General

Guoqiang Chen, PhD, Institute of Process Engineering, Chinese Academy of Sciences

E-mail: gqchen@ipe.ac.cn

Address: 404, Biochemical Science & Research Building, Institute of Process Engineering, Chinese Academy of Sciences, 1 North 2nd Street, Zhongguancun, Haidian District, Beijing 100190, PR China

Post Code: 100190

Research Areas

Bioseparation

Education

09/2009 -01/2014 Chinese Academy of Sciences, Beijing, China

                              Ph D in Biochemical Engineering

09/2006 -07/2008 Beijing Institute of Technology, Beijing, China

                              Master in Biochemical Engineering

09/2001-07/2005  Hefei University of Technology, Hefei, China

                              B Eng in Biological Engineering


Experience

   
Work Experience

12/2020 – present   Institute of Process Engineering, Chinese Academy of Sciences

                                Associate Professor

12/2016 – 10/2020 McMaster University, Hamilton, ON, Canada

                                Postdoctoral fellow

03/2014 – 08/2016 Mabworks Biotech Co. Ltd, Beijing, China

                                National Key Laboratory of Biochemical Engineering, Beijing, China

                                Integrated postdoctoral fellow


Publications

   
Papers

  1. Xiaotian Lu, Jiachen Huang, Manuel Pinelo, Guoqiang Chen*, Yinhua Wan, Jianquan Luo*. Modelling and optimization of pervaporation membrane modules: A critical review. Journal of Membrane Science, 664 (2022), 121084.

  2. Guoqiang Chen, Nikhila Butani, Raja Ghosh*. Fast and high-resolution fractionation of positional isomers of a PEGylated protein using membrane chromatography. Journal of Chromatography B, 1203 (2022) 123292.

  3. Guoqiang Chen, John Pagano, Deqiang Yu, Sanchayita Ghose, Zhengjian Li, Raja Ghosh*. Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device. Journal of Chromatography A, 1652 (2021) 462375.

  4. Guoqiang Chen#, Roxana Roshankhah#, Raja Ghosh*. A cuboid chromatography device having short b e d-height gives better protein separation at a significantly lower pressure drop than a taller column having the same b e d-volume. Journal of Chromatography A 1647 (2021), 462167.

  5. Guoqiang Chen, Umatheny Umatheva, John Pagano, Deqiang Yu, Sanchayita Ghose, Zhengjian Li, Raja Ghosh*. High-resolution purification of a therapeutic PEGylated protein using a cuboid packed-bed device. Journal of Chromatography A 1630 (2020), 461524. 

  6. Raja Ghosh*, Guoqiang Chen, Roxana Roshankhah, Umatheny Umatheva, Paul Gatt. A z2 laterally-fed membrane chromatography device for fast high-resolution purification of biopharmaceuticals. Journal of Chromatography A 1629 (2020), 461453. (First-author: supervisor)

  7. Raja Ghosh*, Guoqiang Chen, Umatheny Umatheva, Paul Gatt. A flow distribution and collection feature for ensuring scalable uniform flow in a chromatography device. Journal of Chromatography A 1618 (2020), 460892. (First-author: supervisor)

  8. Guoqiang Chen, Raja Ghosh*. Simulation and experimental study of the transport of macromolecule bands through cuboid packed-bed devices during chromatographic separations. Journal of Chromatography A 1615 (2020), 460764. 

  9. Guoqiang Chen, Alisha Gerrior, Yves Durocher, Raja Ghosh*. Efficient capture of monoclonal antibodies in the cell culture supernatant using protein-A media containing cuboid packed-bed device. Journal of Chromatography B 1134-1135 (2019), 121853. 

  10. Guoqiang Chen, Umatheny Umatheva, Lionel Alforque, Shuichiro Ogawa, Hironobu Shirataki, Chihiro Kato, Raja Ghosh*. An annular-flow, hollow-fiber membrane chromatography device for fast, high-resolution protein separation at low pressure. Journal of Membrane Science 590 (2019), 117305. 

  11. Guoqiang Chen, Alisha Gerrior, Geoffrey Hale, Raja Ghosh*. Feasibility study of the fractionation of monoclonal antibody charge variants using a cuboid packed-bed device. Biochemical Engineering Journal, 147(2019), 48-56. 

  12. Guoqiang Chen, Igor Zhitomirsky, Raja Ghosh*. Fast, low-pressure chromatographic separation of proteins using hydroxyapatite nanoparticles. Talanta, 199 (2019), 472-477. 

