基本信息
雷和花 女 硕导 中国科学院精密测量科学与技术创新研究院
电子邮件： leihh@wipm.ac.cn
通信地址： 武汉市武昌小洪山西30号物数所波谱楼
邮政编码： 430071
研究领域
环境毒理和环境健康代谢组学研究
招生信息
招生专业
070302-分析化学
招生方向
代谢组学
教育背景
2005-09--2008-06 中国科学院水生生物研究所 博士研究生博士学位
2002-09--2005-06 中南民族大学 研究生硕士学位
1997-09--2001-06 中南民族大学 本科学士学位
2002-09--2005-06 中南民族大学 研究生硕士学位
1997-09--2001-06 中南民族大学 本科学士学位
工作经历
工作简历
2014-10~现在, 中国科学院武汉物理与数学研究所, 副研究员
2011-05~2014-09,中国科学院武汉物理与数学研究所, 助理研究员
2008-07~2011-04,中国科学院武汉物理与数学研究所, 博士后
2011-05~2014-09,中国科学院武汉物理与数学研究所, 助理研究员
2008-07~2011-04,中国科学院武汉物理与数学研究所, 博士后
出版信息
发表论文
[1] Chen, Yujie, Lei, Hehua, Cao, Zheng, Zhang, Cui, Liu, Lijun, Gao, Xin, Qin, Quanzhi, Zhang, Limin, Chen, Gang. In vivo and in vitro insights into the anti-hyperuricemic effects of sacha inchi ( plukenetia volubilis l. ) leaves extract rich in polyphenols. FOOD BIOSCIENCE[J]. 2024, 第 2 作者59: http://dx.doi.org/10.1016/j.fbio.2024.103864.
[2] Chen, Chuan, Cao, Zheng, Lei, Hehua, Zhang, Cui, Wu, Mengjing, Huang, Shaohua, Li, Xinzhi, Xie, Denghui, Liu, Maili, Zhang, Limin, Chen, Gang. Microbial Tryptophan Metabolites Ameliorate Ovariectomy-Induced Bone Loss by Repairing Intestinal AhR-Mediated Gut-Bone Signaling Pathway. ADVANCED SCIENCE[J]. 2024, 第 3 作者11(36): http://dx.doi.org/10.1002/advs.202404545.
[3] Song, Yuchen, Lei, Hehua, Cao, Zheng, Zhang, Cui, Chen, Chuan, Wu, Mengjing, Zhang, Huabao, Du, Ruichen, Lijun, Liu, Chen, Xiaoyu, Zhang, Limin. Long-Term Triclocarban Exposure Induced Enterotoxicity by Triggering Intestinal AhR-Mediated Inflammation and Disrupting Microbial Community in Mice. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2024, 第 2 作者37(4): 658-668, http://dx.doi.org/10.1021/acs.chemrestox.4c00042.
[4] Li, MeiXin, Hu, Sheng, Lei, HeHua, Yuan, Meng, Li, Xu, Hou, WenKui, Huang, XiangJie, Xiao, BingWen, Yu, TengXiang, Zhang, XiaoHui, Wu, XiaoTing, Jing, WenQiang, Lee, HyeonJeong, Li, JuanJuan, Fu, Da, Zhang, LiMin, Yan, Wei. Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice. NATURE COMMUNICATIONS[J]. 2024, 第 3 作者15(1): http://dx.doi.org/10.1038/s41467-024-54706-z.
[5] Deng, Dazhi, Lei, Hehua, Cao, Zheng, Zhang, Cui, Du, Ruichen, Gao, Xin, Wei, Junjie, Lu, Yibo, Zhou, Xiangzhen, Zhang, Limin. Microbiome-gut-brain axis contributes to patients and Bama miniature pigs with acute large ischemic stroke. FRONTIERS IN NEUROSCIENCE[J]. 2024, 第 2 作者18: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272540/.
