基本信息
王发左  男  硕导  中国科学院南海海洋研究所
电子邮件: wangfazuo@scsio.ac.cn
通信地址: 广东省广州市海珠区新港西路164号
邮政编码: 510301

研究领域

1. 海洋特殊环境微生物新资源发现与化学多样性研究
2. 新颖微生物天然产物结构鉴定与生理生态功能研究

招生信息

   
招生专业
070703-海洋生物学
招生方向
海洋特殊环境微生物资源、化学及功能研究
海洋天然药物与资源化学

教育背景

2005-09--2008-06   中国海洋大学   博士
2000-09--2003-07   安徽农业大学   硕士
1996-09--2000-07   安徽农业大学   学士
学历
研究生
学位
博士

工作经历

   
工作简历
2023-03~现在, 中国科学院南海海洋研究所, 仪器设备公共服务中心主任
2018-07~2023-03,中国科学院南海海洋研究所, 人事教育处处长
2017-12~现在, 中国科学院南海海洋研究所, 研究员
2012-07~2018-07,中国科学院南海海洋研究所, 人事教育处副处长
2010-12~2017-12,中国科学院南海海洋研究所, 副研究员
2008-07~2010-12,中国科学院南海海洋研究所, 助理研究员
2003-08~2005-07,中国科学院海洋研究所, 研究助理

专利与奖励

   
奖励信息
(1) 热带海洋软体动物功能蛋白肽的关键利用技术及其产业化, 一等奖, 省级, 2011
专利成果
( 1 ) 含硫双吲哚二酮哌嗪类化合物及其在制备抗肿瘤药物中的应用, 发明专利, 2015, 第 1 作者, 专利号: 201210301553.1

