基本信息
周小龙 男 博导 中国科学院分子细胞科学卓越创新中心
电子邮件: xlzhou@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:
电子邮件: xlzhou@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:
出版信息
发表论文
(1) SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth, Nature Metabolism, 2026, (2) Loss of AlaX, a trans-editing factor for several aminoacyl-tRNA synthetases, activates the unfolded protein response and arrests the cell cycle, SCIENCE CHINA Life Sciences, 2026, (3) Molecular pathogenesis and gene therapy-based intervention of GTPBP3-related mitochondrial disease, Nature Communications, 2026, (4) Tangled but ordered human mitochondrial tRNA maturation, SCIENCE CHINA-LIFE SCIENCES, 2025, 第 2 作者 通讯作者(5) Mammalian tRNA acetylation determines translation efficiency and tRNA quality control, Nature Communications, 2025, (6) Taurine hypomodification underlies mitochondrial tRNA Trp -related genetic diseases, NUCLEIC ACIDS RESEARCH, 2024, 第 8 作者(7) Multifaceted roles of t 6 A biogenesis in efficiency and fidelity of mitochondrial gene expression, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(8) Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(9) Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation, NUCLEIC ACIDS RESEARCH, 2024, 第 2 作者 通讯作者(10) ADATs: roles in tRNA editing and relevance to disease, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2024, 第 3 作者(11) Pathophysiology of human mitochondrial tRNA metabolism, TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2024, 第 3 作者 通讯作者(12) Mammalian trans-editing factor ProX is able to deacylate tRNAThr mischarged with alanine, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 第 9 作者 通讯作者(13) Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 9 作者(14) Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023, 第 10 作者 通讯作者(15) Mitochondrial RNA m3C methyltransferase METTL8 relies on an isoform-specific N-terminal extension and modifies multiple heterogenous tRNAs, SCIENCE BULLETIN, 2023, 第 11 作者 通讯作者(16) Mammalian mitochondrial translation infidelity leads to oxidative stress-induced cell cycle arrest and cardiomyopathy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 11 作者 通讯作者(17) Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者 通讯作者(18) Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022, 第 9 作者 通讯作者(19) Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022, 第 18 作者 通讯作者(20) RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(21) Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(22) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021, 第 27 作者 通讯作者(23) Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 第 3 作者 通讯作者(24) 多氨基酰-tRNA合成酶复合物的发生发展, The development of multiple synthetase complex(MSC), 生命科学, 2021, 第 2 作者(25) The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021, 第 7 作者 通讯作者(26) Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA Life Sciences, 2021, 第 4 作者 通讯作者(27) Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021, 第 9 作者 通讯作者(28) Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020, 第 8 作者 通讯作者(29) Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020, 第 6 作者 通讯作者(30) Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA^(Lys), Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNALys, SCIENCE CHINA Life Sciences, 2020, 第 8 作者 通讯作者(31) 氨基酰-tRNA合成酶与神经系统疾病, Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020, 第 2 作者(32) The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019, 第 8 作者 通讯作者(33) Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019, 第 1 作者 通讯作者(34) Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018, 第 2 作者(35) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018, 第 6 作者 通讯作者(36) A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018, 第 5 作者 通讯作者(37) Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017, 第 1 作者(38) Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 1 作者(39) A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 2 作者 通讯作者(40) C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 5 作者 通讯作者(41) Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者 通讯作者(42) Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者(43) A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014, 第 1 作者(44) Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014, 第 7 作者 通讯作者
发表论文
(1) SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth, Nature Metabolism, 2026, (2) Loss of AlaX, a trans-editing factor for several aminoacyl-tRNA synthetases, activates the unfolded protein response and arrests the cell cycle, SCIENCE CHINA Life Sciences, 2026, (3) Molecular pathogenesis and gene therapy-based intervention of GTPBP3-related mitochondrial disease, Nature Communications, 2026, (4) Tangled but ordered human mitochondrial tRNA maturation, SCIENCE CHINA-LIFE SCIENCES, 2025, 第 2 作者 通讯作者(5) Mammalian tRNA acetylation determines translation efficiency and tRNA quality control, Nature Communications, 2025, (6) Taurine hypomodification underlies mitochondrial tRNA Trp -related genetic diseases, NUCLEIC ACIDS RESEARCH, 2024, 第 8 作者(7) Multifaceted roles of t 6 A biogenesis in efficiency and fidelity of mitochondrial gene