基本信息

严飞  博导  中国科学院深圳先进技术研究院
电子邮件: fei.yan@siat.ac.cn
通信地址: 深圳市南山区西丽大学城学苑大道1068号
邮政编码: 518055

研究领域

1、超声造影剂及其生物医学应用;

2、声控细菌治疗

招生信息

招收细胞生物学,生物化学与分子生物学,生物医学工程相关专业的学生




招生专业
071009-细胞生物学
083100-生物医学工程
招生方向
重大疾病的分子诊断与治疗
超声分子影像

教育背景

2004-09--2007-06   四川大学   细胞生物学博士
2001-09--2004-06   西南大学   生物化学与分子生物学硕士
1997-09--2001-06   江西农业大学   学士

工作经历

2016.01~  今, 中国科学院深圳先进技术研究院, 研究员

2011.08~2016.12, 中国科学院深圳先进技术研究院, 副研究员
2009.12~2011.07,中国科学院深圳先进技术研究院, 助理研究员
2008.09~2010.08,清华大学深圳研究生院, 博士后

专利与奖励

   
专利成果
[1] 严飞, 李振洲, 赖曼琳, 赵萍, 赵帅. 一种双靶向肿瘤的超声分子复合成像方法. CN: CN113521317A, 2021-10-22.
[2] 严飞, 谢丽婷. 离子通道靶向微泡及其制备方法和应用. CN: CN112915216A, 2021-06-08.
[3] 严飞, 蒋天安, 谢丽婷. 一种细胞超声神经调控系统. CN: CN112945918A, 2021-06-11.
[4] 郑海荣, 李飞, 严飞, 蔡飞燕, 孟龙, 肖杨. 超声给药实验装置、超声给药实验方法. CN: CN112553070A, 2021-03-26.
[5] 蒋天安, 谢丽婷, 严飞. 一种稳定的超声分子成像装置的凝胶模型制备系统. CN: CN214323894U, 2021-10-01.
[6] 严飞, 蒋天安, 谢丽婷, 邹俊杰. 一种超声声场适形的基因转染装置. CN: CN212404115U, 2021-01-26.
[7] 严飞, 蒋天安, 谢丽婷, 邹俊杰. 一种超声声场适形的基因转染装置. CN: CN212404115U, 2021-01-26.
[8] 郑海荣, 徐岗, 李飞, 毛一雷, 孟龙, 严飞. 一种待测细胞在体捕获系统. CN: CN211603212U, 2020-09-29.
[9] 严飞, 刘红梅, 王宇, 郑海荣. 纳米超声造影剂及其制备方法. CN: CN111035771A, 2020-04-21.
[10] 邓志婷, 严飞, 郑海荣, 肖杨, 李飞. 一种微囊泡的生产方法、基于该微囊泡的生产方法得到的微囊泡及其应用. CN: CN112980791A, 2021-06-18.
[11] 邓志婷, 郑海荣, 严飞, 肖杨, 李飞. 一种外泌体及其制备方法及应用. CN: CN113061579A, 2021-07-02.
[12] 严飞, 王宇, 郑海荣. 含有伪空胞的浮游藻类的制备方法和应用. CN: CN109758591A, 2019-05-17.
[13] 郑海荣, 严飞, 邓志婷, 肖杨. 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用. CN: CN109554341A, 2019-04-02.
[14] 严飞, 于博, 陈彦, 梁杨标. 超声造影剂及其制备方法和应用. CN: CN109364271A, 2019-02-22.
[15] 张鹏飞, 严飞, 李飞, 毛洋. 一种声辐射力强化炎性细胞致动脉粥样硬化仿生微泡复合体富集与靶向系统. CN: CN107625970A, 2018-01-26.
[16] 蔡飞燕, 张鹏飞, 李飞, 郑海荣, 孟龙, 严飞, 王辰. 体内定点给药装置. CN: CN105854165B, 2019-02-22.
[17] 蔡飞燕, 张鹏飞, 李飞, 郑海荣, 孟龙, 严飞, 王辰. 体内定点给药装置. CN: CN205729963U, 2016-11-30.
[18] 蔡飞燕, 张鹏飞, 李飞, 郑海荣, 孟龙, 严飞, 王辰. 体内定点给药装置及工作方法. CN: CN105854165A, 2016-08-17.
[19] 陈冕, 郑海荣, 王志勇, 刘新, 蔡飞燕, 孟龙, 严飞, 李飞, 王辰. 一种基于声场操控的纳米粒子靶向递送方法. CN: CN105535968A, 2016-05-04.
[20] 周冬良, 严飞, 郑海荣, 王丛知. 一种基于超声波成像对目标物进行自动追踪定位及实时智能刺激的方法及系统. CN: CN105233429A, 2016-01-13.
[21] 肖杨, 严飞, 郑海荣, 张雪, 邓志婷, 唐家伟, 牛丽丽. 一种用于HIFU的超声造影剂及其制备方法与应用. CN: CN105233308A, 2016-01-13.
[22] 郑海荣, 李飞, 蔡飞燕, 孟龙, 王辰, 张成祥, 邱维宝, 李永川, 严飞, 牛丽丽, 耿刘峰, 徐超伟. 基于人工结构声场的微流体系统及操控微粒的方法. CN: CN105214742A, 2016-01-06.
[23] 周冬良, 严飞, 郑海荣, 王丛知. 一种鱼类神经刺激反应研究装置. CN: CN105165674B, 2019-07-05.
[24] 周冬良, 严飞, 郑海荣, 王丛知. 一种鱼类神经刺激反应研究装置. CN: CN105165674A, 2015-12-23.
[25] 郑海荣, 严飞, 靳巧锋, 杨伟, 邓志婷. 制备含氢气微泡水溶液的方法,其产品及应用. CN: CN103099780A, 2013-05-15.
[26] 严飞, 郑海荣, 李翔, 靳巧锋. 靶向载药超声微泡及其制备方法. CN: CN102138889A, 2011-08-03.
[27] 严飞, 孙立涛, 冯亚南, 郝永胜. 一种靶向肿瘤的超声造影剂及其制备方法和应用. CN: CN116370658A, 2023-07-04.
[28] 严飞, 刘辰星. 一种用于RNA递送的转染复合物及其制备方法和应用. CN: CN115948475A, 2023-04-11.
[29] 严飞, 郝永胜, 李振洲, 罗静娜. 一种生物合成靶向纳米超声造影剂的制备方法及其应用. CN: CN116421746A, 2023-07-14.
[30] 严飞, 李振洲, 赖曼琳, 赵萍, 赵帅. 一种双靶向肿瘤的超声分子复合成像方法. CN: CN113521317B, 2023-03-31.