出版信息

   
发表论文
[1] Zhong, Weimao, Chen, Yuchan, Wei, Xiaoyi, Wang, Junfeng, Zeng, Qi, Tian, Xinpeng, Zhang, Weimin, Wang, Fazuo, Zhang, Si. Euroticins C-E, three pairs of polycyclic salicylaldehyde derivative enantiomers from a marine-derived fungus Eurotium sp. SCSIO F452. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 8(7): 1466-1473, http://dx.doi.org/10.1039/d0qo01519a.
[2] Xiang, Yao, Zeng, Qi, Mai, ZhiMao, Chen, YuChan, Shi, XueFeng, Chen, XiaYu, Zhong, WeiMao, Wei, XiaoYi, Zhang, WeiMin, Zhang, Si, Wang, FaZuo. Asperorydines N-P, three new cyclopiazonic acid alkaloids from the marine-derived fungus Aspergillus flavus SCSIO F025. FITOTERAPIA[J]. 2021, 150: http://dx.doi.org/10.1016/j.fitote.2021.104839.
[3] WeiMao Zhong, XiaoYi Wei, YuChan Chen, Qi Zeng, JunFeng Wang, XueFeng Shi, XinPeng Tian, WeiMin Zhang, FaZuo Wang, Si Zhang. Structurally Diverse Polycyclic Salicylaldehyde Derivative Enantiomers from a Marine-Derived Fungus Eurotium sp. SCSIO F452. MARINE DRUGS[J]. 2021, 19(543): https://doaj.org/article/562cedee3ea04c349438ea516da6d61d.
[4] Zhong, Weimao, Chen, Yuchan, Wei, Xiaoyi, Wang, Junfeng, Zhang, Weimin, Wang, Fazuo, Zhang, Si. Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452. JOURNAL OF ANTIBIOTICS[J]. 2021, 74(4): 273-279, http://dx.doi.org/10.1038/s41429-020-00395-x.
[5] 陈夏雨, 仲伟茂, 曾奇, 王发左. 基于OSMAC策略对深海来源真菌Acrostalagmus luteoalbus SCSIO F457化学多样性的初步研究. 中国海洋药物[J]. 2020, 39(4): 7-15, http://lib.cqvip.com/Qikan/Article/Detail?id=7102726579.
[6] Han, Wenrong, Cai, Jia, Zhong, Weimao, Xu, Guangming, Wang, Fazuo, Tian, Xinpeng, Zhou, Xiaojiang, Liu, Qingchao, Liu, Yonghong, Wang, Junfeng. Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007. BIOORGANIC CHEMISTRY[J]. 2020, 96: http://dx.doi.org/10.1016/j.bioorg.2020.103646.
[7] Zhong, Weimao, Chen, Yuchan, Mai, Zhimao, Wei, Xiaoyi, Wang, Junfeng, Zeng, Qi, Chen, Xiayu, Tian, Xinpeng, Zhang, Weimin, Wang, Fazuo, Zhang, Si. Euroticins A and B, Two Pairs of Highly Constructed Salicylaldehyde Derivative Enantiomers from a Marine-Derived Fungus Eurotium sp. SCSIO F452. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(19): 12754-12759, https://www.webofscience.com/wos/woscc/full-record/WOS:000577156600065.
[8] Zhong, WeiMao, Wang, JunFeng, Wei, XiaoYi, Zeng, Qi, Chen, XiaYu, Xiang, Yao, Tian, XinPeng, Zhang, Si, Long, LiJuan, Wang, FaZuo. (+)- and (-)-Eurotone A: A pair of enantiomeric polyketide dimers from a marine-derived fungus Eurotium sp. SCSIO F452. TETRAHEDRON LETTERS[J]. 2019, 60(24): 1600-1603, http://dx.doi.org/10.1016/j.tetlet.2019.05.025.
[9] 王发左. A new butenolide derivative from the deep-sea fungus Aspergillus terreus SCSIO FZQ028. Natural Product Research. 2019, [10] Zhong, Weimao, Wang, Junfeng, Wei, Xiaoyi, Fu, Tingdan, Chen, Yuchan, Zeng, Qi, Huang, Zhonghui, Huang, Xinan, Zhang, Weimin, Zhang, Si, Long, Lijuan, Wang, Fazuo. Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452. FRONTIERS IN CHEMISTRY[J]. 2019, 7: https://doaj.org/article/4a6d4fa736dc406d9454d583bd126abb.
[11] 向瑶, 曾奇, 仲伟茂, 陈夏雨, 肖志会, 王发左. 南海深海沉积环境来源真菌Aspergillus flavus SCSIO F025的次生代谢产物及活性研究. 中国海洋药物[J]. 2019, 38(4): 19-25, http://lib.cqvip.com/Qikan/Article/Detail?id=7002735560.
[12] Chen, RouWen, Wang, KeXin, Wang, FaZuo, He, YuanQiu, Long, LiJuan, Tian, XinPeng. Rubrobacter indicoceani sp nov., a new marine actinobacterium isolated from Indian Ocean sediment. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2018, 68(11): 3487-3493, http://dx.doi.org/10.1099/ijsem.0.003018.
[13] 曾奇, 仲伟茂, 向瑶, 陈夏雨, 田新朋, 张偲, 王发左. 南海深海沉积物中52株真菌的初步分离鉴定及其代谢产物活性. 微生物学通报[J]. 2018, 45(9): 1904-1915, http://lib.cqvip.com/Qikan/Article/Detail?id=676289976.
[14] Zhong, Weimao, Wang, Junfeng, Wei, Xiaoyi, Chen, Yuchan, Fu, Tingdan, Xiang, Yao, Huang, Xinan, Tian, Xinpeng, Xiao, Zhihui, Zhang, Weimin, Zhang, Si, Long, Lijuan, Wang, Fazuo. Variecolortins A-C, Three Pairs of Spirocyclic Diketopiperazine Enantiomers from the Marine-Derived Fungus Eurotium sp SCSIO F452. ORGANIC LETTERS[J]. 2018, 20(15): 4593-4596, https://www.webofscience.com/wos/woscc/full-record/WOS:000441112700046.
[15] 仲伟茂, 曾奇, 向瑶, 田新朋, 王发左, 张偲. 南海深海沉积环境来源真菌Aspergillus sp.SCSIO F063的次生代谢产物研究. 中国海洋药物[J]. 2018, 37(5): 29-35, http://lib.cqvip.com/Qikan/Article/Detail?id=6100113241.
[16] Zhong, WeiMao, Wang, JunFeng, Shi, XueFeng, Wei, XiaoYi, Chen, YuChan, Zeng, Qi, Xiang, Yao, Chen, XiaYu, Tian, XinPeng, Xiao, ZhiHui, Zhang, WeiMin, Wang, FaZuo, Zhang, Si. Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452. MARINE DRUGS[J]. 2018, 16(4): https://doaj.org/article/0c2b3e99c7d2426c8b21fd9b281921a1.