[6] Wu, Mengjing, Chen, Chuan, Lei, Hehua, Cao, Zheng, Zhang, Cui, Du, Ruichen, Zhang, Ce, Song, Yuchen, Qin, Mengyu, Zhou, Jinlin, Lu, Yujing, Wang, Xian, Zhang, Limin. Dietary Isoquercetin Ameliorates Bone Loss via Restoration of the Gut Microbiota and Lipopolysaccharide-Triggered Inflammatory Status in Ovariectomy Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2023, 第 3 作者71(43): 15981-15990, http://dx.doi.org/10.1021/acs.jafc.3c00205.
[7] Shuilin Wei, Xi Ye, Hehua Lei, Zheng Cao, Chuan Chen, Cui Zhang, Li Zhang, Chunxia Chen, Xiaoxia Liu, Limin Zhang, Xiaoyu Chen. Multiomics analyses reveal dose-dependent effects of dicofol exposure on host metabolic homeostasis and the gut microbiota in mice. CHEMOSPHERE. 2023, 第 3 作者341: http://dx.doi.org/10.1016/j.chemosphere.2023.139997.
[8] Cui Zhang, Zheng Cao, Hehua Lei, Chuan Chen, Ruichen Du, Yuchen Song, Ce Zhang, Jinlin Zhou, Yujing Lu, Luodong Huang, Peihong Shen, Limin Zhang. Discovery of a novel small molecule with efficacy in protecting against inflammation in vitro and in vivo by enhancing macrophages activation. BIOMEDICINE & PHARMACOTHERAPY[J]. 2023, 第 3 作者165: 115273, http://dx.doi.org/10.1016/j.biopha.2023.115273.
[9] Chen, Chuan, Lei, Hehua, Zhao, Yitao, Hou, Yu, Zheng, Hui, Zhang, Ce, Cao, Zheng, Wu, Fang, Chen, Gui, Song, Yuchen, Zhang, Cui, Zhou, Jinlin, Lu, Yujing, Xie, Denghui, Zhang, Limin. A novel small molecule effectively ameliorates estrogen deficiency-induced osteoporosis by targeting the gut-bone signaling axis. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2023, 第 2 作者954: http://dx.doi.org/10.1016/j.ejphar.2023.175868.
[10] Zhang, Ce, Shi, Zunji, Lei, Hehua, Wu, Fang, Chen, Chuan, Cao, Zheng, Song, Yuchen, Zhang, Cui, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2023, 第 3 作者71(20): 7723-7733, http://dx.doi.org/10.1021/acs.jafc.3c00952.
[11] Qin, Mengyu, Lei, Hehua, Song, Yuchen, Wu, Mengjing, Chen, Chuan, Cao, Zheng, Zhang, Cui, Du, Ruichen, Zhang, Ce, Wang, Xian, Zhang, Limin. Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and microbial community in mice. FOOD AND CHEMICAL TOXICOLOGY[J]. 2023, 第 2 作者178: http://dx.doi.org/10.1016/j.fct.2023.113908.
[12] Shi, Zunji, Zhang, Ce, Lei, Hehua, Chen, Chuan, Cao, Zheng, Song, Yuchen, Chen, Gui, Wu, Fang, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 第 3 作者70(46): 14732-14743, http://dx.doi.org/10.1021/acs.jafc.2c06212.
[13] Su, Henghai, Yuan, Peihong, Lei, Hehua, Zhang, Li, Deng, Dazhi, Zhang, Limin, Chen, Xiaoyu. Long-term chronic exposure to di-(2-ethylhexyl)-phthalate induces obesity via disruption of host lipid metabolism and gut microbiota in mice. CHEMOSPHERE[J]. 2022, 第 3 作者287: http://dx.doi.org/10.1016/j.chemosphere.2021.132414.
[14] Song, Yuchen, Zhang, Cui, Lei, Hehua, Qin, Mengyu, Chen, Gui, Wu, Fang, Chen, Chuan, Cao, Zheng, Zhang, Ce, Wu, Mengjing, Chen, Xiaoyu, Zhang, Limin. Characterization of triclosan-induced hepatotoxicity and triclocarban- triggered enterotoxicity in mice by multiple omics screening. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2022, 第 3 作者 通讯作者 838: http://dx.doi.org/10.1016/j.scitotenv.2022.156570.
