Radiation biology, Biophysics,  Melecular biology of tumor, Cellular nanomechanics, Biological engineering 

1. Irradiation Effects on Cell Mechanics of Healthy and Tumor Cells.

Radiobiological effects are investigated on the healthy and tumor cells  by exploiting how mechanical changes in the cytoskeleton regulate cell growth, migration, and tissue pattern during morphogenesis.  Our findings have shown a tight coupling interplay between the cellular structures, mechanical properties, and apoptotic protein levels. 

2. Imprinted Genes and Radiation-Induced Risks

 Imprinted genes, important roles in male reproduction, have been identified as susceptible loci to environmental insults because they are functionally haploid. Our findings have shown that there is a differential PEG10 expression in response to different LET radiations, and PEG10 modification might play a critical role in  evaluating the adverse impact of  high-LET radiation , even at the very low doses of radiation 

  3. The Relationships between the Tumour Microenvironment and Angiogenesis or Radiosensitivity

In our study, we found that there are different responds between high-LET irradiation and low-LET irradiation in the tumor microenvironment and angiogenesis. Current data highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.

2014-2016, National Natural Science Foundation of China (No.11305224)

2016-2019, National Natural Science Foundation of China (No.11575262)

2015-2018， Key Program of National Natural Science Foundation of China (U1432248)

[1]Liu Y, Yan J, Sun C, Li G, Li S, Zhang L, Di C, Gan L, Wang Y, Zhou R, Si J, Zhang H. Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway. Redox biology 2018; 17:143-157.(IF:6337)

[2] Zhang B, Li L, Li Z, Liu Y^＊, Zhang H, Wang J. Carbon Ion-Irradiated Hepatoma Cells Exhibit Coupling Interplay between Apoptotic Signaling and Morphological and Mechanical Remodeling. Scientific reports 2016; 6:35131.(IF:4.259)

[3] Mao A, Liu Y^＃, Wang Y, Zhao Q, Zhou X, Sun C, Di C, Si J, Gan L, Zhang H. miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells. Tumour biology 2016; 37:4831-4840.(IF:2.926)

[4] Yan JW, Liu Y^＃, Zhao QY, Li J, Mao AH, Li HY, Di CX, Zhang H. 56Fe irradiation-induced cognitive deficits through oxidative stress in mice. Toxicology research. 2016, 5: 1672-1679.(IF:1.969)

[5] Liu Y, Zhang L, Liu Y, Sun C, Zhang H, Miao G, Di CX, Zhou X, Zhou R, Wang Z. DNA-PKcs deficiency inhibits glioblastoma cell-derived angiogenesis after ionizing radiation. Journal of cellular physiology 2015; 230:1094-1103.(IF:4.080)

[6] Liu Y, Liu Y, Zhang H, Sun C, Zhao Q, Di C, Li H, Gan L, Wang Y. Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells. Cell biology international 2014; 38:1304-1310.(IF:1.831)

[7] Liu Y, Liu Y, Sun C, Gan L, Zhang L, Mao A, Du Y, Zhou R, Zhang H. Carbon ion radiation inhibits glioma and endothelial cell migration induced by secreted VEGF. PloS one 2014; 9:e98448.(IF:3.234)

[8]  Liu Y, Zhang LW, Zhang H, Wu ZH, Wang ZH, Wang YB, Li HY, Ma XF, Xie Y. Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice. Nuclear Science and Techniques. 2013, 24 (6) :61-66.(IF:0.459)

[9] Liu Y, Zhang L, Zhang H, Liu B, Wu Z, Zhao W, Wang Z. Exogenous melatonin modulates apoptosis in the mouse brain induced by high-LET carbon ion irradiation. Journal of pineal research 2012; 52:47-56.(IF:7.304)

[10] Liu Y, Zhang H, Zhang L, Zhang X, Xie Y, Zhao W. Melatonin modulates acute testicular damage induced by carbon ions in mice. Die Pharmazie 2009; 64:685-689.(IF:1.126)

[11]Liu Y, Zhang H, Zhang LW. Evaluation of sex specificity on oxidative stress induced by  ¹²C⁶⁺ ion irradiation in lungs of male and female mice. Nuclear Science and Techniques. 2008.19, 17-21.(IF:0.459)

[12] Liu Y, Zhang H, Zhang L, Zhou Q, Wang X, Long J, Dong T, Zhao W. Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice. European journal of pharmacology 2007; 575:142-148.(IF:2.896)

[13] Liu Y, Zhang Y, Liu J, Huang D. The role of reactive oxygen species in the herbicide acetochlor-induced DNA damage on Bufo raddei tadpole livAquatic toxicologyer.  (Amsterdam, Netherlands) 2006; 78:21-26.(IF:2.964)

[14]Gan L, Wang Z, Si J, Zhou R, Sun C, Liu Y, Ye Y, Zhang Y, Liu Z, Zhang H. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion (56)Fe radiation induced brain injury in mice. Toxicology and applied pharmacology 2018; 341:1-7.