expression, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(8) Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(9) Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation, NUCLEIC ACIDS RESEARCH, 2024, 第 2 作者 通讯作者(10) ADATs: roles in tRNA editing and relevance to disease, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2024, 第 3 作者(11) Pathophysiology of human mitochondrial tRNA metabolism, TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2024, 第 3 作者 通讯作者(12) Mammalian trans-editing factor ProX is able to deacylate tRNAThr mischarged with alanine, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 第 9 作者 通讯作者(13) Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 9 作者(14) Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023, 第 10 作者 通讯作者(15) Mitochondrial RNA m3C methyltransferase METTL8 relies on an isoform-specific N-terminal extension and modifies multiple heterogenous tRNAs, SCIENCE BULLETIN, 2023, 第 11 作者 通讯作者(16) Mammalian mitochondrial translation infidelity leads to oxidative stress-induced cell cycle arrest and cardiomyopathy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 11 作者 通讯作者(17) Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者 通讯作者(18) Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022, 第 9 作者 通讯作者(19) Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022, 第 18 作者 通讯作者(20) RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(21) Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(22) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021, 第 27 作者 通讯作者(23) Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 第 3 作者 通讯作者(24) 多氨基酰-tRNA合成酶复合物的发生发展, The development of multiple synthetase complex(MSC), 生命科学, 2021, 第 2 作者(25) The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021, 第 7 作者 通讯作者(26) Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA Life Sciences, 2021, 第 4 作者 通讯作者(27) Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021, 第 9 作者 通讯作者(28) Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020, 第 8 作者 通讯作者(29) Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020, 第 6 作者 通讯作者(30) Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA^(Lys), Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNALys, SCIENCE CHINA Life Sciences, 2020, 第 8 作者 通讯作者(31) 氨基酰-tRNA合成酶与神经系统疾病, Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020, 第 2 作者(32) The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019, 第 8 作者 通讯作者(33) Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019, 第 1 作者 通讯作者(34) Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018, 第 2 作者(35) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018, 第 6 作者 通讯作者(36) A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018, 第 5 作者 通讯作者(37) Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017, 第 1 作者(38) Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 1 作者(39) A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 2 作者 通讯作者(40) C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 5 作者 通讯作者(41) Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者 通讯作者(42) Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者(43) A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014, 第 1 作者(44) Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014, 第 7 作者 通讯作者
出版信息
发表论文
(1) SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth, Nature Metabolism, 2026, (2) Loss of AlaX, a trans-editing factor for several aminoacyl-tRNA synthetases, activates the unfolded protein response and arrests the cell cycle, SCIENCE CHINA Life Sciences, 2026, (3) Molecular pathogenesis and gene therapy-based intervention of GTPBP3-related mitochondrial disease, Nature Communications, 2026, (4) Tangled but ordered human mitochondrial tRNA maturation, SCIENCE CHINA-LIFE SCIENCES, 2025, 第 2 作者 通讯作者(5) Mammalian tRNA acetylation determines translation efficiency and tRNA quality control, Nature Communications, 2025, (6) Taurine hypomodification underlies mitochondrial tRNA Trp -related genetic diseases, NUCLEIC ACIDS RESEARCH, 2024, 第 8 作者(7) Multifaceted roles of t 6 A biogenesis in efficiency and fidelity of mitochondrial gene expression, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(8) Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(9) Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation, NUCLEIC ACIDS RESEARCH, 2024, 第 2 作者 通讯作者(10) ADATs: roles in tRNA editing and relevance to disease, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2024, 第 3 作者(11) Pathophysiology of human mitochondrial tRNA metabolism, TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2024, 第 3 作者 通讯作者(12) Mammalian trans-editing factor ProX is able to deacylate tRNAThr mischarged with alanine, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 第 9 作者 通讯作者(13) Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 9 作者(14) Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023, 第 10 作者 通讯作者(15) Mitochondrial RNA m3C methyltransferase METTL8 relies on an isoform-specific N-terminal extension and modifies multiple heterogenous tRNAs, SCIENCE BULLETIN, 2023, 第 11 作者 通讯作者(16) Mammalian mitochondrial translation infidelity leads to oxidative stress-induced