发表论文

1.   Xu Z, Liu Hi*, Tian H, Yan F*. Real-time imaging tracking of engineered macrophages as ultrasound-triggered cell bombs for cancer treatment. Adv Funct Mater. 2020, 1910304.

2.   Chen Y, Liang Y, Jiang P, Li F, Yu B*, Yan F*. Lipid/PLGA Hybrid microbubbles as a versatile platform for noninvasive image-guided targeted drug delivery. ACS Appl Mater Interfaces. 2019; 11(45):41842-41852.

3.   Yang C, Du M, Yan F*, Chen Z*. Focused ultrasound improves NK-92MI cells infiltration into tumors. Front Pharmacol. 2019; 10: 326.

4.   Tayier B, Deng Z, Wang Y, Wang W, Mu Y*, Yan F*. Biosynthetic nanobubbles for targeted gene delivery by focused ultrasound. Nanoscale, 2019; 11(31):14757-14768.

5.   Xie Y, Chen Y, Zhang L, Wu M, Deng Z, Yang Y, Wang J, Lv Q, Zheng H, Xie M*, Yan F*. Ultrasound molecular imaging of lymphocyte-endothelium adhesion cascade in acute cellular rejection of cardiac allografts. Transplantation, 2019; 103(8):1603-1611.

6.   Li F, Wang Y, Mo X, Deng Z, Yan F*. Acoustic characteristics of biosynthetic bubbles for ultrasound contrast imaging. Langmuir, 2019; 35(31):10213-10222.

7.   Mo X, Yan F*, Zhang B*. Molecular ultrasound monitoring of early artery injury after carotid balloon angioplasty. Front. Pharmacol. 2019; 9:1569.

8.   Wu M, Zhang H, Tie C, Yan C, Deng Z, Wan Q, Liu X, Yan F*, Zheng H*. MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma. Nature Communications, 2018; 9(1):4777.

9.   Wu M, Chen W, Chen Y, Zhang H, Liu C, Deng Z, Sheng Z, Chen J, Liu X, Yan F*, Zheng H*. Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment. Adv Sci (Weinh). 2018; 5(4):1700474.

10. Zhang R, Yan F*, Chen Y*. Exogenous physical irradiation on titania semiconductors: materials chemistry and tumor-specific nanomedicine. Adv Sci (Weinh). 2018; 5(12):1801175.

11. Yan F, Sun Y, Mao Y, Wu M, Deng Z, Li S, Liu X, Xue L*, Zheng H*. Ultrasound Molecular imaging of atherosclerosis for early diagnosis and therapeutic evaluation through leucocyte-like multiple targeted microbubbles. Theranostics, 2018; 8(7):1879-1891.

12. Zhang N#, Yan F#, Liang X, Wu M, Shen Y, Chen M, Xu Y, Zou G, Jiang P, Tang C, Zheng H, Dai Z. Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy. Theranostics, 2018; 8(8):2264-2277.