[15] Sun C, Liu X, Di C, Wang Z, Mi X, Liu Y, Zhao Q, Mao A, Chen W, Gan L, Zhang H. MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential. Autophagy 2017; 13:730-738.

[16] Zhang L, Yan J, Liu Y, Zhao Q, Di C, Chao S, Jie L, Liu Y, Zhang H. Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams. Oncology reports 2017; 37:2994-3000.

[17] Si J, Zhou R, Song J, Gan L, Zhou X, Di C, Liu Y, Mao A, Zhao Q, Wang Y, Zhang H. Toxic effects of (56)Fe ion radiation on the zebrafish (Danio rerio) embryonic development. Aquatic toxicology (Amsterdam, Netherlands) 2017; 186:87-95.

[18] Qin J, Li S, Zhang C, Gao DW, Li Q, Zhang H, Jin XD, Liu Y. Apoptosis and injuries of heavy ion beam and x-ray radiation on malignant melanoma cell. Experimental biology and medicine (Maywood, N.J.) 2017; 242:953-960.

[19] Zhao Q, Mao A, Yan J, Si J, Zhou R, Gan L, Liu Y, Zhang H. (56)Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis. Life sciences 2016; 157:32-37.

[20] Miao GY, Zhou X, Zhang X, Xie Y, Sun C, Liu Y, Gan L, Zhang H. Telomere-Mitochondrion Links Contribute to Induction of Senescence in MCF-7 Cells after Carbon-Ion Irradiation. Asian Pacific journal of cancer prevention : APJCP 2016; 17:1993-1998.

[21] Zheng Q, Liu Y, Zhou HJ, Du YT, Zhang BP, Zhang J, Miao GY, Liu B, Zhang H. X-ray radiation promotes the metastatic potential of tongue squamous cell carcinoma cells via modulation of biomechanical and cytoskeletal properties. Human & experimental toxicology 2015; 34:894-903.

[22] Zhou R, Zhang H, Wang Z, Zhou X, Si J, Gan L, Li J, Liu Y. The developmental toxicity and apoptosis in zebrafish eyes induced by carbon-ion irradiation. Life sciences 2015; 139:114-122.

[23] Gan L, Wang ZH, Zhang H, Zhou R, Sun C, Liu Y, Si J, Liu YY, Wang ZG. Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice. Biomedical and environmental sciences : BES 2015; 28:148-151.

[24] Sun C, Wang Z, Liu Y, Liu Y, Li H, Di C, Wu Z, Gan L, Zhang H. Carbon ion beams induce hepatoma cell death by NADPH oxidase-mediated mitochondrial damage. Journal of cellular physiology 2014; 229:100-107.

[25] Mao A, Liu Y, Zhang H, Di C, Sun C. microRNA expression and biogenesis in cellular response to ionizing radiation. DNA and cell biology 2014; 33:667-679.

[26] Xie Y, Zhao QY, Li HY, Zhou X, Liu Y, Zhang H. Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways. Pharmacology, biochemistry, and behavior 2014; 126:181-186.

[27] Wu Z, Wang X, Yang R, Liu Y, Zhao W, Si J, Ma X, Sun C, Liu Y, Tan Y, Liu W, Zhang X, Di C, Wang Z, Zhang H, Zhang Z. Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice. Experimental and therapeutic medicine 2013; 5:771-776.

[28] Hirano T, Kazama Y, Ohbu S, Shirakawa Y, Liu Y, Kambara T, Fukunishi N, Abe T. Molecular nature of mutations induced by high-LET irradiation with argon and carbon ions in Arabidopsis thaliana. Mutation research 2012; 735:19-31.

[29] Kazama Y, Hirano T, Saito H, Liu Y, Ohbu S, Hayashi Y, Abe T. Characterization of highly efficient heavy-ion mutagenesis in Arabidopsis thaliana. BMC plant biology 2011; 11:161.

[30] Zhang H, Zhao W, Wang Y, Li N, Wu Z, Liu Y, Chen J, Cai Y. Induction of cytogenetic adaptive response in spermatogonia and spermatocytes by pre-exposure of mouse testis to low-dose (12)C(6+) ions. Mutation research 2008; 653:109-112.

现指导学生

胡晓莉  硕士研究生  071011-生物物理学