​本研究组主要研究超灵敏生物物理技术的发展及其在细胞生物学和临床样本的多维度检测应用研究，具体研究内容包括：

1. 聚焦超分辨冷冻光学与电子显微成像前沿新技术的发展，在纳米尺度研究细胞中的细胞器和相关蛋白的原位结构与功能；

2. 利用多组学技术，整合临床表型、基因型和表达谱等多维度组学数据，从健康与疾病人群、组织、细胞和分子层面剖析疾病相关因素，深入探索常见疾病比如糖尿病和呼吸系统相关疾病的病因学和精准诊疗研究；

3. 专注于开发超灵敏的基于微小细胞外囊泡-外泌体的下一代检测技术，开展便捷和无创的疾病早期诊断和动态监测。

   

071011-生物物理学

超灵敏生物物理技术的发展及其在细胞生物学和临床样本的多维度检测应用研究

1997-07--1999-01   德国马普生物物理研究所（Max-Planck-Institute for Biophysical）   博士后
1995-12--1997-06   德国马普生物物理研究所（Max-Planck-Institute for Biophysical）   联合培养博士
1992-09--1996-12   华中科技大学（原华中理工大学）   博士
1988-09--1992-06   华中科技大学（原华中理工大学）   学士

华中理工大学 -- 研究生

华中理工大学 -- 博士

工作简历

2021－  广州国家实验室 副主任

2018－  中国科学院生物物理研究所生物大分子国家重点实验室主任

2007－2017年  中国科学院生物物理研究所所长

2007－2011年  中国科学院生物物理研究所生物大分子国家重点实验室主任

2003－2007年  中国科学院生物物理研究所研究员、副所长、生物大分子国家重点实验室副主任

2000－2003年  华中科技大学生物物理与生物化学研究所教授、所长、生命科学学院副院长

1999－2000年  美国华盛顿大学(University of Washington)生理与生物物理系 高级研究员 

学术职务

2017-  第十一届中国生物物理学会 理事长

2016-  《生物化学与生物物理进展》编委会委员

2015-  Biophysics Reports 主编

2014年   谈家桢生命科学奖评审专家委员会委员

2013-2017年  北京大学分子医学研究所学术委员会委员

2010-   《生物化学与生物物理进展》副主编

2010-   第九届中国生物物理学会 副理事长

2008-   Biochemical Journal Editorial Board , Vice Chair

2007-   Journal of Biological Chemistry，Editorial Board Member

2006-2010年  中国生物物理学会第八届膜与细胞生物物理专业委员会主任、第八届理事会常务理事

2004-   《科学通报》特邀编辑

2002-2007年   中德马普合作小组主任 

社会职务

2018 当选中国人民政治协商会议第十三届全国委员会常务委员

2014  中华全国青年联合会第十二届全国青联副主席

2014  中国青年科技工作者协会 副会长 （第五届一次理事会上当选）

2013  当选中国人民政治协商会议第十二届全国委员会委员

2010-（2015）中国科学院第三届青年联合会， 主席

奖励信息

2020年   全国先进工作者

2020年   第二届全国创新争先奖

2018年   当选发展中国家科学院（TWAS）院士

2017年   当选中国科学院院士（生命科学和医学学部）

2015年   2015年度第八届“谈家桢生命科学创新奖”

2013年   万人计划（亦称“国家高层次人才特支计划”）第一批

科技创新领军人才获得者

2012年  “创新人才推进计划”创新创业人才获得者

2012年   中国科学院优秀导师奖

2012年   何梁何利基金科学与技术进步奖

2008年   国家自然科学奖二等奖

2007年   第三世界科学院（TWAS）青年会士（Young Affiliate）

2006年   第十届中国青年五四奖章

2004年   国务院政府特殊津贴

2004年   突出贡献中青年专家

2004年   中国科学院“****”获得者

2003年   新世纪百千万人才工程国家级人选

2003年   湖北省教育系统教书育人先进个人

2003年   湖北省青年科技奖

2001/2002年   美国李氏基金杰出成就奖

2000年   教育部“长江学者奖励计划”特聘教授

2000年   国家杰出青年基金

代表性论文
（* Corresponding Author

1)Han Feng, Linpu Yang, Hang Yang, Dongwan Cheng, Min Li, Eli Song*, Tao Xu*. A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion. Molecular Therapy. 2024, 32(1):218-226.  

