General

Minghai Chen is an  Associate Professor in Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences. Dr. Chen received his B.Sc. degree in Biotechnology from Henan University. He obtained a Ph.D. in Microbiology from the Wuhan Institute of Virology, Chinese Academy of Sciences. He obtained his postdoctoral training at University of Virginia. His current research interest focuses on virus-host interaction, fluorescence imaging, biomolecular interaction. 

Research Areas

biomolecular interaction, fluorescence imaging, biosensors, virus-host interaction


Education

07/2012  B.S. Biotechnology  Henan University, China. 


07/2017 Ph.D Microbiology  Wuhan Institute of Virology, Chinese Academy of Sciences. 

Experience

2017/09-2019/07:Postdoctoral Fellow,  University of Virginia, USA.

2019/07-now:Associate Professor, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences.


Publications

(1Minghai Chen#, Shen Zhang#, Yuan Xing, Xinyu Li, Yi He, Yong Wang, José Oberholzer, and Hui-wang Ai*. Genetically Encoded, Photostable Indicators to Image Dynamic Zn2+ Secretion of Pancreatic Islets. Analytical Chemistry, 2019, 91(19):12212-12219. 

(2) Hsien-Wei Yeh, Ying Xiong, Tianchen Wu, Minghai ChenAo Ji and Hui-wang Ai*. ATP-independent bioluminescent reporter variants to improve in vivo imaging. ACS Chemical Biology2019,14(5):959-965. 

(3) Hsien-Wei Yeh, Tianchen Wu, Minghai Chen, and Hui-wang Ai*. Identification of Factors Complicating Bioluminescence Imaging. Biochemistry, 2019,58 (12):1689-1697.

(4) Minghai Chen#, Wei Li#, Zhi-Ping Zhang, Jingdi Pan, Yuhan Sun, Xiaowei Zhang, Xian-En Zhang and Zongqiang Cui*. Three-Fragment Fluorescence Complementation for Imaging of Ternary Complexes under Physiological Conditions. Analytical Chemistry, 2018,90:13299-13305. 

(5) Minghai Chen#, Sanying Liu#, Wei Li, Zhi-Ping Zhang, Xiaowei Zhang, Xian-En Zhang* and Zongqiang Cui*. Three-Fragment Fluorescence Complementation Coupled with Photoactivated Localization Microscopy for Nanoscale Imaging of Ternary Complexes. ACS Nano, 2016,10(9):8482-90. 

(6) Siting Li, Minghai Chen, Qian Xiong, Jia Zhang, Zongqiang Cui*, and Feng Ge*; Characterization of the translationally controlled tumor protein (TCTP) interactome reveals novel binding partners in human cancer cells. Journal of Proteome Research, 2016, 15(10):3741-3751. 

(7) Minghai Chen, Wei Li, Zhiping Zhang, Sanying Liu, Xiaowei Zhang, Xian-En Zhang*, Zongqiang Cui*Novel near-infrared BiFC systems from a bacterial phytochrome for imaging protein interactions and drug evaluation under physiological conditions. Biomaterials, 2015, 48:97-107. 

Research Interests

biomolecular interaction, fluorescence imaging, biosensors, virus-host interaction