酶的定向化、蛋白质工程、高通量筛选以及天然及非天然化合物的生物全合成

   

071010-生物化学与分子生物学

合成生物学，定向进化，蛋白质工程，高通量筛选，生物合成

2010-08--2016-05   斯克里普斯研究所   博士
2006-08--2010-05   南洋理工大学   学士

   

2019-09~现在, 中国科学院深圳先进技术研究院, 研究员
2016-09~2019-09,加州大学伯克利分校, 博士后
2016-06~2016-08,斯克里普斯研究所, 博士后

   

[1] 胡如云, 张嵩亚, 蒙海林, 余函, 张建志, 罗小舟, 司同, 刘陈立, 乔宇. 面向合成生物学的机器学习方法及应用. 科学通报. 2021, 66(3): 284-299, http://lib.cqvip.com/Qikan/Article/Detail?id=7104239787.
[2] 张云丰, 何丹, 卢欢, 黄建东, 罗小舟. 代谢工程改造酿酒酵母底盘细胞. 科学通报. 2021, 66(3): 310-318, http://lib.cqvip.com/Qikan/Article/Detail?id=7104239789.
[3] Wang, Yong, Chen, Xiaoxu, Cai, Wenkang, Tan, Linzhi, Yu, Yutong, Han, Boyang, Li, Yuxuan, Xie, Yuanzhe, Su, Yeyu, Luo, Xiaozhou, Liu, Tao. Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(18): 10040-10048, https://www.webofscience.com/wos/woscc/full-record/WOS:000631542300001.
[4] Tang, Hongting, Wu, Yanling, Deng, Jiliang, Chen, Nanzhu, Zheng, Zhaohui, Wei, Yongjun, Luo, Xiaozhou, Keasling, Jay D. Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae. METABOLITESnull. 2020, 10(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000564190100001.
[5] Hongting Tang, Yanling Wu, Jiliang Deng, Nanzhu Chen, Zhaohui Zheng, Yongjun Wei, Xiaozhou Luo, Jay D Keasling. Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae. Metabolites[J]. 2020, 10(320): https://doaj.org/article/baeb786d00a34f0c836e7da21e57f32c.
[6] Luo, Xiaozhou, Reiter, Michael A, dEspaux, Leo, Wong, Jeff, Denby, Charles M, Lechner, Anna, Zhang, Yunfeng, Grzybowski, Adrian T, Harth, Simon, Lin, Weiyin, Lee, Hyunsu, Yu, Changhua, Shin, John, Deng, Kai, Benites, Veronica T, Wang, George, Baidoo, Edward E K, Chen, Yan, Dev, Ishaan, Petzold, Christopher J, Keasling, Jay D. Complete biosynthesis of cannabinoids and their unnatural analogues in yeast. NATURE[J]. 2019, 567(7746): 123-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000460426900054.
[7] Luo, Xiaozhou, Fu, Guangsen, Wang, Rongsheng E, Zhu, Xueyong, Zambaldo, Claudio, Liu, Renhe, Liu, Tao, Lyu, Xiaoxuan, Du, Jintang, Xuan, Weimin, Yao, Anzhi, Reed, Sean A, Kang, Mingchao, Zhang, Yuhan, Guo, Hui, Huang, Chunhui, Yang, PengYu, Wilson, Ian A, Schultz, Peter G, Wang, Feng. Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. NATURE CHEMICAL BIOLOGY[J]. 2017, 13(8): 845-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000405819300011.
[8] Luo, Xiaozhou, Zambaldo, Claudio, Liu, Tao, Zhang, Yuhan, Xuan, Weimin, Wang, Chen, Reed, Sean A, Yang, PengYu, Wang, Rongsheng E, Javahishvili, Tsotne, Schultz, Peter G, Young, Travis S. Recombinant thiopeptides containing noncanonical amino acids. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(13): 3615-3620, [9] Luo, Xiaozhou, Wang, TsungShing Andrew, Zhang, Yong, Wang, Feng, Schultz, Peter G. Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator. CELL CHEMICAL BIOLOGY[J]. 2016, 23(9): 1098-1102, http://dx.doi.org/10.1016/j.chembiol.2016.08.007.

   

（ 1 ） 抗肿瘤、抗感染等活性天然产物的微生物高效制造, 主持, 国家级, 2019-07--2024-06
（ 2 ） 非天然原核生物的构建, 参与, 国家级, 2020-01--2024-12