1. development of efficient and practical catalytic asymmetric methodology

2. development of high efficient organocatalyst and organometallic catalyst

3. high efficient synthesis of bioactive natural products and pharmaceuticals

   

070303-有机化学

不对称催化
天然产物合成

2007-10--2010-09 东京大学 博士
2004-09--2007-06 南开大学 硕士
2000-09--2004-06 南开大学 学士

   

2012-04--2014-10 日本微生物化学研究所 JSPS特别研究员
2011-04--2012-03 哈佛大学 博士后
2010-10--2011-03 东京大学 博士后

   

[1] 殷亮, 张海军. 一种(R)-(-)-massoialactone的制备方法. CN: CN110551089A, 2019-12-10.

[2] 殷亮, 钟锋. 一种5-苯基戊醇类化合物及其中间体的合成方法. CN: CN110551069A, 2019-12-10.

   

[1] Wang, SiQing, Liu, ZongCi, Yue, WenJun, Yin, Liang. Copper(I)-Catalyzed Asymmetric Vinylogous Aldol-Type Reaction of Allylazaarenes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(9): 4604-4608, http://dx.doi.org/10.1002/anie.202013207.
[2] Gu Xingwei, Xu Liwen. Copper(I)-Catalyzed Regioselective Asymmetric Addition of 1,4-Pentadiene to Ketones. CHINESE JOURNAL OF ORGANIC CHEMISTRY. 2021, 41(6): 2528-2529, http://dx.doi.org/10.6023/cjoc202100046.
[3] Shi, ChangYun, Eun, Jungmin, Newhouse, Timothy R, Yin, Liang. Copper(I)-Catalyzed Asymmetric Conjugate 1,6-, 1,8-, and 1,10-Borylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(17): 9493-9499, http://dx.doi.org/10.1002/anie.202016081.
[4] Li, YanBo, Tian, Hu, Yin, Liang. Copper(I)-Catalyzed Asymmetric 1,4-Conjugate Hydrophosphination of alpha,beta-Unsaturated Amides. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(47): 20098-20106, https://www.webofscience.com/wos/woscc/full-record/WOS:000595544800042.
[5] Zhong, Feng, Xue, QiYan, Yin, Liang. Construction of Chiral 2,3-Allenols through a Copper(I)-Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(4): 1562-1566, https://www.webofscience.com/wos/woscc/full-record/WOS:000501330900001.
[6] Yue WenJun, Xiao JunZhao, Zhang Shuai, Yin Liang. Rapid Synthesis of Chiral 1,2-Bisphosphine Derivatives through Copper(I)-Catalyzed Asymmetric Conjugate Hydrophosphination. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(18): 7057-7062, http://dx.doi.org/10.1002/anie.201916076.
[7] 殷亮. Asymmetric Borylative Coupling of Vinylazaarenes and Ketones Catalyzed by a Copper(I) Complex. CCSCHEMISTRY. 2020, [8] Yue, WenJun, Zhang, ChengYuan, Yin, Liang. Asymmetric Vinylogous Aldol-type Reactions of Aldehydes with Allyl Phosphonate and Sulfone. ISCIENCE[J]. 2019, 14: 88-+, http://dx.doi.org/10.1016/j.isci.2019.03.010.
[9] HaiJun Zhang, YanCheng Xie, Liang Yin. Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines. NATURE COMMUNICATIONS[J]. 2019, 10(1): https://doaj.org/article/ed7b3065028a4df28df652bc7064c488.
[10] Gan, XuCheng, Zhang, Qi, Jia, XueShun, Yin, Liang. Asymmetric Construction of Fluoroalkyl Tertiary Alcohols through a Three-Component Reaction of (Bpin)(2), 1,3-Enynes, and Fluoroalkyl Ketones Catalyzed by a Copper(I) Complex. ORGANIC LETTERS[J]. 2018, 20(4): 1070-1073, http://www.corc.org.cn/handle/1471x/2181604.
[11] Li, Hui, Yin, Liang. Recent progress on direct catalytic asymmetric vinylogous reactions. TETRAHEDRON LETTERS[J]. 2018, 59(47): 4121-4135, http://dx.doi.org/10.1016/j.tetlet.2018.10.012.
[12] Zhang, HaiJun, Yin, Liang. Asymmetric Synthesis of alpha,beta-Unsaturated delta-Lactones through Copper(I)-Catalyzed Direct Vinylogous Aldol Reaction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(38): 12270-12279, [13] Zhong, Feng, Yue, Wen Jun, Zhang, HaiJun, Zhang, ChengYuan, Yin, Liang. Catalytic Asymmetric Construction of Halogenated Stereogenic Carbon Centers by Direct Vinylogous Mannich-Type Reaction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(45): 15170-15175, http://dx.doi.org/10.1021/jacs.8b09484.
[14] Li, ZhaoKun, Jia, XueShun, Yin, Liang. Recent Advances in Copper(II)-Mediated or -Catalyzed C-H Functionalization. SYNTHESIS-STUTTGART[J]. 2018, 50(21): 4165-4188, http://www.corc.org.cn/handle/1471x/2171886.
[15] Zhang, HaiJun, Schuppe, Alexander W, Pan, ShiTao, Chen, JinXiang, Wang, BoRan, Newhouse, Timothy R, Yin, Liang. Copper-Catalyzed Vinylogous Aerobic Oxidation of Unsaturated Compounds with Air. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(15): 5300-5310, http://dx.doi.org/10.1021/jacs.8b01886.
[16] Yidan, E, Yuan, Teng, Yin, Liang, Xu, Youjun. Asymmetric sulfenylation of 3-CF3-Oxindoles through organocatalysis with a quinidine derivative. TETRAHEDRON LETTERS[J]. 2017, 58(26): 2521-2524, http://dx.doi.org/10.1016/j.tetlet.2017.05.015.