2)Jinping Yang#, Buyun Tian#, Pei Wang#, Rongrong Chen#, Ke Xiao, Xubin Long, Xinyue Zheng, Yun Zhu, Fei Sun, Yongxia Shi*, Yaming Jiu*, Wei Ji*, Yanhong Xue*, Tao Xu*, Zonghong Li*. SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12. Journal of Cell Biology. 

3)Zhuo Ma, Xiaofei Zhang, Wen Zhong, Hongyan Yi, Xiaowei Chen, Yinsuo Zhao, Yanlin Ma*, Eli Song*, Tao Xu*. Deciphering early human pancreas development at the single-cell level. Nature Communications, 2023, 14(1): 5354.

4)Weixing Li, Jing Lu, Ke Xiao, Maoge Zhou, Yuanyuan Li, Xiang Zhang, Zhixun Li, Lusheng Gu, Xiaojun Xu, Qiang Guo*, Tao Xu*, Wei Ji*.Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation. Nature Methods 2023 Feb;20(2):268-275.

5)Wanyan Wu, Shihang Luo, Chunyan Fan, Tianjie Yang, Shuwen Zhang, Wenxiang Meng, Tao Xu*,Wei Ji*, Lusheng*. Tetra-color superresolution microscopy based on excitation spectral demixing. Light: Science & Applications 2023, 12(1):9

6)Huaxia Luo, Peng Zhang, Wanyu Zhang, Yu Zheng, Di Hao, Yirong Shi, Yiwei Niu, Tingrui Song, Yanyan Li, Shilei Zhao, Hua Chen*, Tao Xu*, Shunmin He*. Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population. Science Bulletin 2023, 68(20), 2391-2404.

7)Yirong Shi, Yiwei Niu, Peng Zhang, Huaxia Luo, Shuai Liu, Sijia Zhang, Jiajia Wang, Yanyan Li, Xinyue Liu, Tingrui Song, Tao Xu*, Shunmin He*. Characterization of genome-wide STR variation in 6487 human genomes. Nature Communications 2023, 14(1): 2092.

8)Maoge Zhou, Bingjie Kong, Xiang Zhang, Ke Xiao, Jing Lu, Weixing Li, Min Li, Zonghong Li, Wei Ji*, Junjie Hou*, Tao Xu*. A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts. Iscience 2023, 26(7). 

9)Liqing Liu, Shuxin Yang, Yang Liu, Xixia Li, Junjie Hu*, Li Xiao* and Tao Xu*. DeepContact: High-throughput quantification of membrane contact sites based on electron microscopy imaging. Journal of Cell Biology 2022, 221(9): e2021061900.

10)Min Li, Fengping Feng, Han Feng, Pengkai Hu, Yanhong Xue, Tao Xu*, Eli Song*. VAMP4 regulates insulin levels by targeting secretory granules to lysosomes. Journal of Cell Biology 2022, 221(10):e202110164.

11)Linlin Wang, Hongyang Liu, Xiaofei Zhang, Eli Song, You Wang, Tao Xu* & Zonghong Li *. WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells. Nat Commun. 2021, 2(1):6996. 

12)Peng Zhang, Huaxia Luo, Yanyan Li, You Wang, Jiajia Wang, Yu Zheng, Yiwei Niu, Yirong Shi, Honghong Zhou, Tingrui Song, Quan Kang, The Han100K Initiative, Tao Xu,* and Shunmin He,*. NyuWa Genome resource: A deep whole-genome sequencing-based variation profile and reference panel for the Chinese population. Cell Rep. 2021, 37(7):110017.

13)Xiaofei Zhang, Zhuo Ma, Eli Song* & Tao Xu*. Islet organoid as a promising model for diabetes. Protein Cell. 2021, 10:1-19.

14)Lusheng Gu, Yuanyuan Li, Shuwen Zhang, Maoge Zhou, Yanhong Xue, Weixing Li, Tao Xu* and Wei Ji*. Molecular-scale axial localization by repetitive optical selective exposure, Nature Methods 2021, 18(4):369-373.

15)Zhifei Fu, Dingming Peng, Mingshu Zhang*, Fudong Xue, Rui Zhang, Wenting He, Tao Xu* and Pingyong Xu*. mEosEM withstands osmium staining and Epon embedding for super-resolution CLEM. Nature Methods 2020, 17:(55-58).

16)Mingshu Zhang, Zhifei Fu, Changqing Li, Anyuan Liu, Dingming Peng, Fudong Xue,  Wenting He, Shan Gao, Fan Xu, Dan Xu, Ling Yuan, Fa Zhang, Zhiheng Xu, Tao Xu*,  Pingyong Xu*. Fast super-resolution imaging technique and immediate early nanostructure capturing by a photo-convertible fluorescent protein. Nano Letters. 2020, 20(4): 2197-2208. 

