膜蛋白（离子通道）的结构功能及其天然药物研究

   

100706-药理学
100701-药物化学
071010-生物化学与分子生物学

膜蛋白（离子通道)天然活性分子的发现、机理及成药性研究
膜蛋白（离子通道)结构功能研究

2009-05--2010-04   美国伊利诺伊斯大学芝加哥分校   访问学生
2005-09--2011-01   中国科学院昆明植物研究所   博士学位
2001-09--2005-07   广东中山大学   学士学位

   

2020-07~2021-05,中国科学院昆明植物研究所, 副研究员（课题组长）
2019-01~2020-06,中国科学院昆明动物研究所, 副研究员
2016-03~2017-03,美国贝勒医学院, 博士后
2013-11~2018-12,中国科学院昆明动物研究所, 助理研究员
2011-05~2013-10,云南生物谷灯盏花花药业有限公司和中国科学院昆明植物研究所, 企业联合培养博士后

   

（ 1 ） 去芳化异戊烯基酰化间苯三酚杂萜类化合物及其药物组合物和应用, 发明专利, 2020, 第 2 作者, 专利号: CN111233886A

（ 2 ） 酰基间苯三酚类衍生物及其药物组合物和应用, 发明专利, 2020, 第 2 作者, 专利号: CN111170967A

（ 3 ） 去芳化异戊烯基酰基间苯三酚类衍生物及其药物组合物和应用, 发明专利, 2020, 第 2 作者, 专利号: CN111056935A

（ 4 ） 石松生物碱lycoplanineA及其药物组合物与其制备方法和应用, 发明专利, 2019, 第 4 作者, 专利号: CN107365316B

（ 5 ） 蜘蛛香环烯醚萜部位在制备N-型钙通道抑制剂中的应用, 发明专利, 2018, 第 3 作者, 专利号: CN104721180B

   

