Principal investigator;
Email: guocx@big.ac.cn
Mailing address:
Beijing Institute of Genomics,
No.1 Beichen West Rd, Chaoyang District, Beijing
Postcode: 100101
Research Areas
DNA damage response, genome instability and tumor drug resistance.
Education
Ph.D. 1996-1999
Institute of Zoology
Chinese Academy of Sciences
M.S. 1991-1994
Wuhan University, China
B.S. 1987-1991
Wuhan University, China
Experience
Principal Investigator 2009-present
Beijing Institute of Genomics
Research Assistant Professor of Dep. Pathology 2008-2009
UT Southwestern Medical Center at Dallas
Instructor of Dep. Pathology 2004-2008
UT Southwestern Medical Center at Dallas
Postdoctoral Research Fellowship 2001-2004
UT Southwestern Medical Center at Dallas
Postdoctoral Research Fellowship 1999-2001
University of Kentucky
Publications
1 Ma X, Cheng Z, Guo C. Insights into the DNA damage response and tumor drug resistance. Cancer Biol Med. 2025. 22(3):197-204.
2 Fu H, Huang M, Wu H, Zheng H, Gong Y, Xing L, Gong J, An R, Li Q, Jie X, Ma X, Tang TS, Guo C*. SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection. Nat Commun. 2025. 16(1):2244.
3 Wu W, Fan Z, Fu H, Ma X, Wang D, Liu H, Zhang C, Zheng H, Yang Y, Wu H, Miao X, An R, Gong Y, Tang TS, Guo C*. VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair. Sci Adv. 2024.10(41):eadr2643.
4 Ma X, Fu H, Sun C, Wu W, Hou W, Zhou Z, Zheng H, Gong Y, Wu H, Qin J, Lou H, Li J, Tang TS, Guo C*. RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair. Cell Death Dis. 2024. 15(5):321.
5 Ma X, Wang C, Zhou B, Cheng Z, Mao Z, Tang TS*, Guo C*. DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1. J Biol Chem. (2022). 298(5):101861.
6 Zhang C, Zhou B*, Gu F, Liu H, Wu H, Yao F, Zheng H, Fu H, Chong W, Cai S, Huang M, Ma X, Guo Z, Li T, Deng W, Zheng M, Ji Q, Zhao Y, Ma Y, Wang QE, Tang TS*, Guo C*. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. Mol Cell (2022). 82(7):1297-1312.e8.