17)Lusheng Gu, Yuanyuan Li, Shuwen Zhang, Yanhong Xue, Weixing Li, Dong Li, Tao Xu*, Wei Ji*. Molecular resolution imaging by repetitive optical selective exposure (ROSE). Nature Methods 2019, 16(11):1114-1118.

18)Wenjuan Zou, Jiajun Fu, Haining Zhang, Kang Du, Wenming Huang, Junwei Yu, Shitian Li, Yuedan Fan, Howard A. Baylis, Shangbang Gao, Rui Xiao, Wei Ji*, Lijun Kang* and Tao Xu*. Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron. Nature Communications 2018, 9:4311.

19)Zonghong Li, Maoge Zhou, Zhaokui Cai, Wen Zhong, Qiang Hao, Dongwan Chen, Xihao Hu, Junjie Hou, Pingyong Xu, Yuanchao Xue, Yifa Zhou*, Tao Xu*. RNA binding protein DDX1 is responsible for fatty acid mediated repression of insulin translation. Nucleic Acids Research. 2018. 1-16. doi: 10.1093/nar/gky867.

20)Junjie Hou, Zonghong Li, Wen Zhong, Qiang Hao, Lei Lei, Linlin Wang, Dongyu Zhao, Pingyong Xu, Yifa Zhou, You Wang*, and Tao Xu*. Temporal Transcriptomic and Proteomic Landscapes of Deteriorating Pancreatic Islets in Type 2 Diabetic Rats. Diabetes. 2017, 66:2188-2200. 

21)Ruotong Ren, Liping Deng, Yanhong Xue, Keiichiro Suzuki, Weiqi Zhang, Yang Yu, Jun Wu, Liang Sun, Xiaojun Gong, Huiqin Luan, Fan Yang, Zhenyu Ju, Xiaoqing Ren, Si Wang, Hong Tang, Lingling Geng, Weizhou Zhang, Jian Li, Jie Qiao, Tao Xu*, Jing Qu*, Guanghui Liu*. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017, 27:483-504. 

22)Wen Du, Maoge Zhou, Wei Zhao, Dongwan Cheng, Lifen Wang, Jingze Lu, Eli Song,Wei Feng, Yanhong Xue*, Pingyong Xu*, Tao Xu*. HID-1 is required for homotypic fusion of immature secretory granules during maturation. Elife 2016, DOI: 10.7554/eLife.18134.001.

23)Xi Lan, Chunyan Fan, Wei Ji, Fuyun Tian, Tao Xu*, Zhaobing Gao*. Grafting voltage and pharmacological sensitivity in potassium channels. Cell Research 2016, 1-11. 

24) Xiaoyu Yang, Shen Wang, Yi Sheng, Mingshu Zhang, Wenjuan Zou, Lijie Wu, Lijun Kang, Josep Rizo, Rongguang Zhang, Tao Xu* & Cong Ma*. Syntaxin Opening by the MUN Domain Underlies the Function of Munc13 in Synaptic Vesicle Priming.

Nature Structural & Molecular Biology. 2015, accepted

25) Sanyou Chen, Lei Li, Jiangli Li, Bei Liu, Xinyu Zhu, Li Zheng, Rongying Zhang*, Tao Xu*. SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in C. elegans.

Proceedings of the National Academy of Sciences USA. 2014,111(43): 15432–15437

26) Mingshu Zhang, Hao Chang, Yongdeng Zhang, Junwei Yu, Lijie Wu, Wei Ji , Juanjuan Chen, Bei Liu, Jingze Lu, Yingfagn Liu, Junlong Zhang, Pingyong Xu, Tao Xu*. Rational design of true monomeric and bright photoactivatable fluorescent proteins. Nature Methods. 9(7): 727-9. 2012.

27) Yu Chen, Yan Wang, Jinzhong Zhang, Yongqiang Deng, Li Jiang, Eli Song, Xufeng S. Wu, John A. Hammer, Tao Xu* and Jennifer Lippincott-Schwartz. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. Journal of Cell Biology. 198(4): 545-60. 2012.

28) Hao Chang, Mingshu Zhang, Wei Ji, Juanjuan Chen, Yongdeng Zhang, Bei Liu, Jingze Lu, Junlong Zhang, Pingyong Xu, Tao Xu*. A unique series of reversibly switchable fluorescent proteins with beneficial properties for various applications. Proceedings of the National Academy of Sciences USA. 109(12): 4455-60. 2012.

