Female
Ph.D. supervisor
Chengdu Institute of Biology, Chinese Academy of Sciences
Email: wuzhl@cib.ac.cn
Tel: 028-82890434
Address: 9 South Renmin Road, 4th Section, Chengdu, Sichuan, China, 610041
Prof. Dr. Zhong-Liu Wu got her Ph.D. degree from Shanghai Institute of Organic Chemistry, CAS. After postdoctoral work at Vanderbilt University, she joined Chengdu Institute of Biology as a professor. Current research are applying microorganism screening, microbial metagenome screening, and directed molecular evolution techniques for novel enzyme finding and modification, and developing biochemical processes to use the enzymes in the production of value-added substances.
Research Areas
Research interests
Diversity-Oriented Biotransformations for active compounds screening
Molecular directed evolution of lignocellulose-degrading enzymes
Enzyme-mediated Organic synthesis design
Education
B. S. East China University of Science and Technology, Shanghai, P.R.China (Applied Organic Chemistry) 1998.
Ph.D. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R.China (Organic Chemistry / Bioorganic Chemistry) 2003. (with professor Zu-Yi Li)
Thesis: “Screening for Novel Nitrile-converting Enzymes and Their Applications in the Synthesis of Several Classes of Chiral Molecules”
Experience
2003.9-2007.5 Research Fellow, Postdoctoral Scholar, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University, School of Medicine, Nashville, Tennessee, USA (with Professor F.P. Guengerich)
2007.5- Professor, Center in Applied and Environmental Microbiology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China
Honors & Distinctions
2003 Yonglin Liu Scholarship for Outstanding Graduates, CAS
1997 BASF Scholarship, BASF China
1995 BaoGang Scholarship, BaoSteel Group
Publications
Papers
Please visit our website:
http://sourcedb.cib.cas.cn/zw/rck/200908/t20090803_2296874.html
Patents
1. 吴中柳，刘育昌；一种可调控多酶级联反应用于合成光学纯烯丙型环氧酮或醇（ZL201510489144.2），授权日2020.02.21
2. 吴中柳，赵凤佼，刘艳，裴小琼，郭超；羰基还原酶ChKRED20突变体及其用途（ZL201610562094.0），2019.10.08
3. 吴中柳，赵凤佼，任志强，刘艳；一种羰基还原酶突变体及其用途（ZL201510487573.6），授权日2018.02.24
4. 吴中柳，任志强，刘艳；羰基还原酶生物催化生产噻吩基手性醇类化合物(ZL201510257701.8)，授权日2018.02.09
5. 吴中柳，任志强，刘艳，汤脱险，裴小琼；羰基还原酶、其基因及用于度洛西汀手性中间体的制备
（ZL201410012492.6），授权日2016. 06.01
6. 吴中柳，汤脱险，刘艳；羰基还原酶ChKRED20在催化羰基底物中的用途（ZL201410103481.9），授权日2016.04.13
7. 吴中柳，刘艳，裴小琼；一种新型羰基还原酶、其基因及应用（ZL 201410012867.9），授权日2015.12.09
8. 吴中柳，刘艳，汤脱险，裴小琼；一株金黄杆菌及其羰基还原酶用于阿瑞匹坦手性中间体生产（ZL201310399109.2），授权日2015.03.25
9. 吴中柳，刘艳，张超，汤传根，田小亮，裴小琼；氧化微杆菌及其制备手性双三氟甲基苯乙醇的方法.
(ZL201010271579.7), 授权日 2013.02.13.
10. 吴中柳，张帅兵，裴小琼，刘艳；一种阿魏酸酯酶A突变体及其用途. (ZL201110102026.3)，授权日2013.03.13.
11. 吴中柳，张志刚，刘艳；一种1, 4-b-D-木聚糖酶突变体. (ZL201010187324.2)，授权日 2013.06.05
12. 吴中柳，张志刚，刘艳；一种1, 4-b-D-木聚糖酶突变体（分案申请, ZL201210426297.9), 授权日 2014.12.24
13. 吴中柳，刘艳杰，林晖；一株无色杆菌及其不对称催化还原碳碳双键的方法 (ZL201210004039.1), 授权日2013.06.05.
14. 吴中柳，林晖，刘艳，乔婧；一种苯乙烯环氧化酶基因及其用途 (ZL201010120969.4)，授权日2014.09.17
15. 吴中柳，汤传根，张超，杨涛，刘章琴，林晖；一株粘红酵母及其制备(S)-羟基丙酰胺的方法 (ZL201010509822.4)， 授权日2014.03.12
16. 李祖义，吴中柳；Rhodococcus sp. D12 and Its Culture Method and Application, CN 1128874C, ZL 00127452.X, CN 1291648 A 18 Apr 2001, 17 pp. 2003.11.26
Financial Support
2.The Knowledge Innovation Program of the Chinese Academy of Sciences KSCX2-YW-G-075-8
3.Provincial Sci & Tech Foundation of Sichuan, China 2010SZ0128
4.National Natural Science Foundation of China 20802073/B020104
5.The 100 Talents Program of the Chinese Academy of Sciences
6.Provincial Sci & Tech Foundation for Young Scholars of Sichuan, China 08ZQ026-023 7.The Knowledge Innovation Program of the Chinese Academy of Sciences KSCX1-YW-11B2