1. 化学生物学

2. 天然药物化学

拟招收硕士研究生1名

100706-药理学

化学生物学
药理学

2009-09--2012-12   福建农林大学   农学博士
2006-09--2009-01   国立华侨大学   工学硕士
2002-09--2006-06   国立华侨大学   工学学士

   

2022-02~现在, 中国科学院昆明植物研究所, 副研究员
2017-02~2022-01,中国科学院昆明植物研究所, 助理研究员
2013-10~2017-01,中国科学院昆明植物研究所, 博士后

2018-09-10-今,中南药学期刊编委, 青年编委

   

（ 1 ） 巨大戟醇及其衍生物在增强溶酶体生成中的应用, 专利授权, 2019, 第 5 作者, 专利号: CN106619600B

   

[1] Wang, YiTing, Long, XinYan, Ding, Xiao, Fan, ShiRui, Cai, JieYun, Yang, BiJuan, Zhang, XinFang, Luo, Ronghua, Yang, Lian, Ruan, Ting, Ren, Juan, Jing, ChenXu, Zheng, YongTang, Hao, XiaoJiang, Chen, DuoZhi. Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 227: http://dx.doi.org/10.1016/j.ejmech.2021.113966.
[2] Zhao, Yueqin, Yang, Xu, Fei, Jimin, Dong, Xianxiang, Wang, Yinyuan, Yang, Shan, Hao, Xiaojiang, Ding, Xiao, Zhao, Yuhan. Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines. FITOTERAPIA[J]. 2022, 157: http://dx.doi.org/10.1016/j.fitote.2021.105120.
[3] Yang, BaoJia, Wang, Juan, Zeng, ZhengQuan, Yang, Xu, Huang, AiYing, Hao, XiaoJiang, Ding, Xiao, Li, ShunLin. Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy. NATURAL PRODUCT RESEARCH[J]. 2022, 36(12): 3207-3210, http://dx.doi.org/10.1080/14786419.2021.1955881.
[4] Lan, Mingxian, Gao, Xi, Duan, Xiuan, Li, Hongmei, Yu, Hang, Li, Jinliang, Zhao, Yueqin, Hao, Xiaojiang, Zhao, Yuhan, Ding, Xiao, Wu, Guoxing. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES[J]. 2022, 57(1): 54-61, http://dx.doi.org/10.1080/03601234.2021.2022945.
[5] Xiao Ding, Xu Yang, Yueqin Zhao, Yinyuan Wang, Jimin Fei, Zhenpeng Niu, Xianxiang Dong, Xuenan Wang, Biao Liu, Hongmei Li, Xiaojiang Hao, Yuhan Zhao. Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation. Heliyon[J]. 2022, http://dx.doi.org/10.1016/j.heliyon.2022.e11179.
[6] Chen, YanNi, Ding, Xiao, Li, DongMei, Sun, Mao, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(7): 1541-1545, https://www.webofscience.com/wos/woscc/full-record/WOS:000621563000010.
[7] Zhao, NingDong, Li, YuLin, Song, Yu, Yang, BaoJia, Ding, Xiao, Gao, Fang, Ye, Jian, Hao, XiaoJiang, Zhang, Yu, Li, ShunLin. Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities. FITOTERAPIA[J]. 2021, 153: http://dx.doi.org/10.1016/j.fitote.2021.104989.
[8] Wei, Ruiran, Zhao, Yueqin, Wang, Juan, Yang, Xu, Li, Shunlin, Wang, Yinyuan, Yang, Xingzhi, Fei, Jimin, Hao, Xiaojiang, Zhao, Yuhan, Gui, Liming, Ding, Xiao. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2021, 17(11): 2703-2717, http://dx.doi.org/10.7150/ijbs.59404.
[9] Chen, Chen, Ding, Xiao, Han, Lingling, Zhu, Wentao, Huang, Kepu, Hao, Xiaojiang, Zhang, Yu. Two new monoterpenoid indole alkaloids from the kernels of Kopsia arborea. NATURAL PRODUCT RESEARCH[J]. 2021, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701452100001.
[10] Wang, Yajie, Tan, Jiabin, Hu, Peng, Pei, Qiang, Wen, Yan, Ma, Wenqing, Shi, Keqian, Li, Zengzheng, Li, Huiyuan, Cheng, Fengyu, Gu, Xuezhong, Yao, Xiangmei, Man, Yan, Zhao, Renbin, Feng, Shuai, Ding, Xiao, Yang, Tonghua. Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling. BIOMEDICINE & PHARMACOTHERAPY[J]. 2021, 134: http://dx.doi.org/10.1016/j.biopha.2020.111107.
[11] Chen, YanNi, Ding, Xiao, Li, DongMei, Lu, QingYun, Liu, Shuai, Li, YingYao, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway.. Natural products and bioprospecting[J]. 2021, 11(3): 357-364, http://lib.cqvip.com/Qikan/Article/Detail?id=7105123644.
