实验室主要以非洲爪蛙为模型，研究神经系统早期发育中图式形成和神经嵴发育的分子机制，以期为预防和治疗人类神经系统发育相关疾病提供理论依据。同时，以脊椎动物的祖先类型—文昌鱼为模型，开展过对其神经发育机制的比较研究，以揭示神经系统发育机制的演化过程。

   

071009-细胞生物学
071008-发育生物学

早期胚胎发育的基因调控

1989-1993，山东大学生物系，获学士学位
1993-1998，山东大学生命科学学院，获博士学位

-- 研究生

-- 博士

1998-2003， 德国癌症研究中心，博士后

2004年至今 中国科学院昆明动物研究所，研究员

   

[1] Ma, Pengcheng, Mao, Bingyu. The many faces of the E3 ubiquitin ligase, RNF220, in neural development and beyond. DEVELOPMENT GROWTH & DIFFERENTIATIONnull. 2022, 64(2): 98-105, http://dx.doi.org/10.1111/dgd.12756.
[2] Pengcheng Ma, Li Pear Wan, Yuwei Li, ChunHui He, NingNing Song, Shiping Zhao, Huishan Wang, YuQiang Ding, Bingyu Mao, Nengyin Sheng. RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission. SCIENCE ADVANCES[J]. 2022, 8(39): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524831/.
[3] Li, Yuwei. Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression (vol 14, mjab082, 2022). JOURNAL OF MOLECULAR CELL BIOLOGY. 2022, 14(2): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000803296800005.
[4] Ma, Pengcheng, Liu, Xingyan, Xu, Zaoxu, Liu, Huimin, Ding, Xiangning, Huang, Zhen, Shi, Chenggang, Liang, Langchao, Xu, Luohao, Li, Xiaolu, Li, Guimei, He, Yuqi, Ding, Zhaoli, Chai, Chaochao, Wang, Haoyu, Qiu, Jiaying, Zhu, Jiacheng, Wang, Xiaoling, Ding, Peiwen, Zhou, Si, Yuan, Yuting, Wu, Wendi, Wan, Cen, Yan, Yanan, Zhou, Yitao, Zhou, QiJun, Wang, GuoDong, Zhang, Qiujin, Xu, Xun, Li, Guang, Zhang, Shihua, Mao, Bingyu, Chen, Dongsheng. Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution. CELL REPORTS[J]. 2022, 39(12): http://dx.doi.org/10.1016/j.celrep.2022.110979.
[5] Zhou, QiJun, Liu, Xingyan, Zhang, Longlong, Wang, Rong, Yin, Tingting, Li, Xiaolu, Li, Guimei, He, Yuqi, Ding, Zhaoli, Ma, Pengcheng, Wang, ShiZhi, Mao, Bingyu, Zhang, Shihua, Wang, GuoDong. A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication. NATIONAL SCIENCE REVIEW[J]. 2022, 9(11): 103-115, http://dx.doi.org/10.1093/nsr/nwac147.
[6] Guo, Xiaomin, Ma, Pengcheng, Li, Yuwei, Yang, Yanan, Wang, Chaoming, Xu, Tao, Wang, Huishan, Li, Chaocui, Mao, Bingyu, Qi, Xiaopeng. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. CELL DEATH AND DIFFERENTIATION[J]. 2021, 28(2): 640-656, http://dx.doi.org/10.1038/s41418-020-00609-7.
[7] Pengcheng Ma, Yuwei Li, Huishan Wang, Bingyu Mao. Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2021, 13(5): 374-382, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000692102000005.
[8] Ma, Pengcheng, An, Tao, Zhu, Liang, Zhang, Longlong, Wang, Huishan, Ren, Biyu, Sun, Bin, Zhou, Xia, Li, Yan, Mao, Bingyu. RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling. DEVELOPMENT[J]. 2020, 147(21): [9] Zhang, Longlong, Ye, Maosen, Zhu, Liang, Cha, Jingmei, Li, Chaocui, Yao, YongGang, Mao, Bingyu. Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation and Promotes Neuronal Differentiation. CELLS[J]. 2020, 9(7): https://doaj.org/article/56bfe7164a964125a98f31ed62fedfaf.
[10] Ma, Pengcheng, Song, NingNing, Cheng, Xiaoning, Zhu, Liang, Zhang, Qiong, Zhang, Long long, Yang, Xiangcai, Wang, Huishan, Kong, Qinghua, Shi, Deli, Ding, YuQiang, Mao, Bingyu. ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2020, 12(5): 337-344, http://lib.cqvip.com/Qikan/Article/Detail?id=7102219896.