13. Yu J, Chen Z*, Li Y, Du M, Yan F*, Zheng H. Echogenic chitosan nanodroplets for spatiotemporally controlled gene delivery. J Biomed Nanotechnol. 2018,14, 1384-1395.

14. Zhang J, Wang S, Deng Z, Li L, Tan G, Liu X, Zheng H, Yan F*. Ultrasound-triggered drug delivery for breast tumor therapy through irgd-targeted paclitaxel-loaded liposome-microbubble complexes. J Biomed Nanotechnol. 2018,14, 1-11.

15. Pan M, Zhang Y, Deng Z, Yan F*, Hong G*. Noninvasive and local delivery of adenoviral-mediated herpes simplex virus thymidine kinase to treat glioma through focused ultrasound-induced blood-brain barrier opening in rats. J Biomed Nanotechnol. 2018;14(12):2031-2041.

16. Wang X#, Yan F#, Liu X#, Wang P, Shao S, Sun Y, Sheng Z, Liu Q, Lovell JF, Zheng H. Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins. J Control Release. 2018; 286:358-368.

17. Li F, Li D*, Yan F*. Improvement of detection sensitivity of microbubbles as sensors to detect ambient pressure. Sensors (Basel). 2018;18(12). pii: E4083.

18. Yu J, Chen Z*, Yan F*. Advances in mechanism studies on ultrasonic gene delivery at cellular level. Prog Biophys Mol Biol. 2018; S0079-6107(18)30109-3.

19. Yan F*, Song Z, Du M, Klibanov AL. Ultrasound molecular imaging for differentiation of benign and malignant tumors in patients. Quant Imaging Med Surg. 2018, 8(11):1078-1083.

20. Wang X, Liu X, Li Y, Wang P, Feng X, Liu Q, Yan F*, Zheng H*. Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome. Biomaterials. 2017; 141:50-62.

21. Shen Y, Pi Z, Yan F*, Yeh C, Zeng X, Diao X, Hu Y, Chen S, Chen X*, Zheng H. Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma. Int J Nanomedicine, 2017:12 5613–5629.

22. Li Y, Wu M, Zhang N, Tang C, Jiang P, Liu X, Yan F*, Zheng H. Mechanisms of enhanced antiglioma efficacy of polysorbate 80-modified paclitaxel-loaded PLGA nanoparticles by focused ultrasound. J Cell Mol Med. 2018; 22(9):4171-4182.

23. Yan F, Wang S, Yang W*, Goldberg SN, Wu H, Duan WL, Deng ZT, Han HB, Zheng HR*. Tumor-penetrating Peptide-integrated Thermally Sensitive Liposomal Doxorubicin Enhances Efficacy of Radiofrequency Ablation in Liver Tumors. Radiology. 2017:162405.

24. He Y, Zhang B, Chen Y, Jin Q, Wu J, Yan F*, Zheng H. Image-Guided Hydrogen Gas Delivery for Protection from Myocardial Ischemia-Reperfusion Injury via Microbubbles. ACS Appl Mater Interfaces. 2017; 9(25):21190-21199.

25. Zhang L, Sun Z, Ren P, You M, Zhang J, Fang L, Wang J, Chen Y, Yan F*, Zheng H*, Xie M*. Localized delivery of shRNA against PHD2 protects the heart from acute myocardial infarction through ultrasound-targeted cationic microbubble destruction. Theranostics, 2017;7(1):51-66.

26. Deng Z, Xiao Y, Pan M, Li F, Duan W, Meng L, Liu X, Yan F*, Zheng H*. Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound. J Control Release. 2016, 243:333-341.

27. Yan F#, Duan W#, Li Y*, Wu H, Zhou Y, Pan M, Liu H, Liu Xin, Zheng H*. NIR-laser-controlled drug release from DOX/IR-780-loaded temperature-sensitive-liposomes for chemo-photothermal synergistic tumor therapy. Theranostics, 2016; 6(13):2337-2351.

28. Ma M#; Yan F#; Yao M; Wei Z; Zhou D; Yao H; Zheng H*; Chen H*; Shi J. Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy. ACS Applied Materials & Interfaces, 2016; 8(44):29986-29996.

29. Yan F#, Wu H#, Liu H, Deng Z, Liu H, Duan W, Liu X*, Zheng H*. Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles. J Control Release. 2016;224:217-28.


科研活动

   
科研项目
( 1 ) 基于iRGD靶向载药脂质体-微泡复合体的超声成像引导给药治疗肿瘤的研究, 主持, 国家级, 2014-01--2017-12
( 2 ) 载氢气微泡的超声可视化传递及其治疗心肌缺血再灌注损伤的研究, 主持, 国家级, 2016-01--2019-12