[17] 王发左. 南海深海沉积物中52株真菌的初步分离鉴定及其代谢产物活性初步研究. 微生物学通报. 2018, [18] 曾奇, 仲伟茂, 王发左. 深海来源真菌次级代谢产物研究进展. 天然产物研究与开发[J]. 2018, 30(3): 501-514, http://lib.cqvip.com/Qikan/Article/Detail?id=7000463545.
[19] Jian Yang, Lizhen Li, Yunzhu Xiao, Jie Li, Lijuan Long, Fazuo Wang, Si Zhang. Identification and thermoadaptation engineering of thermostability conferring residue of deep sea bacterial α-amylase AMY121. JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC. 2016, 126: 56-63, http://dx.doi.org/10.1016/j.molcatb.2015.10.004.
[20] Wang, Junfeng, Wei, Xiaoyi, Qin, Xiaochu, Tian, Xinpeng, Liao, Li, Li, Kemin, Zhou, Xuefeng, Yang, Xianwen, Wang, Fazuo, Zhang, Tianyu, Tu, Zhengchao, Chen, Bo, Liu, Yonghong. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(1): 59-65, http://ir.scsio.ac.cn/handle/344004/15534.
[21] 张偲, 王发左, 杨键. 海洋微生物次生代谢的生理生态效应及其生物合成机制研究. 科技资讯[J]. 2016, 14(19): 173-173, http://lib.cqvip.com/Qikan/Article/Detail?id=7000041003.
[22] Yang, Jian, Li, Lizhen, Xiao, Yunzhu, Li, Jie, Long, Lijuan, Wang, Fazuo, Zhang, Si. Identification and thermoadaptation engineering of thermostability conferring residue of deep sea bacterial alpha-amylase AMY121. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2016, 126: 56-63, http://ir.scsio.ac.cn/handle/344004/15475.
[23] Wang, Fazuo, Li, Ru, Long, Lijuan, Tian, Xinpeng, Xiao, Zhihui, Zhang, Si, Yin, Hao. A Three-Phase Solvent System in High-Speed Counter-Current Chromatographic for the Separation and Purification of Bioactive Constituents from Acanthus ilicifolius. CHROMATOGRAPHIA[J]. 2015, 78(21-22): 1401-1407, https://www.webofscience.com/wos/woscc/full-record/WOS:000363945300010.
[24] Jun Li, Xuan Huang, XiaoHong Jiang, QiFeng Zhu, Yun Yang, GuangChun Gao. ChemInform Abstract: Catunarosides I—L, Four New Triterpenoid Saponins from the Stem Bark of Catunaregam spinosa.. CHEMINFORM. 2015, [25] Yang, Jian, Li, Jie, Hu, Yunfeng, Li, Lizhen, Long, Lijuan, Wang, Fazuo, Zhang, Si. Characterization of a thermophilic hemoglobin-degrading protease from Streptomyces rutgersensis SCSIO 11720 and its application in antibacterial peptides production. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING[J]. 2015, 20(1): 79-90, http://dx.doi.org/10.1007/s12257-013-0771-9.
[26] Huang, XiaoFang, Liu, Yu Juan, Dong, JunDe, Qu, LingYun, Zhang, YanYing, Wang, FaZuo, Tian, XinPeng, Zhang, Si. Mangrovibacterium diazotrophicum gen. nov., sp nov., a nitrogen-fixing bacterium isolated from a mangrove sediment, and proposal of Prolixibacteraceae fam. nov.. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2014, 64: 875-881, http://dx.doi.org/10.1099/ijs.0.052779-0.
[27] Huang, XiaoFang, Wang, FaZuo, Zhang, Wei, Li, Jie, Ling, Juan, Yang, Jian, Dong, JunDe, Tian, XinPeng. Paenibacillus abyssi sp nov., isolated from an abyssal sediment sample from the Indian Ocean. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY[J]. 2014, 106(6): 1089-1095, http://dx.doi.org/10.1007/s10482-014-0277-2.
[28] Tian, XinPeng, Long, LiJuan, Li, SuMei, Zhang, Jing, Xu, Ying, He, Jie, Li, Jie, Wang, FaZuo, Li, WenJun, Zhang, ChangSheng, Zhang, Si. Pseudonocardia antitumoralis sp nov., a deoxynyboquinone-producing actinomycete isolated from a deep-sea sediment. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2013, 63: 893-899, http://dx.doi.org/10.1099/ijs.0.037135-0.
[29] 王发左, 黄智, 史雪凤, 陈玉婵, 田新朋, 李洁, 章卫民, 张偲. 南海沉积环境来源真菌Eurotium sp.SCSIO F452的次生代谢产物研究. 中国海洋药物[J]. 2013, 32(1): 7-12, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4791893&detailType=1.
[30] 黄智, 王发左, 张偲. 海洋沉积环境来源真菌次生代谢产物的研究. 天然产物研究与开发[J]. 2013, 25(1): 129-139, https://d.wanfangdata.com.cn/periodical/trcwyjykf201301029.
[31] 李庆欣, 史雪凤, 黄智, 田新朋, 王发左. 海洋真菌来源吲哚生物碱类化合物的结构和活性研究. 热带海洋学报[J]. 2013, 35-47, http://lib.cqvip.com/Qikan/Article/Detail?id=45881457.
[32] 王发左. A New Flavanone from Abrus precatorius Linn. Chem. Nat. Compd.. 2012, [33] Jie Li, LiJuan Long, LingLing Yang, Ying Xu, FaZuo Wang, QingXin Li, Si Zhang, WenJun Li. Janibacter alkaliphilus sp. nov., isolated from coral Anthogorgia sp. ANTONIE VAN LEEUWENHOEK,. 2012, 102(1): [34] 黄智, 王发左, 田新朋, 李洁, 张偲. 一株南海北部深海沉积环境真菌00457的鉴定及其活性研究. 生物技术通报[J]. 2012, 199-204, https://d.wanfangdata.com.cn/periodical/swjstb201210032.
[35] Huang, Hongbo, Wang, Fazuo, Luo, Minghe, Chen, Yuchan, Song, Yongxiang, Zhang, Weimin, Zhang, Si, Ju, Jianhua. Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 75(7): 1346-1352, https://www.webofscience.com/wos/woscc/full-record/WOS:000306783500014.