[11] Song, NingNing, Ma, Pengcheng, Zhang, Qiong, Zhang, Lei, Wang, Huishan, Zhang, Longlong, Zhu, Liang, He, ChunHui, Mao, Bingyu, Ding, YuQiang. Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. DEVELOPMENT[J]. 2020, 147(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000522795700015.
[12] Ma, Pengcheng, Song, NingNing, Li, Yongxin, Zhang, Qiong, Zhang, Lei, Zhang, Longlong, Kong, Qinghua, Ma, Li, Yang, Xiangcai, Ren, Biyu, Li, Chaocui, Zhao, Xudong, Li, Yan, Xu, Ying, Gao, Xiang, Ding, YuQiang, Mao, Bingyu. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. CELL REPORTS[J]. 2019, 28(2): 541-+, http://dx.doi.org/10.1016/j.celrep.2019.06.017.
[13] Sun Jian, Wang Xiaolei, Shi Yu, Li Jiejing, Li Chaocui, Shi Zhaoying, Chen Yonglong, Mao Bingyu. EphA7 regulates claudin6 and pronephros development in Xenopus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, [14] Xu HaiBo, Li YongXin, Li Yan, Otecko Newton O, Zhang YaPing, Mao Bingyu, Wu DongDong. Origin of new genes after zygotic genome activation in vertebrate.. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2018, 139-146, http://159.226.149.26:8080/handle/152453/12366.
[15] Liu, Xiaoliang, Xia, Yingjie, Tang, Jixin, Ma, Li, Li, Chaocui, Ma, Pengcheng, Mao, Bingyu. Dual roles of Akirin2 protein during Xenopus neural development. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(14): 5676-5684, http://dx.doi.org/10.1074/jbc.M117.777110.
[16] Ma, Pengcheng, Ren, Biyu, Yang, Xiangcai, Sun, Bin, Liu, Xiaoliang, Kong, Qinghua, Li, Chaocui, Mao, Bingyu. ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus. OPEN BIOLOGY[J]. 2017, 7(8): http://www.corc.org.cn/handle/1471x/2200613.
[17] Yang, Kevin Yi, Chen, Yuan, Zhang, Zuming, Ng, Patrick KwokShing, Zhou, Wayne Junwei, Zhang, Yinfeng, Liu, Minghua, Chen, Junyuan, Mao, Bingyu, Tsui, Stephen KwokWing. Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development. SCIENTIFIC REPORTS[J]. 2016, 6(X): http://dx.doi.org/10.1038/srep23195.
[18] Yang, Xiangcai, Li, Jiejing, Zeng, Wanli, Li, Chaocui, Mao, Bingyu. Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus. SCIENTIFIC REPORTS[J]. 2016, 6(X): https://www.webofscience.com/wos/woscc/full-record/WOS:000375995500001.
[19] Sun, Jian, Wang, Xiaolei, Li, Chaocui, Mao, Bingyu. Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2015, 462(3): 178-183, https://www.webofscience.com/wos/woscc/full-record/WOS:000356319900002.
[20] Jiang, Shiyou, Du, Jiacheng, Kong, Qinghua, Li, Chaocui, Li, Yan, Sun, Handong, Pu, Jianxin, Mao, Bingyu. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation. PLOS ONE[J]. 2015, 10(10): http://www.irgrid.ac.cn/handle/1471x/1028977.
[21] Pengcheng Ma, Xiangcai Yang, Qinghua Kong, Chaocui Li, Shuangjuan Yang, Yan Li, Bingyu Mao. The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of β-Catenin. MOLECULAR AND CELLULAR BIOLOGY. 2014, 34(23): 4355-4366, [22] Zhang, Zuming, Shi, Yu, Zhao, Shuhua, Li, Jiejing, Li, Chaocui, Mao, Bingyu. Xenopus Nkx6.3 Is a Neural Plate Border Specifier Required for Neural Crest Development. PLOS ONE[J]. 2014, 9(12): http://159.226.149.42:8080:8088/handle/152453/8265.