29) Zhaoyu Li, Yidong Li, Yalan Yi, Wenming Huang, Song Yang, Weipin Niu, Li Zhang, Zijing Xu, Anlian Qu, Zhengxing Wu and Tao Xu*. Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation. Nature Communications.776: 1-8. 2012.

30) Yong Yu, Lifen Wang, Yaming Jiu, Yi Zhan, Lin Liu, Zhiping Xia, Eli Song, Pingyong Xu and Tao Xu*. HID-1 is a novel player in the regulation of neuropeptide sorting. Biochemical Journal. 434: 383-390. 2011.

31) Zhengzheng Li, Lin Liu, Yongqiang Deng, Wei Ji, Wen Du, Pingyong Xu, Liangyi Chen, Tao Xu*. Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits. Cell Research. 21: 305-315. 2011.

32) Yu Chen, Yongqiang Deng, Jinzhong Zhang, Lu Yang, Xiangyang Xie and Tao Xu*. GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation. Biochemical Journal. 422: 229-235. 2009.

33) Ping Zhao, Lu Yang, Jamie A. Lopez, Junmei Fan, James G. Burchfield, Li Bai, Wanjin Hong, Tao Xu*, and David E. James. Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. Journal of Cell Science. 122 (19): 3472-3480. 2009.

34) Wei Ji, Pingyong Xu, Zhengzheng Li, Jingze Lu, Lin Liu, Yi Zhan, Yu Chen, Bertil Hille, Tao Xu*, and Liangyi Chen. Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proceedings of the National Academy of Sciences USA. 105(36): 13668-13673. 2008.

35) Zixuan He, Junmei Fan, Lijun Kang, Jingze Lu, Yanhong Xue, Pingyong Xu, Tao Xu* and Liangyi Chen. Ca2+ Triggers a Novel Clathrin-Independent but Actin-Dependent Fast Endocytosis in Pancreatic Beta Cells. Traffic. 9: 910-923. 2008.

36) Li Jiang, Junmei Fan, Li Bai, Yan Wang, Yu Chen, Lu Yang, Liangyi Chen, and Tao Xu*. Direct Quantification of Fusion Rate Reveals a Distal Role for AS160 in Insulin-stimulated Fusion of GLUT4 Storage Vesicles. The Journal of Biological Chemistry. 283(13): 8508-8516. 2008.

37) Yu Chen, Yan Wang, Wei Ji, Pingyong Xu and Tao Xu*. A pre-docking role for microtubules in insulin-stimulated glucose transporter 4 translocation. FEBS Journal. 275: 705-712. 2008.

38) Caixia Lv, Maorong Chen, Geliang Gan, Lifen Wang, Tao Xu*, and Jiuping Ding. Four-turn α-Helical Segment Prevents Surface Expression of the Auxiliary hβ2 Subunit of BK-type Channel. The Journal of Biological Chemistry. 283(5): 2709-2715. 2008.

39) Zhaohua Guo, Caixia Lv, Hong Yi, Yu Xiong, Yingliang Wu, Wenxin Li, Tao Xu*, Jiuping Ding. A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity. Biophysical Journal. 94(9): 3714-25. 2008

40) Li Bai, Yan Wang, Junmei Fan, Yu Chen, Wei Ji, Anlian Qu, Pingyong Xu, David E. James, and Tao Xu*. Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metabolism. 5: 47-57. 2007.

41) Keming Zhou, Yongming Dong, Qian Ge, Dan Zhu, Wei Zhou, Xianguang Lin, Tao Liang, Zhengxing Wu, Tao Xu*. PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C.elegans neurons. Neuron. 56: 657-669. 2007.

42) Zhengzheng Li, Jingze Lu, Pingyong Xu, Xiangyang Xie, Liangyi Chen, and Tao Xu*. Mapping the Interacting Domains of STIM1 and Orai1 in Ca2+Release-activated Ca2+ Channel Activation. The Journal of Biological Chemistry. 282(40): 29448-29456. 2007.

43) Hui Li, Jing Yao, Xiaotian Tong, Zhaohua Guo, Ying Wu, Liang Sun, Na Pan, Houming Wu, Tao Xu*, and Jiuping Ding. Interaction Sites between the Slo1 Pore and the NH2 Terminus of the 2 Subunit, Probed with a Three-residue Sensor. The Journal of Biological Chemistry. 282(24): 17720-17728. 2007.