[17] Zhang, HaiJun, Shi, ChangYun, Zhong, Feng, Yin, Liang. Direct Asymmetric Vinylogous and Bisvinylogous Mannich-Type Reaction Catalyzed by a Copper(I) Complex. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(6): 2196-2199, https://www.webofscience.com/wos/woscc/full-record/WOS:000394482200018.
[18] Li, Xiuming, Jia, Xueshun, Yin, Liang. Recent Progress on Post-Ugi Reaction. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 37(9): 2237-2249, http://dx.doi.org/10.6023/cjoc201704026.
[19] Li Xiuming, Jia Xueshun, Yin Liang. Recent Progress on Post-Ugi Reaction. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 37(9): 2237-2249, http://doi.org/10.6023/cjoc201704026.
[20] Brewitz, Lennart, Arteaga, Fernando Arteaga, Yin, Liang, Alagiri, Kaliyamoorthy, Kumagai, Naoya, Shibasaki, Masakatsu. Direct Catalytic Asymmetric Mannich-Type Reaction of alpha- and beta-Fluorinated Amides. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(50): 15929-15939, https://www.webofscience.com/wos/woscc/full-record/WOS:000367562800052.
[21] Majumdar, Nilanjana, Saito, Akira, Yin, Liang, Kumagai, Naoya, Shibasaki, Masakatsu. Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides. ORGANIC LETTERS[J]. 2015, 17(13): 3362-3365, https://www.webofscience.com/wos/woscc/full-record/WOS:000357623900045.
[22] 殷亮. Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to alpha,beta-Unsaturated Thioamides. Angewandte Chemie International Edition. 2014, [23] Yin, Liang, Brewitz, Lennart, Kumagai, Naoya, Shibasaki, Masakatsu. Catalytic Generation of alpha-CF3 Eno late: Direct Catalytic Asymmetric Mannich-Type Reaction of alpha-CF3 Amide. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 136(52): 17958-17961, https://www.webofscience.com/wos/woscc/full-record/WOS:000347438300017.
[24] Yin, Liang, Otsuka, Yasunari, Takada, Hisashi, Mouri, Shinsuke, Yazaki, Ryo, Kumagai, Naoya, Shibasaki, Masakatsu. Direct Catalytic Asymmetric Alkynylation of Ketoimines. ORGANIC LETTERS[J]. 2013, 15(3): 698-701, https://www.webofscience.com/wos/woscc/full-record/WOS:000314559000070.
[25] Yin, Liang, Bao, Youmei, Kumagai, Naoya, Shibasaki, Masakatsu. Catalytic Asymmetric Hydrophosphonylation of Ketimines. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(28): 10338-10341, https://www.webofscience.com/wos/woscc/full-record/WOS:000322103000040.
[26] Yin, Liang, Takada, Hisashi, Kumagai, Naoya, Shibasaki, Masakatsu. Direct Catalytic Asymmetric Vinylogous Mannich-Type Reaction of gamma-Butenolides with Ketimines. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(28): 7310-7313, https://www.webofscience.com/wos/woscc/full-record/WOS:000321298800053.
[27] Yin, Liang, Kanai, Motomu, Shibasaki, Masakatsu. Cu(I)-catalyzed decarboxylative aldol-type and Mannich-type reactions for asymmetric construction of contiguous trisubstituted and quaternary stereocenters. TETRAHEDRON[J]. 2012, 68(17): 3497-3506, http://dx.doi.org/10.1016/j.tet.2011.05.108.
[28] 殷亮. A Facile Pathway to Enantiomerically-Enriched 3-Hydroxy-2-Oxindoles: Asymmetric Intramolecular Aryl-Transfer Reaction to Ketones Catalyzed by a Palladium-DifluorPhos Complex. Angewandte Chemie International Edition. 2011, [29] Yin, Liang, Kanai, Motomu, Shibasaki, Masakatsu. Nucleophile Generation via Decarboxylation: Asymmetric Construction of Contiguous Trisubstituted and Quaternary Stereocenters through a Cu(I)-Catalyzed Decarboxylative Mannich-Type Reaction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2009, 131(28): 9610-9611, https://www.webofscience.com/wos/woscc/full-record/WOS:000268399800005.
[30] Yamatsugu, Kenzo, Yin, Liang, Kamijo, Shin, Kimura, Yasuaki, Kanai, Motomu, Shibasaki, Masakatsu. A Synthesis of Tamiflu by Using a Barium-Catalyzed Asymmetric Diels-Alder-Type Reaction. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2009, 48(6): 1070-1076, https://www.webofscience.com/wos/woscc/full-record/WOS:000263082300006.
[31] Chen, IHon, Yin, Liang, Itano, Wataru, Kanai, Motomu, Shibasaki, Masakatsu. Catalytic Asymmetric Synthesis of Chiral Tertiary Organoboronic Esters through Conjugate Boration of beta-Substituted Cyclic Enones. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2009, 131(33): 11664-+, http://dx.doi.org/10.1021/ja9045839.

   

（1） “青年****”，主持，国家级，2015-09--2018-08
（2） 上海市“科技启明星”计划，主持，省级，2015-07--2018-06
（3） 中科院上海有机化学研究所“**”计划，主持，研究所（学校）级，2014-10--2019-10

现指导学生

甘绪成  硕士研究生  070303-有机化学  

张海军  硕士研究生  070303-有机化学