General

Prof. Liu is a Pengcheng Distinguished Professor in Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, the Vice President of SIAT, the Director of CAS Key Laboratory for Quantitative Engineering Biology, the Director of Shenzhen Institute of Synthetic Biology (iSynBio), the Chief Scientist of Shenzhen Synthetic Biology Core Facility. Liu also serves as the Executive Editor-in-Chief of Synthetic Biology Journal (Chinese), Associate Editor of Engineering Biology, and mLife, and as Editorial Advisory Board member of the journals ACS Synthetic Biology, Systems and Synthetic Biotechnology, and Quantitative Biology, Journal of Genetics and Genomics, and reviewer of THE XPLORER PRIZE of Tencent, MIT Technology Review 35 under 35, and other awards. Liu obtained a Ph.D. in Biochemistry from the University of Hong Kong, and postdoctoral training in MCB, Harvard University, where he worked on RNAs roles in chromosome organization. He also is the recipients of several prestigious awards, e.g. "Young Scientists Award of the Chinese Academy of Sciences", "Excellent Mentor Award of the Chinese Academy of Sciences", "State Council Expert for Special Allowance", "VCANBIO Award for Biosciences and Medicine", "Li Ka Shing Award", "Hong Kong Young Scientist Award", etc.

Research Areas

Synthetic Quantitative Microbiology

SynBio Tumor Therapy

Directed Evolution System

Chromosome Biology


Education

Ph.D. (Biochemistry): The University of Hong Kong, China, 2006-2011

Supervisor: Dr. Jian-Dong Huang (jdhuang@hku.hk)

M.Sc. B.Sc. (Biochemistry and Molecular Biology): Xiamen University, China, 1998-2005

Supervisor: Prof. Zongze Shao (shaozz@163.com)


Publications



Papers

1. Shuxin Yang#, Wenjuan Zhao#, Muchun Zhu#, Huijuan Hu, Weijie Wang, Zhongsheng Zang, Meiling Jin, Jiacheng Bi, Jiandong Huang, Chenli Liu, Xuefei Li, Peng Yin, Nan Li*. (2021) Tumor Temporal Proteome Profiling Reveals the Immunological Triple Offensive Induced by Synthetic Anti-Cancer Salmonella. Frontiers in Immunology, 12:712936. DOI: 10.3389/fimmu.2021.712936.

2. Hui Wu#, Ting Wei#, Bingbing Yu, Rui Cheng, Fengtao Huang, Xuelin Lu, Yan Yan, Xionglue Wang, Chenli Liu*, Bin Zhu*. (2021) A single mutation attenuates both the transcription termination and RNA-dependent RNA polymerase activity of T7 RNA polymerase. RNA Biology, 2021; 1-16. DOI: 10.1080/15476286.2021.1954808. 

3. Weirong Liu#, Taku A. Tokuyasu, Xiongfei Fu*, Chenli Liu* (2021) The spatial organization of microbial communities during range expansion. Current Opinion in Microbiology, 63: 109-116. DOI: 10.1016/j.mib.2021.07.005.

4. Ning Mao#, Nikhil Aggarwal#, Chueh Loo Poh, Byung Kwan Cho, Akihiko Kondo, Chenli Liu, Wen Shan Yew, Matthew Wook Chang*. (2021) Future trends in synthetic biology in Asia. Advanced Genetics, 2:e10038. DOI: 10.1002/ggn2.10038. 

5. Yang Li#, Yuqi Wang#, Xuefei Li*, Chenli Liu*. (2021) Hunting field: insights on distribution pattern of bacteria and immune cells in solid tumors. National Science Review, 8: nwab023. DOI: 10.1093/nsr/nwab023. 

6. A. I. Curatolo#, N. Zhou#, Y. Zhao#, C. Liu, A. Daerr, J. Tailleur*, J. Huang*. (2020) Cooperative pattern formation in multi-component bacterial systems through reciprocal motility regulation. Nature Physics, 16, 1152-1157. DOI: 10.1038/s41567-020-0964-z.

