1.微生物来源抗肿瘤先导化合物研究。从放线菌中分离抗肿瘤活性优异的天然产物，目前已获得抗肿瘤活性优于紫杉醇超过1000-3000倍的先导化合物。

2. 植物及微生物活性天然产物生物合成。从基因层面回答天然产物形成机制，向大自然学习化学。以动态视角研究天然产物，探究天然产物的化学生物学功能。

招收化学、生物学、及药学相关专业。欢迎对天然产物分离纯化、结构解析、抗肿瘤活性、及生物合成感兴趣的同学报考。

100701-药物化学

天然药物化学，天然产物生物合成，微生物药物

2009-09--2014-06   中国科学院昆明植物研究所   理学博士（硕博连读），导师：郝小江
2005-09--2009-06   西北农林科技大学   理学学士

   

2024-02~现在, 中国科学院昆明植物研究所, 研究员
2021-09~2024-02,中国科学院昆明植物研究所, 副研究员
2018-01~2020-01,The Scripps Research Institute, 博士后，合作导师：Ben Shen
2017-01~2021-08,南京农业大学, 副教授
2014-07~2016-12,南京农业大学, 讲师

2022年入选中国科学院青年促进会会员

2023年入选云南省‘兴滇英才支持计划’青年人才（引进）

   

[1] The Journal of Antibiotics. 2024,   通讯作者  
[2] The Journal of Antibiotics. 2024,   通讯作者  
[3] Cao, Mingming, Yang, Dong, Adhikari, Ajeeth, Ye, Fei, Zheng, Chengjian, Yan, Wei, Meng, Song, Su, Ping, Shen, Ben. Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. ORGANIC LETTERS. 2023, 第 1 作者http://dx.doi.org/10.1021/acs.orglett.2c04303.
[4] Li, XiaoHui, Zhang, JiaHui, Zhang, Yu, Di, YingTong, Gu, YuCheng, Cao, Mingming, Hao, XiaoJiang. Four new Myrioneuron alkaloids from Mycetia effusa (Myrioneuron effusum). PHYTOCHEMISTRY LETTERS[J]. 2023, 第 6 作者  通讯作者  53: 175-178, http://dx.doi.org/10.1016/j.phytol.2022.12.007.
[5] Natural Products and Bioprospecting. 2023,   通讯作者  
[6] Zhang, JiaHui, Cao, Mingming, Zhang, Yu, Li, XiaoHui, Gu, YuCheng, Li, XiaoNian, Di, YingTong, Hao, XiaoJiang. Scalemic myrionsumamide A, tetracyclic skeleton alkaloids from Myrioneuron effusum. RSC ADVANCES[J]. 2022, 第 2 作者12(43): 28147-28151, http://dx.doi.org/10.1039/d2ra05342j.
[7] Mingming Cao, Chengjian Zheng, Dong Yang, Edward Kalkreuter, Ajeeth Adhikari, YuChen Liu, Mostafa E Rateb, Ben Shen. Cryptic sulfur incorporation in thioangucycline biosynthesis. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2021, 第 1 作者60(13): 7140-7147, 
[8] Li, XiaoHui, Cao, MingMing, Zhang, Yu, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Fluevirines A-D, four new securinega-type alkaloids from Flueggea virosa. TETRAHEDRON LETTERS[J]. 2014, 第 2 作者55(44): 6101-6104, http://dx.doi.org/10.1016/j.tetlet.2014.09.046.
[9] Cao, MingMing, Huang, ShengDian, Di, YingTong, Yuan, ChunMao, Zuo, GuoYing, Gu, YuCheng, Zhang, Yu, Hao, XiaoJiang. Myrifabine, the First Dimeric Myrioneuron Alkaloid from Myrioneuron faberi. ORGANIC LETTERS[J]. 2014, 第 1 作者16(2): 528-531, http://dx.doi.org/10.1021/ol403408m.
[10] Cao, MingMing, Zhang, Yu, Li, XiaoHui, Peng, ZongGen, Jiang, JianDong, Gu, YuCheng, Di, YingTong, Li, XiaoNian, Chen, DuoZhi, Xia, ChengFeng, He, HongPing, Li, ShunLin, Hao, XiaoJiang. Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus. JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 第 1 作者79(17): 7945-7950, http://dx.doi.org/10.1021/jo501076x.
[11] Ming-Ming Cao, Hong-Ping He, Yu-Cheng Gu, Qiang Zhang, Xiao-Nian Li, Guo-Ying Zuo, Ying-Tong Di, Chun-Mao Yuan, Shun-Lin Li, Yu Zhang, Xiao-Jiang Hao. Daphmacrodins A and B, alkaloids from Daphniphyllum macropodum. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2013, 第 1 作者3(1): [[[29-32]]], http://dx.doi.org/10.1007/s13659-012-0095-z.
[12] Huang ShengDian, Zhang Yu, He HongPing, Li ShiFei, Tang GuiHua, Chen DuoZhi, Cao MingMing, Di YingTong, Hao XiaoJiang. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2013, 第 7 作者11(4): 406-410, http://dx.doi.org/10.1016/S1875-5364(13)60060-6.
[13] Cao, MingMing, Wang, Lei, Zhang, Yu, He, HongPing, Gu, YuCheng, Zhang, Qiang, Li, Yan, Yuan, ChunMao, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Daphmacromines K-O, alkaloids from Daphniphyllum macropodum. FITOTERAPIA[J]. 2013, 第 1 作者89: 205-209, http://dx.doi.org/10.1016/j.fitote.2013.06.005.
[14] Cao, Mingming, Zhang, Yu, He, Hongping, Li, Shifei, Huang, Shendian, Chen, Duozhi, Tang, Guihua, Li, Shunlin, Di, Yingtong, Hao, Xiaojiang. Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 1 作者75(6): 1076-1082, http://dx.doi.org/10.1021/np200960z.
[15] Cao, Mingming, Zhang, Yu, He, Hongping, Li, Shifei, Huang, Shendian, Chen, Duozhi, Tang, Guihua, Li, Shunlin, Di, Yingtong, Hao, Xiaojiang. Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 1 作者75(6): 1076-1082, http://www.irgrid.ac.cn/handle/1471x/522636.
[16] Li Hou, Cui-Xuan Mei, Chun-Mao Yuan, Gui-Hua Tang, Duo-Zhi Chen, Qing Zhao, Hong-Ping He, Ming-Ming Cao, Xiao-Jiang Hao. Five new limonoids isolated from Walsura robusta. NATURAL PRODUCTS AND BIOPROSPECTING. 第 8 作者13(1): http://dx.doi.org/10.1007/s13659-023-00371-6.

   

（ 1 ） 难培养放线菌卤化天然产物生物合成基因簇激活, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 抗菌天然产物发掘及生物合成, 负责人, 中国科学院计划, 2022-01--2026-01
（ 3 ） 难培养放线菌核苷类活性天然产物挖掘及生物合成研究, 负责人, 地方任务, 2023-01--2027-01
（ 4 ） 难培养放线菌天然产物生物合成基因簇激活, 负责人, 研究所自选, 2021-09--2026-09
（ 5 ） 抗肿瘤活性分子云海霉素的生物合成研究及理性改造, 负责人, 地方任务, 2023-04--2025-05