[1] Jianjun Zhao, Shuzong Du, Kun Hu, Yali Hu, Fan Xia, Yansong Ye, Jian Yang, Yin Nian, Gang Xu. Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides. CHINESE CHEMICAL LETTERS[J]. 2023, 34(4): 107737-, http://dx.doi.org/10.1016/j.cclet.2022.08.017.
[2] Ye, YanSong, Liu, Rui, Jiang, NaNa, Li, SongYu, Nian, Yin, Xu, Gang. Caged polycyclic polyprenylated acylphloroglucinols as Ca(v)3.2 low voltage-gated Ca2+ channel inhibitors from Hypericum curvisepalum. CHEMICAL COMMUNICATIONS[J]. 2022, 58(94): 13135-13138, http://dx.doi.org/10.1039/d2cc05396a.
[3] Xia, Fan, Du, ShuZong, Wu, MingKun, Liu, Rui, Ye, YanSong, Yang, Jian, Xu, Gang, Nian, Yin. Icetexane diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and analgesic effect of their Semi-synthesized derivatives. BIOORGANIC CHEMISTRY[J]. 2022, 128: http://dx.doi.org/10.1016/j.bioorg.2022.106059.
[4] Su, Deyuan, Gong, Ye, Li, Songyu, Yang, Jian, Nian, Yin. Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels. FRONTIERS IN PHARMACOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fphar.2022.1081697.
[5] Hu, Guilin, Dong, Ding, Du, Shuzong, Peng, Xingrong, Wu, Mingkun, Shi, Qiangqiang, Hu, Kun, Hong, Defu, Wang, Xiaoyuan, Zhou, Lin, Nian, Yin, Qiu, Minghua. Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel. FOOD CHEMISTRY[J]. 2022, 376: http://dx.doi.org/10.1016/j.foodchem.2021.131923.
[6] Hu, GuiLin, Peng, XingRong, Dong, Ding, Nian, Yin, Gao, Ya, Wang, XiaoYuan, Hong, DeFu, Qiu, MingHua. New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase. FOOD CHEMISTRY[J]. 2021, 345: http://dx.doi.org/10.1016/j.foodchem.2020.128823.
[7] Zhan, Rui, Du, ShuZong, Duan, ZhiHang, Nian, Yin, Chen, YeGao. Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris. TETRAHEDRON LETTERS[J]. 2020, 61(1): http://dx.doi.org/10.1016/j.tetlet.2019.151354.
[8] Wang Lie, Qian Hongwu, Nian Yin, Han Yimo, Ren Zhenning, Zhang Hanzhi, Hu Liya, Prasad, B V Venkataram, Laganowsky, Arthur, Yan Nieng, Zhou Ming. Structure and mechanism of human diacylglycerol O-acyltransferase 1. NATURE[J]. 2020, 581(7808): 329-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255049/.
[9] Ye, YanSong, Li, WenYan, Du, ShuZong, Yang, Jian, Nian, Yin, Xu, Gang. Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(4): 1709-1716, https://www.webofscience.com/wos/woscc/full-record/WOS:000517673100018.
[10] Ye, YanSong, Du, ShuZong, Jiang, NaNa, Xu, HongXi, Yang, Jian, Fu, WenWei, Nian, Yin, Xu, Gang. Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors. ORGANIC LETTERS[J]. 2020, 22(16): 6339-6343, http://dx.doi.org/10.1021/acs.orglett.0c02170.
[11] Jiang, NaNa, Du, ShuZong, Ye, YanSong, Yan, Hui, Yang, XingWei, Yang, Jian, Nian, Yin, Xu, Gang. Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Ca(v)3.1 T-type calcium channel inhibitor from Hypericum henryi. TETRAHEDRON LETTERS[J]. 2019, 60(45): https://www.webofscience.com/wos/woscc/full-record/WOS:000495490500006.
[12] Xia, Fan, Li, WenYan, Yang, XingWei, Yang, Jian, Li, Xian, Nian, Yin, Xu, Gang. Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii. ORGANIC LETTERS[J]. 2019, 21(14): 5670-5674, https://www.webofscience.com/wos/woscc/full-record/WOS:000476957200062.
[13] Nian Yin. Two Diterpenoids with Two Skeletons from Euphorbia peplus.. Organic Letters. 2018, [14] Zhou, Jun, Dong, Fa-Wu, Jiang, He-Hai, Yang, Liu, Gong, Ye, Zi, Cheng-Ting, Yang, Dan, Ye, Chen-Jun, Li, Huan, Yang, Jian, Nian, Yin, Hu, Jiang-Miao. Valepotriates From the Roots and Rhizomes of Valeriana jatamansi Jones as Novel N-Type Calcium Channel Antagonists. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2018, 222: 208-216, http://www.irgrid.ac.cn/handle/1471x/1781692.
[15] Nian, Yin, Lu, NiHong, Liu, XiaoLing, Li, DaShan, Zhou, Lin, Qiu, MingHua. Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis. RSCADVANCES[J]. 2018, 8(14): 7832-7838, https://www.webofscience.com/wos/woscc/full-record/WOS:000425647000058.
[16] Ren, Zhenning, Lee, Jumin, Moosa, Mahdi Muhammad, Nian, Yin, Hu, Liya, Xu, Zhichun, McCoy, Jason G, Ferreon, Allan Chris M, Im, Wonpil, Zhou, Ming. Structure of an EIIC sugar transporter trapped in an inward-facing conformation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(23): 5962-5967, http://dx.doi.org/10.1073/pnas.1800647115.
[17] 代晓丽, 刘静, 年寅, 邱明华, 张继虹. 环阿尔廷烷型四环三萜化合物对HCT116细胞增殖、细胞周期和凋亡的影响. 中国药理学通报[J]. 2018, 34(1): 91-96, http://lib.cqvip.com/Qikan/Article/Detail?id=674133335.
[18] Dai, Xiaoli, Liu, Jing, Nian, Yin, Qiu, MingHua, Luo, Ying, Zhang, Jihong. A novel cycloartane triterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells. ONCOLOGY REPORTS[J]. 2017, 37(4): 2079-2086, http://www.irgrid.ac.cn/handle/1471x/1185345.
[19] Jiang, HeHai, Dong, Wu, Zhou, Jun, Hu, JiangMiao, Yang, Jian, Nian, Yin. Ca(v)2.2 and Ca(v)3.1 calcium channel inhibitors from Valeriana jatamansi Jones. RSC ADVANCES[J]. 2017, 7(72): 45878-45884, https://www.webofscience.com/wos/woscc/full-record/WOS:000412147000075.
[20] Nian, Yin, Yan, Hui, Li, XiaoNian, Zhou, Lin, Qiu, MingHua. Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida. RSC ADVANCES[J]. 2017, 7(61): 38557-38564, https://www.webofscience.com/wos/woscc/full-record/WOS:000407442000053.
[21] Nian Yin. Cimifrigines A-G, Cytotoxic Triterpenes with an Oxime Group from the Flowers of Cimicifuga frigid.. RSCADVANCES. 2017, [22] Yang, YeKun, Xie, Sida, Xu, Wanxuan, Nian, Yin, Liu, XiaoLing, Peng, XingRong, Ding, ZhongTao, Qiu, MingHua. Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity. FITOTERAPIA[J]. 2016, 112: 144-152, http://www.irgrid.ac.cn/handle/1471x/1175693.
