Soft condensed matter physics and liquid at interface: interfacial pinning, hysteresis, and dynamics near the moving contact line, contact angle hysteresis and relaxation, microrheology, viscoelastic and poroelastic properties of hydrogels and thin polymer films, and transport, interactions, and dynamics of colloidal particles, bubbles and droplets.

Biological physics and mechanobiology: mechanical properties of soft and living matters, such as protein condensates, living cells and tissues, multi-scale mechanics of living cells, mitotic cell rounding, and biological liquid-liquid phase separation.

Atomic force microscopy (AFM) applications: AFM under a varieties of operation modes (noncontact, frequency modulation, and duel frequency imaging) with modified probes, such as long-needle probe and colloidal probe, topographical and mechanical measurements of soft materials in liquid, viscoelastic imaging of live cells, and optical force measurement in meta- materials.

2010-2016  Ph.D. in Physics, Hong Kong University of Science and Technology (HKUST), Hong Kong (Supervisor: Penger Tong)

2006-2010  B.Sc. in Physics, Beijing Normal University, Beijing, China

2020 Dec-Now  Professor, The State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences.

2021 Jun-Now  Professor, School of Engineering Science, University of Chinese Academy of Sciences.

2019 Jan-2020 Dec  Associate Professor, The State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences.

2017 Apr-2019 Jan  Research Assistant Professor, Department of Physics, HKUST

2017 Apr-2019 Jan  Junior Fellow of the Institute for Advanced Study, HKUST

2016 Apr-2017 Apr  Post-doctoral Fellow, Department of Physics, HKUST

2014 Mar-May and 2015 Sep-Dec  Visiting Scholar, LiPhy, Université Joseph Fourier, Grenoble, France

1. “Manipulation of  Contact Angle Hysteresis at Electrified Ionic Liquid-Solid Interfaces”, Pengcheng Nie, Xikai Jiang, Xu Zheng, and Dongshi Guan.  Physical Review Letters, 132, 044002 (2024).

2. “Avalanches and extreme value statistics of a mesoscale moving contact line”, Caishan Yan, Dongshi Guan, Yin Wang, Pik-Yin Lai, Hsuan-Yi Chen, and Penger Tong.  Physical Review Letters, 132, 084003 (2024) (Editors’Suggestion).

3. “Soft Wetting: Droplet Receding Contact Angles on Soft Superhydrophobic Surfaces”, Youhua Jiang, Zhijia Xu, Bin Li, Juan Li, and Dongshi Guan. Langmuir, 39, 43, 15401-15408 (2023).

4. “Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion”,  Chao Jiang, Hong-Yu Luo, Xinpeng Xu, Shuo-Xing Dou, Wei Li, Dongshi Guan, Fangfu Ye, Xiaosong Chen, Ming Guo, Peng-Ye Wang & Hui Li. Nature Communications, 14, 5166 (2023).

5. “Crossover behavior in stress relaxations of poroelastic and viscoelastic dominant hydrogels”, Hangyu Li, Xinyi Lian and Dongshi Guan, Soft matter, 19, 5443-5451, (2023) (Sellected in Soft Matter Emerging Investigators Series (https://blogs.rsc.org/sm/2023/08/17/soft-matter-emerging-investigator-dongshi-guan/) and a Journal Cover (https://pubs.rsc.org/en/content/articlepdf/2023/sm/d3sm90100a)).  

6. “Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling”, Xiaochen Wang, Hangyu Li, Yu Zheng, Dongshi Guan, Aidan Wang, Qihui Fan, Yang Jiao, Fangfu Ye, Advanced Functional Materials, 33, 2305414 (2023). 

7. “Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates”,  Zheng Wang, Chun Yang, Dongshi Guan, Jiaqi Li, Hong Zhang, Developmental Cell, 58(11), 919-932 (2023). (Featured article and highlighted in Developmental Cell, see “Soaping up transcriptional condensates”). 

8. “Stiff Extracellular Matrix Promotes Invasive Behaviors of Trophoblast Cells”, Jialing Cao, Hangyu Li, Hongyan Tang, Xuenan Gu, Yan Wang*, Dongshi Guan*, Jing Du* and Yubo Fan*,  Bioengineering, 10(3), 384 (2023).

9. “Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers", Yang Liu, Xu Zheng, Dongshi Guan, Xikai Jiang and Guoqing Hu, ACS Nano, 16, 10, 16054–16066(2022).

10. “Multimodal Bubble Microrobot Near an Air–Water Interface”, Leilei Wang, Li Chen, Xu Zheng, Zexiong Yu, Wenchao Lv, Minjia Sheng, Lina Wang, Pengcheng Nie, Hangyu Li, Dongshi Guan and Haihang Cui, Small, 18, 2203872 (2022).

11. “Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway”, Zheng Wang, Di Chen, Dongshi Guan, Xiaobo Liang, Jianfeng Xue, Hongyu Zhao, Guangtao Song, Jizhong Lou, Yan He and Hong Zhang, Journal of Cell Biology 221, e202112024 (2022).

12. “Unified description of compressive modulus revealing multi-scale mechanics of living cells”, Dongshi Guan, Yusheng Shen, Rui Zhang, Pingbo Huang, Pik-Yin Lai and Penger Tong, Physical Review Research 3, 043166 (2021).

13.  “Programmable light-driven swimming actuators via wavelength signal switching”, Kai Hou, Dongshi Guan, Hangyu Li, Yongqi Sun, Yue Long and Kai Song, Science Advances, 7 (37), eabh3051, (2021).

