基本信息
丁骁 男 中国科学院昆明植物研究所
电子邮件: dingxiao@mail.kib.ac.cn
通信地址: 云南省昆明市盘龙区蓝黑路132号
邮政编码: 650201
电子邮件: dingxiao@mail.kib.ac.cn
通信地址: 云南省昆明市盘龙区蓝黑路132号
邮政编码: 650201
研究领域
1. 化学生物学
2. 天然药物化学
招生信息
拟招收硕士研究生1名
招生专业
100706-药理学
招生方向
化学生物学药理学
教育背景
2009-09--2012-12 福建农林大学 农学博士2006-09--2009-01 国立华侨大学 工学硕士2002-09--2006-06 国立华侨大学 工学学士
学历
工作经历
工作简历
2022-02~现在, 中国科学院昆明植物研究所, 副研究员2017-02~2022-01,中国科学院昆明植物研究所, 助理研究员2013-10~2017-01,中国科学院昆明植物研究所, 博士后
社会兼职
2018-09-10-今,中南药学期刊编委, 青年编委
专利与奖励
专利成果
( 1 ) 巨大戟醇及其衍生物在增强溶酶体生成中的应用, 专利授权, 2019, 第 5 作者, 专利号: CN106619600B
出版信息
发表论文
[1] Jinliang Li, Fengchao Li, Guoxing Wu, Furong Gui, Hongmei Li, Lili Xu, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Xiaoping Qin. Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta. FRONTIERS IN PLANT SCIENCE[J]. 2023, 14: https://doaj.org/article/59e82ba731984819bc8ce72b62a97753.[2] Cui, JinJin, Li, Rui, Ma, XiaoLei, Yu, HaoYang, Luo, ZhiGang, Du, Peng, Ren, Ling, Ding, Xiao, Guo, XiuPing, Zheng, WenSheng, Jiang, JianDong, Che, Yongsheng, Wang, LuLu. Prebiotic-Based Nanoamorphous Atorvastatin Attenuates Nonalcoholic Fatty Liver Disease by Retrieving Gut and Liver Health. SMALL STRUCTURES[J]. 2023, [3] HuiHui Guo, HaoRan Shen, MingZe Tang, Ning Sheng, Xiao Ding, Yuan Lin, JinLan Zhang, JianDong Jiang, TianLe Gao, LuLu Wang, YanXing Han. Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut–brain axis. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2023, 306: http://dx.doi.org/10.1016/j.jep.2023.116158.[4] Zhenpeng Niu, Guihua Tang, Xuenan Wang, Xu Yang, Yueqin Zhao, Yinyuan Wang, Qin Liu, Fan Zhang, Yuhan Zhao, Xiao Ding, Xiaojiang Hao. Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress. PHYTOMEDICINE[J]. 2023, http://dx.doi.org/10.1016/j.phymed.2023.154720.[5] Wang, YiTing, Long, XinYan, Ding, Xiao, Fan, ShiRui, Cai, JieYun, Yang, BiJuan, Zhang, XinFang, Luo, Ronghua, Yang, Lian, Ruan, Ting, Ren, Juan, Jing, ChenXu, Zheng, YongTang, Hao, XiaoJiang, Chen, DuoZhi. Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 227: http://dx.doi.org/10.1016/j.ejmech.2021.113966.[6] Zhao, Yueqin, Yang, Xu, Fei, Jimin, Dong, Xianxiang, Wang, Yinyuan, Yang, Shan, Hao, Xiaojiang, Ding, Xiao, Zhao, Yuhan. Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines. FITOTERAPIA[J]. 2022, 157: http://dx.doi.org/10.1016/j.fitote.2021.105120.[7] Yu, Hang, Li, Jinliang, Wu, Guoxing, Tang, Qingbo, Duan, Xiuan, Liu, Quanjun, Lan, Mingxian, Zhao, Yuhan, Hao, Xiaojiang, Qin, Xiaoping, Ding, Xiao. Antifeedant Mechanism of Dodonaea viscosa Saponin A Isolated from the Seeds of Dodonaea viscosa. MOLECULES[J]. 2022, 27(14): [8] Yang, BaoJia, Wang, Juan, Zeng, ZhengQuan, Yang, Xu, Huang, AiYing, Hao, XiaoJiang, Ding, Xiao, Li, ShunLin. Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy. NATURALPRODUCTRESEARCH[J]. 2022, 36(12): 3207-3210, http://dx.doi.org/10.1080/14786419.2021.1955881.[9] Lan, Mingxian, Gao, Xi, Duan, Xiuan, Li, Hongmei, Yu, Hang, Li, Jinliang, Zhao, Yueqin, Hao, Xiaojiang, Zhao, Yuhan, Ding, Xiao, Wu, Guoxing. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium. JOURNALOFENVIRONMENTALSCIENCEANDHEALTHPARTBPESTICIDESFOODCONTAMINANTSANDAGRICULTURALWASTES[J]. 2022, 57(1): 54-61, http://dx.doi.org/10.1080/03601234.2021.2022945.[10] Chen, YanNi, Ding, Xiao, Li, DongMei, Sun, Mao, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(7): 1541-1545, https://www.webofscience.com/wos/woscc/full-record/WOS:000621563000010.[11] Zhao, NingDong, Li, YuLin, Song, Yu, Yang, BaoJia, Ding, Xiao, Gao, Fang, Ye, Jian, Hao, XiaoJiang, Zhang, Yu, Li, ShunLin. Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities. FITOTERAPIA[J]. 2021, 153: http://dx.doi.org/10.1016/j.fitote.2021.104989.[12] Wei, Ruiran, Zhao, Yueqin, Wang, Juan, Yang, Xu, Li, Shunlin, Wang, Yinyuan, Yang, Xingzhi, Fei, Jimin, Hao, Xiaojiang, Zhao, Yuhan, Gui, Liming, Ding, Xiao. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2021, 17(11): 2703-2717, http://dx.doi.org/10.7150/ijbs.59404.[13] Chen, Chen, Ding, Xiao, Han, Lingling, Zhu, Wentao, Huang, Kepu, Hao, Xiaojiang, Zhang, Yu. Two new monoterpenoid indole alkaloids from the kernels of Kopsia arborea. NATURAL PRODUCT RESEARCH[J]. 2021, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701452100001.[14] YanNi Chen, Xiao Ding, DongMei Li, QingYun Lu, Shuai Liu, YingYao Li, YingTong Di, Xin Fang, XiaoJiang Hao. Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway. 应用天然产物(英文)[J]. 2021, 11(3): 357-364, http://lib.cqvip.com/Qikan/Article/Detail?id=7105123644.[15] Wang, Yajie, Tan, Jiabin, Hu, Peng, Pei, Qiang, Wen, Yan, Ma, Wenqing, Shi, Keqian, Li, Zengzheng, Li, Huiyuan, Cheng, Fengyu, Gu, Xuezhong, Yao, Xiangmei, Man, Yan, Zhao, Renbin, Feng, Shuai, Ding, Xiao, Yang, Tonghua. Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling. BIOMEDICINE & PHARMACOTHERAPY[J]. 2021, 134: http://dx.doi.org/10.1016/j.biopha.2020.111107.[16] Zhao, Qian, Zhu, WenTao, Ding, Xiao, Huo, ZongQing, Donkor, Paul O, Adelakun, Tiwalade A, Hao, XiaoJiang, Zhang, Yu. Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity. PHYTOCHEMISTRY[J]. 2021, 181: http://dx.doi.org/10.1016/j.phytochem.2020.112566.[17] Zhang, Yu, Ding, Xiao, Yuan, YuXi, Guo, LingLi, Hao, XiaoJiang. Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(5): 1432-1439, http://ir.kib.ac.cn/handle/151853/72090, http://www.irgrid.ac.cn/handle/1471x/6927926, http://ir.kib.ac.cn/handle/151853/72091, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537539300010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.[18] Si, Yu, Ding, Xiao, Adelakuna, Tiwalade A, Zhang, Yu, Hao, XiaoJiang. Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis. FITOTERAPIA[J]. 2020, 147: http://dx.doi.org/10.1016/j.fitote.2020.104738.[19] Li, Mengyue, Gao, Xi, Lan, Mingxian, Liao, Xianbin, Su, Fawu, Fan, Liming, Zhao, Yuhan, Hao, Xiaojiang, Wu, Guoxing, Ding, Xiao. Inhibitory activities of flavonoids from Eupatorium adenophorum against acetylcholinesterase. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY[J]. 2020, 170: http://dx.doi.org/10.1016/j.pestbp.2020.104701.[20] Yi, WenFang, Ding, Xiao, Chen, YuanZhi, Adelakun, Tiwalade A, Zhang, Yu, Hao, XiaoJiang. Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(11): 3215-3222, https://www.webofscience.com/wos/woscc/full-record/WOS:000595546200001.[21] Adelakun, Tiwalade A, Ding, Xiao, Ombati, Rose M, Zhao, NingDong, ObodozieOfoegbu, Obiageri, Di, YingTong, Zhang, Yu, Hao, XiaoJiang. A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud. NATURAL PRODUCT RESEARCH[J]. 2020, 34(21): 3027-3035, https://www.webofscience.com/wos/woscc/full-record/WOS:000469633400001.[22] Chen, YanNi, Ding, Xiao, Lu, QingYun, Li, DongMei, Li, BoTing, Liu, Shuai, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Macrocyclic diterpenoids from the seeds of Euphorbia peplus with potential activity in inducing lysosomal biogenesis. BIOORGANIC CHEMISTRY[J]. 2020, 105: http://dx.doi.org/10.1016/j.bioorg.2020.104464.[23] Gui, PengYan, Yan, XiaoHui, Yuan, WenJuan, Ma, YuanLiang, Ding, Xiao, Liu, Shuai, Di, YingTong, Zhu, WeiMing, Hao, XiaoJiang. 12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata. NATURAL PRODUCT RESEARCH[J]. 