  13. Guoqiang Chen, Raja Ghosh*. Effect of the Length-to-Width Aspect Ratio of a Cuboid Packed-Bed Device on Efficiency of Chromatographic Separation. Processes, 6 (2018) 160. 
  14. Guoqiang Chen, Raja Ghosh*. Effects of process parameters on the efficiency of chromatographic separations using a cuboid packed-bed device. Journal of Chromatography B, 1086 (2018) 23-28. 
  15. Guoqiang Chen, Alisha Gerrior, Raja Ghosh*. Feasibility study for high-resolution multi-component separation of protein mixture using a cation-exchange cuboid packed-bed device. Journal of Chromatography A, 1549 (2018) 25-30. 
  16. Raja Ghosh*, Guoqiang Chen. Mathematical modelling and evaluation of performance of cuboid packed-bed devices for chromatographic separations. Journal of Chromatography A, 1515 (2017) 138-145. (First-author: supervisor)
  17. Guoqiang Chen, Zhiguo Su, Feng Li, Hui Fang Liu*. Application of calcium phosphate flocculation in high-density cell culture fluid with high product titer of monoclonal antibody. Bioprocess and Biosystems Engineering, 40 (2017) 703–714. 
  18. Guoqiang Chen, Weijie Song, Benkun Qi, Raja Ghosh, Yinhua Wan*. Separation of human serum albumin and polyethylene glycol by electro-ultrafiltration. Biochemical Engineering Journal, 109 (2016) 127-136. 
  19. Guoqiang Chen, Weijie Song, Benkun Qi, Jing Li, Raja Ghosh, Yinhua Wan*. Separation of protein mixtures by an integrated electro-ultrafiltration–electrodialysis process. Separation and Purification Technology, 147(2015) 32-43. 
  20. Guoqiang Chen, Weijie Song, Benkun Qi, Jianren Lu, Yinhua Wan*. Recycling cellulase from enzymatic hydrolyzate of acid treated wheat straw by electroultrafiltration. Bioresource Technology, 144 (2013) 186-193. 
  21. Umatheny Umatheva, Guoqiang Chen, Raja Ghosh*. Computational fluid dynamic simulation of a cuboid packed-bed chromatography device. Chemical Engineering Research and Design 152 (2019) 393-401. 
  22. Yang cao, Guoqiang Chen, Yinhua Wan, Jianquan Luo*. Nanofiltration membrane for bio-separation: Process-oriented materials innovation. Engineering in Life sciences, (2021), 1-12.
  23. Benkun Qi, Jianquan Luo, Guoqiang Chen, Xiangrong Chen, Yinhua Wan*. Application of ultrafiltration and nanofiltration for recycling cellulase and concentrating glucose from enzymatic hydrolyzate of steam exploded wheat straw. Bioresource Technology, 104 (2012) 466-472. 
  24. Guoqiang Chen, Weijie Song, Yi Su, Yinhua Wan*. Application of ultrafiltration techniques in bioseparation. Biotechnology & Biobusiness (China), 3 (2010) 69-74.
  25. Weijie Song, Guoqiang Chen, Yi Su, Yinhua Wan*. Application of microfiltration techniques in fermentational industry. Biotechnology & Biobusiness (China), 4 (2010) 65-72.
  26. Weijie Song, Guoqiang Chen, Benkun Qi, Yi Su, Yinhua Wan*. Study of electric field intensified ultrafiltration process on cellulase solution. Chemical Engineering (China), 39 (2011) 98-102.


Patents

  1. ​Raja Ghosh, Guoqiang Chen, Paul Gatt. ANNULAR-FLOW HOLLOW FIBER MEMBRANE DEVICE. (US Patent, application number: 62802527)

  2. Raja Ghosh, Paul Gatt, Umatheny Umatheva, Guoqiang Chen. FLOW DISTRIBUTION AND COLLECTION FEATURES FOR ENSURING SCALABLE UNIFORM FLOW IN A CHROMATOGRAPHY OR MEMBRANE SEPARATION DEVICE. (US Patent, application number: 62883891)


Research Interests

Functional media preparation, process intensification, device design, process integration, membrane reactor.

Conferences


Students

现指导学生

陶璐  博士研究生  081703-生物化工  

Honors & Distinctions

The 7th National Congress on Membranes and Membrane Processes outstanding paper award, 2011.