[23] Zhu, GuoLei, Nian, Yin, Zhu, DiFan, Wan, LuoSheng, Bao, NiMan, Wang, WeiHua, Zhou, Lin, Qiu, MingHua. Cytotoxic 9,19-cycloartane triterpenoids from the roots of Cimicifuga foetida L.. PHYTOCHEMISTRY LETTERS[J]. 2016, 18(1): 105-112, http://dx.doi.org/10.1016/j.phytol.2016.06.002.
[24] Kong, Yanjie, Li, Fubin, Nian, Yin, Zhou, Zhongmei, Yang, Runxiang, Qiu, MingHua, Chen, Ceshi. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway. THERANOSTICS[J]. 2016, 6(6): 875-886, http://www.irgrid.ac.cn/handle/1471x/1109578.
[25] Yue, Grace GarLee, Xie, Sida, Lee, Julia KinMing, Kwok, HinFai, Gao, Si, Nian, Yin, Wu, XiaoXiao, Wong, ChunKwok, Qiu, MingHua, Lau, Clara BikSan. New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment. SCIENTIFIC REPORTS[J]. 2016, 6(1): http://www.irgrid.ac.cn/handle/1471x/1140919.
[26] Wang, WeiHua, Nian, Yin, He, YuJiao, Wan, LuoSheng, Bao, NiMan, Zhu, GuoLei, Wang, Fei, Qiu, Minghua. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. TETRAHEDRON[J]. 2015, 71(42): 8018-8025, http://dx.doi.org/10.1016/j.tet.2015.08.057.
[27] Nian, Yin, Yang, Jing, Liu, TongYang, Luo, Ying, Zhang, JiHong, Qiu, MingHua. New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis. SCIENTIFIC REPORTS[J]. 2015, 5: http://www.irgrid.ac.cn/handle/1471x/959063.
[28] Chen, JianChao, Yuan, XiaoXi, Zhou, Lin, Liu, JieQing, Nian, Yin, Li, ZhongRong, Li, Yan, Xie, MingJin, Qiu, MingHua. Four New Cucurbitacins from the Fruit of Momordica charantia. HELVETICA CHIMICA ACTA[J]. 2014, 97(11): 1546-1554, http://www.irgrid.ac.cn/handle/1471x/929653.
[29] Bao, NiMan, Nian, Yin, Zhu, GuoLei, Wang, WeiHua, Zhou, Lin, Qiu, MingHua. Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis. FITOTERAPIA[J]. 2014, 99: 191-197, http://www.irgrid.ac.cn/handle/1471x/959035.
[30] Zhu DiFan, Nian Yin, Wang HaiYan, Zhang ZhiRun, Song YanBo, Li RongTao, Qiu MingHua. New 9, 19-cycloartane triterpenoid from the root of Cimicifuga foetida. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2014, 12(4): 294-296, http://dx.doi.org/10.1016/S1875-5364(14)60057-1.
[31] 王卫华, 曽晓鹰, 年寅, 杨元凤, 夏建军, 邓媛元, 李忠荣, 邱明华. 姜酮的NMR解析. 云南大学学报(自然科学版)[J]. 2013, 35(4): 530-535, http://www.irgrid.ac.cn/handle/1471x/832411.
[32] Yin Nian, HaiYanWang, Lin Zhou, Jia Su, Yan Li, MingHua Qiu. Cytotoxic Cycloartane Triterpenes of the TraditionalChinese Medicine "Shengma" (Cimicifuga dahurica). PLANTA MED[J]. 2013, 79: 60–69-, http://ir.kib.ac.cn/handle/151853/52984.
[33] Nian, Yin, Zhu, Hui, Tang, WenRu, Luo, Yin, Du, Jiang, Qiu, MingHua. Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 76(5): 896-902, http://www.irgrid.ac.cn/handle/1471x/660284.
[34] Lu, Lu, Chen, JianChao, Li, Yan, Qing, Chen, Wang, YuanYuan, Nian, Yin, Qiu, MingHua. Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities. CHEMICAL & PHARMACEUTICAL BULLETIN[J]. 2012, 60(5): 571-577, http://dx.doi.org/10.1248/cpb.60.571.
[35] Wang Haiyan, Nian Yin, Ma Chengyou, Liu Jieqing, Song Yanho, Zhou Lin, Qiu Minghua. Four New 9,19-Cyclolanostane Triterpenes from the Rhizomes of Cimicifuga foetida Collected in Yulong. CHINESE JOURNAL OF CHEMISTRY[J]. 2012, 30(6): 1265-1268, http://lib.cqvip.com/Qikan/Article/Detail?id=42601398.
[36] Nian, Yin, Wang, HaiYan, Su, Jia, Zhou, Lin, Qiu, MingHua. A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L. FITOTERAPIA[J]. 2012, 83(2): 293-297, http://www.irgrid.ac.cn/handle/1471x/448456.
[37] Fang, ZhongZe, Nian, Yin, Li, Wei, Wu, JingJing, Ge, GuangBo, Dong, PeiPei, Zhang, YanYan, Qiu, MingHua, Liu, Lei, Yang, Ling. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway. PHYTOTHERAPY RESEARCH[J]. 2011, 25(1): 17-24, http://dx.doi.org/10.1002/ptr.3222.
[38] Li, DaShan, Nian, Yin, Sun, Yun, Qiu, MingHua. Three New Cycloartane (= 9,19-Cyclolanostane) Glycosides from Cimicifuga foetida. HELVETICA CHIMICA ACTA[J]. 2011, 94(4): 632-638, http://www.irgrid.ac.cn/handle/1471x/392907.
[39] Lu, Lu, Chen, JianChao, Song, HeJiao, Li, Yan, Nian, Yin, Qui, MingHua. Five New Triterpene Bisglycosides with Acyclic Side Chains from the Rhizomes of Cimicifuga foetida L.. CHEMICAL & PHARMACEUTICAL BULLETIN[J]. 2010, 58(5): 729-733, https://www.webofscience.com/wos/woscc/full-record/WOS:000277019100024.
[40] Lu, Lu, Chen, Jianchao, Nian, Yin, Sun, Yun, Qiu, Minghua. Trinor-cycloartane Glycosides from the Rhizomes of Cimicifuga foetida. MOLECULES[J]. 2009, 14(4): 1578-1584, https://doaj.org/article/cfd0407cbeed4415a150ab5658f4dd6f.
[41] Sun, Lirong, Yan, Jian, Nian, Yin, Zhou, Lin, Zhang, Hongjie, Qiu, Minghua. New triterpene diglycosides from the rhizome of Cimifuga foetida. MOLECULES[J]. 2008, 13(8): 1712-1721, https://doaj.org/article/0340c46d86b245f39358871e75e1337e.
[42] Yin Nian, HaiYan Wang, Lin Zhou, Jia Su, Yan Li, MingHua Qiu. Cytotoxic Cycloartane Triterpenes of Traditional Chinese Medicine "Shengma" (Cimicifugadahurica). PLANTA MED[J]. 1-51, http://ir.kib.ac.cn/handle/151853/53141.
[43] Fan Xia, ShuZong Du, MingKun Wu, Rui Liu, YanSong Ye, Jian Yang, Gang Xu, Yin Nian. Icetexane Diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and Analgesic Effect of Their Semi-synthesized Derivatives. BIOORGANIC CHEMISTRY. http://dx.doi.org/10.1016/j.bioorg.2022.106059.