[23] Ma, Pengcheng, Xia, Yingjie, Ma, Li, Zhao, Shuhua, Mao, Bingyu. Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development. DEVELOPMENT GENES AND EVOLUTION[J]. 2013, 223(4): 253-259, http://www.irgrid.ac.cn/handle/1471x/666727.
[24] Xia Yingjie, Zhao Shuhua, Mao Bingyu. Involvement of XZFP36L1, an RNA-binding protein,in Xenopus neural development. ZOOLOGICAL RESEARCH[J]. 2012, 33(E5−6): E82−E88-, http://159.226.149.42:8080:8088/handle/152453/7641.
[25] YANG QiuTan, LV XiaoYan, KONG QingHua, LI ChaoCui, ZHOU Qin, MAO BingYu. Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis. 中国科学：生命科学英文版[J]. 2011, 54(10): 897-903, http://lib.cqvip.com/Qikan/Article/Detail?id=39732726.
[26] Li, Jiejing, Shi, Yu, Sun, Jian, Zhang, Yanfeng, Mao, Bingyu. Xenopus Reduced Folate Carrier Regulates Neural Crest Development Epigenetically. PLOS ONE[J]. 2011, 6(11): http://dx.doi.org/10.1371/journal.pone.0027198.
[27] Ma, Pengcheng, Zhao, Shuhua, Zeng, Wanli, Yang, Qiutan, Li, Chaocui, Lv, Xiaoyan, Zhou, Qin, Mao, Bingyu. Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2011, 412(1): 170-174, http://dx.doi.org/10.1016/j.bbrc.2011.07.068.
[28] Chen, Yuan, Ding, Yun, Zhang, Zuming, Wang, Wen, Chen, JunYuan, Ueno, Naoto, Mao, Bingyu. Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes. JOURNAL OF GENETICS AND GENOMICS[J]. 2011, 38(12): 577-584, http://dx.doi.org/10.1016/j.jgg.2011.10.004.
[29] Yujun Zhang, Bingyu Mao. Embryonic expression and evolutionary analysis of the amphioxus Dickkopf and Kremen family genes. 遗传学报[J]. 2010, 637-645, http://lib.cqvip.com/Qikan/Article/Detail?id=35345490.
[30] Zeng, Wanli, Kong, Qinghua, Li, Chaocui, Mao, Bingyu. Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2010, 394(4): 1024-1029, http://dx.doi.org/10.1016/j.bbrc.2010.03.115.
[31] Wu, Jingyang, Li, Chaocui, Zhao, Shuhua, Mao, Bingyu. Differential expression of the Brunol/CELF family genes during Xenopus laevis early development. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY[J]. 2010, 54(1): 209-214, http://dx.doi.org/10.1387/ijdb.082685jw.
[32] Kong, Qinghua, Zeng, Wanli, Wu, Jingyang, Hu, Wanling, Li, Chaocui, Mao, Bingyu. RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2010, 393(4): 708-713, http://dx.doi.org/10.1016/j.bbrc.2010.02.066.
[33] Bingyu Mao. Islet-1 is required for ventral neuron survival in Xenopus. Biochem.. Biophys. Res. Commun.. 2009, 

已指导学生

孔清华  博士研究生  071002-动物学  

武景阳  博士研究生  071002-动物学  

马莉  博士研究生  071002-动物学  

张煜珺  硕士研究生  071009-细胞生物学  

赵树华  博士研究生  071002-动物学  

魏云虎  硕士研究生  071009-细胞生物学  

胡晚玲  硕士研究生  071009-细胞生物学  

陈源  博士研究生  071009-细胞生物学  

石宇  博士研究生  071009-细胞生物学  

曾婉俐  博士研究生  071009-细胞生物学  

现指导学生

夏英杰  博士研究生  071009-细胞生物学  

江世友  硕士研究生  071009-细胞生物学  

孙健  硕士研究生  071009-细胞生物学  

李杰晶  博士研究生  071009-细胞生物学  

汤济鑫  硕士研究生  071009-细胞生物学  

杨相彩  硕士研究生  071009-细胞生物学  

马鹏程  博士研究生  071009-细胞生物学  

张祖明  博士研究生  071009-细胞生物学