[15] Wu, Fang, Lei, Hehua, Chen, Gui, Chen, Chuan, Song, Yuchen, Cao, Zheng, Zhang, Ce, Zhang, Cui, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Multiomics Analyses Reveal That Long-Term Intake of Hesperetin-7-O-glucoside Modulates the Gut Microbiota and Bile Acid Metabolism in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 第 2 作者70(47): 14831-14840, http://dx.doi.org/10.1021/acs.jafc.2c05053.
[16] Chen, Gui, Huang, Jiajun, Lei, Hehua, Wu, Fang, Chen, Chuan, Song, Yuchen, Cao, Zheng, Zhang, Ce, Zhang, Cui, Ma, Yuxi, Huang, Mingtao, Zhou, Jinlin, Lu, Yujing, Zhao, Yanxia, Zhang, Limin. Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape. BIOMEDICINE & PHARMACOTHERAPY[J]. 2022, 第 3 作者153: https://doaj.org/article/a461312a0457479da0f82d5ee076bb57.
[17] Shi, Zunji, Lei, Hehua, Chen, Gui, Yuan, Peihong, Cao, Zheng, Ser, HooiLeng, Zhu, Xuehang, Wu, Fang, Liu, Caixiang, Dong, Manyuan, Song, Yuchen, Guo, Yangyang, Chen, Chuan, Hu, Kexin, Zhu, Yifan, Zeng, Xinan, Zhou, Jinlin, Lu, Yujing, Patterson, Andrew D, Zhang, Limin. Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice. MSYSTEMS[J]. 2021, 第 2 作者6(1): https://doaj.org/article/dad310dbc35846e993460fb9a4563b07.
[18] Lei, Hehua, Song, Yuchen, Dong, Manyuan, Chen, Gui, Cao, Zheng, Wu, Fang, Chen, Chuan, Zhang, Ce, Liu, Caixiang, Shi, Zunji, Zhang, Limin. Metabolomics safety assessments of microcystin exposure via drinking water in rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2021, 第 1 作者212: https://doaj.org/article/979bb0447d85483eae937f03ae000591.
[19] Shi, Zunji, Chen, Gui, Cao, Zheng, Wu, Fang, Lei, Hehua, Chen, Chuan, Song, Yuchen, Liu, Caixiang, Li, Jinquan, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 第 5 作者69(13): 3982-3991, http://dx.doi.org/10.1021/acs.jafc.0c07467.
[20] Wu, Fang, Lei, Hehua, Chen, Gui, Chen, Chuan, Song, Yuchen, Cao, Zheng, Zhang, Ce, Zhang, Cui, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 第 2 作者69(43): 12753-12762, http://dx.doi.org/10.1021/acs.jafc.1c05793.
[21] Wu, Fang, Shi, Zunji, Lei, Hehua, Chen, Gui, Yuan, Peihong, Cao, Zheng, Chen, Chuan, Zhu, Xuehang, Liu, Caixiang, Dong, Manyuan, Song, Yuchen, Guo, Yangyang, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 第 3 作者69(5): 1478-1486, https://www.webofscience.com/wos/woscc/full-record/WOS:000619637900004.
[22] Chen, Gui, Cao, Zheng, Shi, Zunji, Lei, Hehua, Chen, Chuan, Yuan, Peihong, Wu, Fang, Liu, Caixiang, Dong, Manyuan, Song, Yuchen, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model. BIOMEDICINE & PHARMACOTHERAPY[J]. 2021, 第 4 作者140: https://doaj.org/article/b13e029017774d319fa1f08a3e8bb601.
[23] Manyuan Dong, Peihong Yuan, Yuchen Song, Hehua Lei, Gui Chen, Xuehang Zhu, Fang Wu, Chuan Chen, Caixiang Liu, Zunji Shi, Limin Zhang. In vitro effects of Triclocarban on adipogenesis in murine preadipocyte and human hepatocyte. JOURNAL OF HAZARDOUS MATERIALS[J]. 2020, 第 4 作者 通讯作者 399(null):
[24] Yuan, Peihong, Dong, Manyuan, Lei, Hehua, Xu, Guangyong, Chen, Gui, Song, Yuchen, Ma, Jianfeng, Cheng, Liming, Zhang, Limin. Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice. ENVIRONMENTAL POLLUTION[J]. 2020, 第 3 作者259: http://dx.doi.org/10.1016/j.envpol.2019.113820.