44) Wei Li, Shangbang Gao, Caixia Lv, Ying Wu, Zhaohua Guo, Jiuping Ding, and Tao Xu*. Characterization of Voltage- and Ca2+-Activated K+ Channels in Rat Dorsal Root Ganglion Neurons. Journal of Cellular Physiology. 212(2): 348-357. 2007.

45) Lijun Kang, Zixuan He, Pingyong Xu, Junmei Fan, Andrea Bet, Nils Brose, and Tao Xu*. Munc13-1 is required for the sustained release of insulin from pancreatic beta cells. Cell Metabolism. 3: 463-468. 2006.

46) Li Bai, Dan Zhu, Keming Zhou, Wei Zhou, Dongdong Li, Yan Wang, Rongying Zhang and Tao Xu*. Differential Properties of GTP- and Ca2+-Stimulated Exocytosis from Large Dense Core Vesicles. Traffic. 7: 416-428. 2006.

47) Li Xie, Ming Zhang, Wei Zhou, Zhengxing Wu, Jiuping Ding, Liangyi Chen, Tao Xu*. Extracellular ATP Stimulates Cells.？ Exocytosis via Localized Ca2+ Release from acidic stores in Rat Pancreatic. Traffic. 7: 429-439. 2006.

48) Xiaofei Yang, Pingyong Xu, Yang Xiao, Xiong Xiong, Tao Xu*. Domain requirement for the membrane trafficking and targeting of Syntaxin 1A. J. Biol. Chem. 281(22): 15457-15463. 2006.

49) Huisheng Liu, Zhitao Hu, Keming Zhou, Yaming Jiu, Hua Yang, Zhengxing Wu, and Tao Xu*. Heterogeneity of the Ca2+ Sensitivity of Secretion in a Pituitary Gonadotrope Cell Line and its Modulation by Protein Kinase C and Ca2+. Journal of Cellular Physiology. 207: 668-674. 2006.

50) Dongfang Liu, Liang Xu, Fan Yang, Dongdong Li, Feili Gong, and Tao Xu*. Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition. Proceedings of the National Academy of Sciences USA. 102(1): 123-127. 2005.

51) Jie Liu, Qunfang Wan, Xianguang Lin, Hongliang Zhu, Kirill Volynski, Yuri Ushkaryov and Tao Xu*. α-Latrotoxin Modulates the Secretory Machinery via Receptor-Mediated Activation of Protein Kinase C. Traffic. 6: 756- 765. 2005.

52) Jing Yao, Xiang Chen, Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu*, Houming Wu, and Jiuping Ding. BmP09, a "Long Chain" Scorpion Peptide Blocker of BK Channels. J. Biol. Chem. 280: 14819-14828. 2005.

53) Hua Yang, Huisheng Liu, Zhitao Hu, Hongliang Zhu, and Tao Xu*. PKC-induced sensitization of Ca2+-dependent exocytosis is mediated by reducing the Ca2+-cooperativity in pituitary gonadotropes. Journal of General Physiology. 125: 327-334. 2005.

54) Qunfang Wan, Yongming Dong, Hua Yang, Xuelin Lou, Jiuping Ding, and Tao Xu*. Protein Kinase Activation Increases Insulin Secretion by Sensitizing the Secretory Machinery to Ca2+. Journal of General Physiology. 124: 653-662. 2004.

55) Chenhong Li, Li Bai, Dongdong Li, Sheng Xia, Tao Xu*. Dynamic tracking and Mobility analysis of single GLUT4 storage Vesicle in live 3T3-L1 Cells. Cell Research. 14(6): 480- 486. 2004

56) Dongdong Li, Jun Xiong, Anlian Qu, Tao Xu*. Three-dimensional tracking of single secretory granules in live PC12 cells. Biophysical Journal. 87(3): 1991-2001. 2004.

57) Hongliang Zhu, Bertil Hille, Tao Xu*. Sensitization of regulated exocytosis by protein kinase C. Proceedings of the National Academy of Sciences USA. 99(26): 17055-17059. 2002.

58) Tao Xu, Sandra M. Bajjalieh. SV2 modulates the size of the readily releasable pool of secretory vesicles. Nature Cell Biology. 3(8): 691-698. 2001.

36) Tao Xu, Burkhard Rammner, Martin Margittai, Antonio R. Artalejo, Erwin Neher, Reinhard Jahn. Inhibition of SNARE complex assembly differentially affects kinetic components of exocytosis. Cell. 99(7): 713-722. 1999.

