表观遗传学

果实成熟过程中DNA甲基化作用

植物逆境生物学

071007-遗传学

表观遗传，果实成熟

2009-09--2014-12   美国普渡大学   博士学位
2005-09--2009-06   北京师范大学   学士学位

研究生

博士

博士后   2014. 12   2016.10   美国普渡大学

研究员   2016. 10    至今  中科院上海逆境生物学中心

2016-10~现在, 中科院上海逆境生物学中心, 研究员
2014-12~2016-09,美国普渡大学, 博士后

   

[1] Liu, Pan, Nie, WenFeng, Xiong, Xiansong, Wang, Yuhua, Jiang, Yuwei, Huang, Pei, Lin, Xueqiang, Qin, Guochen, Huang, Huan, Niu, Qingfeng, Du, Jiamu, Lang, Zhaobo, LozanoDuran, Rosa, Zhu, JianKang. A novel protein complex that regulates active DNA demethylation in Arabidopsis. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2021, 63(4): 772-786, http://dx.doi.org/10.1111/jipb.13045.
[2] Liu, Ruie, Lang, Zhaobo. The mechanism and function of active DNA demethylation in plants. JOURNAL OF INTEGRATIVE PLANT BIOLOGYnull. 2020, 62(1): 148-159, http://dx.doi.org/10.1111/jipb.12879.
[3] Wang, Xingang, Ren, Min, Liu, Danni, Zhang, Dabao, Zhang, Cuijun, Lang, Zhaobo, Macho, Alberto P, Zhang, Min, Zhu, JianKang. Large-scale identification of expression quantitative trait loci in Arabidopsis reveals novel candidate regulators of immune responses and other processes. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2020, 62(10): 1469-1483, http://lib.cqvip.com/Qikan/Article/Detail?id=7103155347.
[4] Li, Jingwen, Yang, DongLei, Huang, Huan, Zhang, Guiping, He, Li, Pang, Jia, LozanoDuran, Rosa, Lang, Zhaobo, Zhu, JianKang. Epigenetic memory marks determine epiallele stability at loci targeted by de novo DNA methylation. NATURE PLANTS[J]. 2020, 6(6): 661-674, https://www.webofscience.com/wos/woscc/full-record/WOS:000538961400005.
[5] Vilchez, Juan, I, Yang, Yu, He, Danxia, Zi, Hailing, Peng, Li, Lv, Suhui, Kaushal, Richa, Wang, Wei, Huang, Weichang, Liu, Renyi, Lang, Zhaobo, Miki, Daisuke, Tang, Kai, Pare, Paul W, Song, ChunPeng, Zhu, JianKang, Zhang, Huiming. DNA demethylases are required for myo-inositol-mediated mutualism between plants and beneficial rhizobacteria. NATURE PLANTS[J]. 2020, 6(8): 983-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000548197800003.
[6] Tang, Dengguo, Gallusci, Philippe, Lang, Zhaobo. Fruit development and epigenetic modifications. NEW PHYTOLOGISTnull. 2020, 228(3): 839-844, https://www.webofscience.com/wos/woscc/full-record/WOS:000574926500011.
[7] Niu, Qingfeng, Wu, Siqun, Li, Yansha, Yang, Xiaoxuan, Liu, Ping, Xu, Yaping, Lang, Zhaobo. Expanding the scope of CRISPR/Cas9-mediated genome editing in plants using an xCas9 and Cas9-NG hybrid. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2020, 62(4): 398-402, https://www.webofscience.com/wos/woscc/full-record/WOS:000522794300002.
[8] Xinlong Xiao, Jieqiong Zhang, Tao Li, Xing Fu, Viswanathan Satheesh, Qingfeng Niu, Zhaobo Lang, JianKang Zhu, Mingguang Lei. A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS1 in Arabidopsis. 植物学报:英文版[J]. 2019, 110-119, http://lib.cqvip.com/Qikan/Article/Detail?id=90878866504849574850484851.
[9] Yang, Yu, Tang, Kai, Datsenka, Tatsiana U, Liu, Wenshan, Lv, Suhui, Lang, Zhaobo, Wang, Xingang, Gao, Jinghui, Wang, Wei, Nie, Wenfeng, Chu, Zhaoqing, Zhang, Heng, Handa, Avtar K, Zhu, JianKang, Zhang, Huiming. Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2019, 61(12): 1224-1242, http://lib.cqvip.com/Qikan/Article/Detail?id=7100584713.
[10] Huang, Huan, Liu, Ruie, Niu, Qingfeng, Tang, Kai, Zhang, Bo, Zhang, Heng, Chen, Kunsong, Zhu, JianKang, Lang, Zhaobo. Global increase in DNA methylation during orange fruit development and ripening. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(4): 1430-1436, https://www.webofscience.com/wos/woscc/full-record/WOS:000456336100051.