7. Hai Zheng#, Yang Bai#, Meiling Jiang#, Taku A. Tokuyasu, Xiongliang Huang, Fajun Zhong, Yuqian Wu, Xiongfei Fu, Nancy Kleckner, Terence Hwa, Chenli Liu*. (2020) General quantitative relations linking cell growth and the cell cycle in Escherichia coli. Nature Microbiology, 5 (8): 995-1001. DOI: 10.1038/s41564-020-0717-x. 

8. Weirong Liu#, Jonas Cremer#, Dengjin Li, Terence Hwa*, Chenli Liu*. (2019) An evolutionarily stable strategy to colonize spatially extended habitats. Nature, 575 (7784): 664-668. DOI: 10.1038/s41586-019-1734-x. 

9. Nathan Hillson#, Mark Caddick, Yizhi Cai, Jose A. Carrasco, Matthew Wook Chang, Natalie C. Curach, David J. Bell, Rosalind Le Feuvre, Douglas C. Friedman, Xiongfei Fu, Nicholas D. Gold, Markus J. Herrgård, Maciej B. Holowko, James R. Johnson, Richard A. Johnson, Jay D. Keasling, Richard I. Kitney, Akihiko Kondo, Chenli Liu, Vincent J. J. Martin, Filippo Menolascina, Chiaki Ogino, Nicola J. Patron, Marilene Pavan, Chueh Loo Poh, Isak S. Pretorius, Susan J. Rosser, Nigel S. Scrutton, Marko Storch, Hille Tekotte, Evelyn Travnik, Claudia E. Vickers, Wen Shan Yew, Yingjin Yuan, Huimin Zhao, Paul S. Freemont* (2019) Building a global alliance of biofoundries. Nature Communications, 10:2040. DOI: 10.1038/s41467-019-10079-2. 

10. Arieh Zaritsky*, Waldemar Vollmer, Jaan Männik, Chenli Liu. (2019) Does the nucleoid determine cell dimensions in Escherichia coli? Frontiers in Microbiology 6;10:1717. DOI: 10.3389/fmicb.2019.01717.

11. Mindong Liang#, Zilong Li#, Weishan Wang#, Jiakun Liu#, Leshi Liu, Guoliang Zhu, Loganathan Karthik, Man Wang, Kefeng Wang, Zhong Wang, Jing Yu, Yuting Shuai, Jiaming Yu, Lu Zhang, Zhiheng Yang, Chuan Li, Qian Zhang, Tong Shi, Liming Zhou, Feng Xie, Huanqin Dai, Xueting Liu, Jingyu Zhang, Guang Liu, Ying Zhuo, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gil Alterovitz, Gao-Yi Tan*, Lixin Zhang*. (2019) A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nature Communications, 10:3672. DOI: 10.1038/s41467-019-11648-1. 

12. Fuming Chen#, Zhongsheng Zang#, Ze Chen#, Liao Cui, Zhiguang Chang, Aiqing Ma, Ting Yin, Ruijing Liang, Yutong Han, Zhihao Wu, Mingbin Zheng*, Chenli Liu*, Lintao Cai*. (2019) Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy. Biomaterials, 214(2019)119226. DOI: 10.1016/j.biomaterials.2019.119226

13. Zhiguang Chang#, Yue Shen#, Qi Lang#, Hai Zheng,  Taku. Tokuyasu, Shuqiang Huang, Chenli Liu*. (2019) Microfluidic synchronizer using a synthetic nanoparticle-capped bacterium. ACS Synthetic Biology. DOI: 10.1021/acssynbio.9b00058

 

14. Jinming Cui#, Guoqin Mai, zuowei wang, Quan Liu, Yan Zhou, Yingfei Ma*, Chenli Liu*. (2019) Metagenomic insights into a cellulose-rich niche reveal microbial cooperation in cellulose degradationFrontiers in Microbiology , 10 (618) : 1-12 doi:10.3389/fmicb.2019.00618 

 

15. He Lia, Xia-qing Shi, Mingji Huang, Xiao Chena, Minfeng Xiao, Chenli Liu, Hugues Chaté, Hepeng Zhang*. (2018) Data-driven quantitative modeling of bacterial active nematicsPNAS, 116(3): 777-785 doi.org/10.1073/pnas.1812570116 

16. 崔金明#, 张炳照马迎飞傅雄飞王猛刘陈立*. (2018) 合成生物学研究的工程化平台中国科学院院刊, 33 (11) : 1249-1257.  