59) Tao Xu, Uri Ashery, Robert D.Burgoyne, Erwin Neher. Early requirement for alpha-SNAP and NSF in the secretory cascade in chromaffin cells. The EMBO Journal. 18(12): 3293-304. 1999.

60) Tao Xu*, Thomas Binz, Heiner Niemann, Erwin Neher. Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity. Nature Neuroscience. 1(3): 192-200. 1998.

61) Tao Xu, Mohammad Naraghi, Huaguang Kang, Erwin Neher. Kinetic studies of Ca2+ binding and Ca2+ clearance in the cytosol of adrenal chromaffin cells. Biophysical Journal. 73(1): 532-545. 1997.

科研项目

主持重大、重点项目情况(部分项目)

2021-2025年  主持国家自然科学基金委国家重大科研仪器研制项目

项目名称：“细胞图谱超微结构高通量分析系统”

2021-2023年  主持中国科学院科研仪器设备研制项目

项目名称“原位生物冷冻电镜关键技术团队二期”

2018-2022年  主持国家自然科学基金委重点项目

项目名称“致密核心囊泡成熟的分子机制研究”

2019-2021年  主持北京市科技计划项目

项目名称“原位生物成像的关键技术与应用研究二期”

2018-2019年  主持北京市科技计划项目

项目名称“原位生物成像的关键技术与应用研究”

2018-2020年  主持中国科学院科研仪器设备研制项目

项目名称“原位生物冷冻电镜关键核心技术研发团队”

2015-2020年  中国科学院战略性先导科技专项（A类）

项目名称“代谢性疾病药物分层与生物标记物”

2014-2015年  主持国家自然科学基金委重大研究计划

项目名称“面向信号转导的蛋白质靶向探针及应用”

2012-2016年 主持国家自然基金委重点项目

项目名称“致密核心大囊泡分泌的分子机制研究”

2012-2015年 主持国家自然基金委专项基金项目

项目名称“光学锁相放大成像系统的研制”

2010-2014年 主持科技部国家重点基础研究发展计划

项目名称“生物膜动态变化的分子机理与功能研究”

2007-2010年 主持国家自然基金委重点项目

项目名称“囊泡转运及其与细胞膜融合分子机理研究”

2004-2009年 973项目首席科学家

项目名称“生物膜和膜蛋白的结构与功能研究”

2002-2005年 主持国家自然基金委重点项目

项目名称“细胞内蛋白质和膜转运的分子机理研究”

2001-2004年 主持国家杰出青年基金

项目名称“细胞生物学及发育生物学”

参加国际会议
2013.1.25-2.6    美国 科罗拉多州Keystone,宾夕法尼亚州费城 1. Diabetes-New Insights into Mechanism of Disease and its Treatment（美国Keystone专题研讨会）; 2. Biophysical Society 57th Annual Meeting（第58届美国生物物理大会）
2013.7.20-7.27   英国 伯明翰（Birmingham） International Union of Physiological Sciences （IUPS） 2013（2013年国际生理学大会(IUPS)）
2013.9.13-9.23   法国 蒙彼利埃（Montpellier） 进行糖尿病分子机制及超分辨成像领域的学术交流与合作研究
2013.12.2-12.5   新加坡 16th Asia-Pacific International Molecular Biology Network (A-IMBN) Annual Conference 2013
2014.2.14-2.21    美国 旧金山 The 58th Annual Meeting of the Biophysical Society（第58届美国生物物理大会）
2014.5.16-5.20   以色列 特拉维夫 深度创新研讨会（Deep Innovation with a special focus on Nano and Brain Techonologies)
2014.8.1-8.5    澳大利亚 布里斯班 International Union of Pure and Applied Biophysics (IUPAB)参加国际纯粹和应用生物物理学联盟大会 （IUPAB）
2014.11.30-12.4    台湾 台北 第二届海峡两岸生命科学论坛
2014.12.4-12.6    香港 The first International Conference on Organelle Biogenesis and Function in Hong Kong 香港第一届细胞器生物合成和功能国际研讨会
2015.5.9-5.12   中国 杭州 The 9th Asian Biophysics Association Symposium（第九届亚洲生物物理大会）
2015.6.20-6.27   美国 新伦敦 美国2015年三维电子显微镜戈登会议（2015 Gordon Research Conference on Three-dimensional
Electron Microscopy (3DEM)）
2015.8.17-8.22   澳大利亚 凯恩斯 2015年第18届嗜铬细胞生物学国际研讨会（ISCCB 2015 – the 18th International Symposium on Chromaffin Cell Biology）