[11] Zhang, Huiming, Lang, Zhaobo, Zhu, JianKang. Dynamics and function of DNA methylation in plants. NATURE REVIEWS MOLECULAR CELL BIOLOGYnull. 2018, 19(8): 489-506, http://dx.doi.org/10.1038/s41580-018-0016-z.
[12] Qi, Meifang, Li, Zijuan, Liu, Chunmei, Hu, Wenyan, Ye, Luhuan, Xie, Yilin, Zhuang, Yili, Zhao, Fei, Teng, Wan, Zheng, Qi, Fan, Zhenjun, Xu, Lin, Lang, Zhaobo, Tong, Yiping, Zhang, Yijing. CGT-seq: epigenome-guided de novo assembly of the core genome for divergent populations with large genome. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(18): https://www.webofscience.com/wos/woscc/full-record/WOS:000450953200002.
[13] Lang, Zhaobo, Gong, Zhizhong. A role of OsROS1 in aleurone development and nutrient improvement in rice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAnull. 2018, 115(46): 11659-11660, https://www.webofscience.com/wos/woscc/full-record/WOS:000449934400026.
[14] Cheng, Jingfei, Niu, Qingfeng, Zhang, Bo, Chen, Kunsong, Yang, Ruihua, Zhu, JianKang, Zhang, Yijing, Lang, Zhaobo. Downregulation of RdDM during strawberry fruit ripening. GENOME BIOLOGY[J]. 2018, 19(1): https://doaj.org/article/b92c08b8fa594e189e2d089151769152.
[15] Srivastava, Ashish Kumar, Lu, Yuming, Zinta, Gaurav, Lang, Zhaobo, Zhu, JianKang. UTR-Dependent Control of Gene Expression in Plants. TRENDS IN PLANT SCIENCEnull. 2018, 23(3): 248-259, http://dx.doi.org/10.1016/j.tplants.2017.11.003.
[16] Lang, Zhaobo, Wang, Yihai, Tang, Kai, Tang, Dengguo, Datsenka, Tatsiana, Cheng, Jingfei, Zhang, Yijing, Handa, Avtar K, Zhu, JianKang. Critical roles of DNA demethylation in the activation of ripening-induced genes and inhibition of ripening-repressed genes in tomato fruit. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(22): E4511-E4519, https://www.webofscience.com/wos/woscc/full-record/WOS:000402296700025.
[17] Lang, Zhaobo, Xie, Shaojun, Zhu, JianKang. The 1001 Arabidopsis DNA Methylomes: An Important Resource for Studying Natural Genetic, Epigenetic, and Phenotypic Variation. TRENDS IN PLANT SCIENCEnull. 2016, 21(11): 906-908, http://dx.doi.org/10.1016/j.tplants.2016.09.001.
[18] Tang, Kai, Lang, Zhaobo, Zhang, Heng, Zhu, JianKang. The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications. NATURE PLANTS[J]. 2016, 2(11): 16169-16169, https://www.webofscience.com/wos/woscc/full-record/WOS:000395792200010.
[19] Zhang, Qingzhu, Wang, Dong, Lang, Zhaobo, He, Li, Yang, Lan, Zeng, Liang, Li, Yanqiang, Zhao, Cheng, Huang, Huan, Zhang, Heng, Zhang, Huiming, Zhu, JianKang. Methylation interactions in Arabidopsis hybrids require RNA-directed DNA methylation and are influenced by genetic variation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(29): E4248-E4256, [20] Lang, Zhaobo, Gong, Zhizhong. SMALL RNA BIOGENESIS Novel roles of an RNase III enzyme. NATURE PLANTSnull. 2016, 2(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000375395000004.
[21] Zhan, Xiangqiang, Yang, Lan, Wang, Dong, Zhu, Jian Kang, Lang, Zhaobo. De novo assembly and analysis of the transcriptome of Ocimum americanum var. pilosum under cold stress. BMC GENOMICS[J]. 2016, 17(1): http://dx.doi.org/10.1186/s12864-016-2507-7.
[22] Zhan, Xiangqiang, Zhu, JianKang, Lang, Zhaobo. Increasing Freezing Tolerance: Kinase Regulation of ICE1. DEVELOPMENTAL CELLnull. 2015, 32(3): 257-258, http://dx.doi.org/10.1016/j.devcel.2015.01.004.