14.  “Distinct dynamics of self-propelled bowl-shaped micromotors caused by shape effect: Concave vs convex”, Duo Wang, Dongshi Guan, Jinghong Su, Xu Zheng and Guoqing Hu, Physics of Fluids, 33(12), 122004 (2021).

15.  “Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte”, QWS Lai, MSS Guo, KQ Wu, Z Liao, D Guan, TT Dong, P Tong and KWK Tsim, Frontiers in Pharmacology, 12:685982 (2021).

16. "State- and rate-dependent contact line dynamics over an aging soft surface,” Dongshi Guan, Elisabeth Charlaix and Penger Tong, Physical Review Letters 124, 188003 (2020).

17.  "Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity,” Menglong Zeng, Xudong Chen, Dongshi Guan, Jia Xu, Haowei Wu, Penger Tong, and Mingjie Zhang, Cell 174, 1172 (2018) (Selected as Cell “Best of 2018”).

18.  "Noncontact viscoelastic imaging of living cells using a long-needle atomic force microscope with duel-frequency modulation," Dongshi Guan, Elisabeth Charlaix, Robert Z. Qi, and Penger Tong, Physical Review Applied 8, 044010 (2017) (Editor’s Suggestion ,  Featured in Physics, see: Probing Cell Squishiness, Physics 10, 117).

19. "Noncontact viscoelastic measurement of polymer thin films in a liquid medium using long-needle atomic force microscopy," Dongshi Guan, Chloé Barraud, Elisabeth Charlaix, and Penger Tong, Langmuir 33, 1385−1390 (2017).

20.  "A simple fabricated thickness-based stiffness gradient for cell studies," Yiwei Shu, Ho Nam Chan, Dongshi Guan, Lan Ma and Hongkai Wu, Science Bulletin 62, 222–228 (2017).

21. "Mechanical characterization of microengineered epithelial cysts by using atomic force microscopy," Yusheng Shen,† Dongshi Guan,† Daniela Serien, Shoji Takeuchi, Penger Tong, Levent Yobas and Pingbo Huang, († authors contributed equally) Biophysical Journal 112, 398–409 (2017).

22.  "Asymmetric and speed-dependent capillary force hysteresis and relaxation of a suddenly stopped moving contact line," Dongshi Guan, Yong Jian Wang, Elisabeth Charlaix and Penger Tong, Physical Review Letters 116, 066102 (2016).

23. "Simultaneous observation of asymmetric speed-dependent capillary force hysteresis and slow relaxation of a suddenly stopped moving contact line," Dongshi Guan, Yong Jian Wang, Elisabeth Charlaix and Penger Tong, Physical Review E 94, 042802 (2016).

24. "Direct measurement of optical force induced by near-field plasmonic cavity using dynamic mode AFM," Dongshi Guan, Zhi Hong Hang, Zsolt Marcet, Hui Liu, I.I. Kravchenko, C. T. Chan, H. B. Chan and Penger Tong, Scientific Reports 5, 16216 (2015).

25.  "The impact of light polarization on imaging visibility of Nth-order intensity correlation with thermal light," Hongchao Liu, Dongshi Guan, Lu Li, Suheng Zhang, Jun Xiong, Optics Communications 283, 405-408, (2010).

26.  "Effect of Light Polarization on Hanbury Brown-Twiss Experiment," Lu Li, Dongshi Guan, Hongchao Liu, Suheng Zhang, Jun Xiong, Acta Sinica Quantum Optica 3, 002, (2009).

1. "Unified description of compressive modulus revealing multi-scale mechanics of living cells", oral, 9th Would Congress of Biomechanics (WCB), Taipei (Virtual), July 10-14, 2022.

2. "State- and rate-dependent contact line dynamics over an aging soft surface," oral, 25th International Congress of Theoretical and Applied Mechanics (ictam2020+1), Milano, Italy (Virtual), August 22-27, 2021. Selected with a Congress Grant.

3. "State- and rate-dependent contact line dynamics over an aging soft surface," oral, APS March Meeting, USA (online), March 15-19, 2021.

4. "Viscoelastic imaging of living cells using a long-needle atomic force microscope," oral, Invited presentation, the Second International Conference of Microfluidics, Nanofluidics and Lab-on-a-Chip, Beijing, June 08-10, 2018.

5. "Viscoelastic imaging of living cells using a noncontact long-needle atomic force microscope," oral, APS March Meeting, Los Angeles, USA, March 05-09, 2018.

6. "Noncontact viscoelastic measurement of polymer thin films in a liquid medium using a long-needle AFM," oral, March Meeting of American Physical Society, New Orleans, USA, March 13-17, 2017.

7. "Asymmetric and speed-dependent contact angle hysteresis and relaxation of a suddenly stopped moving contact line," oral, March Meeting of American Physical Society, Baltimore, USA, March 14-18, 2016.

8. "Viscoelastic mapping of living cells using FM-AFM," poster, Liquids at Interfaces winter school, Les Houches, France, October 25-30, 2015.

9. "Optical force measurement in plasmonic resonant cavities using dynamic mode AFM," oral, March Meeting of the American Physical Society, Baltimore, USA, March 18–22, 2013.

10. "Measurement of giant optical force in plasmonic cavity via dynamic mode atomic force microscope," oral, the 15th Annual Meeting of Physical Society of Hong Kong, City University of Hong Kong, June 16, 2013.