   

（ 1 ） 金丝桃属植物中特色间苯三酚类T-型钙通道活性成分的研究, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 第二次青藏高原综合科学考察研究，“藏药资源的挖掘利用”专题子课题“藏药中特色化学成分的活性研究”, 负责人, 国家任务, 2019-01--2023-12
（ 3 ） 中国科学院西部之光“西部青年学者”项目, 负责人, 中国科学院计划, 2021-01--2023-12
（ 4 ） 云南省杰出青年研究专项, 负责人, 地方任务, 2021-01--2023-12
（ 5 ） 云南省青年拔尖人才专项经费, 负责人, 地方任务, 2021-01--2025-12
（ 6 ） 灵芝杂萜GMs15抗典型失神癫痫机理研究, 负责人, 地方任务, 2020-09--2023-08
（ 7 ） 优秀人才启动经费, 负责人, 研究所自选, 2020-07--2025-06

（1）Discovery of Novel Natural Small Molecules Targeting Ion Channels   第十四届生物毒素毒理学术大会   2019-08-16
（2）作用于离子通道天然活性分子的挖掘   第一届中国科学院药物创新研究院“百草”论坛   2019-07-26
（3）Discovery of novel natural small molecules targeting ion channels   2018精准医疗暨离子通道国际论坛   2018-11-14

现指导学生

李松谕  硕士研究生  105500-药学  

伍铭坤  硕士研究生  105500-药学  

马梦蝶  硕士研究生  105500-药学