2019, 33(19): 2830-2836, http://dx.doi.org/10.1080/14786419.2018.1508139.[24] HaiLi Yu, Qin Long, WenFang Yi, BaoJia Yang, Yu Song, Xiao Ding, ShunLin Li, XiaoJiang Hao. Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2019, 9(3): 209-214, http://dx.doi.org/10.1007/s13659-019-0205-2.[25] Zhang, Yu, Ding, Xiao, Shao, Shun, Guo, LingLi, Zhao, Qing, Hao, XiaoJiang, He, HongPing. Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis. ORGANIC LETTERS[J]. 2019, 21(22): 9272-9275, https://www.webofscience.com/wos/woscc/full-record/WOS:000497259500086.[26] Duan, XiaoXiang, Qin, Dan, Song, HongChuan, Gao, TianCong, Zuo, ShiHao, Yan, Xiao, Wang, JunQi, Ding, Xiao, Di, YingTong, Dong, JinYan. Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense. PHYTOCHEMISTRY LETTERS[J]. 2019, 32: 151-156, http://dx.doi.org/10.1016/j.phytol.2019.06.001.[27] YuanLiang Ma, XiaoHan Tang, WenJuan Yuan, Xiao Ding, YingTong Di, XiaoJiang Hao. Abietane Diterpernoids from the Roots of Euphorbia ebracteolata. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2018, 8(2): 131-135, http://ir.kib.ac.cn/handle/151853/64821.[28] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.[29] Li, Yang, Zhang, Yu, Gan, Qiwen, Xu, Meng, Ding, Xiao, Tang, Guihua, Liang, Jingjing, Liu, Kai, Liu, Xuezhao, Wang, Xin, Guo, Lingli, Gao, Zhiyang, Hao, Xiaojiang, Yang, Chonglin. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. PROTEIN & CELL[J]. 2018, 9(12): 1013-1026, http://lib.cqvip.com/Qikan/Article/Detail?id=6100018010.[30] Zhao, NingDong, Ding, Xiao, Song, Yu, Yang, DongQiong, Adelakun, Tiwalade Adegoke, Qian, WenDan, Zhang, Yu, Di, YingTong, Gao, Fang, Hao, XiaoJiang, Li, ShunLin. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(5): 1209-1218, https://www.webofscience.com/wos/woscc/full-record/WOS:000433635500010.[31] Yan, Chen, Zhang, WeiQing, Sun, Mao, Liang, Wei, Wang, TianYuan, Zhang, YunDong, Ding, Xiao. Carpescernolides A and B, rare oxygen bridge-containing sesquiterpene lactones from Carpesium cernuum. TETRAHEDRON LETTERS[J]. 2018, 59(46): 4063-4066, http://dx.doi.org/10.1016/j.tetlet.2018.09.067.[32] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFICREPORTS[J]. 2017, 7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.[33] Li, Yang, Xu, Meng, Ding, Xiao, Yan, Chen, Song, Zhiqin, Chen, Lianwan, Huang, Xiahe, Wang, Xin, Jian, Youli, Tang, Guihua, Tang, Changyong, Di, Yingtong, Mu, Shuzhen, Liu, Xuezhao, Liu, Kai, Li, Ting, Wang, Yingchun, Miao, Long, Guo, Weixiang, Hao, Xiaojiang, Yang, Chonglin. Protein kinase C controls lysosome biogenesis independently of mTORC1. NATURE CELL BIOLOGY[J]. 2016, 18(10): 1065-1077, http://www.irgrid.ac.cn/handle/1471x/1140918.[34] Chunxiang Wang, Xiao Ding, ShiXiu Feng, Qiunong Guan, XiaoPing Zhang, Caigan Du, YingTong Di, Tao Chen. Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth. 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科研活动
科研项目
( 1 ) 肿柄菊内酯C诱导溶酶体生成分子探针的构建及分子作用机制研究, 负责人, 国家任务, 2018-01--2020-12( 2 ) 溶酶体稳态的调控机制研究(化学研究), 负责人, 国家任务, 2018-01--2022-12( 3 ) Wedelolide A介导内质网促进溶酶体生成及自噬的机制研究, 负责人, 地方任务, 2020-09--2023-08( 4 ) 天然小分子化合物介导内质网应激调控溶酶体生成的作用机制研究, 负责人, 研究所自选, 2018-10--2021-09( 5 ) 巴戟天活性天然化合物的筛选及其作用机制探索, 负责人, 地方任务, 2020-10--2022-09( 6 ) 加热卷烟原料和烟气关键成分检测技术开发, 负责人, 企业委托, 2021-01--2023-12( 7 ) Hdj-15介导内质网应激促进溶酶体生成的分子机制研究, 负责人, 国家任务, 2021-01--2024-12
参与会议
(1)溶酶体稳态调控的天然活性成分发现及机制研究 上海新华罕见病、遗传病高峰论坛暨第二届国际溶酶体贮积症高峰论坛 2021-12-04(2)肿柄菊内酯C诱导结直肠肿瘤细胞铁死亡的作用机制研究 13th全国天然有机化学学术会议 2021-09-18(3)传统药用植物中活性成分的发现及机制研究 中华医学会血液学分会第一次中西整合医学学术会议 2021-07-03