[25] 郭阳阳, 雷和花, 王玉兰. 亚甲基丁二酸在雄性C57BL/6J小鼠体内半数致死量和半衰期的测定. 上海交通大学学报(医学版)[J]. 2020, 第 2 作者40(11): 1473-1476, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzMw4l1HSOJoTa6GJaEm_ulFfIE3ao4VCAmfzHBFS3I8-&uniplatform=NZKPT.
[26] 张利民, Fang Wu, Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Chuan Chen, Xuehang Zhu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Jinlin Zhou, Yujing Lu, and Limin Zhang. Short-Term Intake of Hesperetin-7‑O‑Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 69: 1478-1486,
[27] Journal of Hazardous Materials. 2020, 通讯作者
[28] Dong, Manyuan, Xu, Xiaoyi, Huang, Qingxia, Lei, Hehua, Xu, Guangyong, Ma, Jianfeng, Hatzakis, Emmanuel, Wang, Xian, Zhang, Limin. Dose-Dependent Effects of Triclocarban Exposure on Lipid Homeostasis in Rats. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 第 4 作者 通讯作者 32(11): 2320-2328, http://dx.doi.org/10.1021/acs.chemrestox.9b00316.
[29] 陈炜, 雷和花, 宋涛, 张利民, 雷皓. 小鼠脑代谢物活体磁共振波谱分析及与离体样本磁共振波谱与质谱定量分析的比较研究. 分析化学[J]. 2019, 第 2 作者47(10): 1671-1679,
[30] 黄庆霞, 雷和花, 唐惠儒, 王玉兰. 基于超高效液相色谱-质谱联用技术的神经酰胺定量分析. 上海交通大学学报(医学版)[J]. 2019, 第 2 作者39(12): 1353-1359, http://lib.cqvip.com/Qikan/Article/Detail?id=7100826127.
[31] Huang, Qingxia, Lei, Hehua, Dong, Manyuan, Tang, Huiru, Wang, Yulan. Quantitative analysis of 10 classes of phospholipids by ultrahigh-performance liquid chromatography tandem triple-quadrupole mass spectrometry. ANALYST[J]. 2019, 第 2 作者144(13): 3980-3987,
[32] Liu, Caixiang, Chen, Fangfang, Zhang, Jingtao, Liu, Laixing, Lei, Hehua, Li, Heping, Wang, Yulan, Liao, YuCai, Tang, Huiru. Metabolic Changes of Fusarium graminearum Induced by TPS Gene Deletion. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 第 5 作者18(9): 3317-3327, http://dx.doi.org/10.1021/acs.jproteome.9b00259.
[33] Lei Hehua. Quantitative analysis of 10 classes of phospholipids by ultrahighperformance liquid chromatography tandem triple-quadrupole mass spectrometer. Analyst. 2019, 第 1 作者
[34] Huang, Qingxia, Lei, Hehua, Ding, Laifeng, Wang, Yulan. Stimulated phospholipid synthesis is key for hepatitis B virus replications. SCIENTIFIC REPORTS[J]. 2019, 第 2 作者9(1): http://dx.doi.org/10.1038/s41598-019-49367-8.
[35] Chen, Fangfang, Liu, Caixiang, Zhang, Jingtao, Lei, Hehua, Li, HePing, Liao, YuCai, Tang, Huiru. Combined Metabonomic and Quantitative RT-PCR Analyses Revealed Metabolic Reprogramming Associated with Fusarium graminearum Resistance in Transgenic Arabidopsis thaliana. FRONTIERS IN PLANT SCIENCE[J]. 2018, 第 4 作者8: https://doaj.org/article/40f9f6cf2eaf459192418c5ebb208020.
[36] Wang, Qi, Zeng, Shaohua, Wu, Xiangyu, Lei, Hehua, Wang, Ying, Tang, Huiru. Interspecies Developmental Differences in Metabonomic Phenotypes of Lycium ruthenicum and L-barbarum Fruits. JOURNAL OF PROTEOME RESEARCH[J]. 2018, 第 4 作者17(9): 3223-3236, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364700025.
