMin. A new synthesis of tetrahydrofuran fragment of amphidinolides X and Y. SYNLETT[J]. 2006, 1177-1180, https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2006-932487.