[36] Tian, XinPeng, Long, LiJuan, Wang, FaZuo, Xu, Ying, Li, Jie, Zhang, Jing, Zhang, ChangSheng, Zhang, Si, Li, WenJun. Streptomyces nanhaiensis sp nov., a marine streptomycete isolated from a deep-sea sediment. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2012, 62: 864-868, http://dx.doi.org/10.1099/ijs.0.031591-0.
[37] Li, Jie, Zhang, GuangTao, Yang, Jian, Tian, XinPeng, Wang, FaZuo, Zhang, Chang Sheng, Zhang, Si, Li, WenJun. Marininema mesophilum gen. nov., sp nov., a thermoactinomycete isolated from deep sea sediment, and emended description of the family Thermoactinomycetaceae. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2012, 62: 1383-1388, http://dx.doi.org/10.1099/ijs.0.035071-0.
[38] 王发左. Rhodococcus nanhaiensis sp. nov., a novel actinobacterium isolated from marine sediment of the South China Sea. Int. J. Syst. Evol. Microbiol.. 2012, [39] Lin, Xiuping, Zhou, Xuefeng, Wang, Fazuo, Liu, Kaisheng, Yang, Bin, Yang, Xianwen, Peng, Yan, Liu, Juan, Ren, Zhe, Liu, Yonghong. A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample. MARINE DRUGS[J]. 2012, 10(1): 106-115, http://www.irgrid.ac.cn/handle/1471x/767881.
[40] Wang, FaZuo, Huang, Zhi, Shi, XueFeng, Chen, YuChan, Zhang, WeiMin, Tian, XinPeng, Li, Jie, Zhang, Si. Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2012, 22(23): 7265-7267, http://dx.doi.org/10.1016/j.bmcl.2012.08.115.
[41] Wang, FaZuo, Wei, HongJuan, Zhu, TianJiao, Li, DeHai, Lin, ZhenJian, Gu, QianQun. Three New Cytochalasins from the Marine-Derived Fungus Spicaria elegans KLA03 by Supplementing the Cultures with L- and D-Tryptophan. CHEMISTRY & BIODIVERSITY[J]. 2011, 8(5): 887-894, http://dx.doi.org/10.1002/cbdv.201000133.
[42] Wang, FaZuo, Li, DeHai, Zhu, TianJiao, Zhang, Min, Gu, QianQun. Pseurotin A(1) and A(2), two new 1-oxa-7-azaspiro4.4non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE[J]. 2011, 89(1): 72-76, https://www.webofscience.com/wos/woscc/full-record/WOS:000286474600011.
[43] Si Zhang, CaiGuo Huang, ChuanRong Li, ZhiHui Xiao, FaZuo Wang, AiJun Sun. A New Triterpenoid Saponin from Abrus precatorius Linn. MOLECULES[J]. 2011, 17(1): 295-302, https://doaj.org/article/70a311461fe246c0aa24047d50c40af9.
[44] 王发左, 朱天骄, 张敏, 林爱群, 顾谦群. 海洋真菌Rhizopus sp.2-PDA-61化学成分的研究(英文). 天然产物研究与开发[J]. 2011, 23(2): 199-201, http://lib.cqvip.com/Qikan/Article/Detail?id=37802558.
[45] Wang, Fazuo, Tian, Xinpeng, Huang, Caiguo, Li, Qingxin, Zhang, Si. Marinactinones A-C, new gamma-pyrones from marine actinomycete Marinactinospora thermotolerans SCSIO 00606. JOURNAL OF ANTIBIOTICS[J]. 2011, 64(2): 189-192, https://www.webofscience.com/wos/woscc/full-record/WOS:000288144900004.
[46] Gao, Guangchun, Lu, Zhongxian, Tao, Shuhong, Zhang, Si, Wang, Fazuo. Triterpenoid saponins with antifeedant activities from stem bark of Catunaregam spinosa (Rubiaceae) against Plutella xylostella (Plutellidae). CARBOHYDRATE RESEARCH[J]. 2011, 346(14): 2200-2205, http://dx.doi.org/10.1016/j.carres.2011.07.022.
[47] Wang, Fazuo, Zhu, Tianjiao, Zhang, Min, Lin, Aiqun, Zhu, Weiming, Gu, Qianqun. Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp 2-PDA-61, by 1D and 2D NMR spectroscopy. MAGNETIC RESONANCE IN CHEMISTRY[J]. 2010, 48(2): 155-158, http://www.irgrid.ac.cn/handle/1471x/767428.
[48] 张偲, 张长生, 田新朋, 王发左, 李洁. 中国海洋微生物多样性研究. 中国科学院院刊[J]. 2010, 651-658, http://lib.cqvip.com/Qikan/Article/Detail?id=35994085.
[49] Lin, AiQun, Du, Lin, Fang, YuChun, Wang, FaZuo, Zhu, TianJiao, Gu, QianQun, Zhu, WeiMing. iso-alpha-Cyclopiazonic acid, a new natural product isolated from the marine-derived fungus Aspergillus flavus C-F-3. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2009, 45(5): 677-680, https://www.webofscience.com/wos/woscc/full-record/WOS:000272158100015.
[50] Wang, Fazuo, Fang, Yuchun, Zhang, Min, Lin, Aiqun, Zhu, Anjiao, Gu, Qianqun, Zhu, Weiming. Six new ergosterols from the marine-derived fungus Rhizopus sp.. STEROIDS[J]. 2008, 73(1): 19-26, http://dx.doi.org/10.1016/j.steroids.2007.08.008.
[51] Wang, Fazuo, Fang, Yuchun, Zhu, Tianjiao, Zhang, Min, Lin, Aiqun, Gu, Qianqun, Zhu, Weiming. Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus. TETRAHEDRON[J]. 2008, 64(34): 7986-7991, http://dx.doi.org/10.1016/j.tet.2008.06.013.
发表著作
(1) 中国海洋微生物多样性(具体负责第五章第二节“海洋真菌化学及其生物活性多样性” 的编写), Diversity of Marine Microbes in China, 科学出版社, 2013-05, 第 1 作者