cell cycle arrest and cardiomyopathy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 11 作者 通讯作者(17) Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者 通讯作者(18) Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022, 第 9 作者 通讯作者(19) Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022, 第 18 作者 通讯作者(20) RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(21) Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(22) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021, 第 27 作者 通讯作者(23) Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 第 3 作者 通讯作者(24) 多氨基酰-tRNA合成酶复合物的发生发展, The development of multiple synthetase complex(MSC), 生命科学, 2021, 第 2 作者(25) The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021, 第 7 作者 通讯作者(26) Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA Life Sciences, 2021, 第 4 作者 通讯作者(27) Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021, 第 9 作者 通讯作者(28) Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020, 第 8 作者 通讯作者(29) Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020, 第 6 作者 通讯作者(30) Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA^(Lys), Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNALys, SCIENCE CHINA Life Sciences, 2020, 第 8 作者 通讯作者(31) 氨基酰-tRNA合成酶与神经系统疾病, Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020, 第 2 作者(32) The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019, 第 8 作者 通讯作者(33) Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019, 第 1 作者 通讯作者(34) Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018, 第 2 作者(35) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018, 第 6 作者 通讯作者(36) A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018, 第 5 作者 通讯作者(37) Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017, 第 1 作者(38) Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 1 作者(39) A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 2 作者 通讯作者(40) C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 5 作者 通讯作者(41) Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者 通讯作者(42) Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 6 作者(43) A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014, 第 1 作者(44) Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014, 第 7 作者 通讯作者
发表论文
(1) SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth, Nature Metabolism, 2026, (2) Loss of AlaX, a trans-editing factor for several aminoacyl-tRNA synthetases, activates the unfolded protein response and arrests the cell cycle, SCIENCE CHINA Life Sciences, 2026, (3) Molecular pathogenesis and gene therapy-based intervention of GTPBP3-related mitochondrial disease, Nature Communications, 2026, (4) Tangled but ordered human mitochondrial tRNA maturation, SCIENCE CHINA-LIFE SCIENCES, 2025, 第 2 作者 通讯作者(5) Mammalian tRNA acetylation determines translation efficiency and tRNA quality control, Nature Communications, 2025, (6) Taurine hypomodification underlies mitochondrial tRNA Trp -related genetic diseases, NUCLEIC ACIDS RESEARCH, 2024, 第 8 作者(7) Multifaceted roles of t 6 A biogenesis in efficiency and fidelity of mitochondrial gene expression, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(8) Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation, NUCLEIC ACIDS RESEARCH, 2024, 第 5 作者 通讯作者(9) Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation, NUCLEIC ACIDS RESEARCH, 2024, 第 2 作者 通讯作者(10) ADATs: roles in tRNA editing and relevance to disease, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2024, 第 3 作者(11) Pathophysiology of human mitochondrial tRNA metabolism, TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2024, 第 3 作者 通讯作者(12) Mammalian trans-editing factor ProX is able to deacylate tRNAThr mischarged with alanine, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 第 9 作者 通讯作者(13) Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023, 第 9 作者(14) Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023, 第 10 作者 通讯作者(15) Mitochondrial RNA m3C methyltransferase METTL8 relies on an isoform-specific N-terminal extension and modifies multiple heterogenous tRNAs, SCIENCE BULLETIN, 2023, 第 11 作者 通讯作者(16) Mammalian mitochondrial translation infidelity leads to oxidative stress-induced cell cycle arrest and cardiomyopathy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 11 作者 通讯作者(17) Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022, 第 11 作者 通讯作者(18) Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022, 第 9 作者 通讯作者(19) Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022, 第 18 作者 通讯作者(20) RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(21) Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022, 第 8 作者 通讯作者(22) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021, 第 27 作者 通讯作者(23) Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 第 3 作者 通讯作者(24) 多氨基酰-tRNA合成酶复合物的发生发展, The development of multiple synthetase complex(MSC), 生命科学, 2021, 第 2 作者(25) The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021, 第 7 作者 通讯作者(26) Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA Life Sciences, 2021, 第 4 作者 通讯作者(27) Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and 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