[23] Chunlei Wang, Xiaomei Dong, Dan Jin, Yusheng Zhao, Shaojun Xie, Xiaojie Li, Xinjian He, Zhaobo Lang, Jinsheng Lai, JianKang Zhu, Zhizhong Gong. Methyl-CpG-Binding Domain Protein MBD7 Is Required for Active DNA Demethylation in Arabidopsis 1 OPEN. Plant Physiology. 2015, 167(3): 905-914, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348759/.
[24] Wan, Yizhen, Tang, Kai, Zhang, Dayong, Xie, Shaojun, Zhu, Xiaohong, Wang, Zegang, Lang, Zhaobo. Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana. GENOME BIOLOGY[J]. 2015, 16: http://dx.doi.org/10.1186/s13059-015-0839-2.
[25] Zhao, Chunzhao, Lang, Zhaobo, Zhu, JianKang. Cold responsive gene transcription becomes more complex. TRENDS IN PLANT SCIENCEnull. 2015, 20(8): 466-468, http://dx.doi.org/10.1016/j.tplants.2015.06.001.
[26] Lang ZhaoBo, Zuo JianRu. Say "NO" to ABA signaling in guard cells by S-nitrosylation of OST1. SCIENCE CHINA-LIFE SCIENCESnull. 2015, 58(3): 313-314, https://www.webofscience.com/wos/woscc/full-record/WOS:000351809200014.
[27] Lang, Zhaobo, Lei, Mingguang, Wang, Xingang, Tang, Kai, Miki, Daisuke, Zhang, Huiming, Mangrauthia, Satendra K, Liu, Wenshan, Nie, Wenfeng, Ma, Guojie, Yan, Jun, Duan, ChengGuo, Hsu, ChuanChih, Wang, Chunlei, Tao, W Andy, Gong, Zhizhong, Zhu, JianKang. The Methyl-CpG-Binding Protein MBD7 Facilitates Active DNA Demethylation to Limit DNA Hyper-Methylation and Transcriptional Gene Silencing. MOLECULAR CELL[J]. 2015, 57(6): 971-983, http://dx.doi.org/10.1016/j.molcel.2015.01.009.
[28] Duan, ChengGuo, Zhang, Huiming, Tang, Kai, Zhu, Xiaohong, Qian, Weiqiang, Hou, YuehJu, Wang, Bangshing, Lang, Zhaobo, Zhao, Yang, Wang, Xingang, Wang, Pengcheng, Zhou, Jianping, Liang, Gaimei, Liu, Na, Wang, Chunguo, Zhu, JianKang. Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBO JOURNAL[J]. 2015, 34(5): 581-592, https://www.webofscience.com/wos/woscc/full-record/WOS:000350693400002.
[29] Wang, Pengcheng, Zhu, JianKang, Lang, Zhaobo. Nitric oxide suppresses the inhibitory effect of abscisic acid on seed germination by S-nitrosylation of SnRK2 proteins. PLANT SIGNALING & BEHAVIOR[J]. 2015, 10(6): 1-3, https://www.webofscience.com/wos/woscc/full-record/WOS:000356862400001.
[30] Lang ZhaoBo, Zhu JianKang. OST1 phosphorylates ICE1 to enhance plant cold tolerance. SCIENCE CHINA-LIFE SCIENCESnull. 2015, 58(3): 317-318, https://www.webofscience.com/wos/woscc/full-record/WOS:000351809200016.
[31] Zhang, Huiming, Tang, Kai, Wang, Bangshing, Duan, ChengGuo, Lang, Zhaobo, Zhu, JianKang. Protocol: a beginner's guide to the analysis of RNA-directed DNA methylation in plants. PLANT METHODS[J]. 2014, 10(1): 18-18, https://www.webofscience.com/wos/woscc/full-record/WOS:000338372600001.
[32] Qian Weiqiang, Miki Daisuke, Lei Mingguang, Zhu Xiaohong, Zhang Huiming, Liu Yunhua, Li Yan, Lang Zhaobo, Wang Jing, Tang Kai, Liu Renyi, Zhu Jian-Kang. Regulation of Active DNA Demethylation by an α-Crystallin Domain Protein in Arabidopsis. Molecular Cell. 2014, 55(3): 361-371, http://dx.doi.org/10.1016/j.molcel.2014.06.008.
[33] Zhang, Huiming, Tang, Kai, Qian, Weiqiang, Duan, ChengGuo, Wang, Bangshing, Zhang, Heng, Wang, Pengcheng, Zhu, Xiaohong, Lang, Zhaobo, Yang, Yu, Zhu, JianKang. An Rrp6-like Protein Positively Regulates Noncoding RNA Levels and DNA Methylation in Arabidopsis. MOLECULAR CELL[J]. 2014, 54(3): 418-430, http://dx.doi.org/10.1016/j.molcel.2014.03.019.

   

（ 1 ） 第十四批****（青年项目）, 主持, 国家级, 2018-03--2021-03
（ 2 ） 上海市青年拔尖人才, 主持, 省级, 2018-01--2020-12
（ 3 ） 国家重点实验室稳定支持项目, 主持, 部委级, 2018-01--2018-12
（ 4 ） 大学生科创计划, 主持, 部委级, 2018-01--2018-12

现指导学生

吴思群  硕士研究生  071010-生物化学与分子生物学  

李林竹  硕士研究生  071007-遗传学  

许雅萍  硕士研究生  071007-遗传学  

彭元  硕士研究生  071007-遗传学  

马宇  硕士研究生  0710J3-生物信息学