科研活动

   
科研项目
( 1 ) 深海微生物活性物质的挖掘及其利用技术, 参与, 国家任务, 2012-01--2015-12
( 2 ) 季风环流影响下的南海海洋细菌多样性特征及其生物海洋学意义, 参与, 国家任务, 2013-01--2017-12
( 3 ) 基于培养调控开展两株深海来源真菌化学多样性及抗肿瘤活性研, 负责人, 国家任务, 2015-01--2018-12
( 4 ) 深海药源天然产物底盘宿主细胞和异源表达体系的构建, 参与, 国家任务, 2020-01--2021-12
( 5 ) 南海海洋微生物药物先导物资源发现及活性评价, 参与, 地方任务, 2020-12--2023-12
参与会议
(1)海洋微生物天然产物研究的机遇与挑战   2012年中国水产食品科技大会   王发左   2012-09-29

指导学生

已指导学生

曾奇  硕士研究生  070703-海洋生物学  

仲伟茂  博士研究生  070703-海洋生物学  

向瑶  硕士研究生  085238-生物工程  

陈夏雨  硕士研究生  085238-生物工程  

曾奇  博士研究生  070703-海洋生物学  

现指导学生

车逸豪  博士研究生  070703-海洋生物学  

吴家敏  硕士研究生  070703-海洋生物学