基本信息
陈洋  男    中国科学院大连化学物理研究所
电子邮件: chenyang2808@dicp.ac.cn
通信地址: 辽宁省大连市沙河口区中山路457号
邮政编码: 116023

研究领域

癌症相关蛋白的功能和作用机理以及潜在药物发现的研究

招生信息

   
招生专业
070302-分析化学
招生方向
细胞分子生物学,肿瘤生物学,生物化学

教育背景

2013-08--2017-06   中山大学   理学博士
2010-09--2013-06   东南大学   医学硕士
2006-09--2010-07   江西中医药大学   理学学士
学历
博士研究生

学位
理学博士

工作经历

   
工作简历
2021-01~现在, 中国科学院大连化学物理研究所, 研究组长/副研究员
2018-09~2019-09,美国辛辛那提大学医学院, 博士后
2017-04~2020-11,美国国立卫生研究院(NIH), 博士后

专利与奖励

   
奖励信息
(1) 赣江新区“赣江海智”人才, 市地级, 2021
(2) 大连市引进高层次人才, 市地级, 2021
(3) 大连市青年科技之星, 市地级, 2021
(4) 江西省“双千计划”创新领军人才, 省级, 2020
(5) 美国国立卫生研究院访问学者奖, 院级, 2019
(6) 美国国立卫生研究院访问学者奖, 院级, 2017
(7) 第五届国际暨第十四届全国膜生物学研讨会最佳墙报奖, 其他, 2016