[12] Zhao, Qian, Zhu, WenTao, Ding, Xiao, Huo, ZongQing, Donkor, Paul O, Adelakun, Tiwalade A, Hao, XiaoJiang, Zhang, Yu. Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity. PHYTOCHEMISTRY[J]. 2021, 181: http://dx.doi.org/10.1016/j.phytochem.2020.112566.
[13] Adelakun, Tiwalade A, Ding, Xiao, Ombati, Rose M, Zhao, NingDong, ObodozieOfoegbu, Obiageri, Di, YingTong, Zhang, Yu, Hao, XiaoJiang. A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud. NATURAL PRODUCT RESEARCH[J]. 2020, 34(21): 3027-3035, https://www.webofscience.com/wos/woscc/full-record/WOS:000469633400001.
[14] Chen, YanNi, Ding, Xiao, Lu, QingYun, Li, DongMei, Li, BoTing, Liu, Shuai, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Macrocyclic diterpenoids from the seeds of Euphorbia peplus with potential activity in inducing lysosomal biogenesis. BIOORGANIC CHEMISTRY[J]. 2020, 105: http://dx.doi.org/10.1016/j.bioorg.2020.104464.
[15] Zhang, Yu, Ding, Xiao, Yuan, YuXi, Guo, LingLi, Hao, XiaoJiang. Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(5): 1432-1439, http://ir.kib.ac.cn/handle/151853/72090, http://www.irgrid.ac.cn/handle/1471x/6927926, http://ir.kib.ac.cn/handle/151853/72091, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537539300010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[16] Si, Yu, Ding, Xiao, Adelakuna, Tiwalade A, Zhang, Yu, Hao, XiaoJiang. Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis. FITOTERAPIA[J]. 2020, 147: http://dx.doi.org/10.1016/j.fitote.2020.104738.
[17] Li, Mengyue, Gao, Xi, Lan, Mingxian, Liao, Xianbin, Su, Fawu, Fan, Liming, Zhao, Yuhan, Hao, Xiaojiang, Wu, Guoxing, Ding, Xiao. Inhibitory activities of flavonoids from Eupatorium adenophorum against acetylcholinesterase. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY[J]. 2020, 170: http://dx.doi.org/10.1016/j.pestbp.2020.104701.
[18] Yi, WenFang, Ding, Xiao, Chen, YuanZhi, Adelakun, Tiwalade A, Zhang, Yu, Hao, XiaoJiang. Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(11): 3215-3222, https://www.webofscience.com/wos/woscc/full-record/WOS:000595546200001.
[19] Gui, PengYan, Yan, XiaoHui, Yuan, WenJuan, Ma, YuanLiang, Ding, Xiao, Liu, Shuai, Di, YingTong, Zhu, WeiMing, Hao, XiaoJiang. 12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata. NATURAL PRODUCT RESEARCH[J]. 2019, 33(19): 2830-2836, http://dx.doi.org/10.1080/14786419.2018.1508139.
[20] HaiLi Yu, Qin Long, WenFang Yi, BaoJia Yang, Yu Song, Xiao Ding, ShunLin Li, XiaoJiang Hao. Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2019, 9(3): 209-214, http://dx.doi.org/10.1007/s13659-019-0205-2.
[21] Zhang, Yu, Ding, Xiao, Shao, Shun, Guo, LingLi, Zhao, Qing, Hao, XiaoJiang, He, HongPing. Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis. ORGANIC LETTERS[J]. 2019, 21(22): 9272-9275, https://www.webofscience.com/wos/woscc/full-record/WOS:000497259500086.
[22] Duan, XiaoXiang, Qin, Dan, Song, HongChuan, Gao, TianCong, Zuo, ShiHao, Yan, Xiao, Wang, JunQi, Ding, Xiao, Di, YingTong, Dong, JinYan. Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense. PHYTOCHEMISTRY LETTERS[J]. 2019, 32: 151-156, http://dx.doi.org/10.1016/j.phytol.2019.06.001.
[23] YuanLiang Ma, XiaoHan Tang, WenJuan Yuan, Xiao Ding, YingTong Di, XiaoJiang Hao. Abietane Diterpernoids from the Roots of Euphorbia ebracteolata. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2018, 8(2): 131-135, http://ir.kib.ac.cn/handle/151853/64821.