 

17. 崔金明#, 王力为常志广臧中盛刘陈立*. (2018) 合成生物学的医学应用研究进展. 中国科学院院刊, 33 (11) : 1218-1226. 

 

18. Ling Chen#, Shengjian Yuan, Liu Quan, Guoqing Mai, Jinfang Yang, Deng Deng, Bingzhao Zhang, Chenli Liu, Yingfei Ma*. (2018) In vitro design and evaluation of phage cocktails against Aeromonas salmonicida. Frontiers in Microbiology. 9: 1476 . doi: 10.3389/fmicb.2018.01476. 

 

19. Yingfei Ma*, Xiaoyan You, Guoqin Mai, Taku Tokuyasu and Chenli Liu*. (2018) A human gut phage catalog correlates the gut phageome with type 2 diabetes. Microbiome, 6: 24. doi:10.1186/s40168-018-0410-y. 

 

20. Arieh Zaritsky*, Avinoam Rabinovitch, Chenli Liu, Conrad L. Woldringh c. (2017) Does the eclipse limit bacterial nucleoid complexity and cell width? Synthetic and Systems Biotechnology. 2, 267-275. doi: 10.1016/j.synbio.2017.11.004. eCollection 2017 Dec. Review. 

 

21. Yang Bai#, Meng Gao, Lingling Wen, Caiyun He, Yuan Chen, Chenli Liu, Xiongfei Fu*, Shuqiang Huang*. (2017) Applications of Microfluidics in Quantitative Biology. Biotechnology Journal. doi: 10.1002/biot.201700170. [Epub ahead of print] Review. 

 

22. Jinming Cui#, Minfeng Xiao#, Mingzhu Liu, Zuowei Wang, Furong Liu, Hailin Meng, Honggang Zhang, Jinfang Yang, Deng Deng, Huang, Shuqiang Huang, Yingfei Ma*, Chenli Liu*. (2017) Coupling metagenomics with cultivation to select host-specific probiotic micro-organisms for subtropical aquaculture. Journal of Applied Microbiology 123, 1274-1285. doi: 10.1111/jam.13555 

 

23Hailin Meng, Yingfei Ma, Guoqin Mai, Yong Wang* and Chenli Liu*. (2017) Construction of precise support vector machine based models for predicting promoter strength. Quantitative Biology 5, 90-98. doi: 10.1007/s40484-017-0096-3.  

24Lizhong Liu#, Yang Bai, Hai Zheng, Xiongfei Fu*, Chenli Liu*. (2017) Fundamental aspects of synthetic biology. Chinese journal of biotechnology 33, 315-323. doi: 10.13345/j.cjb.160477-en  

 

25. Chenli Liu#, Claudia Danilowicz, Nancy Kleckner* and Mara Prentiss. (2017) Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA. Nucleic Acids Research 45, 894-901. doi: 10.1093/nar/gkw758  

 

26. Hai Zheng#, Po-Yi Ho, Meiling Jiang, Bin Tang, Weirong Liu, Dengjin Li, Xuefeng Yu, Nancy E. Kleckner, Ariel Amir*, and Chenli Liu*. (2016) Interrogating the Escherichia coli cell cycle by cell dimension perturbations. PNAS , 15000-15005. doi: 10.1073/pnas.1617932114. 

 

27. Bingzhao Zhang#, Wangsheng Lai and Chenli Liu*. (2015) Methodology and Philosophy of Synthetic Biology. SCIENTIA SINICA Vitae (Chinese), 45. doi: 10.1360/N052015-00045. 

 

28. Minfeng Xiao#, Bingzhao Zhang and Chenli Liu.* (2015) Synthetic Biology in Studying the Origin of Life, Evolution, and Structure-Function Relation. SCIENTIA SINICA Vitae (Chinese), 45. doi: 10.1360/N052015-00046. 