[37] Lei Hehua. ombined Metabonomic and Quantitative RT-PCR Analyses Revealed Metabolic Reprogramming Associated with Fusarium graminearum Resistance in Transgenic Arabidopsis thaliana. FRONTIERS IN PLANT SCIENCE. 2018, 第 1 作者
[38] Wang, Jin, Zhou, Lihong, Lei, Hehua, Hao, Fuhua, Liu, Xin, Wang, Yulan, Tang, Huiru. Simultaneous Quantification of Amino Metabolites in Multiple Metabolic Pathways Using Ultra-High Performance Liquid Chromatography with Tandemmass Spectrometry. SCIENTIFIC REPORTS[J]. 2017, 第 3 作者7(1): https://doaj.org/article/e67b50712e324c568660366d51ee3e68.
[39] Liu, Caixiang, Du, Ba, Hao, Fuhua, Lei, Hehua, Wan, Qianfen, He, Guangcun, Wang, Yulan, Tang, Huiru. Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants. PLANT BIOTECHNOLOGY JOURNAL[J]. 2017, 第 4 作者15(10): 1346-1357,
[40] Liu, Caixiang, Ding, Feng, Hao, Fuhua, Yu, Men, Lei, Hehua, Wu, Xiangyu, Zhao, Zhengxi, Guo, Hongxiang, Yin, Jun, Wang, Yulan, Tang, Huiru. Reprogramming of Seed Metabolism Facilitates Pre-harvest Sprouting Resistance of Wheat. SCIENTIFIC REPORTS[J]. 2016, 第 5 作者6: http://dx.doi.org/10.1038/srep20593.
[41] Wu, Junfang, Fu, Bin, Lei, Hehua, Tang, Huiru, Wang, Yulan. GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE. NEUROSCIENCE[J]. 2016, 第 3 作者332: 160-169, http://dx.doi.org/10.1016/j.neuroscience.2016.06.049.
[42] Li, Hongde, Zhu, Wandi, Zhang, Leike, Lei, Hehua, Wu, Xiangyu, Guo, Lin, Chen, Xinwen, Wang, Yulan, Tang, Huiru. The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment. SCIENTIFIC REPORTS[J]. 2015, 第 4 作者5: http://dx.doi.org/10.1038/srep08421.
[43] Jiang, Limiao, Zhao, Xiuju, Huang, Chongyang, Lei, Hehua, Tang, Huiru, Wang, Yulan. Dynamic changes in metabolic profiles of rats subchronically exposed to mequindox. MOLECULAR BIOSYSTEMS[J]. 2014, 第 4 作者10(11): 2914-2922, http://dx.doi.org/10.1039/c4mb00218k.
[44] Zhang, Limin, Wang, Yulan, Xu, Yunxiang, Lei, Hehua, Zhao, Ying, Li, Huihui, Lin, Xiaosheng, Chen, Guizhen, Tang, Huiru. Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism. SCIENTIFIC REPORTS[J]. 2014, 第 4 作者4: http://dx.doi.org/10.1038/srep03641.
[45] 李莉, 雷和花, 侯杰, 龙萌, 苏玉晶, 吴宁. 微囊藻毒素在银鲫肠道中的累积及其病理学影响. 生态毒理学报[J]. 2014, 第 2 作者9(6): 1189, http://lib.cqvip.com/Qikan/Article/Detail?id=663202070.
[46] Zhu, Xiaoyang, Lei, Hehua, Wu, Junfang, Li, Jia V, Tang, Huiru, Wang, Yulan. Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection. JOURNAL OF PROTEOME RESEARCH[J]. 2014, 第 2 作者13(10): 4436-4445, http://dx.doi.org/10.1021/pr500770x.
[47] Li, Li, Xie, Ping, Lei, Hehua, Zhang, Xuezhen. Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus). TOXICON[J]. 2013, 第 3 作者70: 62-69, http://dx.doi.org/10.1016/j.toxicon.2013.03.022.