[24] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.
[25] Li, Yang, Zhang, Yu, Gan, Qiwen, Xu, Meng, Ding, Xiao, Tang, Guihua, Liang, Jingjing, Liu, Kai, Liu, Xuezhao, Wang, Xin, Guo, Lingli, Gao, Zhiyang, Hao, Xiaojiang, Yang, Chonglin. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. PROTEIN & CELL[J]. 2018, 9(12): 1013-1026, http://lib.cqvip.com/Qikan/Article/Detail?id=6100018010.
[26] Zhao, NingDong, Ding, Xiao, Song, Yu, Yang, DongQiong, Adelakun, Tiwalade Adegoke, Qian, WenDan, Zhang, Yu, Di, YingTong, Gao, Fang, Hao, XiaoJiang, Li, ShunLin. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(5): 1209-1218, https://www.webofscience.com/wos/woscc/full-record/WOS:000433635500010.
[27] Yan, Chen, Zhang, WeiQing, Sun, Mao, Liang, Wei, Wang, TianYuan, Zhang, YunDong, Ding, Xiao. Carpescernolides A and B, rare oxygen bridge-containing sesquiterpene lactones from Carpesium cernuum. TETRAHEDRON LETTERS[J]. 2018, 59(46): 4063-4066, http://dx.doi.org/10.1016/j.tetlet.2018.09.067.
[28] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.
[29] Li, Yang, Xu, Meng, Ding, Xiao, Yan, Chen, Song, Zhiqin, Chen, Lianwan, Huang, Xiahe, Wang, Xin, Jian, Youli, Tang, Guihua, Tang, Changyong, Di, Yingtong, Mu, Shuzhen, Liu, Xuezhao, Liu, Kai, Li, Ting, Wang, Yingchun, Miao, Long, Guo, Weixiang, Hao, Xiaojiang, Yang, Chonglin. Protein kinase C controls lysosome biogenesis independently of mTORC1. NATURE CELL BIOLOGY[J]. 2016, 18(10): 1065-1077, http://www.irgrid.ac.cn/handle/1471x/1140918.
[30] Chunxiang Wang, Xiao Ding, ShiXiu Feng, Qiunong Guan, XiaoPing Zhang, Caigan Du, YingTong Di, Tao Chen. Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth. Molecules[J]. 2015, 20(12): 22565-22577, https://doaj.org/article/d07fda9194324dccba0c4834ca82a821.
[31] Shao, Shun, Zhang, Hao, Yuan, ChunMao, Zhang, Yu, Cao, MingMing, Zhang, HaiYuan, Feng, Yan, Ding, Xiao, Zhou, Qiang, Zhao, Qing, He, HongPing, Hao, XiaoJiang. Cytotoxic indole alkaloids from the fruits of Melodinus cochinchinensis. PHYTOCHEMISTRY[J]. 2015, 116: 367-373, http://dx.doi.org/10.1016/j.phytochem.2015.02.028.
[32] Pan, YaMei, Zou, Tao, Chen, YongJu, Chen, JianYong, Ding, Xiao, Zhang, Yu, Hao, XiaoJiang, He, HongPing. Two new pentacyclic triterpenoids from the stems of Manihot esculenta. PHYTOCHEMISTRY LETTERS[J]. 2015, 12: 273-276, http://dx.doi.org/10.1016/j.phytol.2015.04.018.
[33] Ding, Xiao, Ouyang, MingAn, Shen, YuanShuai. Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents from Plumula nelumbinis. JOURNAL OF CHEMISTRY[J]. 2015, 2015: http://www.irgrid.ac.cn/handle/1471x/1055496.
[34] Ding, Xiao, Ouyang, MingAn, Liu, Xiang, Wang, ReiZhen. Acetylcholinesterase Inhibitory Activities of Flavonoids from the Leaves of Ginkgo biloba against Brown Planthopper. JOURNAL OF CHEMISTRY[J]. 2013, 2013: https://doaj.org/article/0a3c0f456e4a46dabfceed3bbc85065d.
[35] Shen, Shuo, Ding, Xiao, Ouyang, MingAn, Wu, ZuJian, Xie, LianHui. A new phenolic glycoside and cytotoxic constituents from Celosia argentea. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2010, 12(9): 821-827, https://www.webofscience.com/wos/woscc/full-record/WOS:000281762900015.

   

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（ 2 ） 溶酶体稳态的调控机制研究（化学研究）, 负责人, 国家任务, 2018-01--2022-12
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