 

29.Yue Zhuo# and Chenli Liu* (2015) Outline of Bacterial Cancer TherapyJournal of Integration Technology, 4 (4) : 83-89. 

 

30. Honggang Zhang#, Xinzhi Li, Bingzhao Zhang and Chenli Liu* (2015) Draft Genome Sequence of Acinetobacter sp. Strain YZS-X1-1, a Denitrifying Bacterium Isolated from Freshwater Pond Sludge in China. Genome Announcements 3. doi: 10.1128/genomeA.01579-14. 

 

31. Xiongfei Fu#, Leihan Tang, Chenli Liu, Jiandong Huang, Terence Hwa, Lenz P. (2012) Stripe formation in bacterial systems with density-suppressed motility. Physical Review Letters 108, 198102. 

 

32. Chenli Liu#, Xiongfei Fu and Jian-Dong Huang*. (2013) Synthetic biology: a new approach to study biological pattern formation. Quantitative Biology, 1, 7. doi: 10.1007/s40484-013-0021-3. 

33. Chenli Liu#, Xiongfei Fu#, Lizhong Liu, Xiaojing Ren, Carlos K.L. Chau, Sihong Li, Lu Xiang, Hualing Zeng, Guanhua Chen, Lei-Han Tang, Peter Lenz, Xiaodong Cui, Wei Huang*, Terence Hwa* and Jian-Dong Huang*. (2011) Sequential establishment of stripe patterns in an expanding cell population. Science 334, 238-241. doi: 10.1126/science.1209042. 

 

34. Chenli Liu#, Wanpeng Wang#, Yehui Wu, Zhongwen Zhou, Qiliang Lai and Zongze Shao*. (2011) Multiple alkane hydroxylase systems in a marine alkane degrader, Alcanivorax dieselolei B-5. Environmental Microbiology 13, 1168-1178. doi: 10.1111/j.1462-2920.2010.02416.x. 

 

35. Chenli Liu#, Zai Wang, Michael S.Y. Huen, Lin-Yu Lu, De-Pei Liu and Jian-Dong Huang*. (2009) Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genomic sequence modification. Oligonucleotides 19, 281-286. doi: 10.1089/oli.2009.0191. 

 

36. Chenli Liu#, Yehui Wu, Li Li, Yingfei Ma and Zongze Shao*. (2007) Thalassospira xiamenensis sp. nov. and Thalassospira profundimaris sp. nov. International Journal of Systematic and Evolutionary Microbiology 57, 316-320. doi: 10.1099/ijs.0.64544-0. 

 

37. Chenli Liu#, Li Xia Xie, Min Li*, Siva Sundara Kumar Durairajan, Shinya Goto, Jian-Dong Huang*. (2007) Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling. PloS One 2. 12 doi:10.1371/journal.pone.0001321. 

 

38Chenli Liu#, Zongze Shao.* (2005) Alcanivorax dieselolei sp. nov., a novel alkane-degrading bacterium isolated from sea water and deep-sea sediment. International Journal of Systematic and Evolutionary Microbiology 55, 1181-1186. doi: 10.1099/ijs.0.63443-0. 

 


Students

现指导学生

刘为荣  博士研究生  071010-生物化学与分子生物学  

周燕  硕士研究生  085238-生物工程  

郑海  博士研究生  071010-生物化学与分子生物学  

孙陈健  博士研究生  071010-生物化学与分子生物学  

陈茜  博士研究生  071010-生物化学与分子生物学  

黄雄亮  博士研究生  071010-生物化学与分子生物学  

董宇轩  硕士研究生  085238-生物工程  

Honors & Distinctions

Liu has won the “1000 Talents Plan Professorship for Young Scholars” from the Organization Department of the CPC Central Committee, China, “Distinguished Young Scholar” from Guangdong Natural Science Funds, China, “Young Scientist Award” from Hong Kong Institution of Science, and “Li Ka Shing Prize” from The University of Hong Kong.