出版信息

   
发表论文
[1] Zhang, Caiying, Li, Yuelong, Samad, Abdus, He, Hongliang, Ma, Huan, Chen, Yang, Jin, Tengchuan. Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2024, 第 6 作者254: http://dx.doi.org/10.1016/j.ijbiomac.2023.127856.
[2] DaQian Chen, Yuhao Xie, LuQi Cao, Joshua S Fleishman, Yang Chen, Tiesong Wu, DongHua Yang. The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond. DRUG RESISTANCE UPDATES. 2024, 第 5 作者  通讯作者  73: http://dx.doi.org/10.1016/j.drup.2024.101062.
[3] Lili Gao, Junzhe Zhang, Qianqian Long, Yang Yang, Yiming Li, Guoqiang Li, Peng Pu, Shanshi Tong, Yamin He, Qing Li, Yang Chen, Yingbin Liu, Xianming Kong. SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation. BBA - MOLECULAR BASIS OF DISEASE. 2023, 第 11 作者  通讯作者  1869(7): http://dx.doi.org/10.1016/j.bbadis.2023.166780.
[4] Liu, Yanqing, Guo, Shicheng, Yuan, Tao, Chen, Yang. Editorial: Novel advances in gastrointestinal cancer treatment. FRONTIERS IN MOLECULAR BIOSCIENCES. 2023, 第 4 作者  通讯作者  10: http://dx.doi.org/10.3389/fmolb.2023.1238098.
[5] Wu, Yetian, Zhang, Pei, Fan, Hongjie, Zhang, Caiying, Yu, Pengfei, Liang, Xinmiao, Chen, Yang. GPR35 acts a dual role and therapeutic target in inflammation. FRONTIERS IN IMMUNOLOGY. 2023, 第 7 作者  通讯作者  14: http://dx.doi.org/10.3389/fimmu.2023.1254446.
[6] Jingrong Liu, Hongjie Fan, Xinmiao Liang, Yang Chen. Polycomb repressor complex: Its function in human cancer andtherapeutic target strategy. BIOMEDICINE & PHARMACOTHERAPY[J]. 2023, 第 4 作者169: 115897, https://doaj.org/article/8720bf71936f48b796071ade2cd30e0b.
[7] Wei, Lai, Xiang, Kaijing, Kang, Hongjian, Yu, Yancheng, Fan, Hongjie, Zhou, Han, Hou, Tao, Ge, Yonglin, Wang, Jixia, Guo, Zhimou, Chen, Yang, Zhao, Yaopeng, Liang, Xinmiao. Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2023, 第 11 作者14(4): 411-416, http://dx.doi.org/10.1021/acsmedchemlett.2c00461.
[8] Chen, Gang, Khan, Imran Mahmood, He, Wensen, Li, Yongxin, Jin, Peng, Campanella, Osvaldo H, Zhang, Haihua, Huo, Yanrong, Chen, Yang, Yang, Huqing, Miao, Ming. Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects. Comprehensive Reviews in Food Science and Food Safety[J]. 2022, 第 9 作者  通讯作者  21(3): 2688-2714, https://pubmed.ncbi.nlm.nih.gov/35470946/.
[9] Zhang, Hong, Zhang, ShiHui, Hu, JiaLi, Wu, YuTong, Ma, XiaoYan, Chen, Yang, Yu, Bing, Liao, Shuang, Huang, Huilin, Gao, Song. Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. CANCER COMMUNICATIONS[J]. 2021, 第 6 作者41(7): 615-630, http://lib.cqvip.com/Qikan/Article/Detail?id=7105205598.
[10] Chen, Qixin, Hao, Mingang, Wang, Lei, Li, Linsen, Chen, Yang, Shao, Xintian, Tian, Zhiqi, Pfuetzner, Richard A, Zhong, Qing, Brunger, Axel T, Guan, JunLin, Diao, Jiajie. Prefused lysosomes cluster on autophagosomes regulated by VAMP8. CELL DEATH & DISEASE[J]. 2021, 第 5 作者12(10): http://dx.doi.org/10.1038/s41419-021-04243-0.
[11] Jun Yin, Emma Spillman, Ethan S Cheng, Jacob Short, Yang Chen, Jingce Lei, Mary Gibbs, Justin S Rosenthal, Chengyu Sheng, Yuki X Chen, Kelly Veerasammy, Tenzin Choetso, Rinat Abzalimov, Bei Wang, Chun Han, Ye He, Quan Yuan. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. NATURE COMMUNICATIONS[J]. 2021, 第 5 作者12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065144/.
[12] Hu, JiaLi, Liang, He, Zhang, Hong, Yang, MingZhu, Sun, Wei, Zhang, Peng, Luo, Li, Feng, JianXiong, Bai, Huajun, Liu, Fang, Zhang, Tianpeng, Yang, JinYu, Gao, Qingsong, Long, Yongkang, Ma, XiaoYan, Chen, Yang, Zhong, Qian, Yu, Bing, Liao, Shuang, Wang, Yongbo, Zhao, Yong, Zeng, MuSheng, Cao, Nan, Wang, Jichang, Chen, Wei, Yang, HuangTian, Gao, Song. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 16 作者48(5): 2733-2748, https://www.webofscience.com/wos/woscc/full-record/WOS:000525957100044.
[13] TaeSung Kim, Liang Zhang, Jong Il Ahn, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, YunXing Wang, Bo Yeon Kim, JungEun Park, Kyung S Lee. Molecular architecture of a cylindrical self-assembly at human centrosomes. NATURE COMMUNICATIONS[J]. 2019, 第 5 作者10(1): 1-15, https://doaj.org/article/5400f07be0494a47a4919ee1084eef02.
[14] YingNan Wang, YunXin Lu, Jie Liu, Ying Jin, HuiChang Bi, Qi Zhao, ZeXian Liu, YingQin Li, JiaJia Hu, Hui Sheng, YiMing Jiang, Chao Zhang, Feng Tian, Yang Chen, ZhiZhong Pan, Gong Chen, ZhaoLei Zeng, KaiYan Liu, Marcia Ogasawara, JinPing Yun, HuaiQiang Ju, JianXiong Feng, Dan Xie, Song Gao, WeiHua Jia, Scott Kopetz, RuiHua Xu, Feng Wang. AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation. ONCOGENE[J]. 2019, 第 14 作者39(3): 637-650, https://www.nature.com/articles/s41388-019-1004-2.
[15] Chen Qixin, Shao Xintian, Tian Zhiqi, Chen Yang, Mondal Payel, Liu Fei, Wang Fengshan, Ling Peixue, He Weijiang, Zhang Kai, Guo Zijian, Diao Jiajie. Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery. NANO RESEARCH[J]. 2019, 第 4 作者12(5): 1009-1015, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6619154&detailType=1.
[16] JinYu Yang, XiangYu Deng, YiSheng Li, XianCai Ma, JianXiong Feng, Bing Yu, Yang Chen, YiLing Luo, Xi Wang, MeiLing Chen, ZhiXin Fang, FuXiang Zheng, YiPing Li, Qian Zhong, TieBang Kang, LiBing Song, RuiHua Xu, MuSheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao. Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. NATURE COMMUNICATIONS[J]. 2018, 第 7 作者9(1): https://doaj.org/article/970dc6c72ffc4e9cbce88e5095a77123.
[17] Cao, YuLu, Meng, Shuxia, Chen, Yang, Feng, JianXiong, Gu, DongDong, Yu, Bing, Li, YuJie, Yang, JinYu, Liao, Shuang, Chan, David C, Gao, Song. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. NATURE[J]. 2017, 第 3 作者542(7641): 372-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000394451600042.
[18] Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao, Song Gao. Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET. NATURE COMMUNICATIONS[J]. 2017, 第 1 作者8(1): https://doaj.org/article/238a897e890a4cd0ae63f68efa6cfb0a.
[19] Hu, JiaLi, Hua, YiJun, Chen, Yang, Yu, Bing, Gao, Song. Structural analysis of tumor-related single amino acid mutations in human MxA protein. CHINESE JOURNAL OF CANCER[J]. 2015, 第 3 作者34(12): http://lib.cqvip.com/Qikan/Article/Detail?id=667815215.
[20] He, Ze, Tian, Tian, Guo, Dan, Wu, Huijuan, Chen, Yang, Zhang, Yongchen, Wan, Qing, Zhao, Huzi, Wang, Congyang, Shen, Hongjing, Zhao, Lei, Bu, Xiaodong, Wan, Meiling, Shen, Chuanlu. Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling. PLOS ONE[J]. 2014, 第 5 作者9(4): https://doaj.org/article/61812b304b994c6f8c89e616a3f06350.

科研活动

   
科研项目
( 1 ) 癌蛋白TBC1D3的结构及其在胰腺癌发生中的功能研究, 负责人, 国家任务, 2022-01--2024-12
( 2 ) CHD1L对乳腺癌化疗耐药的作用和结构机制研究, 负责人, 国家任务, 2021-01--2024-12
( 3 ) TBC1D3 蛋白的结构测定及其与胰腺癌发生的关系研究, 负责人, 地方任务, 2022-01--2023-12
( 4 ) 肿瘤疾病关键蛋白的结构和功能研究, 负责人, 地方任务, 2021-01--2022-12