[48] An, Yanpeng, Xu, Wenxin, Li, Huihui, Lei, Hehua, Zhang, Limin, Hao, Fuhua, Duan, Yixuan, Yan, Xing, Zhao, Ying, Wu, Junfang, Wang, Yulan, Tang, Huiru. High-Fat Diet Induces Dynamic Metabolic Alterations in Multiple Biological Matrices of Rats. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 第 4 作者12(8): 3755-3768, http://dx.doi.org/10.1021/pr400398b.
[49] Li, Huihui, An, Yanpeng, Zhang, Lulu, Lei, Hehua, Zhang, Limin, Wang, Yulan, Tang, Huiru. Combined NMR and GC-MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 第 4 作者12(12): 5520-5534, http://dx.doi.org/10.1021/pr400440d.
[50] Huang, Chongyang, Lei, Hehua, Zhao, Xiuju, Tang, Huiru, Wang, Yulan. Metabolic Influence of Acute Cyadox Exposure on Kunming Mice. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 第 2 作者12(1): 537-538, http://dx.doi.org/10.1021/pr301033a.
[51] Zhao, XiuJu, Hao, Fuhua, Huang, Chongyang, Rantalainen, Mattias, Lei, Hehua, Tang, Huiru, Wang, Yulan. Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling. JOURNAL OF PROTEOME RESEARCH[J]. 2012, 第 5 作者11(9): 4712-4721, http://dx.doi.org/10.1021/pr300533a.
[52] Zhao, XiuJu, Huang, Chongyang, Lei, Hehua, Nie, Xiu, Tang, Huiru, Wang, Yulan. Dynamic Metabolic Response of Mice to Acute Mequindox Exposure. JOURNAL OF PROTEOME RESEARCH[J]. 2011, 第 3 作者10(11): 5183-5190, http://dx.doi.org/10.1021/pr2006457.
[2] Chen, Chuan, Cao, Zheng, Lei, Hehua, Zhang, Cui, Wu, Mengjing, Huang, Shaohua, Li, Xinzhi, Xie, Denghui, Liu, Maili, Zhang, Limin, Chen, Gang. Microbial Tryptophan Metabolites Ameliorate Ovariectomy-Induced Bone Loss by Repairing Intestinal AhR-Mediated Gut-Bone Signaling Pathway. ADVANCED SCIENCE[J]. 2024, 第 3 作者11(36): http://dx.doi.org/10.1002/advs.202404545.
[3] Song, Yuchen, Lei, Hehua, Cao, Zheng, Zhang, Cui, Chen, Chuan, Wu, Mengjing, Zhang, Huabao, Du, Ruichen, Lijun, Liu, Chen, Xiaoyu, Zhang, Limin. Long-Term Triclocarban Exposure Induced Enterotoxicity by Triggering Intestinal AhR-Mediated Inflammation and Disrupting Microbial Community in Mice. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2024, 第 2 作者37(4): 658-668, http://dx.doi.org/10.1021/acs.chemrestox.4c00042.
[4] Li, MeiXin, Hu, Sheng, Lei, HeHua, Yuan, Meng, Li, Xu, Hou, WenKui, Huang, XiangJie, Xiao, BingWen, Yu, TengXiang, Zhang, XiaoHui, Wu, XiaoTing, Jing, WenQiang, Lee, HyeonJeong, Li, JuanJuan, Fu, Da, Zhang, LiMin, Yan, Wei. Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice. NATURE COMMUNICATIONS[J]. 2024, 第 3 作者15(1): http://dx.doi.org/10.1038/s41467-024-54706-z.
[5] Deng, Dazhi, Lei, Hehua, Cao, Zheng, Zhang, Cui, Du, Ruichen, Gao, Xin, Wei, Junjie, Lu, Yibo, Zhou, Xiangzhen, Zhang, Limin. Microbiome-gut-brain axis contributes to patients and Bama miniature pigs with acute large ischemic stroke. FRONTIERS IN NEUROSCIENCE[J]. 2024, 第 2 作者18: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272540/.
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科研活动
科研项目
（ 1 ） 微囊藻毒素低剂量暴露影响大鼠代谢组变化的核磁共振研究, 主持, 国家级, 2013-01--2015-12